Details for: SIM2

Gene ID: 6493

Symbol: SIM2

Ensembl ID: ENSG00000159263

Description: SIM bHLH transcription factor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 5.63
    Marker Score: 18020.5
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 4.57
    Marker Score: 13555
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.56
    Marker Score: 30108
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.18
    Marker Score: 2468
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.13
    Marker Score: 2144
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.67
    Marker Score: 1697
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1168
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.56
    Marker Score: 4183
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.36
    Marker Score: 3891
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.33
    Marker Score: 2521
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 854
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5330
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9
    Marker Score: 14078
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.88
    Marker Score: 404
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.87
    Marker Score: 3380
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.82
    Marker Score: 1665
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 500
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.75
    Marker Score: 239
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.67
    Marker Score: 719
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2754
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.64
    Marker Score: 163
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 379
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.57
    Marker Score: 164
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 450
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 231
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.53
    Marker Score: 199
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 315
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.49
    Marker Score: 1397
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.44
    Marker Score: 999
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.43
    Marker Score: 136
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.42
    Marker Score: 199
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.41
    Marker Score: 183
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 391.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.39
    Marker Score: 91.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.39
    Marker Score: 2481
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.38
    Marker Score: 101
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.38
    Marker Score: 98
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.37
    Marker Score: 3170
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.33
    Marker Score: 171
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.33
    Marker Score: 192
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.31
    Marker Score: 261
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.3
    Marker Score: 176.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.29
    Marker Score: 716
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.29
    Marker Score: 129
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.28
    Marker Score: 119
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.28
    Marker Score: 190
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.27
    Marker Score: 2120
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.27
    Marker Score: 238
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.27
    Marker Score: 511.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.26
    Marker Score: 601
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.24
    Marker Score: 77
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.24
    Marker Score: 158
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.23
    Marker Score: 217
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.22
    Marker Score: 53
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.22
    Marker Score: 80
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.21
    Marker Score: 121
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.21
    Marker Score: 127
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.21
    Marker Score: 200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.2
    Marker Score: 136
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.19
    Marker Score: 469
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.19
    Marker Score: 60
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.19
    Marker Score: 72
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.18
    Marker Score: 106
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.18
    Marker Score: 192
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.17
    Marker Score: 133
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.17
    Marker Score: 406
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.16
    Marker Score: 150
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.16
    Marker Score: 193
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.15
    Marker Score: 193
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.15
    Marker Score: 68
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.15
    Marker Score: 44
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.15
    Marker Score: 162
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.14
    Marker Score: 685
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.14
    Marker Score: 82
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.14
    Marker Score: 30
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.13
    Marker Score: 80
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.13
    Marker Score: 31
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.12
    Marker Score: 31

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** SIM2 is a basic helix-loop-helix (bHLH) transcription factor, which belongs to a family of transcription factors that regulate gene expression by binding to specific DNA sequences. SIM2 is characterized by its ability to interact with other transcription factors, RNA polymerase II, and chromatin-modifying enzymes, thereby regulating the expression of target genes. Its expression is highly tissue-specific, with significant levels detected in cells of the nervous system, epithelial tissues, and hematopoietic cells. **Pathways and Functions:** SIM2 is involved in various signaling pathways that regulate cell differentiation, development, and homeostasis. Some of the key pathways and functions of SIM2 include: 1. **Cell Differentiation:** SIM2 regulates the expression of genes involved in cell differentiation, particularly in the development of the nervous system and epithelial tissues. 2. **Embryonic Pattern Specification:** SIM2 plays a crucial role in embryonic pattern specification, regulating the expression of genes involved in mesoderm and neural crest development. 3. **Nervous System Development:** SIM2 is involved in the development of the nervous system, regulating the expression of genes involved in neuronal differentiation and glial cell development. 4. **Regulation of Transcription by RNA Polymerase II:** SIM2 interacts with RNA polymerase II to regulate the expression of target genes, influencing transcriptional regulation and gene expression. 5. **Chromatin Regulation:** SIM2 interacts with chromatin-modifying enzymes to regulate chromatin structure and gene expression. **Clinical Significance:** SIM2 dysregulation has been implicated in various diseases and disorders, including: 1. **Neurodevelopmental Disorders:** SIM2 mutations have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Cancer:** SIM2 dysregulation has been implicated in various types of cancer, including lung, colon, and kidney cancer. 3. **Cardiovascular Disease:** SIM2 expression has been linked to cardiovascular disease, with altered expression levels associated with atherosclerosis and cardiac hypertrophy. 4. **Inflammatory Disorders:** SIM2 dysregulation has been implicated in inflammatory disorders, such as rheumatoid arthritis and asthma. In conclusion, SIM2 is a crucial transcription factor that regulates various developmental processes and tissue homeostasis. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of further research into the molecular mechanisms underlying SIM2 function and disease pathogenesis.

Genular Protein ID: 3179921106

Symbol: SIM2_HUMAN

Name: Single-minded homolog 2

UniProtKB Accession Codes:

Q14190 O60766 Q15470 Q15471 Q15472 Q15473 Q16532 Q2TBD8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9199934

Title: Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region.

PubMed ID: 9199934

DOI: 10.1101/gr.7.6.615

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8905236

Title: A 19-kb CpG island associated with single-minded gene 2 in Down syndrome chromosomal region.

PubMed ID: 8905236

DOI: 10.1093/dnares/3.3.175

PubMed ID: 7647800

Title: Single-minded and Down syndrome?

PubMed ID: 7647800

DOI: 10.1038/ng0595-9

PubMed ID: 9503011

Title: Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome.

PubMed ID: 9503011

DOI: 10.1006/geno.1997.5146

PubMed ID: 7568099

Title: Down syndrome-critical region contains a gene homologous to Drosophila sim expressed during rat and human central nervous system development.

PubMed ID: 7568099

DOI: 10.1073/pnas.92.20.9191

PubMed ID: 8661114

Title: The mammalian single-minded (SIM) gene: mouse cDNA structure and diencephalic expression indicate a candidate gene for Down syndrome.

PubMed ID: 8661114

DOI: 10.1006/geno.1996.0332

PubMed ID: 14697214

Title: A novel nuclear localization signal in the human single-minded proteins SIM1 and SIM2.

PubMed ID: 14697214

DOI: 10.1016/j.bbrc.2003.11.168

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 667
  • Mass: 73219
  • Checksum: A100880541A74E6B
  • Sequence:
    • MKEKSKNAAK TRREKENGEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL KMRAVFPEGL 
GDAWGQPSRA GPLDGVAKEL GSHLLQTLDG FVFVVASDGK IMYISETASV HLGLSQVELT 
GNSIYEYIHP SDHDEMTAVL TAHQPLHHHL LQEYEIERSF FLRMKCVLAK RNAGLTCSGY 
KVIHCSGYLK IRQYMLDMSL YDSCYQIVGL VAVGQSLPPS AITEIKLYSN MFMFRASLDL 
KLIFLDSRVT EVTGYEPQDL IEKTLYHHVH GCDVFHLRYA HHLLLVKGQV TTKYYRLLSK 
RGGWVWVQSY ATVVHNSRSS RPHCIVSVNY VLTEIEYKEL QLSLEQVSTA KSQDSWRTAL 
STSQETRKLV KPKNTKMKTK LRTNPYPPQQ YSSFQMDKLE CGQLGNWRAS PPASAAAPPE 
LQPHSESSDL LYTPSYSLPF SYHYGHFPLD SHVFSSKKPM LPAKFGQPQG SPCEVARFFL 
STLPASGECQ WHYANPLVPS SSSPAKNPPE PPANTARHSL VPSYEAPAAA VRRFGEDTAP 
PSFPSCGHYR EEPALGPAKA ARQAARDGAR LALARAAPEC CAPPTPEAPG APAQLPFVLL 
NYHRVLARRG PLGGAAPAAS GLACAPGGPE AATGALRLRH PSPAATSPPG APLPHYLGAS 
VIITNGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.