Details for: SCNN1G
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: taste receptor cell (CL0000209)
Fold Change: 5.4941
Cell Significance Index: 63.8700 - Cell Name: epidermal cell (CL0000362)
Fold Change: 3.0772
Cell Significance Index: 6.9400 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.9780
Cell Significance Index: 26.4400 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 2.4847
Cell Significance Index: 25.6300 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 1.6192
Cell Significance Index: 6.2000 - Cell Name: salivary gland glandular cell (CL1001596)
Fold Change: 1.5954
Cell Significance Index: 8.8800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.4254
Cell Significance Index: 64.6100 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.3096
Cell Significance Index: 8.0800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1.1138
Cell Significance Index: -2.4400 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.0309
Cell Significance Index: 24.9700 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.5981
Cell Significance Index: 6.3300 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.5825
Cell Significance Index: 2.0000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.5571
Cell Significance Index: 5.1300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3046
Cell Significance Index: 8.5100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2855
Cell Significance Index: 51.4600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2721
Cell Significance Index: 14.1400 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.1967
Cell Significance Index: 2.8000 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1835
Cell Significance Index: 3.1500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1522
Cell Significance Index: 18.7200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1395
Cell Significance Index: 76.1800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.1319
Cell Significance Index: 1.8000 - Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.1296
Cell Significance Index: 1.4100 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.1268
Cell Significance Index: 2.0900 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.1103
Cell Significance Index: 1.5300 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.0919
Cell Significance Index: 0.6100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0500
Cell Significance Index: 1.3600 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.0383
Cell Significance Index: 0.2500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0204
Cell Significance Index: 7.3200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0190
Cell Significance Index: 8.3900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0158
Cell Significance Index: 1.0600 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.0092
Cell Significance Index: 0.1000 - Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.0091
Cell Significance Index: 0.0200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0005
Cell Significance Index: -0.4000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0019
Cell Significance Index: -3.5300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0022
Cell Significance Index: -4.0300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0029
Cell Significance Index: -4.3900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0030
Cell Significance Index: -0.6000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0031
Cell Significance Index: -4.2500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0041
Cell Significance Index: -1.1900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0061
Cell Significance Index: -4.5000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0066
Cell Significance Index: -4.2200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0074
Cell Significance Index: -5.4700 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: -0.0077
Cell Significance Index: -0.0700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0089
Cell Significance Index: -5.0400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0092
Cell Significance Index: -5.7700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0102
Cell Significance Index: -4.6500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0118
Cell Significance Index: -1.3500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0141
Cell Significance Index: -2.0500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0144
Cell Significance Index: -0.6700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0157
Cell Significance Index: -2.6800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0186
Cell Significance Index: -3.7000 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: -0.0232
Cell Significance Index: -0.2500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0235
Cell Significance Index: -2.7400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0245
Cell Significance Index: -5.1600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0264
Cell Significance Index: -0.6800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0293
Cell Significance Index: -4.0200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0306
Cell Significance Index: -3.9500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0308
Cell Significance Index: -2.1300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0317
Cell Significance Index: -3.2400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0409
Cell Significance Index: -2.8900 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0469
Cell Significance Index: -1.9200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0474
Cell Significance Index: -4.9400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0479
Cell Significance Index: -2.4200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0529
Cell Significance Index: -3.9400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0580
Cell Significance Index: -4.5900 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.0612
Cell Significance Index: -0.8700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0619
Cell Significance Index: -3.9000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0668
Cell Significance Index: -3.4800 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0680
Cell Significance Index: -1.4700 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0681
Cell Significance Index: -0.9800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0719
Cell Significance Index: -5.5200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0735
Cell Significance Index: -4.5200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.0765
Cell Significance Index: -4.6000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0774
Cell Significance Index: -3.6400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0824
Cell Significance Index: -5.0500 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -0.0964
Cell Significance Index: -2.0100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1009
Cell Significance Index: -5.3000 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1032
Cell Significance Index: -3.0400 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.1050
Cell Significance Index: -1.5500 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.1054
Cell Significance Index: -1.5800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1060
Cell Significance Index: -5.9500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1062
Cell Significance Index: -3.9000 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.1132
Cell Significance Index: -2.2100 - Cell Name: fast muscle cell (CL0000190)
Fold Change: -0.1156
Cell Significance Index: -1.5100 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1218
Cell Significance Index: -3.8800 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.1247
Cell Significance Index: -2.1000 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1249
Cell Significance Index: -3.1200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1250
Cell Significance Index: -5.5300 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: -0.1255
Cell Significance Index: -1.2000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1268
Cell Significance Index: -4.0600 - Cell Name: epithelial cell (CL0000066)
Fold Change: -0.1270
Cell Significance Index: -1.3400 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.1271
Cell Significance Index: -1.3500 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1307
Cell Significance Index: -4.5800 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1309
Cell Significance Index: -5.6900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1329
Cell Significance Index: -4.3500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1341
Cell Significance Index: -3.5800 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1358
Cell Significance Index: -4.7200 - Cell Name: ependymal cell (CL0000065)
Fold Change: -0.1375
Cell Significance Index: -1.6200 - Cell Name: thymocyte (CL0000893)
Fold Change: -0.1425
Cell Significance Index: -1.8000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1462
Cell Significance Index: -5.5400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 942791421
Symbol: SCNNG_HUMAN
Name: Amiloride-sensitive sodium channel subunit gamma
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7490094
Title: Cloning, chromosomal localization, and physical linkage of the beta and gamma subunits (SCNN1B and SCNN1G) of the human epithelial amiloride-sensitive sodium channel.
PubMed ID: 7490094
PubMed ID: 7762608
Title: Cloning and expression of the beta- and gamma-subunits of the human epithelial sodium channel.
PubMed ID: 7762608
PubMed ID: 12107247
Title: Novel mutations responsible for autosomal recessive multisystem pseudohypoaldosteronism and sequence variants in epithelial sodium channel alpha-, beta-, and gamma-subunit genes.
PubMed ID: 12107247
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8824247
Title: Genomic organization and the 5' flanking region of the gamma subunit of the human amiloride-sensitive epithelial sodium channel.
PubMed ID: 8824247
PubMed ID: 7550319
Title: Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome.
PubMed ID: 7550319
DOI: 10.1038/ng0995-76
PubMed ID: 9169421
Title: Identification of novel human WW domain-containing proteins by cloning of ligand targets.
PubMed ID: 9169421
PubMed ID: 11244092
Title: The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.
PubMed ID: 11244092
PubMed ID: 12167593
Title: Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel.
PubMed ID: 12167593
PubMed ID: 8640238
Title: A novel splice-site mutation in the gamma subunit of the epithelial sodium channel gene in three pseudohypoaldosteronism type 1 families.
PubMed ID: 8640238
DOI: 10.1038/ng0696-248
PubMed ID: 12473862
Title: Liddle's syndrome associated with a point mutation in the extracellular domain of the epithelial sodium channel gamma subunit.
PubMed ID: 12473862
PubMed ID: 17634077
Title: A novel epithelial sodium channel gamma-subunit de novo frameshift mutation leads to Liddle syndrome.
PubMed ID: 17634077
PubMed ID: 18650438
Title: Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation.
PubMed ID: 18650438
PubMed ID: 19017867
Title: Genetic analysis of Rwandan patients with cystic fibrosis-like symptoms: identification of novel cystic fibrosis transmembrane conductance regulator and epithelial sodium channel gene variants.
PubMed ID: 19017867
PubMed ID: 22207244
Title: Epithelial sodium channels (ENaC) are uniformly distributed on motile cilia in the oviduct and the respiratory airways.
PubMed ID: 22207244
PubMed ID: 22493497
Title: Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9).
PubMed ID: 22493497
PubMed ID: 24124190
Title: Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures.
PubMed ID: 24124190
PubMed ID: 23547933
PubMed ID: 26772908
Title: Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases.
PubMed ID: 26772908
PubMed ID: 10404817
Title: Polymorphisms of amiloride-sensitive sodium channel subunits in five sporadic cases of pseudohypoaldosteronism: do they have pathologic potential?
PubMed ID: 10404817
PubMed ID: 10391210
Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.
PubMed ID: 10391210
DOI: 10.1038/10297
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 18507830
Title: Could a defective epithelial sodium channel lead to bronchiectasis.
PubMed ID: 18507830
Sequence Information:
- Length: 649
- Mass: 74270
- Checksum: F67ED45F03A9BF3F
- Sequence:
MAPGEKIKAK IKKNLPVTGP QAPTIKELMR WYCLNTNTHG CRRIVVSRGR LRRLLWIGFT LTAVALILWQ CALLVFSFYT VSVSIKVHFR KLDFPAVTIC NINPYKYSTV RHLLADLEQE TREALKSLYG FPESRKRREA ESWNSVSEGK QPRFSHRIPL LIFDQDEKGK ARDFFTGRKR KVGGSIIHKA SNVMHIESKQ VVGFQLCSND TSDCATYTFS SGINAIQEWY KLHYMNIMAQ VPLEKKINMS YSAEELLVTC FFDGVSCDAR NFTLFHHPMH GNCYTFNNRE NETILSTSMG GSEYGLQVIL YINEEEYNPF LVSSTGAKVI IHRQDEYPFV EDVGTEIETA MVTSIGMHLT ESFKLSEPYS QCTEDGSDVP IRNIYNAAYS LQICLHSCFQ TKMVEKCGCA QYSQPLPPAA NYCNYQQHPN WMYCYYQLHR AFVQEELGCQ SVCKEACSFK EWTLTTSLAQ WPSVVSEKWL LPVLTWDQGR QVNKKLNKTD LAKLLIFYKD LNQRSIMESP ANSIEMLLSN FGGQLGLWMS CSVVCVIEII EVFFIDFFSI IARRQWQKAK EWWAWKQAPP CPEAPRSPQG QDNPALDIDD DLPTFNSALH LPPALGTQVP GTPPPKYNTL RLERAFSNQL TDTQMLDEL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.