Details for: SRSF6

Gene ID: 6431

Symbol: SRSF6

Ensembl ID: ENSG00000124193

Description: serine and arginine rich splicing factor 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.13
    Marker Score: 72433
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.04
    Marker Score: 20663
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.03
    Marker Score: 2283
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.97
    Marker Score: 2106
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.93
    Marker Score: 5163
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.88
    Marker Score: 4734
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.78
    Marker Score: 2952
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.61
    Marker Score: 3362
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.61
    Marker Score: 6932
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.6
    Marker Score: 6280
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.6
    Marker Score: 2788
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.59
    Marker Score: 1616
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.58
    Marker Score: 54811
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.58
    Marker Score: 1673
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.57
    Marker Score: 17738
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.57
    Marker Score: 1050
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.57
    Marker Score: 586
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.56
    Marker Score: 2305
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.56
    Marker Score: 1670
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.54
    Marker Score: 4260
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.52
    Marker Score: 1092
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.51
    Marker Score: 2568
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.51
    Marker Score: 1485
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.51
    Marker Score: 6166
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.5
    Marker Score: 5559
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.5
    Marker Score: 1592
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.49
    Marker Score: 1693
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.47
    Marker Score: 591
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.46
    Marker Score: 348
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.44
    Marker Score: 356
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.44
    Marker Score: 697
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.42
    Marker Score: 2016
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.4
    Marker Score: 4975
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.38
    Marker Score: 3305
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.37
    Marker Score: 765
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.37
    Marker Score: 823
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.36
    Marker Score: 320
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.36
    Marker Score: 1416
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.36
    Marker Score: 6690
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.36
    Marker Score: 3090
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.35
    Marker Score: 465
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.34
    Marker Score: 915
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.34
    Marker Score: 468
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.33
    Marker Score: 1251
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.32
    Marker Score: 2033
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.32
    Marker Score: 380
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.31
    Marker Score: 639
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.31
    Marker Score: 532
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.3
    Marker Score: 2447
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.3
    Marker Score: 490
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.3
    Marker Score: 2063
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.29
    Marker Score: 457
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.29
    Marker Score: 488
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.29
    Marker Score: 1355
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.29
    Marker Score: 1181
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.28
    Marker Score: 318
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.27
    Marker Score: 1573
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.27
    Marker Score: 403
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.27
    Marker Score: 4889
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.27
    Marker Score: 1346
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.27
    Marker Score: 674
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.26
    Marker Score: 655
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.26
    Marker Score: 476
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.26
    Marker Score: 786
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.26
    Marker Score: 526
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.25
    Marker Score: 1344
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.24
    Marker Score: 317.5
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.24
    Marker Score: 363
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.24
    Marker Score: 69398
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.23
    Marker Score: 839
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.23
    Marker Score: 16200
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.22
    Marker Score: 268
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.22
    Marker Score: 2433
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 1.22
    Marker Score: 360
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.22
    Marker Score: 799
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.22
    Marker Score: 275
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.21
    Marker Score: 765
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.21
    Marker Score: 761
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.21
    Marker Score: 810
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.21
    Marker Score: 2753
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.21
    Marker Score: 7166
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.2
    Marker Score: 385
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.2
    Marker Score: 597
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 1.19
    Marker Score: 464
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.19
    Marker Score: 543
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.19
    Marker Score: 1193
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.19
    Marker Score: 1060
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.18
    Marker Score: 483
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.18
    Marker Score: 1177
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.18
    Marker Score: 530
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.17
    Marker Score: 2790
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 1.17
    Marker Score: 353
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.17
    Marker Score: 7642
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.17
    Marker Score: 2759
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.17
    Marker Score: 712
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.17
    Marker Score: 6147
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.17
    Marker Score: 4017
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.17
    Marker Score: 1506
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.16
    Marker Score: 2459
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.16
    Marker Score: 260

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** SRSF6 is a member of the serine/arginine (SR) protein family, characterized by its rich content of serine and arginine residues. It belongs to the Arg/RS domain-containing protein family, which is involved in RNA binding and splicing regulation. SRSF6 is a heterochromatic protein that localizes to nuclear specks, where it interacts with other RNA-binding proteins to regulate alternative splicing. **Pathways and Functions:** SRSF6 is involved in various RNA processing pathways, including: 1. **Alternative mRNA splicing**: SRSF6 regulates the inclusion or exclusion of specific exons in pre-mRNA, leading to the production of diverse isoforms. 2. **Gene expression (transcription)**: SRSF6 interacts with RNA polymerase II to regulate transcription initiation and elongation. 3. **Metabolism of RNA**: SRSF6 is involved in RNA processing, including 3'-end processing and transport of mature mRNA. 4. **Negative regulation of keratinocyte differentiation**: SRSF6 represses the expression of genes involved in keratinocyte differentiation. 5. **Negative regulation of type B pancreatic cell apoptotic process**: SRSF6 inhibits apoptosis in type B pancreatic cells. 6. **Positive regulation of epithelial cell proliferation involved in lung morphogenesis**: SRSF6 promotes epithelial cell proliferation during lung development. 7. **Regulation of alternative mRNA splicing**: SRSF6 regulates the inclusion or exclusion of specific exons in pre-mRNA. **Clinical Significance:** Dysregulation of SRSF6 has been implicated in various diseases, including: 1. **Cancer**: Alterations in SRSF6 expression have been observed in several types of cancer, including lung, breast, and colon cancer. 2. **Neurological disorders**: SRSF6 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Wound healing**: SRSF6 plays a critical role in wound healing, and its dysregulation can impair tissue repair. In conclusion, SRSF6 is a multifunctional protein that plays a crucial role in regulating alternative splicing and various cellular processes. Its dysregulation has been implicated in several diseases, highlighting the importance of SRSF6 in maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the functions of SRSF6 and its role in human disease.

Genular Protein ID: 1581535607

Symbol: SRSF6_HUMAN

Name: Serine/arginine-rich splicing factor 6

UniProtKB Accession Codes:

Q13247 B7Z6J3 E1P5W6 Q13244 Q13245 Q96J06 Q9UJB8 Q9Y3N7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7556075

Title: Identification and characterization of three members of the human SR family of pre-mRNA splicing factors.

PubMed ID: 7556075

DOI: 10.1002/j.1460-2075.1995.tb00108.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1577277

Title: SR proteins: a conserved family of pre-mRNA splicing factors.

PubMed ID: 1577277

DOI: 10.1101/gad.6.5.837

PubMed ID: 10757789

Title: Identification and characterization of a novel serine-arginine-rich splicing regulatory protein.

PubMed ID: 10757789

DOI: 10.1128/mcb.20.9.3049-3057.2000

PubMed ID: 12549914

Title: SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing.

PubMed ID: 12549914

DOI: 10.1021/bi026753a

PubMed ID: 15009664

Title: Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.

PubMed ID: 15009664

DOI: 10.1046/j.1471-4159.2003.02232.x

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22767602

Title: Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion.

PubMed ID: 22767602

DOI: 10.1074/jbc.m112.355412

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24440982

Title: Splicing factor SRSF6 promotes hyperplasia of sensitized skin.

PubMed ID: 24440982

DOI: 10.1038/nsmb.2756

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 344
  • Mass: 39587
  • Checksum: 72305506CE948B94
  • Sequence:
    • MPRVYIGRLS YNVREKDIQR FFSGYGRLLE VDLKNGYGFV EFEDSRDADD AVYELNGKEL 
CGERVIVEHA RGPRRDRDGY SYGSRSGGGG YSSRRTSGRD KYGPPVRTEY RLIVENLSSR 
CSWQDLKDFM RQAGEVTYAD AHKERTNEGV IEFRSYSDMK RALDKLDGTE INGRNIRLIE 
DKPRTSHRRS YSGSRSRSRS RRRSRSRSRR SSRSRSRSIS KSRSRSRSRS KGRSRSRSKG 
RKSRSKSKSK PKSDRGSHSH SRSRSKDEYE KSRSRSRSRS PKENGKGDIK SKSRSRSQSR 
SNSPLPVPPS KARSVSPPPK RATSRSRSRS RSKSRSRSRS SSRD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.