Details for: SGTA
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 161.1428
Cell Significance Index: -25.0700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 105.1476
Cell Significance Index: -26.6700 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 64.6760
Cell Significance Index: -30.5400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 61.8574
Cell Significance Index: -25.1300 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 56.5918
Cell Significance Index: -29.1100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 26.4967
Cell Significance Index: -25.3000 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 23.9222
Cell Significance Index: -29.5000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.6053
Cell Significance Index: -28.4100 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 8.0711
Cell Significance Index: -24.7900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.7343
Cell Significance Index: -30.5200 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.7428
Cell Significance Index: -10.3800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.9829
Cell Significance Index: 231.0800 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.9843
Cell Significance Index: 59.0900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.8524
Cell Significance Index: 11.6300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.6751
Cell Significance Index: 42.5500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6678
Cell Significance Index: 19.2400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.6197
Cell Significance Index: 32.5400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.5940
Cell Significance Index: 20.6400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5791
Cell Significance Index: 116.1600 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.5629
Cell Significance Index: 6.1200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5577
Cell Significance Index: 25.2800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.5463
Cell Significance Index: 14.8700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5183
Cell Significance Index: 13.8400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5113
Cell Significance Index: 70.2100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.4814
Cell Significance Index: 13.8000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4786
Cell Significance Index: 432.1400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.4687
Cell Significance Index: 24.4200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4391
Cell Significance Index: 239.7900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4206
Cell Significance Index: 19.6100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4112
Cell Significance Index: 50.5600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4008
Cell Significance Index: 20.8200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3966
Cell Significance Index: 18.6400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3897
Cell Significance Index: 77.3300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.3325
Cell Significance Index: 6.9600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3257
Cell Significance Index: 21.0100 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.3121
Cell Significance Index: 3.7200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3011
Cell Significance Index: 54.2700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2948
Cell Significance Index: 34.7700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2879
Cell Significance Index: 21.4600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2737
Cell Significance Index: 121.0100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2648
Cell Significance Index: 6.6200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2477
Cell Significance Index: 88.8300 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.2460
Cell Significance Index: 31.7800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2069
Cell Significance Index: 39.3800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1460
Cell Significance Index: 101.0000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1445
Cell Significance Index: 11.0900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1430
Cell Significance Index: 23.2500 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1157
Cell Significance Index: 14.8300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0930
Cell Significance Index: 1.9800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0879
Cell Significance Index: 3.0900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0790
Cell Significance Index: 5.5900 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0705
Cell Significance Index: 1.8600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0420
Cell Significance Index: 4.1500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0386
Cell Significance Index: 1.0800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0340
Cell Significance Index: 5.8000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0051
Cell Significance Index: 9.5400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0070
Cell Significance Index: -12.9400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0123
Cell Significance Index: -18.9100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0147
Cell Significance Index: -10.7500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0147
Cell Significance Index: -11.1400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0206
Cell Significance Index: -28.0500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0213
Cell Significance Index: -13.5500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0323
Cell Significance Index: -3.3000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0346
Cell Significance Index: -25.6600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0395
Cell Significance Index: -17.9500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0469
Cell Significance Index: -0.7900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0507
Cell Significance Index: -28.5900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0550
Cell Significance Index: -1.7600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0551
Cell Significance Index: -34.3900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0770
Cell Significance Index: -5.1800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0837
Cell Significance Index: -24.0900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0845
Cell Significance Index: -12.2800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1305
Cell Significance Index: -8.0200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1597
Cell Significance Index: -33.6400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1638
Cell Significance Index: -4.8100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1852
Cell Significance Index: -21.2200 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.1922
Cell Significance Index: -2.8800 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.2362
Cell Significance Index: -1.5400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2402
Cell Significance Index: -6.4400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2629
Cell Significance Index: -14.7500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2830
Cell Significance Index: -29.4700 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2987
Cell Significance Index: -7.6300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3021
Cell Significance Index: -23.9300 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.3842
Cell Significance Index: -6.7900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.4091
Cell Significance Index: -7.0100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4158
Cell Significance Index: -11.1200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4197
Cell Significance Index: -25.7300 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.4205
Cell Significance Index: -12.0000 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.4347
Cell Significance Index: -3.5500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4509
Cell Significance Index: -19.9400 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.5387
Cell Significance Index: -6.1200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5601
Cell Significance Index: -21.2100 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5843
Cell Significance Index: -17.2100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.5854
Cell Significance Index: -10.8200 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.6301
Cell Significance Index: -8.0700 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.6374
Cell Significance Index: -8.9400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.6457
Cell Significance Index: -16.6000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.6497
Cell Significance Index: -23.8500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.6682
Cell Significance Index: -21.2800 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.6754
Cell Significance Index: -14.0100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 195491716
Symbol: SGTA_HUMAN
Name: Small glutamine-rich tetratricopeptide repeat-containing protein alpha
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9740675
Title: Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans.
PubMed ID: 9740675
PubMed ID: 10567422
Title: Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats.
PubMed ID: 10567422
PubMed ID: 9573291
Title: Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family.
PubMed ID: 9573291
PubMed ID: 11230166
Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
PubMed ID: 11230166
DOI: 10.1101/gr.gr1547r
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15708368
Title: Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions.
PubMed ID: 15708368
PubMed ID: 16580629
Title: SGT, a Hsp90beta binding partner, is accumulated in the nucleus during cell apoptosis.
PubMed ID: 16580629
PubMed ID: 16580632
Title: Severe acute respiratory syndrome coronavirus protein 7a interacts with hSGT.
PubMed ID: 16580632
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17034881
Title: Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells.
PubMed ID: 17034881
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23129660
Title: SGTA antagonizes BAG6-mediated protein triage.
PubMed ID: 23129660
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25179605
Title: SGTA regulates the cytosolic quality control of hydrophobic substrates.
PubMed ID: 25179605
DOI: 10.1242/jcs.155648
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24675744
Title: A cytosolic chaperone complexes with dynamic membrane J-proteins and mobilizes a nonenveloped virus out of the endoplasmic reticulum.
PubMed ID: 24675744
PubMed ID: 25535373
Title: Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.
PubMed ID: 25535373
PubMed ID: 27193484
Title: Structural and functional insights into the E3 ligase, RNF126.
PubMed ID: 27193484
DOI: 10.1038/srep26433
PubMed ID: 28104892
Title: Mechanistic basis for a molecular triage reaction.
PubMed ID: 28104892
PubMed ID: 18759457
Title: Structural and functional characterization of human SGT and its interaction with Vpu of the human immunodeficiency virus type 1.
PubMed ID: 18759457
DOI: 10.1021/bi800758a
Sequence Information:
- Length: 313
- Mass: 34063
- Checksum: 80B3C71B41F3CB55
- Sequence:
MDNKKRLAYA IIQFLHDQLR HGGLSSDAQE SLEVAIQCLE TAFGVTVEDS DLALPQTLPE IFEAAATGKE MPQDLRSPAR TPPSEEDSAE AERLKTEGNE QMKVENFEAA VHFYGKAIEL NPANAVYFCN RAAAYSKLGN YAGAVQDCER AICIDPAYSK AYGRMGLALS SLNKHVEAVA YYKKALELDP DNETYKSNLK IAELKLREAP SPTGGVGSFD IAGLLNNPGF MSMASNLMNN PQIQQLMSGM ISGGNNPLGT PGTSPSQNDL ASLIQAGQQF AQQMQQQNPE LIEQLRSQIR SRTPSASNDD QQE
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.