Details for: SCNN1G

Gene ID: 6340

Symbol: SCNN1G

Ensembl ID: ENSG00000166828

Description: sodium channel epithelial 1 subunit gamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 5.4941
    Cell Significance Index: 63.8700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 3.0772
    Cell Significance Index: 6.9400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.9780
    Cell Significance Index: 26.4400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.4847
    Cell Significance Index: 25.6300
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 1.6192
    Cell Significance Index: 6.2000
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 1.5954
    Cell Significance Index: 8.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4254
    Cell Significance Index: 64.6100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.3096
    Cell Significance Index: 8.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.1138
    Cell Significance Index: -2.4400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.0309
    Cell Significance Index: 24.9700
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.5981
    Cell Significance Index: 6.3300
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.5825
    Cell Significance Index: 2.0000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5571
    Cell Significance Index: 5.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3046
    Cell Significance Index: 8.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2855
    Cell Significance Index: 51.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2721
    Cell Significance Index: 14.1400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1967
    Cell Significance Index: 2.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1835
    Cell Significance Index: 3.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1522
    Cell Significance Index: 18.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1395
    Cell Significance Index: 76.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1319
    Cell Significance Index: 1.8000
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.1296
    Cell Significance Index: 1.4100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1268
    Cell Significance Index: 2.0900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1103
    Cell Significance Index: 1.5300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0919
    Cell Significance Index: 0.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0500
    Cell Significance Index: 1.3600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0383
    Cell Significance Index: 0.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0204
    Cell Significance Index: 7.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0190
    Cell Significance Index: 8.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0158
    Cell Significance Index: 1.0600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0092
    Cell Significance Index: 0.1000
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.0091
    Cell Significance Index: 0.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0005
    Cell Significance Index: -0.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0022
    Cell Significance Index: -4.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0029
    Cell Significance Index: -4.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0030
    Cell Significance Index: -0.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0031
    Cell Significance Index: -4.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0041
    Cell Significance Index: -1.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0061
    Cell Significance Index: -4.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0066
    Cell Significance Index: -4.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0074
    Cell Significance Index: -5.4700
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0077
    Cell Significance Index: -0.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0089
    Cell Significance Index: -5.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0092
    Cell Significance Index: -5.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0102
    Cell Significance Index: -4.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0118
    Cell Significance Index: -1.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0141
    Cell Significance Index: -2.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0144
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0157
    Cell Significance Index: -2.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0186
    Cell Significance Index: -3.7000
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0232
    Cell Significance Index: -0.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0235
    Cell Significance Index: -2.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0245
    Cell Significance Index: -5.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0264
    Cell Significance Index: -0.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0293
    Cell Significance Index: -4.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0306
    Cell Significance Index: -3.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0308
    Cell Significance Index: -2.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0317
    Cell Significance Index: -3.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0409
    Cell Significance Index: -2.8900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0469
    Cell Significance Index: -1.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0474
    Cell Significance Index: -4.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0479
    Cell Significance Index: -2.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0529
    Cell Significance Index: -3.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0580
    Cell Significance Index: -4.5900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0612
    Cell Significance Index: -0.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0619
    Cell Significance Index: -3.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0668
    Cell Significance Index: -3.4800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0680
    Cell Significance Index: -1.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0681
    Cell Significance Index: -0.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0719
    Cell Significance Index: -5.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0735
    Cell Significance Index: -4.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0765
    Cell Significance Index: -4.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0774
    Cell Significance Index: -3.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0824
    Cell Significance Index: -5.0500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0964
    Cell Significance Index: -2.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1009
    Cell Significance Index: -5.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1032
    Cell Significance Index: -3.0400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1050
    Cell Significance Index: -1.5500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1054
    Cell Significance Index: -1.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1060
    Cell Significance Index: -5.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1062
    Cell Significance Index: -3.9000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1132
    Cell Significance Index: -2.2100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1156
    Cell Significance Index: -1.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1218
    Cell Significance Index: -3.8800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1247
    Cell Significance Index: -2.1000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1249
    Cell Significance Index: -3.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1250
    Cell Significance Index: -5.5300
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.1255
    Cell Significance Index: -1.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1268
    Cell Significance Index: -4.0600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1270
    Cell Significance Index: -1.3400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.1271
    Cell Significance Index: -1.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1307
    Cell Significance Index: -4.5800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1309
    Cell Significance Index: -5.6900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1329
    Cell Significance Index: -4.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1341
    Cell Significance Index: -3.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1358
    Cell Significance Index: -4.7200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1375
    Cell Significance Index: -1.6200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1425
    Cell Significance Index: -1.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1462
    Cell Significance Index: -5.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Function:** The SCNN1G gene encodes for a subunit of the ENaC complex, which is responsible for regulating sodium ion transport across epithelial membranes. 2. **Expression:** The SCNN1G gene is highly expressed in the kidney, taste buds, and the central nervous system, highlighting its importance in multiple physiological processes. 3. **Pathway involvement:** SCNN1G is involved in various signaling pathways, including the regulation of blood pressure, cellular response to acidic pH, and cellular response to aldosterone. 4. **Binding partners:** SCNN1G interacts with other subunits of the ENaC complex, as well as with other proteins, to regulate its activity. **Pathways and Functions:** 1. **Ion Homeostasis:** ENaC, which contains the SCNN1G subunit, regulates sodium ion transport across epithelial membranes, maintaining sodium balance and blood pressure. 2. **Taste Perception:** SCNN1G is expressed in taste receptor cells and is involved in the regulation of salty and sour taste. 3. **Regulation of Blood Pressure:** ENaC activity is modulated by various hormones and signaling pathways, including the renin-angiotensin system, to regulate blood pressure. 4. **Neurotransmission:** SCNN1G interacts with other subunits of the ENaC complex and with G-proteins to modulate neurotransmitter release and synaptic transmission. **Clinical Significance:** 1. **Hypertension:** Dysregulation of ENaC activity, mediated by the SCNN1G gene, has been implicated in the development of hypertension. 2. **Taste Disorders:** Mutations in the SCNN1G gene have been associated with taste disorders, including impaired salty and sour taste perception. 3. **Neurological Disorders:** SCNN1G has been implicated in various neurological disorders, including epilepsy, Parkinson's disease, and Alzheimer's disease. 4. **Cancer:** ENaC activity has been linked to cancer progression, and SCNN1G has been identified as a potential target for cancer therapy. In conclusion, the SCNN1G gene plays a critical role in regulating ion homeostasis, taste perception, and blood pressure. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of ENaC activity and its potential therapeutic applications.

Genular Protein ID: 942791421

Symbol: SCNNG_HUMAN

Name: Amiloride-sensitive sodium channel subunit gamma

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7490094

Title: Cloning, chromosomal localization, and physical linkage of the beta and gamma subunits (SCNN1B and SCNN1G) of the human epithelial amiloride-sensitive sodium channel.

PubMed ID: 7490094

DOI: 10.1006/geno.1995.1188

PubMed ID: 7762608

Title: Cloning and expression of the beta- and gamma-subunits of the human epithelial sodium channel.

PubMed ID: 7762608

DOI: 10.1152/ajpcell.1995.268.5.c1157

PubMed ID: 12107247

Title: Novel mutations responsible for autosomal recessive multisystem pseudohypoaldosteronism and sequence variants in epithelial sodium channel alpha-, beta-, and gamma-subunit genes.

PubMed ID: 12107247

DOI: 10.1210/jcem.87.7.8674

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8824247

Title: Genomic organization and the 5' flanking region of the gamma subunit of the human amiloride-sensitive epithelial sodium channel.

PubMed ID: 8824247

DOI: 10.1074/jbc.271.42.26062

PubMed ID: 7550319

Title: Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome.

PubMed ID: 7550319

DOI: 10.1038/ng0995-76

PubMed ID: 9169421

Title: Identification of novel human WW domain-containing proteins by cloning of ligand targets.

PubMed ID: 9169421

DOI: 10.1074/jbc.272.23.14611

PubMed ID: 11244092

Title: The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.

PubMed ID: 11244092

DOI: 10.1074/jbc.c000906200

PubMed ID: 12167593

Title: Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel.

PubMed ID: 12167593

DOI: 10.1152/ajprenal.00080.2002

PubMed ID: 8640238

Title: A novel splice-site mutation in the gamma subunit of the epithelial sodium channel gene in three pseudohypoaldosteronism type 1 families.

PubMed ID: 8640238

DOI: 10.1038/ng0696-248

PubMed ID: 12473862

Title: Liddle's syndrome associated with a point mutation in the extracellular domain of the epithelial sodium channel gamma subunit.

PubMed ID: 12473862

DOI: 10.1097/00004872-200212000-00017

PubMed ID: 17634077

Title: A novel epithelial sodium channel gamma-subunit de novo frameshift mutation leads to Liddle syndrome.

PubMed ID: 17634077

DOI: 10.1111/j.1365-2265.2007.02967.x

PubMed ID: 18650438

Title: Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation.

PubMed ID: 18650438

DOI: 10.1074/jbc.m803931200

PubMed ID: 19017867

Title: Genetic analysis of Rwandan patients with cystic fibrosis-like symptoms: identification of novel cystic fibrosis transmembrane conductance regulator and epithelial sodium channel gene variants.

PubMed ID: 19017867

DOI: 10.1378/chest.08-2246

PubMed ID: 22207244

Title: Epithelial sodium channels (ENaC) are uniformly distributed on motile cilia in the oviduct and the respiratory airways.

PubMed ID: 22207244

DOI: 10.1007/s00418-011-0904-1

PubMed ID: 22493497

Title: Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9).

PubMed ID: 22493497

DOI: 10.1074/jbc.m112.363382

PubMed ID: 24124190

Title: Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures.

PubMed ID: 24124190

DOI: 10.1152/ajplung.00103.2013

PubMed ID: 23547933

Title: ENaC modulators and renal disease.

PubMed ID: 23547933

DOI: 10.2174/1874467211306010005

PubMed ID: 26772908

Title: Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases.

PubMed ID: 26772908

DOI: 10.1016/j.gene.2015.12.061

PubMed ID: 10404817

Title: Polymorphisms of amiloride-sensitive sodium channel subunits in five sporadic cases of pseudohypoaldosteronism: do they have pathologic potential?

PubMed ID: 10404817

DOI: 10.1210/jcem.84.7.5857

PubMed ID: 10391210

Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

PubMed ID: 10391210

DOI: 10.1038/10297

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 18507830

Title: Could a defective epithelial sodium channel lead to bronchiectasis.

PubMed ID: 18507830

DOI: 10.1186/1465-9921-9-46

Sequence Information:

  • Length: 649
  • Mass: 74270
  • Checksum: F67ED45F03A9BF3F
  • Sequence:
  • MAPGEKIKAK IKKNLPVTGP QAPTIKELMR WYCLNTNTHG CRRIVVSRGR LRRLLWIGFT 
    LTAVALILWQ CALLVFSFYT VSVSIKVHFR KLDFPAVTIC NINPYKYSTV RHLLADLEQE 
    TREALKSLYG FPESRKRREA ESWNSVSEGK QPRFSHRIPL LIFDQDEKGK ARDFFTGRKR 
    KVGGSIIHKA SNVMHIESKQ VVGFQLCSND TSDCATYTFS SGINAIQEWY KLHYMNIMAQ 
    VPLEKKINMS YSAEELLVTC FFDGVSCDAR NFTLFHHPMH GNCYTFNNRE NETILSTSMG 
    GSEYGLQVIL YINEEEYNPF LVSSTGAKVI IHRQDEYPFV EDVGTEIETA MVTSIGMHLT 
    ESFKLSEPYS QCTEDGSDVP IRNIYNAAYS LQICLHSCFQ TKMVEKCGCA QYSQPLPPAA 
    NYCNYQQHPN WMYCYYQLHR AFVQEELGCQ SVCKEACSFK EWTLTTSLAQ WPSVVSEKWL 
    LPVLTWDQGR QVNKKLNKTD LAKLLIFYKD LNQRSIMESP ANSIEMLLSN FGGQLGLWMS 
    CSVVCVIEII EVFFIDFFSI IARRQWQKAK EWWAWKQAPP CPEAPRSPQG QDNPALDIDD 
    DLPTFNSALH LPPALGTQVP GTPPPKYNTL RLERAFSNQL TDTQMLDEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.