Details for: SIM1

Gene ID: 6492

Symbol: SIM1

Ensembl ID: ENSG00000112246

Description: SIM bHLH transcription factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 8.2119
    Cell Significance Index: 135.3200
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 5.1239
    Cell Significance Index: 61.9300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.6288
    Cell Significance Index: 62.0300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.4909
    Cell Significance Index: 28.9600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.2440
    Cell Significance Index: 9.9300
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 1.1596
    Cell Significance Index: 4.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5833
    Cell Significance Index: 12.2100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.2435
    Cell Significance Index: 1.0600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.1871
    Cell Significance Index: 2.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1794
    Cell Significance Index: 20.9100
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.1573
    Cell Significance Index: 0.5400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1302
    Cell Significance Index: 1.4200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0827
    Cell Significance Index: 1.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0539
    Cell Significance Index: 39.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0495
    Cell Significance Index: 14.2600
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.0368
    Cell Significance Index: 0.3500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0330
    Cell Significance Index: 0.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0322
    Cell Significance Index: 3.6900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0239
    Cell Significance Index: 0.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0088
    Cell Significance Index: 6.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0063
    Cell Significance Index: 0.6500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0021
    Cell Significance Index: 0.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0015
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0026
    Cell Significance Index: -4.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0027
    Cell Significance Index: -0.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0033
    Cell Significance Index: -1.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0049
    Cell Significance Index: -8.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0058
    Cell Significance Index: -8.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0059
    Cell Significance Index: -3.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0067
    Cell Significance Index: -9.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0070
    Cell Significance Index: -1.2600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0078
    Cell Significance Index: -0.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0081
    Cell Significance Index: -4.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0085
    Cell Significance Index: -5.4100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0099
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0122
    Cell Significance Index: -2.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0131
    Cell Significance Index: -2.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0134
    Cell Significance Index: -1.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0138
    Cell Significance Index: -4.9600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0143
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0149
    Cell Significance Index: -3.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0156
    Cell Significance Index: -3.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0158
    Cell Significance Index: -7.1900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0172
    Cell Significance Index: -0.1800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0176
    Cell Significance Index: -0.4300
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.0181
    Cell Significance Index: -0.1800
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0187
    Cell Significance Index: -0.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0242
    Cell Significance Index: -2.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0261
    Cell Significance Index: -0.6700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0266
    Cell Significance Index: -0.2400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0269
    Cell Significance Index: -0.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0332
    Cell Significance Index: -0.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0336
    Cell Significance Index: -4.8800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0338
    Cell Significance Index: -0.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0344
    Cell Significance Index: -4.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0381
    Cell Significance Index: -4.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0469
    Cell Significance Index: -1.3800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0475
    Cell Significance Index: -0.7100
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.0539
    Cell Significance Index: -0.5700
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0542
    Cell Significance Index: -0.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0571
    Cell Significance Index: -5.9500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0650
    Cell Significance Index: -1.1200
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.0665
    Cell Significance Index: -0.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0666
    Cell Significance Index: -4.9600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0706
    Cell Significance Index: -1.3800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0715
    Cell Significance Index: -0.9800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0718
    Cell Significance Index: -0.6100
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0736
    Cell Significance Index: -0.8000
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0752
    Cell Significance Index: -0.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0796
    Cell Significance Index: -5.3600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0831
    Cell Significance Index: -1.0800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0862
    Cell Significance Index: -2.4700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0880
    Cell Significance Index: -1.2200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0887
    Cell Significance Index: -0.9200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0919
    Cell Significance Index: -1.0400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0929
    Cell Significance Index: -1.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0953
    Cell Significance Index: -5.8600
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0954
    Cell Significance Index: -0.9200
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0955
    Cell Significance Index: -1.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0955
    Cell Significance Index: -7.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0972
    Cell Significance Index: -4.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1044
    Cell Significance Index: -4.7300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1163
    Cell Significance Index: -0.7200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1210
    Cell Significance Index: -1.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1274
    Cell Significance Index: -4.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1303
    Cell Significance Index: -7.3100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1305
    Cell Significance Index: -2.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1306
    Cell Significance Index: -4.5400
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1322
    Cell Significance Index: -0.8100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1328
    Cell Significance Index: -2.1300
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1337
    Cell Significance Index: -1.2800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1401
    Cell Significance Index: -3.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1456
    Cell Significance Index: -5.1000
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.1460
    Cell Significance Index: -1.1600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1525
    Cell Significance Index: -1.0300
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.1559
    Cell Significance Index: -1.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1567
    Cell Significance Index: -4.9900
  • Cell Name: tongue muscle cell (CL0002673)
    Fold Change: -0.1576
    Cell Significance Index: -1.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1584
    Cell Significance Index: -4.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1623
    Cell Significance Index: -7.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** SIM1 is a transcription factor that regulates gene expression by binding to specific DNA sequences and interacting with RNA polymerase II. 2. **Cellular Differentiation:** SIM1 plays a crucial role in the development and differentiation of various cell types, including erythrocytes, megakaryocytes, and hematopoietic stem cells. 3. **Heterodimerization:** SIM1 can form heterodimers with other transcription factors, enhancing its transcriptional activity. 4. **Specific Expression:** SIM1 is highly expressed in specific cell types, including erythrocytes, megakaryocytes, and epithelial cells in the kidney and blood vessels. **Pathways and Functions:** 1. **Cell Differentiation Pathway:** SIM1 regulates the differentiation of various cell types by interacting with other transcription factors and influencing the expression of target genes. 2. **RNA Polymerase II-Specific Transcriptional Regulation:** SIM1 binds to specific DNA sequences and interacts with RNA polymerase II to regulate transcription. 3. **DNA Binding:** SIM1 exhibits specific DNA-binding activity, allowing it to regulate gene expression by interacting with target DNA sequences. 4. **Nervous System Development:** SIM1 plays a crucial role in the development of the nervous system, regulating the expression of genes involved in neuronal differentiation and function. 5. **Kidney Development:** SIM1 is involved in the development of the kidney, regulating the expression of genes involved in nephrogenesis and renal function. **Clinical Significance:** 1. **Hematological Disorders:** SIM1 dysregulation has been implicated in various hematological disorders, including anemia and leukemia. 2. **Kidney Disease:** SIM1 expression is altered in kidney disease, including renal failure and nephrotic syndrome. 3. **Neurological Disorders:** SIM1 plays a role in the development and function of the nervous system, and its dysregulation has been implicated in neurological disorders, including Parkinson's disease and Alzheimer's disease. 4. **Cancer:** SIM1 is involved in the regulation of cell growth and differentiation, and its dysregulation has been implicated in various types of cancer, including leukemia and lymphoma. In conclusion, SIM1 is a complex transcriptional regulator that plays a crucial role in cellular differentiation and development in various tissues. Its dysregulation has been implicated in various disease states, highlighting the importance of further research into the functions and clinical significance of this gene.

Genular Protein ID: 3463611171

Symbol: SIM1_HUMAN

Name: Single-minded homolog 1

UniProtKB Accession Codes:

P81133 Q5TDP7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9199934

Title: Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region.

PubMed ID: 9199934

DOI: 10.1101/gr.7.6.615

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 14697214

Title: A novel nuclear localization signal in the human single-minded proteins SIM1 and SIM2.

PubMed ID: 14697214

DOI: 10.1016/j.bbrc.2003.11.168

Sequence Information:

  • Length: 766
  • Mass: 85515
  • Checksum: 05988D428A84431F
  • Sequence:
    • MKEKSKNAAR TRREKENSEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL KMRVVFPEGL 
GEAWGHSSRT SPLDNVGREL GSHLLQTLDG FIFVVAPDGK IMYISETASV HLGLSQVELT 
GNSIYEYIHP ADHDEMTAVL TAHQPYHSHF VQEYEIERSF FLRMKCVLAK RNAGLTCGGY 
KVIHCSGYLK IRQYSLDMSP FDGCYQNVGL VAVGHSLPPS AVTEIKLHSN MFMFRASLDM 
KLIFLDSRVA ELTGYEPQDL IEKTLYHHVH GCDTFHLRCA HHLLLVKGQV TTKYYRFLAK 
HGGWVWVQSY ATIVHNSRSS RPHCIVSVNY VLTDTEYKGL QLSLDQISAS KPAFSYTSSS 
TPTMTDNRKG AKSRLSSSKS KSRTSPYPQY SGFHTERSES DHDSQWGGSP LTDTASPQLL 
DPADRPGSQH DASCAYRQFS DRSSLCYGFA LDHSRLVEER HFHTQACEGG RCEAGRYFLG 
TPQAGREPWW GSRAALPLTK ASPESREAYE NSMPHIASVH RIHGRGHWDE DSVVSSPDPG 
SASESGDRYR TEQYQSSPHE PSKIETLIRA TQQMIKEEEN RLQLRKAPSD QLASINGAGK 
KHSLCFANYQ QPPPTGEVCH GSALANTSPC DHIQQREGKM LSPHENDYDN SPTALSRISS 
PNSDRISKSS LILAKDYLHS DISPHQTAGD HPTVSPNCFG SHRQYFDKHA YTLTGYALEH 
LYDSETIRNY SLGCNGSHFD VTSHLRMQPD PAQGHKGTSV IITNGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.