Details for: TRA2B
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 479.2497
Cell Significance Index: -74.5500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 313.2745
Cell Significance Index: -79.4600 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 253.2604
Cell Significance Index: -104.3300 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 223.1835
Cell Significance Index: -105.3700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 220.7961
Cell Significance Index: -89.7000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 200.4237
Cell Significance Index: -103.1000 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 157.3570
Cell Significance Index: -105.5900 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 95.9106
Cell Significance Index: -91.5700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 78.0888
Cell Significance Index: -96.2800 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 33.5049
Cell Significance Index: -89.7600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 25.8753
Cell Significance Index: -102.1100 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 23.2333
Cell Significance Index: -71.3600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 16.6112
Cell Significance Index: -36.3600 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 4.4782
Cell Significance Index: 47.5800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 4.0049
Cell Significance Index: 258.3800 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 3.0812
Cell Significance Index: 107.0700 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.8907
Cell Significance Index: 39.4400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.6834
Cell Significance Index: 73.0400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.6723
Cell Significance Index: 366.9800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.2675
Cell Significance Index: 118.1100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.2603
Cell Significance Index: 102.4500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 2.1580
Cell Significance Index: 45.1700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.0419
Cell Significance Index: 240.8000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.0099
Cell Significance Index: 57.6200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.9952
Cell Significance Index: 53.2800 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.9263
Cell Significance Index: 246.9400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.8525
Cell Significance Index: 103.9500 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.8305
Cell Significance Index: 19.9000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.5900
Cell Significance Index: 702.9800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.5438
Cell Significance Index: 72.5600 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 1.4986
Cell Significance Index: 22.7600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.4923
Cell Significance Index: 296.1500 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.4585
Cell Significance Index: 38.3500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.4580
Cell Significance Index: 292.4700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.4564
Cell Significance Index: 158.4200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.4115
Cell Significance Index: 105.2000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.3805
Cell Significance Index: 753.9500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.3511
Cell Significance Index: 166.1300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.2726
Cell Significance Index: 27.5700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.0893
Cell Significance Index: 196.3800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.9951
Cell Significance Index: 28.6700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.9428
Cell Significance Index: 66.6800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.8499
Cell Significance Index: 587.8500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.8466
Cell Significance Index: 303.6800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6109
Cell Significance Index: 99.3600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.5973
Cell Significance Index: 27.8500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.5528
Cell Significance Index: 15.4500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4303
Cell Significance Index: 388.5200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4034
Cell Significance Index: 39.9100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.4023
Cell Significance Index: 21.1200 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.3970
Cell Significance Index: 51.3000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2374
Cell Significance Index: 446.9600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2343
Cell Significance Index: 44.5800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1676
Cell Significance Index: 28.6200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1616
Cell Significance Index: 9.9300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1446
Cell Significance Index: 11.1000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0788
Cell Significance Index: 50.0300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0766
Cell Significance Index: 34.7500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0545
Cell Significance Index: 83.9000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0350
Cell Significance Index: 1.8200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0257
Cell Significance Index: 47.4100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0066
Cell Significance Index: 0.1100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0083
Cell Significance Index: -6.3100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0244
Cell Significance Index: -2.7900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0446
Cell Significance Index: -60.7000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0460
Cell Significance Index: -34.0600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0643
Cell Significance Index: -47.1500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0984
Cell Significance Index: -10.0500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1063
Cell Significance Index: -66.3900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1177
Cell Significance Index: -3.7700 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1282
Cell Significance Index: -2.3700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1434
Cell Significance Index: -80.8700 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.1900
Cell Significance Index: -2.8500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1985
Cell Significance Index: -12.5100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.2472
Cell Significance Index: -17.1000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2640
Cell Significance Index: -55.6100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3039
Cell Significance Index: -87.4400 - Cell Name: kidney cell (CL1000497)
Fold Change: -0.3106
Cell Significance Index: -2.4800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3324
Cell Significance Index: -48.3200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.3710
Cell Significance Index: -13.0400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.6162
Cell Significance Index: -71.8100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.6543
Cell Significance Index: -74.9600 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.6745
Cell Significance Index: -17.2300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.7153
Cell Significance Index: -48.1000 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.7859
Cell Significance Index: -23.0800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.7984
Cell Significance Index: -83.1300 - Cell Name: theca cell (CL0000503)
Fold Change: -0.8902
Cell Significance Index: -5.2300 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -1.0091
Cell Significance Index: -6.2100 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -1.0449
Cell Significance Index: -18.4700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.1812
Cell Significance Index: -93.5500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -1.1954
Cell Significance Index: -13.5800 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -1.2659
Cell Significance Index: -9.7600 - Cell Name: preadipocyte (CL0002334)
Fold Change: -1.2860
Cell Significance Index: -25.1000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.3289
Cell Significance Index: -58.7800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.4702
Cell Significance Index: -37.7900 - Cell Name: peg cell (CL4033014)
Fold Change: -1.4859
Cell Significance Index: -34.3300 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -1.5282
Cell Significance Index: -32.6700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.5622
Cell Significance Index: -95.7800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.6204
Cell Significance Index: -34.5100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.6574
Cell Significance Index: -62.7600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3104958231
Symbol: TRA2B_HUMAN
Name: Splicing factor, arginine/serine-rich 10
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9212162
Title: Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing.
PubMed ID: 9212162
PubMed ID: 9790768
Title: Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform.
PubMed ID: 9790768
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9546399
Title: Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing.
PubMed ID: 9546399
PubMed ID: 10339552
Title: The SRm160/300 splicing coactivator is required for exon-enhancer function.
PubMed ID: 10339552
PubMed ID: 10749975
Title: RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing.
PubMed ID: 10749975
DOI: 10.1093/hmg/9.5.685
PubMed ID: 12165565
Title: hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1.
PubMed ID: 12165565
PubMed ID: 12761049
Title: HnRNP G and Tra2beta: opposite effects on splicing matched by antagonism in RNA binding.
PubMed ID: 12761049
DOI: 10.1093/hmg/ddg136
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 15009664
Title: Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.
PubMed ID: 15009664
PubMed ID: 15169763
Title: Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization.
PubMed ID: 15169763
PubMed ID: 14729963
Title: Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo.
PubMed ID: 14729963
PubMed ID: 15782174
Title: Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.
PubMed ID: 15782174
DOI: 10.1038/nmeth715
PubMed ID: 14765198
Title: Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock.
PubMed ID: 14765198
DOI: 10.1038/nature02288
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19282290
Title: Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA.
PubMed ID: 19282290
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
Sequence Information:
- Length: 288
- Mass: 33666
- Checksum: 60B310C8BA443E28
- Sequence:
MSDSGEQNYG ERESRSASRS GSAHGSGKSA RHTPARSRSK EDSRRSRSKS RSRSESRSRS RRSSRRHYTR SRSRSRSHRR SRSRSYSRDY RRRHSHSHSP MSTRRRHVGN RANPDPNCCL GVFGLSLYTT ERDLREVFSK YGPIADVSIV YDQQSRRSRG FAFVYFENVD DAKEAKERAN GMELDGRRIR VDFSITKRPH TPTPGIYMGR PTYGSSRRRD YYDRGYDRGY DDRDYYSRSY RGGGGGGGGW RAAQDRDQIY RRRSPSPYYS RGGYRSRSRS RSYSPRRY
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.