Details for: TRA2B

Gene ID: 6434

Symbol: TRA2B

Ensembl ID: ENSG00000136527

Description: transformer 2 beta homolog

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 479.2497
    Cell Significance Index: -74.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 313.2745
    Cell Significance Index: -79.4600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 253.2604
    Cell Significance Index: -104.3300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 223.1835
    Cell Significance Index: -105.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 220.7961
    Cell Significance Index: -89.7000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 200.4237
    Cell Significance Index: -103.1000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 157.3570
    Cell Significance Index: -105.5900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 95.9106
    Cell Significance Index: -91.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 78.0888
    Cell Significance Index: -96.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 33.5049
    Cell Significance Index: -89.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 25.8753
    Cell Significance Index: -102.1100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 23.2333
    Cell Significance Index: -71.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.6112
    Cell Significance Index: -36.3600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.4782
    Cell Significance Index: 47.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.0049
    Cell Significance Index: 258.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.0812
    Cell Significance Index: 107.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.8907
    Cell Significance Index: 39.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.6834
    Cell Significance Index: 73.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.6723
    Cell Significance Index: 366.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.2675
    Cell Significance Index: 118.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.2603
    Cell Significance Index: 102.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.1580
    Cell Significance Index: 45.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.0419
    Cell Significance Index: 240.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.0099
    Cell Significance Index: 57.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.9952
    Cell Significance Index: 53.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.9263
    Cell Significance Index: 246.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.8525
    Cell Significance Index: 103.9500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.8305
    Cell Significance Index: 19.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.5900
    Cell Significance Index: 702.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5438
    Cell Significance Index: 72.5600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.4986
    Cell Significance Index: 22.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4923
    Cell Significance Index: 296.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.4585
    Cell Significance Index: 38.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4580
    Cell Significance Index: 292.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4564
    Cell Significance Index: 158.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.4115
    Cell Significance Index: 105.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3805
    Cell Significance Index: 753.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3511
    Cell Significance Index: 166.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2726
    Cell Significance Index: 27.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0893
    Cell Significance Index: 196.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9951
    Cell Significance Index: 28.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9428
    Cell Significance Index: 66.6800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8499
    Cell Significance Index: 587.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8466
    Cell Significance Index: 303.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6109
    Cell Significance Index: 99.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5973
    Cell Significance Index: 27.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5528
    Cell Significance Index: 15.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4303
    Cell Significance Index: 388.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4034
    Cell Significance Index: 39.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4023
    Cell Significance Index: 21.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3970
    Cell Significance Index: 51.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2374
    Cell Significance Index: 446.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2343
    Cell Significance Index: 44.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1676
    Cell Significance Index: 28.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1616
    Cell Significance Index: 9.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1446
    Cell Significance Index: 11.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0788
    Cell Significance Index: 50.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0766
    Cell Significance Index: 34.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0545
    Cell Significance Index: 83.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0350
    Cell Significance Index: 1.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0257
    Cell Significance Index: 47.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0066
    Cell Significance Index: 0.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0083
    Cell Significance Index: -6.3100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0244
    Cell Significance Index: -2.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0446
    Cell Significance Index: -60.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0460
    Cell Significance Index: -34.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0643
    Cell Significance Index: -47.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0984
    Cell Significance Index: -10.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1063
    Cell Significance Index: -66.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1177
    Cell Significance Index: -3.7700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1282
    Cell Significance Index: -2.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1434
    Cell Significance Index: -80.8700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1900
    Cell Significance Index: -2.8500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1985
    Cell Significance Index: -12.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2472
    Cell Significance Index: -17.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2640
    Cell Significance Index: -55.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3039
    Cell Significance Index: -87.4400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3106
    Cell Significance Index: -2.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3324
    Cell Significance Index: -48.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3710
    Cell Significance Index: -13.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6162
    Cell Significance Index: -71.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6543
    Cell Significance Index: -74.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6745
    Cell Significance Index: -17.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7153
    Cell Significance Index: -48.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7859
    Cell Significance Index: -23.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7984
    Cell Significance Index: -83.1300
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.8902
    Cell Significance Index: -5.2300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.0091
    Cell Significance Index: -6.2100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.0449
    Cell Significance Index: -18.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1812
    Cell Significance Index: -93.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.1954
    Cell Significance Index: -13.5800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.2659
    Cell Significance Index: -9.7600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.2860
    Cell Significance Index: -25.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.3289
    Cell Significance Index: -58.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.4702
    Cell Significance Index: -37.7900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.4859
    Cell Significance Index: -34.3300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.5282
    Cell Significance Index: -32.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5622
    Cell Significance Index: -95.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.6204
    Cell Significance Index: -34.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.6574
    Cell Significance Index: -62.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Alternative Splicing:** TRA2B is involved in the regulation of alternative pre-mRNA splicing, a process that allows for the generation of multiple protein isoforms from a single gene. 2. **Splicing Factor:** TRA2B is a splicing factor, which means it interacts with other proteins to facilitate the splicing process. 3. **Arginine/Serine-Rich Domain:** TRA2B contains an arginine/serine-rich domain, which is a characteristic feature of splicing factors. 4. **Expression in Various Cell Types:** TRA2B is expressed in a wide range of cell types, including fibroblasts, skeletal muscle satellite stem cells, T cells, and B cells. **Pathways and Functions:** 1. **Cellular Response to Glucose Stimulus:** TRA2B is involved in the regulation of cellular response to glucose stimulus, which is essential for proper glucose metabolism. 2. **Cerebral Cortex Regionalization:** TRA2B plays a role in the development and regionalization of the cerebral cortex, which is critical for brain development and function. 3. **Embryonic Brain Development:** TRA2B is involved in the regulation of embryonic brain development, which is essential for proper brain function and behavior. 4. **Signaling by Rho GTPases:** TRA2B interacts with Rho GTPases, which are signaling molecules that regulate various cellular processes, including cell migration, proliferation, and differentiation. **Clinical Significance:** 1. **Immune System Regulation:** TRA2B plays a crucial role in the regulation of the immune system, particularly in the development and function of T cells and B cells. 2. **Autoimmune Diseases:** Abnormalities in TRA2B expression have been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer:** TRA2B is also involved in the regulation of cancer development and progression, particularly in the context of immune system dysregulation. 4. **Neurological Disorders:** TRA2B has been implicated in the development and progression of various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the Transformer 2 Beta Homolog (TRA2B) is a crucial gene that plays a significant role in the regulation of alternative pre-mRNA splicing and its implications in human biology. Further research is necessary to fully understand the mechanisms by which TRA2B regulates cellular processes and to explore its potential therapeutic applications in various diseases.

Genular Protein ID: 3104958231

Symbol: TRA2B_HUMAN

Name: Splicing factor, arginine/serine-rich 10

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9212162

Title: Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing.

PubMed ID: 9212162

DOI: 10.1089/dna.1997.16.679

PubMed ID: 9790768

Title: Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform.

PubMed ID: 9790768

DOI: 10.1006/geno.1998.5471

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9546399

Title: Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing.

PubMed ID: 9546399

DOI: 10.1016/s0092-8674(00)81153-8

PubMed ID: 10339552

Title: The SRm160/300 splicing coactivator is required for exon-enhancer function.

PubMed ID: 10339552

DOI: 10.1073/pnas.96.11.6125

PubMed ID: 10749975

Title: RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing.

PubMed ID: 10749975

DOI: 10.1093/hmg/9.5.685

PubMed ID: 12165565

Title: hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1.

PubMed ID: 12165565

DOI: 10.1093/hmg/11.17.2037

PubMed ID: 12761049

Title: HnRNP G and Tra2beta: opposite effects on splicing matched by antagonism in RNA binding.

PubMed ID: 12761049

DOI: 10.1093/hmg/ddg136

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15009664

Title: Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.

PubMed ID: 15009664

DOI: 10.1046/j.1471-4159.2003.02232.x

PubMed ID: 15169763

Title: Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization.

PubMed ID: 15169763

DOI: 10.1074/jbc.m403927200

PubMed ID: 14729963

Title: Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo.

PubMed ID: 14729963

DOI: 10.1128/mcb.24.3.1174-1187.2004

PubMed ID: 15782174

Title: Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.

PubMed ID: 15782174

DOI: 10.1038/nmeth715

PubMed ID: 14765198

Title: Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock.

PubMed ID: 14765198

DOI: 10.1038/nature02288

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19282290

Title: Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA.

PubMed ID: 19282290

DOI: 10.1074/jbc.m901026200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 288
  • Mass: 33666
  • Checksum: 60B310C8BA443E28
  • Sequence:
  • MSDSGEQNYG ERESRSASRS GSAHGSGKSA RHTPARSRSK EDSRRSRSKS RSRSESRSRS 
    RRSSRRHYTR SRSRSRSHRR SRSRSYSRDY RRRHSHSHSP MSTRRRHVGN RANPDPNCCL 
    GVFGLSLYTT ERDLREVFSK YGPIADVSIV YDQQSRRSRG FAFVYFENVD DAKEAKERAN 
    GMELDGRRIR VDFSITKRPH TPTPGIYMGR PTYGSSRRRD YYDRGYDRGY DDRDYYSRSY 
    RGGGGGGGGW RAAQDRDQIY RRRSPSPYYS RGGYRSRSRS RSYSPRRY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.