Details for: SDHA
Gene ID: 6389
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SDHA
Ensembl ID: ENSG00000073578
Description: succinate dehydrogenase complex flavoprotein subunit A
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 23.28rCSI 51.44%PRS 27.9
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CSI 17.96rCSI 28.96%PRS 47.76
-
CSI 14.83rCSI 19.02%PRS 42.23
-
CSI 14.22rCSI 10.65%PRS 51.97
-
CSI 14.18rCSI 24.25%PRS 58.68
-
CSI 14.02rCSI 16.46%PRS 41.57
-
CSI 13.97rCSI 21.37%PRS 54.03
-
CSI 12.62rCSI 18.47%PRS 40.28
-
CSI 12.27rCSI 11.83%PRS 29.46
-
CSI 11.89rCSI 12.43%PRS 37.71
-
CSI 11.46rCSI 16.45%PRS 30.36
-
CSI 9.12rCSI 20.36%PRS 43.62
-
CSI 8.73rCSI 8.71%PRS 32.59
-
CSI 8.46rCSI 6.07%PRS 49.57
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CSI 7.28rCSI 11.13%PRS 46.31
-
CSI 7rCSI 7.34%PRS 35.34
-
CSI 6.99rCSI 10.54%PRS 39.18
-
CSI 6.35rCSI 23.79%PRS 32.08
-
CSI 6.28rCSI 15.95%PRS 35.06
-
CSI 6.19rCSI 22.42%PRS 56.2
-
CSI 6.16rCSI 30.36%PRS 48.57
-
CSI 5.72rCSI 7.34%PRS 36
-
CSI 5.36rCSI 6.67%PRS 23.04
-
CSI 5.28rCSI 11.69%PRS 35.09
-
CSI 5.04rCSI 37.83%PRS 58.36
-
CSI 5.03rCSI 11.97%PRS 50.29
-
CSI 4.75rCSI 27.22%PRS 48.78
-
CSI 4.67rCSI 8.19%PRS 30.93
-
CSI 4.5rCSI 11.86%PRS 60.79
-
CSI 4.31rCSI 3.26%PRS 49.14
-
CSI 4.29rCSI 4.13%PRS 38.44
-
CSI 4.28rCSI 3.32%PRS 37.65
-
CSI 4.28rCSI 4.2%PRS 52.44
-
CSI 4.2rCSI 7.2%PRS 46.91
-
CSI 4.18rCSI 13.44%PRS 37.67
-
CSI 4.1rCSI 19.63%PRS 35.77
-
CSI 4.01rCSI 2.67%PRS 64.36
-
CSI 3.92rCSI 9.52%PRS 23.63
-
CSI 3.74rCSI 8.38%PRS 24.87
-
CSI 3.67rCSI 5%PRS 66.14
-
CSI 3.42rCSI 2.87%PRS 42.84
-
CSI 3.41rCSI 52.8%PRS 65.73
-
CSI 3.39rCSI 9.62%PRS 38.24
-
CSI 3.36rCSI 2.55%PRS 47.93
-
CSI 3.32rCSI 5.85%PRS 46.1
-
CSI 3.3rCSI 3.01%PRS 52.27
-
CSI 3.27rCSI 4.46%PRS 42.19
-
CSI 3.25rCSI 2.69%PRS 38.52
-
CSI 3.16rCSI 6.15%PRS 39.32
-
CSI 3.16rCSI 3.91%PRS 33.96
-
CSI 3.16rCSI 2.36%PRS 55.86
-
CSI 3.15rCSI 4.04%PRS 34.58
-
CSI 3.08rCSI 2.47%PRS 58.71
-
CSI 3.07rCSI 4.26%PRS 43.83
-
CSI 3.07rCSI 12.4%PRS 36.45
-
CSI 3.02rCSI 4.63%PRS 41.86
-
CSI 3.01rCSI 3.83%PRS 42.6
-
CSI 2.99rCSI 3.51%PRS 51.86
-
CSI 2.93rCSI 4.71%PRS 26.22
-
CSI 2.77rCSI 1.86%PRS 46.72
-
CSI 2.75rCSI 7.86%PRS 52.75
-
CSI 2.74rCSI 3.75%PRS 40.49
-
CSI 2.68rCSI 3.73%PRS 37.64
-
CSI 2.68rCSI 2.79%PRS 38.31
-
CSI 2.67rCSI 54.35%PRS 31.63
-
CSI 2.66rCSI 1.85%PRS 45.25
-
CSI 2.61rCSI 2.99%PRS 60.84
-
CSI 2.61rCSI 7.48%PRS 53.9
-
CSI 2.59rCSI 52.82%PRS 32.86
-
CSI 2.53rCSI 5.94%PRS 47.36
-
CSI 2.52rCSI 12.65%PRS 47.94
-
CSI 2.49rCSI 1.73%PRS 49.71
-
CSI 2.42rCSI 2.14%PRS 37.15
-
CSI 2.39rCSI 2.26%PRS 38.87
-
CSI 2.39rCSI 2.01%PRS 54.4
-
CSI 2.38rCSI 1.66%PRS 39.47
-
CSI 2.37rCSI 2.14%PRS 34.7
-
CSI 2.34rCSI 9.11%PRS 57.18
-
CSI 2.33rCSI 3.77%PRS 36.69
-
CSI 2.29rCSI 5.78%PRS 45.36
-
CSI 2.26rCSI 1.84%PRS 38.7
-
CSI 2.26rCSI 2.42%PRS 35.57
-
CSI 2.25rCSI 1.77%PRS 43.68
-
CSI 2.17rCSI 3.07%PRS 47.3
-
CSI 2.17rCSI 9.62%PRS 36.41
-
CSI 2.17rCSI 5.2%PRS 54.66
-
CSI 2.16rCSI 2.88%PRS 41.81
-
CSI 2.11rCSI 1.93%PRS 44.27
-
CSI 2.1rCSI 29.75%PRS 31.46
-
CSI 2.09rCSI 2.63%PRS 46.75
-
CSI 2.08rCSI 3.04%PRS 48.08
-
CSI 2.07rCSI 6.48%PRS 25.39
-
CSI 2.07rCSI 1.59%PRS 36.19
-
CSI 2.03rCSI 3.1%PRS 34.95
-
CSI 2.02rCSI 3.22%PRS 32.49
-
CSI 2.01rCSI 2.33%PRS 48.55
-
CSI 2.01rCSI 1.73%PRS 47.31
-
CSI 1.99rCSI 1.84%PRS 57.96
-
CSI 1.98rCSI 1.64%PRS 36.28
-
CSI 1.98rCSI 4.53%PRS 37.19
-
CSI 0.1rCSI 0.7%PRS 50.1%
-
CSI 0.2rCSI 3.0%PRS 73.6%
-
CSI 0.2rCSI 1.2%PRS 61.6%
-
CSI 0.2rCSI 3.6%PRS 65.1%
-
CSI 0.2rCSI 3.2%PRS 72.2%
-
CSI 0.3rCSI 2.3%PRS 64.6%
-
CSI 0.4rCSI 2.0%PRS 48.9%
-
CSI 0.4rCSI 3.9%PRS 55.1%
-
CSI 0.4rCSI 7.7%PRS 84.9%
-
CSI 0.4rCSI 0.9%PRS 58.1%
-
CSI 0.5rCSI 4.2%PRS 79.0%
-
CSI 0.5rCSI 1.7%PRS 53.8%
-
CSI 0.5rCSI 1.9%PRS 51.4%
-
CSI 0.5rCSI 0.9%PRS 24.3%
-
CSI 0.5rCSI 1.8%PRS 48.7%
-
CSI 0.5rCSI 1.8%PRS 31.3%
-
CSI 0.5rCSI 3.5%PRS 60.6%
-
CSI 0.6rCSI 1.5%PRS 53.5%
-
CSI 0.6rCSI 2.6%PRS 65.3%
-
CSI 0.6rCSI 14.6%PRS 24.6%
-
CSI 0.6rCSI 2.3%PRS 23.3%
-
CSI 0.7rCSI 1.3%PRS 46.9%
-
CSI 0.7rCSI 16.0%PRS 23.8%
-
CSI 0.7rCSI 1.6%PRS 36.8%
-
CSI 0.7rCSI 1.3%PRS 58.3%
-
CSI 0.7rCSI 1.4%PRS 28.9%
-
CSI 0.8rCSI 2.4%PRS 34.7%
-
CSI 0.8rCSI 1.0%PRS 50.8%
-
CSI 0.8rCSI 2.2%PRS 52.6%
-
CSI 0.8rCSI 1.7%PRS 52.7%
-
CSI 0.8rCSI 1.1%PRS 32.5%
-
CSI 0.9rCSI 1.4%PRS 29.8%
-
CSI 0.9rCSI 1.2%PRS 53.1%
-
CSI 0.9rCSI 1.7%PRS 61.2%
-
CSI 0.9rCSI 1.8%PRS 55.5%
-
CSI 0.9rCSI 0.8%PRS 41.4%
-
CSI 0.9rCSI 2.8%PRS 27.4%
-
CSI 0.9rCSI 2.9%PRS 46.0%
-
CSI 0.9rCSI 2.6%PRS 55.8%
-
CSI 0.9rCSI 1.1%PRS 56.4%
-
CSI 0.9rCSI 1.0%PRS 29.1%
-
CSI 0.9rCSI 1.1%PRS 24.3%
-
CSI 0.9rCSI 2.4%PRS 34.5%
-
CSI 0.9rCSI 1.4%PRS 44.0%
-
CSI 0.9rCSI 1.6%PRS 63.9%
-
CSI 1.0rCSI 1.7%PRS 53.8%
-
CSI 1.0rCSI 3.2%PRS 41.4%
-
CSI 1.0rCSI 1.8%PRS 23.5%
-
CSI 1.0rCSI 1.6%PRS 38.5%
-
CSI 1.0rCSI 1.9%PRS 53.5%
-
CSI 1.1rCSI 1.1%PRS 49.9%
-
CSI 1.1rCSI 1.7%PRS 47.3%
-
CSI 1.1rCSI 2.3%PRS 47.5%
-
CSI 1.1rCSI 2.7%PRS 69.7%
-
CSI 1.1rCSI 2.6%PRS 43.4%
-
CSI 1.1rCSI 1.0%PRS 38.8%
-
CSI 1.1rCSI 0.9%PRS 38.2%
-
CSI 1.1rCSI 1.6%PRS 47.7%
-
CSI 1.1rCSI 4.4%PRS 47.1%
-
CSI 1.2rCSI 1.0%PRS 46.1%
-
CSI 1.2rCSI 0.8%PRS 41.8%
-
CSI 1.2rCSI 3.0%PRS 47.2%
-
CSI 1.2rCSI 2.6%PRS 41.6%
-
CSI 1.2rCSI 1.4%PRS 57.3%
-
CSI 1.2rCSI 1.7%PRS 40.5%
-
CSI 1.2rCSI 1.7%PRS 45.6%
-
CSI 1.2rCSI 3.5%PRS 30.5%
-
CSI 1.2rCSI 1.7%PRS 58.3%
-
CSI 1.2rCSI 3.3%PRS 46.5%
-
CSI 1.2rCSI 1.8%PRS 34.7%
-
CSI 1.2rCSI 2.2%PRS 29.7%
-
CSI 1.3rCSI 2.3%PRS 36.1%
-
CSI 1.3rCSI 1.7%PRS 50.5%
-
CSI 1.3rCSI 3.7%PRS 40.5%
-
CSI 1.3rCSI 3.1%PRS 54.7%
-
CSI 1.3rCSI 3.5%PRS 44.4%
-
CSI 1.3rCSI 3.5%PRS 36.8%
-
CSI 1.3rCSI 1.8%PRS 39.5%
-
CSI 1.4rCSI 2.1%PRS 42.1%
-
CSI 1.4rCSI 2.0%PRS 42.1%
-
CSI 1.4rCSI 3.4%PRS 35.9%
-
CSI 1.4rCSI 2.0%PRS 38.4%
-
CSI 1.4rCSI 1.0%PRS 40.6%
-
CSI 1.4rCSI 1.9%PRS 35.3%
-
CSI 1.4rCSI 8.1%PRS 25.5%
-
CSI 1.4rCSI 1.3%PRS 37.5%
-
CSI 1.4rCSI 2.2%PRS 35.9%
-
CSI 1.4rCSI 1.3%PRS 28.4%
-
CSI 1.4rCSI 2.1%PRS 51.5%
-
CSI 1.4rCSI 2.3%PRS 32.0%
-
CSI 1.4rCSI 9.0%PRS 31.3%
-
CSI 1.5rCSI 3.7%PRS 29.7%
-
CSI 1.5rCSI 1.3%PRS 47.0%
-
CSI 1.5rCSI 1.8%PRS 40.2%
-
CSI 1.5rCSI 2.0%PRS 50.4%
-
CSI 1.5rCSI 2.9%PRS 67.6%
-
CSI 1.5rCSI 2.6%PRS 36.6%
-
CSI 1.5rCSI 3.0%PRS 29.0%
-
CSI 1.5rCSI 2.3%PRS 64.8%
-
CSI 1.5rCSI 1.2%PRS 59.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2260173416
Symbol: SDHA_HUMAN
Name: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7798181
Title: Human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the flavoprotein (Fp) subunit of liver mitochondria.
PubMed ID: 7798181
PubMed ID: 8142412
Title: The cDNA sequence of the flavoprotein subunit of human heart succinate dehydrogenase.
PubMed ID: 8142412
PubMed ID: 10746566
Title: Compound heterozygous mutations in the flavoprotein gene of the respiratory chain complex II in a patient with Leigh syndrome.
PubMed ID: 10746566
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7550341
Title: Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency.
PubMed ID: 7550341
DOI: 10.1038/ng1095-144
PubMed ID: 15242332
Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.
PubMed ID: 15242332
DOI: 10.1042/bj20040647
PubMed ID: 19628817
Title: SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.
PubMed ID: 19628817
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20484225
Title: SDHA is a tumor suppressor gene causing paraganglioma.
PubMed ID: 20484225
DOI: 10.1093/hmg/ddq206
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22823520
Title: Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components.
PubMed ID: 22823520
DOI: 10.1042/bj20120509
PubMed ID: 23747254
Title: The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase.
PubMed ID: 23747254
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28593945
Title: Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes.
PubMed ID: 28593945
DOI: 10.1038/ncomms15614
PubMed ID: 32887801
Title: The roles of SDHAF2 and dicarboxylate in covalent flavinylation of SDHA, the human complex II flavoprotein.
PubMed ID: 32887801
PubMed ID: 37098072
Title: Structure of the human respiratory complex II.
PubMed ID: 37098072
PubMed ID: 10976639
Title: Late-onset optic atrophy, ataxia, and myopathy associated with a mutation of a complex II gene.
PubMed ID: 10976639
DOI: 10.1002/1531-8249(200009)48:3<330::aid-ana7>3.3.co;2-1
PubMed ID: 12794685
Title: Homozygous Gly555Glu mutation in the nuclear-encoded 70 kDa flavoprotein gene causes instability of the respiratory chain complex II.
PubMed ID: 12794685
DOI: 10.1002/ajmg.a.10202
PubMed ID: 20551992
Title: Familial neonatal isolated cardiomyopathy caused by a mutation in the flavoprotein subunit of succinate dehydrogenase.
PubMed ID: 20551992
DOI: 10.1038/ejhg.2010.83
PubMed ID: 24781757
Title: SDHA mutations causing a multisystem mitochondrial disease: novel mutations and genetic overlap with hereditary tumors.
PubMed ID: 24781757
DOI: 10.1038/ejhg.2014.80
PubMed ID: 22972948
Title: Recessive germline SDHA and SDHB mutations causing leukodystrophy and isolated mitochondrial complex II deficiency.
PubMed ID: 22972948
PubMed ID: 26642834
Title: Magnetic resonance imaging spectrum of succinate dehydrogenase-related infantile leukoencephalopathy.
PubMed ID: 26642834
DOI: 10.1002/ana.24572
PubMed ID: 27683074
Title: SDHA mutation with dominant transmission results in complex II deficiency with ocular, cardiac, and neurologic involvement.
PubMed ID: 27683074
DOI: 10.1002/ajmg.a.37986
Sequence Information:
- Length: 664
- Mass: 72692
- Checksum: 180B664E3FFD0B34
- Sequence:
MSGVRGLSRL LSARRLALAK AWPTVLQTGT RGFHFTVDGN KRASAKVSDS ISAQYPVVDH EFDAVVVGAG GAGLRAAFGL SEAGFNTACV TKLFPTRSHT VAAQGGINAA LGNMEEDNWR WHFYDTVKGS DWLGDQDAIH YMTEQAPAAV VELENYGMPF SRTEDGKIYQ RAFGGQSLKF GKGGQAHRCC CVADRTGHSL LHTLYGRSLR YDTSYFVEYF ALDLLMENGE CRGVIALCIE DGSIHRIRAK NTVVATGGYG RTYFSCTSAH TSTGDGTAMI TRAGLPCQDL EFVQFHPTGI YGAGCLITEG CRGEGGILIN SQGERFMERY APVAKDLASR DVVSRSMTLE IREGRGCGPE KDHVYLQLHH LPPEQLATRL PGISETAMIF AGVDVTKEPI PVLPTVHYNM GGIPTNYKGQ VLRHVNGQDQ IVPGLYACGE AACASVHGAN RLGANSLLDL VVFGRACALS IEESCRPGDK VPPIKPNAGE ESVMNLDKLR FADGSIRTSE LRLSMQKSMQ NHAAVFRVGS VLQEGCGKIS KLYGDLKHLK TFDRGMVWNT DLVETLELQN LMLCALQTIY GAEARKESRG AHAREDYKVR IDEYDYSKPI QGQQKKPFEE HWRKHTLSYV DVGTGKVTLE YRPVIDKTLN EADCATVPPA IRSY
Genular Protein ID: 894893134
Symbol: D6RFM5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 583
- Mass: 63567
- Checksum: 0ED1155D7A99BA9A
- Sequence:
MSGVRGLSRL LSARRLALAK AWPTVLQTGT RGFHFTVDGN KRASAKVSDS ISAQYPVVDH EFDAVVVGAG GAGLRAAFGL SEAGFNTACV TKLFPTRSHT VAAQGGINAA LGNMEEDNWR WHFYDTVKGS DWLGDQDAIH YMTEQAPAAV VELENYGMPF SRTEDGKIYQ RAFGGQSLKF GKGGQAHRCC CVADRTGHSL LHTLYGRSLR YDTSYFVEYF ALDLLMENGE CRGVIALCIE DGSIHRIRAK NTVVATGGYG RTYFSCTSAH TSTGDGTAMI TRAGLPCQDL EFVQFHPTGI YGAGCLITEG CRGEGGILIN SQGERFMERY APVAKDLASR DVVSRSMTLE IREGRGCGPE KDHVYLQLHH LPPEQLATRL PGISETAMIF AGVDVTKEPI PVLPTVHYNM GGIPTNYKGQ VLRHVNGQDQ IVPGLYACGE AACASVHGAN RLGANSLLDL VVFGRACALS IEESCRPGDK VPPIKPNAGE ESVMNLDKLR FADGSIRTSE LRLSMQKVRI DEYDYSKPIQ GQQKKPFEEH WRKHTLSYVD VGTGKVTLEY RPVIDKTLNE ADCATVPPAI RSY