Details for: SCML1

Gene ID: 6322

Symbol: SCML1

Ensembl ID: ENSG00000047634

Description: Scm polycomb group protein like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 188.6268
    Cell Significance Index: -29.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 116.1473
    Cell Significance Index: -29.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 61.2553
    Cell Significance Index: -28.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.6174
    Cell Significance Index: -24.2200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 53.3064
    Cell Significance Index: -27.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.3576
    Cell Significance Index: -24.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.8776
    Cell Significance Index: -29.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.7583
    Cell Significance Index: -28.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.4530
    Cell Significance Index: -29.4100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.8172
    Cell Significance Index: -14.9200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.0525
    Cell Significance Index: -18.5900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.4846
    Cell Significance Index: 23.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.2271
    Cell Significance Index: 86.4700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.2256
    Cell Significance Index: 37.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.0200
    Cell Significance Index: 400.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.6353
    Cell Significance Index: 103.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3937
    Cell Significance Index: 39.9500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.3103
    Cell Significance Index: 10.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2786
    Cell Significance Index: 1154.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1492
    Cell Significance Index: 52.0900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.0582
    Cell Significance Index: 25.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0474
    Cell Significance Index: 28.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0189
    Cell Significance Index: 61.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9349
    Cell Significance Index: 26.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9172
    Cell Significance Index: 19.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5897
    Cell Significance Index: 58.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5372
    Cell Significance Index: 7.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5333
    Cell Significance Index: 27.7100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.5201
    Cell Significance Index: 5.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5151
    Cell Significance Index: 39.5300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4447
    Cell Significance Index: 11.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4056
    Cell Significance Index: 51.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4036
    Cell Significance Index: 22.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3950
    Cell Significance Index: 24.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3642
    Cell Significance Index: 50.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3608
    Cell Significance Index: 72.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3474
    Cell Significance Index: 9.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3049
    Cell Significance Index: 109.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2497
    Cell Significance Index: 17.2700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2234
    Cell Significance Index: 4.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2145
    Cell Significance Index: 136.2600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.2109
    Cell Significance Index: 1.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1951
    Cell Significance Index: 23.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1767
    Cell Significance Index: 6.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1765
    Cell Significance Index: 325.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1688
    Cell Significance Index: 8.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1669
    Cell Significance Index: 314.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1658
    Cell Significance Index: 29.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1601
    Cell Significance Index: 26.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1417
    Cell Significance Index: 218.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1229
    Cell Significance Index: 67.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1184
    Cell Significance Index: 52.3500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0855
    Cell Significance Index: 1.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0763
    Cell Significance Index: 34.6300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0758
    Cell Significance Index: 0.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0628
    Cell Significance Index: 11.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0443
    Cell Significance Index: 7.5700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0331
    Cell Significance Index: 0.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0298
    Cell Significance Index: 1.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0094
    Cell Significance Index: 12.7800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0101
    Cell Significance Index: -1.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0163
    Cell Significance Index: -11.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0213
    Cell Significance Index: -16.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0300
    Cell Significance Index: -3.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0310
    Cell Significance Index: -22.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0339
    Cell Significance Index: -2.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0438
    Cell Significance Index: -24.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0513
    Cell Significance Index: -32.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0689
    Cell Significance Index: -19.8200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0725
    Cell Significance Index: -1.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0797
    Cell Significance Index: -5.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1027
    Cell Significance Index: -13.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1212
    Cell Significance Index: -5.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1432
    Cell Significance Index: -30.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1477
    Cell Significance Index: -6.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1564
    Cell Significance Index: -17.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1570
    Cell Significance Index: -18.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1739
    Cell Significance Index: -20.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1739
    Cell Significance Index: -4.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1864
    Cell Significance Index: -19.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2016
    Cell Significance Index: -5.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2496
    Cell Significance Index: -8.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2513
    Cell Significance Index: -16.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2539
    Cell Significance Index: -6.7800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2694
    Cell Significance Index: -5.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2772
    Cell Significance Index: -6.9300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2924
    Cell Significance Index: -2.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3120
    Cell Significance Index: -24.7100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3288
    Cell Significance Index: -5.5300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.3310
    Cell Significance Index: -5.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3448
    Cell Significance Index: -21.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3633
    Cell Significance Index: -23.4400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.3875
    Cell Significance Index: -4.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3917
    Cell Significance Index: -13.6100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4017
    Cell Significance Index: -5.9300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4261
    Cell Significance Index: -7.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4477
    Cell Significance Index: -19.8100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4705
    Cell Significance Index: -6.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5038
    Cell Significance Index: -25.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SCML1 is a highly conserved protein, with its homologues found in Drosophila and other organisms. The protein exhibits a unique structure, consisting of a N-terminal domain involved in chromatin binding and a C-terminal domain that interacts with histones. SCML1 is specifically expressed in various cell types, including skeletal muscle fibers, anterior lens cells, and hepatoblasts, suggesting its involvement in tissue-specific developmental processes. **Pathways and Functions:** SCML1 is associated with several key pathways, including chromatin binding, histone binding, negative regulation of DNA-templated transcription, and nucleus-specific functions. These pathways highlight SCML1's role in maintaining chromatin structure and regulating gene expression. Specifically, SCML1 has been shown to: 1. **Regulate chromatin structure**: SCML1 interacts with histones, modulating chromatin compaction and accessibility to transcription factors. 2. **Influence transcriptional regulation**: SCML1 acts as a negative regulator of DNA-templated transcription, influencing the expression of target genes. 3. **Maintain cellular identity**: SCML1 is expressed in specific cell types, such as skeletal muscle fibers and lens epithelial cells, suggesting its role in maintaining cellular identity and differentiation. **Clinical Significance:** The dysregulation of SCML1 has been implicated in various diseases, including cancer and developmental disorders. For instance: 1. **Cancer**: SCML1 has been shown to act as a tumor suppressor in certain types of cancer, such as breast cancer. 2. **Developmental disorders**: SCML1 mutations have been associated with developmental abnormalities, such as lens defects and skeletal muscle disorders. 3. **Regenerative medicine**: SCML1's role in maintaining cellular identity and differentiation makes it an attractive target for regenerative therapies, such as stem cell-based treatments for tissue repair and replacement. In conclusion, SCML1 is a crucial epigenetic regulator involved in maintaining chromatin structure, regulating transcriptional activity, and maintaining cellular identity. Its dysregulation has significant implications for various diseases, highlighting the need for further research into the molecular mechanisms underlying SCML1's functions. As an expert immunologist, I emphasize the importance of continued investigation into the role of SCML1 in immune system development and function.

Genular Protein ID: 1716614406

Symbol: SCML1_HUMAN

Name: Sex comb on midleg-like protein 1

UniProtKB Accession Codes:

Q9UN30 B0FZN6 B2RA08 Q5H968 Q5H969

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 4 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 6 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9570953

Title: Characterization of SCML1, a new gene in Xp22, with homology to developmental polycomb genes.

PubMed ID: 9570953

DOI: 10.1006/geno.1998.5224

PubMed ID: 18601738

Title: Adaptive evolution of SCML1 in primates, a gene involved in male reproduction.

PubMed ID: 18601738

DOI: 10.1186/1471-2148-8-192

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

Sequence Information:

  • Length: 329
  • Mass: 37447
  • Checksum: 7B9D3679509DE56E
  • Sequence:
    • MMSNSSSEID VIKTRIPTYD EDDNTILYAY ETKPEFVNKE PNIVSDASCN TEEQLKTVDD 
VLIHCQVIYD ALQNLDKKID VIRRKVSKIQ RFHARSLWTN HKRYGYKKHS YRLVKKLKLQ 
KMKKNEVYET FSYPESYSPT LPVSRRENNS PSNLPRPSFC MEEYQRAELE EDPILSRTPS 
PVHPSDFSEH NCQPYYASDG ATYGSSSGLC LGNPRADSIH NTYSTDHASA APPSVTRSPV 
ENDGYIEEGS ITKHPSTWSV EAVVLFLKQT DPLALCPLVD LFRSHEIDGK ALLLLTSDVL 
LKHLGVKLGT AVKLCYYIDR LKQGKCFEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.