Details for: SIM2

Gene ID: 6493

Symbol: SIM2

Ensembl ID: ENSG00000159263

Description: SIM bHLH transcription factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.5119
    Cell Significance Index: -5.7100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 20.4210
    Cell Significance Index: 509.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.6774
    Cell Significance Index: 102.7700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5924
    Cell Significance Index: 14.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5708
    Cell Significance Index: 108.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4302
    Cell Significance Index: 42.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3712
    Cell Significance Index: 335.2100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.3471
    Cell Significance Index: 4.8000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2460
    Cell Significance Index: 3.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1880
    Cell Significance Index: 30.5700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.1825
    Cell Significance Index: 1.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1736
    Cell Significance Index: 20.2300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1637
    Cell Significance Index: 1.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1549
    Cell Significance Index: 16.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1094
    Cell Significance Index: 4.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0954
    Cell Significance Index: 2.7500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0906
    Cell Significance Index: 0.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0763
    Cell Significance Index: 5.2800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0739
    Cell Significance Index: 0.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0638
    Cell Significance Index: 0.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0515
    Cell Significance Index: 37.7700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.0389
    Cell Significance Index: 0.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0371
    Cell Significance Index: 25.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0327
    Cell Significance Index: 0.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0146
    Cell Significance Index: 2.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0143
    Cell Significance Index: 0.3100
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.0033
    Cell Significance Index: 0.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0014
    Cell Significance Index: 0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0014
    Cell Significance Index: 1.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0014
    Cell Significance Index: -0.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0020
    Cell Significance Index: -3.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0025
    Cell Significance Index: -0.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0036
    Cell Significance Index: -0.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0049
    Cell Significance Index: -1.7600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0058
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0075
    Cell Significance Index: -5.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0080
    Cell Significance Index: -5.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0093
    Cell Significance Index: -4.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0095
    Cell Significance Index: -5.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0101
    Cell Significance Index: -5.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0120
    Cell Significance Index: -5.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0126
    Cell Significance Index: -0.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0138
    Cell Significance Index: -3.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0154
    Cell Significance Index: -3.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0157
    Cell Significance Index: -0.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0173
    Cell Significance Index: -3.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0191
    Cell Significance Index: -1.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0209
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0243
    Cell Significance Index: -4.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0244
    Cell Significance Index: -3.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0280
    Cell Significance Index: -5.9000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0291
    Cell Significance Index: -0.1900
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0333
    Cell Significance Index: -0.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0359
    Cell Significance Index: -0.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0365
    Cell Significance Index: -4.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0368
    Cell Significance Index: -5.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0386
    Cell Significance Index: -4.9900
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0458
    Cell Significance Index: -0.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0476
    Cell Significance Index: -5.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0483
    Cell Significance Index: -2.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0493
    Cell Significance Index: -1.5800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0497
    Cell Significance Index: -2.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0527
    Cell Significance Index: -3.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0535
    Cell Significance Index: -5.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0551
    Cell Significance Index: -5.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0565
    Cell Significance Index: -3.5600
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0629
    Cell Significance Index: -0.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0651
    Cell Significance Index: -4.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0700
    Cell Significance Index: -5.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0701
    Cell Significance Index: -4.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0738
    Cell Significance Index: -5.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0739
    Cell Significance Index: -1.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0822
    Cell Significance Index: -1.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0854
    Cell Significance Index: -4.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0856
    Cell Significance Index: -3.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0899
    Cell Significance Index: -4.6700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0942
    Cell Significance Index: -2.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0945
    Cell Significance Index: -4.4400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0965
    Cell Significance Index: -2.4100
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0977
    Cell Significance Index: -1.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0990
    Cell Significance Index: -3.6300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1048
    Cell Significance Index: -1.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1054
    Cell Significance Index: -3.9900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1061
    Cell Significance Index: -1.5100
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1117
    Cell Significance Index: -1.4300
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.1189
    Cell Significance Index: -1.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1193
    Cell Significance Index: -4.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1213
    Cell Significance Index: -2.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1225
    Cell Significance Index: -2.1000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1288
    Cell Significance Index: -2.6200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1392
    Cell Significance Index: -4.1000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1404
    Cell Significance Index: -2.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1414
    Cell Significance Index: -4.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1440
    Cell Significance Index: -4.5900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1485
    Cell Significance Index: -2.1100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1522
    Cell Significance Index: -1.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1551
    Cell Significance Index: -5.3900
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.1587
    Cell Significance Index: -1.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** SIM2 acts as a transcriptional regulator, influencing the expression of target genes through its interaction with RNA polymerase II and other transcriptional machinery components. 2. **DNA Binding:** SIM2 exhibits DNA-binding capabilities, allowing it to directly interact with specific DNA sequences and modulate gene expression. 3. **Protein Heterodimerization:** SIM2 forms heterodimers with other transcription factors, expanding its regulatory scope and facilitating the coordination of gene expression networks. 4. **Tissue-Specific Expression:** SIM2 is differentially expressed across various cell types, including those in the nervous system, epithelial tissues, and hematopoietic lineage, underscoring its role in tissue-specific development and homeostasis. **Pathways and Functions:** SIM2 is involved in several signaling pathways, including: 1. **Cell Differentiation:** SIM2 regulates the expression of genes involved in cell differentiation, influencing the development of specific cell types, such as retinal bipolar neurons and granulocyte-monocyte progenitor cells. 2. **Chromatin Remodeling:** SIM2 interacts with chromatin-modifying complexes, influencing chromatin structure and gene expression. 3. **RNA Polymerase II Regulation:** SIM2 modulates the activity of RNA polymerase II, a key enzyme in transcriptional elongation, thereby regulating the expression of target genes. 4. **Embryonic Pattern Specification:** SIM2 plays a role in embryonic patterning, influencing the specification of embryonic tissues and organs. **Clinical Significance:** SIM2's dysregulation has been implicated in various disease states, including: 1. **Neurological Disorders:** SIM2 mutations have been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Cancer:** SIM2 expression is altered in various cancers, including lung, colon, and kidney cancers, suggesting its potential as a therapeutic target. 3. **Immunological Disorders:** SIM2's involvement in immune cell development and function highlights its potential role in immunological disorders, such as allergies and autoimmune diseases. In conclusion, SIM2 is a multifaceted transcriptional regulator, influencing various cellular processes, including development, differentiation, and homeostasis. Its dysregulation has been implicated in various disease states, underscoring the need for further research into the mechanisms and therapeutic potential of SIM2 in normal physiology and disease.

Genular Protein ID: 3179921106

Symbol: SIM2_HUMAN

Name: Single-minded homolog 2

UniProtKB Accession Codes:

Q14190 O60766 Q15470 Q15471 Q15472 Q15473 Q16532 Q2TBD8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9199934

Title: Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region.

PubMed ID: 9199934

DOI: 10.1101/gr.7.6.615

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8905236

Title: A 19-kb CpG island associated with single-minded gene 2 in Down syndrome chromosomal region.

PubMed ID: 8905236

DOI: 10.1093/dnares/3.3.175

PubMed ID: 7647800

Title: Single-minded and Down syndrome?

PubMed ID: 7647800

DOI: 10.1038/ng0595-9

PubMed ID: 9503011

Title: Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome.

PubMed ID: 9503011

DOI: 10.1006/geno.1997.5146

PubMed ID: 7568099

Title: Down syndrome-critical region contains a gene homologous to Drosophila sim expressed during rat and human central nervous system development.

PubMed ID: 7568099

DOI: 10.1073/pnas.92.20.9191

PubMed ID: 8661114

Title: The mammalian single-minded (SIM) gene: mouse cDNA structure and diencephalic expression indicate a candidate gene for Down syndrome.

PubMed ID: 8661114

DOI: 10.1006/geno.1996.0332

PubMed ID: 14697214

Title: A novel nuclear localization signal in the human single-minded proteins SIM1 and SIM2.

PubMed ID: 14697214

DOI: 10.1016/j.bbrc.2003.11.168

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 667
  • Mass: 73219
  • Checksum: A100880541A74E6B
  • Sequence:
    • MKEKSKNAAK TRREKENGEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL KMRAVFPEGL 
GDAWGQPSRA GPLDGVAKEL GSHLLQTLDG FVFVVASDGK IMYISETASV HLGLSQVELT 
GNSIYEYIHP SDHDEMTAVL TAHQPLHHHL LQEYEIERSF FLRMKCVLAK RNAGLTCSGY 
KVIHCSGYLK IRQYMLDMSL YDSCYQIVGL VAVGQSLPPS AITEIKLYSN MFMFRASLDL 
KLIFLDSRVT EVTGYEPQDL IEKTLYHHVH GCDVFHLRYA HHLLLVKGQV TTKYYRLLSK 
RGGWVWVQSY ATVVHNSRSS RPHCIVSVNY VLTEIEYKEL QLSLEQVSTA KSQDSWRTAL 
STSQETRKLV KPKNTKMKTK LRTNPYPPQQ YSSFQMDKLE CGQLGNWRAS PPASAAAPPE 
LQPHSESSDL LYTPSYSLPF SYHYGHFPLD SHVFSSKKPM LPAKFGQPQG SPCEVARFFL 
STLPASGECQ WHYANPLVPS SSSPAKNPPE PPANTARHSL VPSYEAPAAA VRRFGEDTAP 
PSFPSCGHYR EEPALGPAKA ARQAARDGAR LALARAAPEC CAPPTPEAPG APAQLPFVLL 
NYHRVLARRG PLGGAAPAAS GLACAPGGPE AATGALRLRH PSPAATSPPG APLPHYLGAS 
VIITNGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.