Details for: SRSF6

Gene ID: 6431

Symbol: SRSF6

Ensembl ID: ENSG00000124193

Description: serine and arginine rich splicing factor 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 299.3342
    Cell Significance Index: -46.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 185.8121
    Cell Significance Index: -47.1300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 142.3725
    Cell Significance Index: -58.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 128.4624
    Cell Significance Index: -60.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 123.3948
    Cell Significance Index: -50.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 110.8313
    Cell Significance Index: -57.0100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 90.3845
    Cell Significance Index: -60.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.5272
    Cell Significance Index: -50.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 46.2223
    Cell Significance Index: -56.9900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.0836
    Cell Significance Index: -56.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.1417
    Cell Significance Index: -59.7500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.4562
    Cell Significance Index: -29.4500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.3883
    Cell Significance Index: -38.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.9753
    Cell Significance Index: 274.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.0395
    Cell Significance Index: 131.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.8725
    Cell Significance Index: 65.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4478
    Cell Significance Index: 40.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4353
    Cell Significance Index: 197.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3937
    Cell Significance Index: 39.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3182
    Cell Significance Index: 93.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2978
    Cell Significance Index: 61.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2538
    Cell Significance Index: 248.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1371
    Cell Significance Index: 502.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1202
    Cell Significance Index: 30.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0326
    Cell Significance Index: 563.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0077
    Cell Significance Index: 181.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9642
    Cell Significance Index: 27.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8855
    Cell Significance Index: 113.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8841
    Cell Significance Index: 177.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8364
    Cell Significance Index: 102.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8169
    Cell Significance Index: 38.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6691
    Cell Significance Index: 17.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6664
    Cell Significance Index: 86.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6183
    Cell Significance Index: 558.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5973
    Cell Significance Index: 64.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5902
    Cell Significance Index: 43.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5277
    Cell Significance Index: 189.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5010
    Cell Significance Index: 95.3400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4586
    Cell Significance Index: 9.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4396
    Cell Significance Index: 11.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3948
    Cell Significance Index: 20.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3879
    Cell Significance Index: 17.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3835
    Cell Significance Index: 21.5200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3236
    Cell Significance Index: 223.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3098
    Cell Significance Index: 36.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2179
    Cell Significance Index: 37.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0984
    Cell Significance Index: 6.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0341
    Cell Significance Index: 0.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0315
    Cell Significance Index: 0.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0221
    Cell Significance Index: 0.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0155
    Cell Significance Index: -0.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0184
    Cell Significance Index: -13.4600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0208
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0266
    Cell Significance Index: -19.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0278
    Cell Significance Index: -21.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0315
    Cell Significance Index: -59.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0332
    Cell Significance Index: -20.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0376
    Cell Significance Index: -69.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0415
    Cell Significance Index: -3.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0442
    Cell Significance Index: -4.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0446
    Cell Significance Index: -68.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0506
    Cell Significance Index: -68.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0788
    Cell Significance Index: -44.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0853
    Cell Significance Index: -54.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1048
    Cell Significance Index: -10.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1168
    Cell Significance Index: -1.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1207
    Cell Significance Index: -19.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1294
    Cell Significance Index: -27.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1300
    Cell Significance Index: -7.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1321
    Cell Significance Index: -59.9600
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.1328
    Cell Significance Index: -0.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1381
    Cell Significance Index: -8.2900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1578
    Cell Significance Index: -1.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1703
    Cell Significance Index: -48.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1743
    Cell Significance Index: -20.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1879
    Cell Significance Index: -21.5300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2472
    Cell Significance Index: -28.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3601
    Cell Significance Index: -9.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4065
    Cell Significance Index: -27.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4091
    Cell Significance Index: -59.4700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4442
    Cell Significance Index: -6.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5005
    Cell Significance Index: -16.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5210
    Cell Significance Index: -27.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5318
    Cell Significance Index: -10.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5519
    Cell Significance Index: -7.5300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5607
    Cell Significance Index: -9.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5804
    Cell Significance Index: -60.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6042
    Cell Significance Index: -47.8500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.6240
    Cell Significance Index: -3.8400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6300
    Cell Significance Index: -9.4400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6344
    Cell Significance Index: -7.5600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6666
    Cell Significance Index: -12.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8194
    Cell Significance Index: -41.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8771
    Cell Significance Index: -38.8000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.8811
    Cell Significance Index: -15.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9568
    Cell Significance Index: -58.6600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.9614
    Cell Significance Index: -14.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0487
    Cell Significance Index: -39.7100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.0600
    Cell Significance Index: -31.1300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.0749
    Cell Significance Index: -15.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SRSF6 is a member of the serine/arginine (SR) protein family, characterized by its rich content of serine and arginine residues. It belongs to the Arg/RS domain-containing protein family, which is involved in RNA binding and splicing regulation. SRSF6 is a heterochromatic protein that localizes to nuclear specks, where it interacts with other RNA-binding proteins to regulate alternative splicing. **Pathways and Functions:** SRSF6 is involved in various RNA processing pathways, including: 1. **Alternative mRNA splicing**: SRSF6 regulates the inclusion or exclusion of specific exons in pre-mRNA, leading to the production of diverse isoforms. 2. **Gene expression (transcription)**: SRSF6 interacts with RNA polymerase II to regulate transcription initiation and elongation. 3. **Metabolism of RNA**: SRSF6 is involved in RNA processing, including 3'-end processing and transport of mature mRNA. 4. **Negative regulation of keratinocyte differentiation**: SRSF6 represses the expression of genes involved in keratinocyte differentiation. 5. **Negative regulation of type B pancreatic cell apoptotic process**: SRSF6 inhibits apoptosis in type B pancreatic cells. 6. **Positive regulation of epithelial cell proliferation involved in lung morphogenesis**: SRSF6 promotes epithelial cell proliferation during lung development. 7. **Regulation of alternative mRNA splicing**: SRSF6 regulates the inclusion or exclusion of specific exons in pre-mRNA. **Clinical Significance:** Dysregulation of SRSF6 has been implicated in various diseases, including: 1. **Cancer**: Alterations in SRSF6 expression have been observed in several types of cancer, including lung, breast, and colon cancer. 2. **Neurological disorders**: SRSF6 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Wound healing**: SRSF6 plays a critical role in wound healing, and its dysregulation can impair tissue repair. In conclusion, SRSF6 is a multifunctional protein that plays a crucial role in regulating alternative splicing and various cellular processes. Its dysregulation has been implicated in several diseases, highlighting the importance of SRSF6 in maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the functions of SRSF6 and its role in human disease.

Genular Protein ID: 1581535607

Symbol: SRSF6_HUMAN

Name: Serine/arginine-rich splicing factor 6

UniProtKB Accession Codes:

Q13247 B7Z6J3 E1P5W6 Q13244 Q13245 Q96J06 Q9UJB8 Q9Y3N7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7556075

Title: Identification and characterization of three members of the human SR family of pre-mRNA splicing factors.

PubMed ID: 7556075

DOI: 10.1002/j.1460-2075.1995.tb00108.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1577277

Title: SR proteins: a conserved family of pre-mRNA splicing factors.

PubMed ID: 1577277

DOI: 10.1101/gad.6.5.837

PubMed ID: 10757789

Title: Identification and characterization of a novel serine-arginine-rich splicing regulatory protein.

PubMed ID: 10757789

DOI: 10.1128/mcb.20.9.3049-3057.2000

PubMed ID: 12549914

Title: SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing.

PubMed ID: 12549914

DOI: 10.1021/bi026753a

PubMed ID: 15009664

Title: Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.

PubMed ID: 15009664

DOI: 10.1046/j.1471-4159.2003.02232.x

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22767602

Title: Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion.

PubMed ID: 22767602

DOI: 10.1074/jbc.m112.355412

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24440982

Title: Splicing factor SRSF6 promotes hyperplasia of sensitized skin.

PubMed ID: 24440982

DOI: 10.1038/nsmb.2756

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 344
  • Mass: 39587
  • Checksum: 72305506CE948B94
  • Sequence:
    • MPRVYIGRLS YNVREKDIQR FFSGYGRLLE VDLKNGYGFV EFEDSRDADD AVYELNGKEL 
CGERVIVEHA RGPRRDRDGY SYGSRSGGGG YSSRRTSGRD KYGPPVRTEY RLIVENLSSR 
CSWQDLKDFM RQAGEVTYAD AHKERTNEGV IEFRSYSDMK RALDKLDGTE INGRNIRLIE 
DKPRTSHRRS YSGSRSRSRS RRRSRSRSRR SSRSRSRSIS KSRSRSRSRS KGRSRSRSKG 
RKSRSKSKSK PKSDRGSHSH SRSRSKDEYE KSRSRSRSRS PKENGKGDIK SKSRSRSQSR 
SNSPLPVPPS KARSVSPPPK RATSRSRSRS RSKSRSRSRS SSRD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.