Details for: SGTA

Gene ID: 6449

Symbol: SGTA

Ensembl ID: ENSG00000104969

Description: small glutamine rich tetratricopeptide repeat co-chaperone alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 161.1428
    Cell Significance Index: -25.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 105.1476
    Cell Significance Index: -26.6700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 64.6760
    Cell Significance Index: -30.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 61.8574
    Cell Significance Index: -25.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 56.5918
    Cell Significance Index: -29.1100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.4967
    Cell Significance Index: -25.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.9222
    Cell Significance Index: -29.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.6053
    Cell Significance Index: -28.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.0711
    Cell Significance Index: -24.7900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.7343
    Cell Significance Index: -30.5200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.7428
    Cell Significance Index: -10.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.9829
    Cell Significance Index: 231.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9843
    Cell Significance Index: 59.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8524
    Cell Significance Index: 11.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6751
    Cell Significance Index: 42.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6678
    Cell Significance Index: 19.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6197
    Cell Significance Index: 32.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5940
    Cell Significance Index: 20.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5791
    Cell Significance Index: 116.1600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5629
    Cell Significance Index: 6.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5577
    Cell Significance Index: 25.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5463
    Cell Significance Index: 14.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5183
    Cell Significance Index: 13.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5113
    Cell Significance Index: 70.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4814
    Cell Significance Index: 13.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4786
    Cell Significance Index: 432.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4687
    Cell Significance Index: 24.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4391
    Cell Significance Index: 239.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4206
    Cell Significance Index: 19.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4112
    Cell Significance Index: 50.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4008
    Cell Significance Index: 20.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3966
    Cell Significance Index: 18.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3897
    Cell Significance Index: 77.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3325
    Cell Significance Index: 6.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3257
    Cell Significance Index: 21.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3121
    Cell Significance Index: 3.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3011
    Cell Significance Index: 54.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2948
    Cell Significance Index: 34.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2879
    Cell Significance Index: 21.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2737
    Cell Significance Index: 121.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2648
    Cell Significance Index: 6.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2477
    Cell Significance Index: 88.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2460
    Cell Significance Index: 31.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2069
    Cell Significance Index: 39.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1460
    Cell Significance Index: 101.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1445
    Cell Significance Index: 11.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1430
    Cell Significance Index: 23.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1157
    Cell Significance Index: 14.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0930
    Cell Significance Index: 1.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0879
    Cell Significance Index: 3.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0790
    Cell Significance Index: 5.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0705
    Cell Significance Index: 1.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0420
    Cell Significance Index: 4.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0386
    Cell Significance Index: 1.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0340
    Cell Significance Index: 5.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0051
    Cell Significance Index: 9.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0070
    Cell Significance Index: -12.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0123
    Cell Significance Index: -18.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0147
    Cell Significance Index: -10.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0147
    Cell Significance Index: -11.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0206
    Cell Significance Index: -28.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0213
    Cell Significance Index: -13.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0323
    Cell Significance Index: -3.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0346
    Cell Significance Index: -25.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0395
    Cell Significance Index: -17.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0469
    Cell Significance Index: -0.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0507
    Cell Significance Index: -28.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0550
    Cell Significance Index: -1.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0551
    Cell Significance Index: -34.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0770
    Cell Significance Index: -5.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0837
    Cell Significance Index: -24.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0845
    Cell Significance Index: -12.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1305
    Cell Significance Index: -8.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1597
    Cell Significance Index: -33.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1638
    Cell Significance Index: -4.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1852
    Cell Significance Index: -21.2200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1922
    Cell Significance Index: -2.8800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2362
    Cell Significance Index: -1.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2402
    Cell Significance Index: -6.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2629
    Cell Significance Index: -14.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2830
    Cell Significance Index: -29.4700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2987
    Cell Significance Index: -7.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3021
    Cell Significance Index: -23.9300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3842
    Cell Significance Index: -6.7900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4091
    Cell Significance Index: -7.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4158
    Cell Significance Index: -11.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4197
    Cell Significance Index: -25.7300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4205
    Cell Significance Index: -12.0000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4347
    Cell Significance Index: -3.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4509
    Cell Significance Index: -19.9400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5387
    Cell Significance Index: -6.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5601
    Cell Significance Index: -21.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5843
    Cell Significance Index: -17.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5854
    Cell Significance Index: -10.8200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.6301
    Cell Significance Index: -8.0700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.6374
    Cell Significance Index: -8.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6457
    Cell Significance Index: -16.6000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6497
    Cell Significance Index: -23.8500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6682
    Cell Significance Index: -21.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6754
    Cell Significance Index: -14.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Tetratricopeptide repeat (TPR) domain:** SGTA contains a TPR domain, a conserved motif found in numerous co-chaperones, which facilitates protein-protein interactions and modulates protein folding and degradation. 2. **Glutamine-rich sequence:** The gene's name is derived from its glutamine-rich sequence, which is thought to be involved in protein binding and recognition. 3. **ER localization:** SGTA is primarily localized to the endoplasmic reticulum (ER), where it plays a key role in regulating protein folding, insertion, and degradation. **Pathways and Functions:** SGTA is involved in various cellular pathways, including: 1. **Erd1/ERp57 (Erd1/ErbA1) pathway:** SGTA acts as a co-chaperone for the ERp57 protein, facilitating the folding and degradation of misfolded proteins. 2. **UCP pathway:** SGTA regulates the unfolded protein response (UPR) by modulating the activity of the UCP (ubiquitin carboxyl-terminal hydrolase) pathway. 3. **Protein quality control:** SGTA is involved in the recognition and degradation of misfolded proteins, ensuring protein homeostasis and preventing ER stress. **Clinical Significance:** Dysregulation of SGTA has been implicated in various diseases, including: 1. **Neurodegenerative disorders:** Mutations in SGTA have been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's. 2. **Cancer:** SGTA expression is often downregulated in various types of cancer, suggesting its role as a tumor suppressor. 3. **Metabolic disorders:** SGTA has been linked to metabolic disorders, such as type 2 diabetes and obesity, where ER stress and protein misfolding play critical roles. In conclusion, SGTA is a multifunctional co-chaperone that plays a crucial role in maintaining protein homeostasis and regulating ER stress. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully elucidate the mechanisms by which SGTA regulates protein folding, degradation, and localization, and to explore its therapeutic potential in the treatment of diseases associated with protein misfolding.

Genular Protein ID: 195491716

Symbol: SGTA_HUMAN

Name: Small glutamine-rich tetratricopeptide repeat-containing protein alpha

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9740675

Title: Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans.

PubMed ID: 9740675

DOI: 10.1006/geno.1998.5385

PubMed ID: 10567422

Title: Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats.

PubMed ID: 10567422

DOI: 10.1074/jbc.274.48.34425

PubMed ID: 9573291

Title: Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family.

PubMed ID: 9573291

DOI: 10.1128/jvi.72.6.5189-5197.1998

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15708368

Title: Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions.

PubMed ID: 15708368

DOI: 10.1016/j.abb.2004.12.020

PubMed ID: 16580629

Title: SGT, a Hsp90beta binding partner, is accumulated in the nucleus during cell apoptosis.

PubMed ID: 16580629

DOI: 10.1016/j.bbrc.2006.03.090

PubMed ID: 16580632

Title: Severe acute respiratory syndrome coronavirus protein 7a interacts with hSGT.

PubMed ID: 16580632

DOI: 10.1016/j.bbrc.2006.03.091

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17034881

Title: Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells.

PubMed ID: 17034881

DOI: 10.1016/j.bbamcr.2006.08.054

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23129660

Title: SGTA antagonizes BAG6-mediated protein triage.

PubMed ID: 23129660

DOI: 10.1073/pnas.1209997109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25179605

Title: SGTA regulates the cytosolic quality control of hydrophobic substrates.

PubMed ID: 25179605

DOI: 10.1242/jcs.155648

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24675744

Title: A cytosolic chaperone complexes with dynamic membrane J-proteins and mobilizes a nonenveloped virus out of the endoplasmic reticulum.

PubMed ID: 24675744

DOI: 10.1371/journal.ppat.1004007

PubMed ID: 25535373

Title: Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.

PubMed ID: 25535373

DOI: 10.1073/pnas.1402745112

PubMed ID: 27193484

Title: Structural and functional insights into the E3 ligase, RNF126.

PubMed ID: 27193484

DOI: 10.1038/srep26433

PubMed ID: 28104892

Title: Mechanistic basis for a molecular triage reaction.

PubMed ID: 28104892

DOI: 10.1126/science.aah6130

PubMed ID: 18759457

Title: Structural and functional characterization of human SGT and its interaction with Vpu of the human immunodeficiency virus type 1.

PubMed ID: 18759457

DOI: 10.1021/bi800758a

Sequence Information:

  • Length: 313
  • Mass: 34063
  • Checksum: 80B3C71B41F3CB55
  • Sequence:
  • MDNKKRLAYA IIQFLHDQLR HGGLSSDAQE SLEVAIQCLE TAFGVTVEDS DLALPQTLPE 
    IFEAAATGKE MPQDLRSPAR TPPSEEDSAE AERLKTEGNE QMKVENFEAA VHFYGKAIEL 
    NPANAVYFCN RAAAYSKLGN YAGAVQDCER AICIDPAYSK AYGRMGLALS SLNKHVEAVA 
    YYKKALELDP DNETYKSNLK IAELKLREAP SPTGGVGSFD IAGLLNNPGF MSMASNLMNN 
    PQIQQLMSGM ISGGNNPLGT PGTSPSQNDL ASLIQAGQQF AQQMQQQNPE LIEQLRSQIR 
    SRTPSASNDD QQE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.