Details for: SIPA1

Gene ID: 6494

Symbol: SIPA1

Ensembl ID: ENSG00000213445

Description: signal-induced proliferation-associated 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 93.1562
    Cell Significance Index: -14.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 52.0416
    Cell Significance Index: -13.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 39.5932
    Cell Significance Index: -16.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 37.9668
    Cell Significance Index: -17.9300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 35.4015
    Cell Significance Index: -18.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.3555
    Cell Significance Index: -16.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.1716
    Cell Significance Index: -16.2400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 5.0991
    Cell Significance Index: 13.6600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.4123
    Cell Significance Index: -11.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.2390
    Cell Significance Index: -13.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1877
    Cell Significance Index: -16.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.3512
    Cell Significance Index: 274.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.8837
    Cell Significance Index: 130.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.6054
    Cell Significance Index: 34.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4972
    Cell Significance Index: 96.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.4086
    Cell Significance Index: 73.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3138
    Cell Significance Index: 213.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1487
    Cell Significance Index: 1037.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9666
    Cell Significance Index: 58.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8969
    Cell Significance Index: 97.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8264
    Cell Significance Index: 42.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8193
    Cell Significance Index: 22.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7245
    Cell Significance Index: 33.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5930
    Cell Significance Index: 10.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5124
    Cell Significance Index: 24.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4947
    Cell Significance Index: 58.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4442
    Cell Significance Index: 242.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4194
    Cell Significance Index: 41.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3926
    Cell Significance Index: 48.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3896
    Cell Significance Index: 70.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2931
    Cell Significance Index: 7.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2778
    Cell Significance Index: 3.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1918
    Cell Significance Index: 26.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1704
    Cell Significance Index: 21.8500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1644
    Cell Significance Index: 4.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1475
    Cell Significance Index: 10.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1337
    Cell Significance Index: 6.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1085
    Cell Significance Index: 47.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1011
    Cell Significance Index: 13.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0960
    Cell Significance Index: 2.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0454
    Cell Significance Index: 3.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0414
    Cell Significance Index: 7.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0365
    Cell Significance Index: 7.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0070
    Cell Significance Index: -5.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0079
    Cell Significance Index: -14.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0101
    Cell Significance Index: -7.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0103
    Cell Significance Index: -15.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0110
    Cell Significance Index: -0.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0114
    Cell Significance Index: -1.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0130
    Cell Significance Index: -17.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0144
    Cell Significance Index: -9.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0146
    Cell Significance Index: -0.3900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0168
    Cell Significance Index: -0.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0174
    Cell Significance Index: -11.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0242
    Cell Significance Index: -17.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0302
    Cell Significance Index: -18.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0313
    Cell Significance Index: -1.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0320
    Cell Significance Index: -18.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0325
    Cell Significance Index: -14.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0411
    Cell Significance Index: -7.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0449
    Cell Significance Index: -16.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0516
    Cell Significance Index: -14.8500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0619
    Cell Significance Index: -0.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0675
    Cell Significance Index: -1.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0716
    Cell Significance Index: -1.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0721
    Cell Significance Index: -2.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0798
    Cell Significance Index: -16.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0798
    Cell Significance Index: -9.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0888
    Cell Significance Index: -12.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0889
    Cell Significance Index: -18.7200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0921
    Cell Significance Index: -4.6500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0943
    Cell Significance Index: -0.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1124
    Cell Significance Index: -3.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1186
    Cell Significance Index: -3.0300
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.1372
    Cell Significance Index: -1.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1525
    Cell Significance Index: -4.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1551
    Cell Significance Index: -16.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1716
    Cell Significance Index: -4.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1783
    Cell Significance Index: -10.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1817
    Cell Significance Index: -14.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1827
    Cell Significance Index: -3.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1856
    Cell Significance Index: -5.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1890
    Cell Significance Index: -14.5000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2024
    Cell Significance Index: -3.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2069
    Cell Significance Index: -4.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2074
    Cell Significance Index: -13.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2179
    Cell Significance Index: -6.9800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2200
    Cell Significance Index: -9.0200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.2469
    Cell Significance Index: -2.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2551
    Cell Significance Index: -15.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2687
    Cell Significance Index: -18.0700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2790
    Cell Significance Index: -3.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2821
    Cell Significance Index: -6.5200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2932
    Cell Significance Index: -2.9400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3128
    Cell Significance Index: -4.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3163
    Cell Significance Index: -17.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3625
    Cell Significance Index: -12.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3927
    Cell Significance Index: -17.3700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3950
    Cell Significance Index: -14.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SIPA1 is a non-coding RNA gene that has been identified as a regulator of immune responses. It is highly expressed in various immune cells, including CD8-positive T cells, alpha-beta cytokine-secreting effector T cells, and CD161-positive immature natural killer cells. SIPA1 has been shown to interact with several proteins, including Rap1 GTPase, which is involved in cell signaling and cytoskeleton reorganization. The gene's expression is tightly regulated by various transcription factors, including NF-κB and AP-1, which are key regulators of immune responses. **Pathways and Functions** SIPA1 is involved in several signaling pathways that regulate immune responses, including: 1. **Rap1 Signaling Pathway**: SIPA1 interacts with Rap1 GTPase, which is a key regulator of cell signaling and cytoskeleton reorganization. This interaction plays a crucial role in regulating cell adhesion, migration, and proliferation. 2. **Immune Response Pathway**: SIPA1 has been shown to regulate the expression of genes involved in immune responses, including those involved in cytokine production and cell activation. 3. **Cytoskeleton Organization Pathway**: SIPA1's interaction with Rap1 GTPase regulates cytoskeleton reorganization, which is essential for cell migration, adhesion, and proliferation. 4. **Cell Growth and Differentiation Pathway**: SIPA1 has been shown to regulate cell growth and differentiation by interacting with transcription factors, such as NF-κB and AP-1. **Clinical Significance** SIPA1's involvement in immune responses and cell growth makes it an attractive target for therapeutic interventions in immune-related disorders, including: 1. **Autoimmune Diseases**: SIPA1's role in regulating immune responses makes it a potential target for therapies aimed at modulating autoimmune responses. 2. **Cancer**: SIPA1's involvement in cell growth and differentiation makes it a potential target for therapies aimed at regulating tumor growth and metastasis. 3. **Infectious Diseases**: SIPA1's role in regulating immune responses makes it a potential target for therapies aimed at enhancing immune responses against pathogens. In conclusion, SIPA1 is a multifunctional gene that plays a crucial role in various cellular processes, including immune response, cell growth, and differentiation. Its involvement in several signaling pathways makes it an attractive target for therapeutic interventions in immune-related disorders. Further research is needed to fully understand the mechanisms by which SIPA1 regulates immune responses and to identify potential therapeutic targets for diseases where SIPA1 is dysregulated.

Genular Protein ID: 327042852

Symbol: SIPA1_HUMAN

Name: Signal-induced proliferation-associated protein 1

UniProtKB Accession Codes:

Q96FS4 O14518 O60484 O60618 Q2YD83

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9346962

Title: Human SPA-1 product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2.

PubMed ID: 9346962

DOI: 10.1074/jbc.272.44.28081

PubMed ID: 9651531

Title: Genomic organization and cloning of the human homologue of murine Sipa-1.

PubMed ID: 9651531

DOI: 10.1016/s0378-1119(98)00212-1

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1042
  • Mass: 112149
  • Checksum: FB52C7231EA3B6B9
  • Sequence:
    • MPMWAGGVGS PRRGMAPAST DDLFARKLRQ PARPPLTPHT FEPRPVRGPL LRSGSDAGEA 
RPPTPASPRA RAHSHEEASR PAATSTRLFT DPLALLGLPA EEPEPAFPPV LEPRWFAHYD 
VQSLLFDWAP RSQGMGSHSE ASSGTLASAE DQAASSDLLH GAPGFVCELG GEGELGLGGP 
ASPPVPPALP NAAVSILEEP QNRTSAYSLE HADLGAGYYR KYFYGKEHQN FFGMDESLGP 
VAVSLRREEK EGSGGGTLHS YRVIVRTTQL RTLRGTISED ALPPGPPRGL SPRKLLEHVA 
PQLSPSCLRL GSASPKVPRT LLTLDEQVLS FQRKVGILYC RAGQGSEEEM YNNQEAGPAF 
MQFLTLLGDV VRLKGFESYR AQLDTKTDST GTHSLYTTYQ DHEIMFHVST MLPYTPNNQQ 
QLLRKRHIGN DIVTIVFQEP GSKPFCPTTI RSHFQHVFLV VRAHTPCTPH TTYRVAVSRT 
QDTPAFGPAL PAGGGPFAAN ADFRAFLLAK ALNGEQAAGH ARQFHAMATR TRQQYLQDLA 
TNEVTTTSLD SASRFGLPSL GGRRRAAPRG PGAELQAAGS LVWGVRAAPG ARVAAGAQAS 
GPEGIEVPCL LGISAEALVL VAPRDGRVVF NCACRDVLAW TFSEQQLDLY HGRGEAITLR 
FDGSPGQAVG EVVARLQLVS RGCETRELAL PRDGQGRLGF EVDAEGFVTH VERFTFAETA 
GLRPGARLLR VCGQTLPSLR PEAAAQLLRS APKVCVTVLP PDESGRPRRS FSELYTLSLQ 
EPSRRGAPDP VQDEVQGVTL LPTTKQLLHL CLQDGGSPPG PGDLAEERTE FLHSQNSLSP 
RSSLSDEAPV LPNTTPDLLL ATTAKPSVPS ADSETPLTQD RPGSPSGSED KGNPAPELRA 
SFLPRTLSLR NSISRIMSEA GSGTLEDEWQ AISEIASTCN TILESLSREG QPIPESGDPK 
GTPKSDAEPE PGNLSEKVSH LESMLRKLQE DLQKEKADRA ALEEEVRSLR HNNRRLQAES 
ESAATRLLLA SKQLGSPTAD LA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.