SRSF6 | ENSG00000124193 | NCBI 6431

Details for: SRSF6

Gene ID: 6431

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SRSF6

Ensembl ID: ENSG00000124193

Description: serine and arginine rich splicing factor 6

Cell Significance Landscape

Display Count:

Associated with

Gene expression (transcription)
(R-HSA-74160)
Metabolism of rna
(R-HSA-8953854)
Mrna 3'-end processing
(R-HSA-72187)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Mrna splicing - minor pathway
(R-HSA-72165)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription termination
(R-HSA-73856)
Transport of mature mrna derived from an intron-containing transcript
(R-HSA-159236)
Transport of mature transcript to cytoplasm
(R-HSA-72202)
Alternative mrna splicing, via spliceosome
(GO:0000380)
Mrna splice site recognition
(GO:0006376)
Mrna splicing, via spliceosome
(GO:0000398)
Negative regulation of keratinocyte differentiation
(GO:0045617)
Negative regulation of mrna splicing, via spliceosome
(GO:0048025)
Negative regulation of type b pancreatic cell apoptotic process
(GO:2000675)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Positive regulation of epithelial cell proliferation involved in lung morphogenesis
(GO:0060501)
Pre-mrna binding
(GO:0036002)
Protein binding
(GO:0005515)
Regulation of alternative mrna splicing, via spliceosome
(GO:0000381)
Regulation of keratinocyte proliferation
(GO:0010837)
Regulation of wound healing
(GO:0061041)
Response to insulin
(GO:0032868)
Rna binding
(GO:0003723)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

peripheral nervous system neuron CL2000032

CSI 28.38

rCSI 38.66%

PRS 14.47
stem cell CL0000034

CSI 9.66

rCSI 9.32%

PRS 11.58
T follicular helper cell CL0002038

CSI 9.5

rCSI 7.11%

PRS 26.23
CD14-positive, CD16-positive monocyte CL0002397

CSI 8.98

rCSI 11.77%

PRS 23.01
CD14-positive monocyte CL0001054

CSI 8.39

rCSI 10.45%

PRS 23.06
megakaryocyte-erythroid progenitor cell CL0000050

CSI 7.76

rCSI 7.01%

PRS 14.57
type B pancreatic cell CL0000169

CSI 7.74

rCSI 17.14%

PRS 15.11
podocyte CL0000653

CSI 7.51

rCSI 33.36%

PRS 16
placental villous trophoblast CL2000060

CSI 7.48

rCSI 11.56%

PRS 15.22
regular atrial cardiac myocyte CL0002129

CSI 6.51

rCSI 20.96%

PRS 17.16
immature B cell CL0000816

CSI 6.39

rCSI 4.75%

PRS 24.07
intestinal epithelial cell CL0002563

CSI 5.78

rCSI 6.05%

PRS 17.04
transit amplifying cell of small intestine CL0009012

CSI 5.6

rCSI 24.59%

PRS 30.22
inflammatory macrophage CL0000863

CSI 5.15

rCSI 8.79%

PRS 32.78
bronchial goblet cell CL1000312

CSI 4.84

rCSI 19.36%

PRS 34.8
lymphoid lineage restricted progenitor cell CL0000838

CSI 4.66

rCSI 18.16%

PRS 26.68
bronchus fibroblast of lung CL2000093

CSI 4.55

rCSI 3.7%

PRS 17.23
type L enteroendocrine cell CL0002279

CSI 4.54

rCSI 8.51%

PRS 31.84
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 4.47

rCSI 4.08%

PRS 24.68
double negative thymocyte CL0002489

CSI 3.88

rCSI 2.7%

PRS 19.31
colon goblet cell CL0009039

CSI 3.8

rCSI 9.04%

PRS 24.4
astrocyte of the cerebral cortex CL0002605

CSI 3.75

rCSI 8.41%

PRS 10.05
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 3.72

rCSI 7.41%

PRS 27.48
renal beta-intercalated cell CL0002201

CSI 3.62

rCSI 8.63%

PRS 19.04
skin fibroblast CL0002620

CSI 3.51

rCSI 3.03%

PRS 26
cardiac neuron CL0010022

CSI 3.47

rCSI 11.09%

PRS 12.29
mononuclear phagocyte CL0000113

CSI 3.45

rCSI 7.6%

PRS 18.21
lung macrophage CL1001603

CSI 3.23

rCSI 7.22%

PRS 18.71
forebrain radial glial cell CL0013000

CSI 3.06

rCSI 9.83%

PRS 23.56
squamous epithelial cell CL0000076

CSI 3.03

rCSI 7.2%

PRS 20.27
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 3.03

rCSI 7.83%

PRS 15.18
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 2.99

rCSI 14.98%

PRS 21.45
hepatic stellate cell CL0000632

CSI 2.94

rCSI 11.02%

PRS 13.8
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 2.89

rCSI 3.33%

PRS 14.26
granulocyte monocyte progenitor cell CL0000557

CSI 2.84

rCSI 2.46%

PRS 18.3
epithelial cell of proximal tubule CL0002306

CSI 2.81

rCSI 6.86%

PRS 16.14
transitional stage B cell CL0000818

CSI 2.69

rCSI 8.79%

PRS 43.38
CD1c-positive myeloid dendritic cell CL0002399

CSI 2.68

rCSI 3.24%

PRS 19.35
activated CD4-positive, alpha-beta T cell CL0000896

CSI 2.66

rCSI 2.46%

PRS 29.45
memory T cell CL0000813

CSI 2.64

rCSI 5.08%

PRS 36.41
perivascular cell CL4033054

CSI 2.62

rCSI 3.58%

PRS 18.47
sst GABAergic cortical interneuron CL4023017

CSI 2.59

rCSI 3.34%

PRS 10.08
unswitched memory B cell CL0000970

CSI 2.57

rCSI 2.16%

PRS 25.98
radial glial cell CL0000681

CSI 2.57

rCSI 3.57%

PRS 16.72
secretory cell CL0000151

CSI 2.56

rCSI 2.67%

PRS 16.68
enteroendocrine cell of small intestine CL0009006

CSI 2.54

rCSI 5.6%

PRS 24.82
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 2.51

rCSI 11.52%

PRS 41
CD4-positive, alpha-beta thymocyte CL0000810

CSI 2.5

rCSI 2%

PRS 29.29
megakaryocyte CL0000556

CSI 2.5

rCSI 10.83%

PRS 28.7
pro-B cell CL0000826

CSI 2.49

rCSI 2.06%

PRS 16.43
pulmonary ionocyte CL0017000

CSI 2.44

rCSI 2.97%

PRS 20.5
double-positive, alpha-beta thymocyte CL0000809

CSI 2.36

rCSI 2.4%

PRS 23.28
parietal epithelial cell CL1000452

CSI 2.36

rCSI 6.3%

PRS 13.48
cerebellar granule cell CL0001031

CSI 2.3

rCSI 3.38%

PRS 14.9
ciliated cell CL0000064

CSI 2.26

rCSI 3.66%

PRS 16.54
CD8-positive, alpha-beta thymocyte CL0000811

CSI 2.24

rCSI 3.5%

PRS 38.43
ON-bipolar cell CL0000749

CSI 2.22

rCSI 3.31%

PRS 19.64
myeloid dendritic cell CL0000782

CSI 2.19

rCSI 3.17%

PRS 24.25
blood vessel endothelial cell CL0000071

CSI 2.16

rCSI 4.48%

PRS 16.28
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 2.1

rCSI 2.97%

PRS 15.15
lung secretory cell CL1000272

CSI 2.09

rCSI 5.18%

PRS 15.07
respiratory basal cell CL0002633

CSI 2.06

rCSI 2.14%

PRS 19.14
pancreatic D cell CL0000173

CSI 2.04

rCSI 2.01%

PRS 17.68
cerebral cortex GABAergic interneuron CL0010011

CSI 2.03

rCSI 5.99%

PRS 19.68
precursor B cell CL0000817

CSI 2.01

rCSI 1.76%

PRS 21.64
neuroblast (sensu Vertebrata) CL0000031

CSI 1.97

rCSI 2.52%

PRS 15.83
midzonal region hepatocyte CL0019028

CSI 1.96

rCSI 4.59%

PRS 23.93
effector CD4-positive, alpha-beta T cell CL0001044

CSI 1.95

rCSI 5.59%

PRS 23.9
keratinocyte CL0000312

CSI 1.95

rCSI 1.63%

PRS 19.47
enteroendocrine cell CL0000164

CSI 1.92

rCSI 2.62%

PRS 18.04
mucus secreting cell CL0000319

CSI 1.92

rCSI 3.05%

PRS 21
Kupffer cell CL0000091

CSI 1.91

rCSI 4.38%

PRS 15.76
conjunctival epithelial cell CL1000432

CSI 1.9

rCSI 2.9%

PRS 16.36
naive T cell CL0000898

CSI 1.86

rCSI 1.29%

PRS 23.08
fallopian tube secretory epithelial cell CL4030006

CSI 1.85

rCSI 1.78%

PRS 16.84
myofibroblast cell CL0000186

CSI 1.84

rCSI 2.55%

PRS 23.19
interstitial cell of Cajal CL0002088

CSI 1.83

rCSI 2.33%

PRS 18.91
differentiation-committed oligodendrocyte precursor CL4023059

CSI 1.83

rCSI 3.32%

PRS 13.41
extravillous trophoblast CL0008036

CSI 1.83

rCSI 2.26%

PRS 14.26
vascular leptomeningeal cell CL4023051

CSI 1.8

rCSI 3.16%

PRS 12.16
myeloid leukocyte CL0000766

CSI 1.8

rCSI 1.66%

PRS 16.71
innate lymphoid cell CL0001065

CSI 1.78

rCSI 3.68%

PRS 24.44
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 1.78

rCSI 1.75%

PRS 25.53
plasmacytoid dendritic cell, human CL0001058

CSI 1.75

rCSI 1.22%

PRS 17.24
lung pericyte CL0009089

CSI 1.73

rCSI 4.58%

PRS 19.48
kidney epithelial cell CL0002518

CSI 1.73

rCSI 3.31%

PRS 36.62
paneth cell CL0000510

CSI 1.71

rCSI 2.52%

PRS 25.54
intestine goblet cell CL0019031

CSI 1.66

rCSI 1.47%

PRS 16.32
ciliated epithelial cell CL0000067

CSI 1.64

rCSI 1.44%

PRS 11.82
vascular associated smooth muscle cell CL0000359

CSI 1.64

rCSI 5.31%

PRS 19.82
common dendritic progenitor CL0001029

CSI 1.63

rCSI 2.05%

PRS 20.98
pancreatic A cell CL0000171

CSI 1.63

rCSI 1.71%

PRS 17.41
early lymphoid progenitor CL0000936

CSI 1.62

rCSI 1.42%

PRS 18.53
dopaminergic neuron CL0000700

CSI 1.62

rCSI 9.15%

PRS 7.95
centrilobular region hepatocyte CL0019029

CSI 1.6

rCSI 4.17%

PRS 25.35
goblet cell CL0000160

CSI 1.59

rCSI 1.51%

PRS 17
large pre-B-II cell CL0000957

CSI 1.57

rCSI 4.49%

PRS 28
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 1.56

rCSI 0.92%

PRS 22.51
alveolar type 1 fibroblast cell CL4028004

CSI 1.55

rCSI 1.7%

PRS 18.53
CD4-positive, alpha-beta memory T cell CL0000897

CSI 1.55

rCSI 1.11%

PRS 22.25

activated CD8-positive, alpha-beta T cell, human CL0001049

CSI -1.7

rCSI -2.9%

PRS 32.4%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI -1.3

rCSI -7.8%

PRS 10.0%
medium spiny neuron CL1001474

CSI 0.1

rCSI 0.6%

PRS 6.7%
lung goblet cell CL1000143

CSI 0.1

rCSI 1.6%

PRS 49.6%
amacrine cell CL0000561

CSI 0.2

rCSI 0.7%

PRS 12.5%
acinar cell of salivary gland CL0002623

CSI 0.2

rCSI 5.5%

PRS 30.0%
Cajal-Retzius cell CL0000695

CSI 0.2

rCSI 1.9%

PRS 33.7%
erythroid progenitor cell CL0000038

CSI 0.3

rCSI 1.5%

PRS 24.9%
eosinophil CL0000771

CSI 0.3

rCSI 1.9%

PRS 41.4%
respiratory goblet cell CL0002370

CSI 0.3

rCSI 3.5%

PRS 31.1%
tracheobronchial serous cell CL0019001

CSI 0.3

rCSI 1.5%

PRS 30.4%
pancreatic stellate cell CL0002410

CSI 0.4

rCSI 2.3%

PRS 24.4%
chondrocyte CL0000138

CSI 0.4

rCSI 0.7%

PRS 13.9%
regular ventricular cardiac myocyte CL0002131

CSI 0.4

rCSI 2.6%

PRS 12.7%
deuterosomal cell CL4033044

CSI 0.4

rCSI 1.5%

PRS 26.6%
mesenchymal cell CL0008019

CSI 0.4

rCSI 1.1%

PRS 16.5%
L6b glutamatergic cortical neuron CL4023038

CSI 0.5

rCSI 1.4%

PRS 10.2%
syncytiotrophoblast cell CL0000525

CSI 0.5

rCSI 1.4%

PRS 30.9%
erythroblast CL0000765

CSI 0.5

rCSI 1.3%

PRS 26.4%
retinal cone cell CL0000573

CSI 0.5

rCSI 0.8%

PRS 12.5%
pluripotent stem cell CL0002248

CSI 0.5

rCSI 15.2%

PRS 36.4%
lamp5 GABAergic cortical interneuron CL4023011

CSI 0.5

rCSI 0.9%

PRS 9.6%
small intestine goblet cell CL1000495

CSI 0.5

rCSI 1.1%

PRS 21.8%
enteroendocrine cell of colon CL0009042

CSI 0.5

rCSI 2.4%

PRS 41.5%
mucous neck cell CL0000651

CSI 0.5

rCSI 0.8%

PRS 25.9%
retinal pigment epithelial cell CL0002586

CSI 0.5

rCSI 1.1%

PRS 17.3%
retinal bipolar neuron CL0000748

CSI 0.6

rCSI 1.0%

PRS 11.7%
melanocyte of skin CL1000458

CSI 0.6

rCSI 0.8%

PRS 9.2%
neural progenitor cell CL0011020

CSI 0.6

rCSI 2.6%

PRS 15.6%
endothelial cell of placenta CL0009092

CSI 0.6

rCSI 2.9%

PRS 22.1%
intestinal crypt stem cell of small intestine CL0009017

CSI 0.6

rCSI 1.6%

PRS 21.1%
retina horizontal cell CL0000745

CSI 0.6

rCSI 0.9%

PRS 15.1%
peptic cell CL0000155

CSI 0.6

rCSI 6.1%

PRS 44.6%
pancreatic ductal cell CL0002079

CSI 0.6

rCSI 1.2%

PRS 16.7%
nasal mucosa goblet cell CL0002480

CSI 0.6

rCSI 0.7%

PRS 23.9%
hematopoietic multipotent progenitor cell CL0000837

CSI 0.6

rCSI 1.5%

PRS 26.0%
endothelial cell of uterus CL0009095

CSI 0.6

rCSI 4.6%

PRS 43.1%
fibroblast of breast CL4006000

CSI 0.6

rCSI 2.7%

PRS 40.5%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.6

rCSI 1.6%

PRS 9.4%
stromal cell of ovary CL0002132

CSI 0.6

rCSI 1.8%

PRS 26.9%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 0.7

rCSI 1.5%

PRS 16.8%
suprabasal keratinocyte CL4033013

CSI 0.7

rCSI 1.1%

PRS 9.7%
mammary gland epithelial cell CL0002327

CSI 0.7

rCSI 2.3%

PRS 29.0%
cytotoxic T cell CL0000910

CSI 0.7

rCSI 3.9%

PRS 23.8%
paneth cell of epithelium of small intestine CL1000343

CSI 0.7

rCSI 1.9%

PRS 25.2%
dendritic cell, human CL0001056

CSI 0.7

rCSI 1.1%

PRS 19.3%
pancreatic acinar cell CL0002064

CSI 0.7

rCSI 0.9%

PRS 17.8%
cardiac endothelial cell CL0010008

CSI 0.7

rCSI 2.8%

PRS 14.6%
IgA plasma cell CL0000987

CSI 0.7

rCSI 0.7%

PRS 30.2%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 0.7

rCSI 4.3%

PRS 36.1%
mature B cell CL0000785

CSI 0.7

rCSI 0.6%

PRS 20.2%
myelocyte CL0002193

CSI 0.7

rCSI 4.8%

PRS 49.3%
primitive red blood cell CL0002355

CSI 0.8

rCSI 4.1%

PRS 29.7%
renal principal cell CL0005009

CSI 0.8

rCSI 2.0%

PRS 21.2%
hepatocyte CL0000182

CSI 0.8

rCSI 1.4%

PRS 15.1%
promonocyte CL0000559

CSI 0.8

rCSI 1.4%

PRS 22.0%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 0.8

rCSI 2.5%

PRS 11.0%
intestinal crypt stem cell of colon CL0009043

CSI 0.8

rCSI 6.1%

PRS 29.6%
enteric smooth muscle cell CL0002504

CSI 0.8

rCSI 1.2%

PRS 18.4%
progenitor cell CL0011026

CSI 0.8

rCSI 1.8%

PRS 26.8%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 0.8

rCSI 2.6%

PRS 24.4%
basal cell of epidermis CL0002187

CSI 0.8

rCSI 1.5%

PRS 14.5%
type EC enteroendocrine cell CL0000577

CSI 0.9

rCSI 3.0%

PRS 26.5%
duct epithelial cell CL0000068

CSI 0.9

rCSI 1.3%

PRS 17.2%
helper T cell CL0000912

CSI 0.9

rCSI 1.2%

PRS 22.6%
brush cell CL0002204

CSI 0.9

rCSI 1.7%

PRS 40.5%
tendon cell CL0000388

CSI 0.9

rCSI 2.3%

PRS 41.9%
microcirculation associated smooth muscle cell CL0008035

CSI 0.9

rCSI 2.6%

PRS 18.5%
enterocyte CL0000584

CSI 0.9

rCSI 1.5%

PRS 25.5%
pvalb GABAergic cortical interneuron CL4023018

CSI 0.9

rCSI 1.1%

PRS 8.9%
OFF-bipolar cell CL0000750

CSI 0.9

rCSI 1.3%

PRS 26.0%
lung ciliated cell CL1000271

CSI 0.9

rCSI 1.1%

PRS 11.9%
platelet CL0000233

CSI 0.9

rCSI 3.9%

PRS 31.8%
mesodermal cell CL0000222

CSI 0.9

rCSI 1.1%

PRS 16.0%
intermediate monocyte CL0002393

CSI 0.9

rCSI 1.4%

PRS 16.3%
mesenchymal stem cell CL0000134

CSI 0.9

rCSI 10.3%

PRS 29.2%
alveolar macrophage CL0000583

CSI 1.0

rCSI 1.6%

PRS 19.1%
alternatively activated macrophage CL0000890

CSI 1.0

rCSI 1.2%

PRS 25.0%
foveolar cell of stomach CL0002179

CSI 1.0

rCSI 2.1%

PRS 26.1%
fraction A pre-pro B cell CL0002045

CSI 1.0

rCSI 1.1%

PRS 33.1%
intestinal tuft cell CL0019032

CSI 1.0

rCSI 1.5%

PRS 18.7%
periportal region hepatocyte CL0019026

CSI 1.0

rCSI 3.8%

PRS 22.3%
epicardial adipocyte CL1000309

CSI 1.0

rCSI 3.2%

PRS 19.7%
transit amplifying cell of colon CL0009011

CSI 1.0

rCSI 1.2%

PRS 19.0%
respiratory suprabasal cell CL4033048

CSI 1.0

rCSI 1.3%

PRS 18.8%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.0

rCSI 1.8%

PRS 9.6%
sncg GABAergic cortical interneuron CL4023015

CSI 1.0

rCSI 1.7%

PRS 10.4%
P/D1 enteroendocrine cell CL0002268

CSI 1.0

rCSI 5.6%

PRS 39.0%
near-projecting glutamatergic cortical neuron CL4023012

CSI 1.0

rCSI 3.9%

PRS 9.8%
common myeloid progenitor CL0000049

CSI 1.0

rCSI 0.8%

PRS 16.2%
Bergmann glial cell CL0000644

CSI 1.0

rCSI 1.4%

PRS 16.2%
VIP GABAergic cortical interneuron CL4023016

CSI 1.1

rCSI 1.3%

PRS 9.4%
pulmonary alveolar type 2 cell CL0002063

CSI 1.1

rCSI 1.6%

PRS 24.6%
glioblast CL0000030

CSI 1.1

rCSI 1.7%

PRS 14.0%
M cell of gut CL0000682

CSI 1.1

rCSI 1.1%

PRS 28.4%
Langerhans cell CL0000453

CSI 1.1

rCSI 1.6%

PRS 28.6%
Hofbauer cell CL3000001

CSI 1.1

rCSI 2.0%

PRS 20.4%
cardiac muscle cell CL0000746

CSI 1.1

rCSI 1.6%

PRS 12.6%
glandular epithelial cell CL0000150

CSI 1.1

rCSI 2.9%

PRS 31.7%
enteric neuron CL0007011

CSI 1.1

rCSI 16.3%

PRS 39.2%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [SRSF6](/details-gene/6431), or Serine and Arginine Rich Splicing Factor 6, is a protein-coding gene located on chromosome 20q13.11. As a member of the serine/arginine-rich (SR) protein family, it is a key regulator of pre-mRNA processing, particularly alternative splicing [[Link](https://doi.org/10.1101/gad.6.5.837)]. Its primary function involves binding to pre-mRNA within the [nuclear speck](/details-cell/GO0016607) and participating in the recognition of splice sites, thereby influencing the composition of mature mRNA transcripts [[Link](https://doi.org/10.1002/j.1460-2075.1995.tb00108.x)]. The expression data suggests a broad but significant role across diverse cell types, with its highest cell-specific significance observed in [peripheral nervous system neuron](/details-cell/CL2000032). Its involvement in regulating the splicing of critical genes, such as those involved in cell proliferation, apoptosis, and differentiation, underscores its fundamental importance in cellular homeostasis. ## Cellular Roles and Expression Landscape The expression profile of [SRSF6](/details-gene/6431) indicates its importance in a wide array of cell types, consistent with a fundamental role in RNA processing. **Overall**, the gene shows the highest significance in the [peripheral nervous system neuron](/details-cell/CL2000032) (CSI: 28.38), suggesting a critical role in maintaining the complex transcriptome of neuronal cells. This is consistent with literature implicating SR proteins in the regulation of neural-specific splicing events, such as for the MAPT (Tau) gene [[Link](https://doi.org/10.1046/j.1471-4159.2003.02232.x)]. Beyond the nervous system, [SRSF6](/details-gene/6431) is highly significant in progenitor and undifferentiated populations, including [stem cell](/details-cell/CL0000034) (CSI: 9.66) and [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050) (CSI: 7.76), pointing to a role in developmental processes and lineage commitment through the control of alternative splicing. The gene also plays a notable role in the immune system, with high significance in [T follicular helper cell](/details-cell/CL0002038) (CSI: 9.50) and both [CD14-positive, CD16-positive monocyte](/details-cell/CL0002397) (CSI: 8.98) and [CD14-positive monocyte](/details-cell/CL0001054) (CSI: 8.39). This suggests it is involved in shaping the specific transcriptomes required for the function of these key immune cell subsets. In contrast, its low significance in [activated CD8-positive, alpha-beta T cell, human](/details-cell/CL0001049) (CSI: -1.67) may indicate that its function is less critical or potentially downregulated during terminal cytotoxic T cell differentiation. Furthermore, [SRSF6](/details-gene/6431) is active in various specialized, terminally differentiated cells such as [type B pancreatic cell](/details-cell/CL0000169) (CSI: 7.74), [podocyte](/details-cell/CL0000653) (CSI: 7.51) in the kidney, and [regular atrial cardiac myocyte](/details-cell/CL0002129) (CSI: 6.51), highlighting its ubiquitous but context-dependent importance in maintaining cell-specific functions. ## Pathways and Molecular Function The functional annotations for [SRSF6](/details-gene/6431) confirm its central role in RNA metabolism. As a key component of the spliceosome, it is integral to the biological process of '[Mrna splicing, via spliceosome](/details-cell/GO0000398)' and more specifically, '[Alternative mrna splicing, via spliceosome](/details-cell/GO0000380)'. Its molecular function is defined by its ability to bind RNA ([Rna binding](/details-cell/GO0003723)) and pre-mRNA ([Pre-mrna binding](/details-cell/GO0036002)), which is essential for '[Mrna splice site recognition](/details-cell/GO0006376)'. This is further supported by its involvement in multiple Reactome pathways related to RNA processing, including '[Mrna splicing](/details-cell/R-HSA-72172)' and the broader '[Metabolism of rna](/details-cell/R-HSA-8953854)'. Its participation in processes such as '[Processing of capped intron-containing pre-mrna](/details-cell/R-HSA-72203)' and '[Transport of mature mrna derived from an intron-containing transcript](/details-cell/R-HSA-159236)' demonstrates its involvement throughout the lifecycle of an mRNA molecule, from transcription to its export to the cytoplasm. The gene is also annotated with more specific regulatory functions, such as the '[Negative regulation of type b pancreatic cell apoptotic process](/details-cell/GO2000675)' and '[Positive regulation of epithelial cell proliferation involved in lung morphogenesis](/details-cell/GO0060501)', which are direct consequences of its ability to modulate the splicing of key genes involved in these cellular decisions. ## Research Directions The widespread yet cell-type-specific significance of [SRSF6](/details-gene/6431) provides a basis for several testable hypotheses regarding its role in health and disease. 1. **Hypothesis 1:** Given its exceptionally high significance in [peripheral nervous system neuron](/details-cell/CL2000032) and its known interaction with Tau pre-mRNA [[Link](https://doi.org/10.1074/jbc.m112.355412)], we hypothesize that age-related decline or dysregulation of [SRSF6](/details-gene/6431) activity in neurons is a contributing factor to the aberrant splicing of Tau exon 10, a key pathological event in frontotemporal dementia and other tauopathies. 2. **Hypothesis 2:** Based on its high significance in [type B pancreatic cell](/details-cell/CL0000169) and its role in the '[Negative regulation of type b pancreatic cell apoptotic process](/details-cell/GO2000675)', we hypothesize that [SRSF6](/details-gene/6431) promotes pancreatic beta cell survival by controlling the splicing of specific anti-apoptotic genes (e.g., Bcl-xL). Its downregulation under inflammatory stress may therefore sensitize beta cells to apoptosis, contributing to the pathogenesis of type 1 diabetes. **Proposed Experiment:** To test Hypothesis 1, one could utilize CRISPR interference (CRISPRi) to achieve a targeted knockdown of [SRSF6](/details-gene/6431) in human iPSC-derived cortical neurons. Following knockdown, RNA-sequencing would be performed to globally assess splicing changes, with a specific focus on the inclusion/exclusion ratio of Tau exon 10, which can be validated by RT-qPCR. Downstream functional consequences, such as microtubule stability and neuronal susceptibility to oxidative stress, could be assessed via immunofluorescence and cell viability assays. **Therapeutic Potential:** As an intracellular RNA-binding protein, [SRSF6](/details-gene/6431) is a challenging target for conventional small molecule inhibitors or antibodies. However, its function in regulating specific splicing events presents an opportunity for therapeutic intervention using nucleic acid-based drugs like antisense oligonucleotides (ASOs). For diseases driven by aberrant splicing (e.g., certain cancers or neurodegenerative disorders), ASOs could be designed to specifically block or enhance the binding of [SRSF6](/details-gene/6431) to a target pre-mRNA, thereby correcting the pathogenic splicing event without affecting the global function of the protein. This targeted inhibition approach could offer a high degree of specificity and mitigate off-target effects.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Serine/arginine-rich splicing factor 6

Genular Protein ID: 1581535607

Symbol: SRSF6_HUMAN

Name: Serine/arginine-rich splicing factor 6

UniProtKB Accession Codes:

Q13247 B7Z6J3 E1P5W6 Q13244 Q13245 Q96J06 Q9UJB8 Q9Y3N7

Database IDs:

Citations:

PubMed ID: 7556075

Title: Identification and characterization of three members of the human SR family of pre-mRNA splicing factors.

PubMed ID: 7556075

DOI: 10.1002/j.1460-2075.1995.tb00108.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1577277

Title: SR proteins: a conserved family of pre-mRNA splicing factors.

PubMed ID: 1577277

DOI: 10.1101/gad.6.5.837

PubMed ID: 10757789

Title: Identification and characterization of a novel serine-arginine-rich splicing regulatory protein.

PubMed ID: 10757789

DOI: 10.1128/mcb.20.9.3049-3057.2000

PubMed ID: 12549914

Title: SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing.

PubMed ID: 12549914

DOI: 10.1021/bi026753a

PubMed ID: 15009664

Title: Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.

PubMed ID: 15009664

DOI: 10.1046/j.1471-4159.2003.02232.x

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22767602

Title: Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion.

PubMed ID: 22767602

DOI: 10.1074/jbc.m112.355412

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24440982

Title: Splicing factor SRSF6 promotes hyperplasia of sensitized skin.

PubMed ID: 24440982

DOI: 10.1038/nsmb.2756

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 344
Mass: 39587
Checksum: 72305506CE948B94
Sequence:

MPRVYIGRLS YNVREKDIQR FFSGYGRLLE VDLKNGYGFV EFEDSRDADD AVYELNGKEL 
CGERVIVEHA RGPRRDRDGY SYGSRSGGGG YSSRRTSGRD KYGPPVRTEY RLIVENLSSR 
CSWQDLKDFM RQAGEVTYAD AHKERTNEGV IEFRSYSDMK RALDKLDGTE INGRNIRLIE 
DKPRTSHRRS YSGSRSRSRS RRRSRSRSRR SSRSRSRSIS KSRSRSRSRS KGRSRSRSKG 
RKSRSKSKSK PKSDRGSHSH SRSRSKDEYE KSRSRSRSRS PKENGKGDIK SKSRSRSQSR 
SNSPLPVPPS KARSVSPPPK RATSRSRSRS RSKSRSRSRS SSRD

Details for: SRSF6

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. PubMed ID: 7556075

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

SR proteins: a conserved family of pre-mRNA splicing factors. PubMed ID: 1577277

Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. PubMed ID: 10757789

SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing. PubMed ID: 12549914

Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. PubMed ID: 15009664

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion. PubMed ID: 22767602

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Splicing factor SRSF6 promotes hyperplasia of sensitized skin. PubMed ID: 24440982

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974