Details for: SLAMF1

Gene ID: 6504

Symbol: SLAMF1

Ensembl ID: ENSG00000117090

Description: signaling lymphocytic activation molecule family member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 44.4887
    Cell Significance Index: -6.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 17.5505
    Cell Significance Index: -7.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.6206
    Cell Significance Index: -6.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.3968
    Cell Significance Index: 99.7600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.8035
    Cell Significance Index: 43.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.1875
    Cell Significance Index: -5.8600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.3544
    Cell Significance Index: -4.1600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.5146
    Cell Significance Index: 5.1600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.4118
    Cell Significance Index: 4.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2981
    Cell Significance Index: 35.1500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.2541
    Cell Significance Index: 4.3700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0569
    Cell Significance Index: 0.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0304
    Cell Significance Index: 1.9600
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0236
    Cell Significance Index: 0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0033
    Cell Significance Index: -6.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0051
    Cell Significance Index: -9.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0061
    Cell Significance Index: -9.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0070
    Cell Significance Index: -9.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0086
    Cell Significance Index: -6.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0098
    Cell Significance Index: -7.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0111
    Cell Significance Index: -7.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0114
    Cell Significance Index: -6.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0145
    Cell Significance Index: -0.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0162
    Cell Significance Index: -7.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0194
    Cell Significance Index: -6.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0195
    Cell Significance Index: -3.8700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0255
    Cell Significance Index: -1.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0286
    Cell Significance Index: -8.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0286
    Cell Significance Index: -3.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0315
    Cell Significance Index: -6.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0329
    Cell Significance Index: -6.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0384
    Cell Significance Index: -6.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0390
    Cell Significance Index: -7.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0407
    Cell Significance Index: -2.1200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0463
    Cell Significance Index: -0.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0468
    Cell Significance Index: -6.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0562
    Cell Significance Index: -6.4400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0571
    Cell Significance Index: -0.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0572
    Cell Significance Index: -7.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0593
    Cell Significance Index: -7.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0610
    Cell Significance Index: -7.8800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0621
    Cell Significance Index: -1.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0643
    Cell Significance Index: -2.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0659
    Cell Significance Index: -6.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0679
    Cell Significance Index: -7.0700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0736
    Cell Significance Index: -1.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0763
    Cell Significance Index: -3.5900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0777
    Cell Significance Index: -1.3400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1000
    Cell Significance Index: -1.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1041
    Cell Significance Index: -7.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1044
    Cell Significance Index: -8.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1060
    Cell Significance Index: -7.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1202
    Cell Significance Index: -7.3700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1208
    Cell Significance Index: -1.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1249
    Cell Significance Index: -1.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1298
    Cell Significance Index: -7.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1353
    Cell Significance Index: -3.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1503
    Cell Significance Index: -7.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1583
    Cell Significance Index: -8.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1675
    Cell Significance Index: -4.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1689
    Cell Significance Index: -7.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1825
    Cell Significance Index: -4.6900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1846
    Cell Significance Index: -2.1800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1931
    Cell Significance Index: -2.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1989
    Cell Significance Index: -7.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1990
    Cell Significance Index: -6.9700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1997
    Cell Significance Index: -2.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2109
    Cell Significance Index: -6.9100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2117
    Cell Significance Index: -7.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2159
    Cell Significance Index: -6.8800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2234
    Cell Significance Index: -5.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2243
    Cell Significance Index: -6.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2325
    Cell Significance Index: -8.1700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2355
    Cell Significance Index: -7.4500
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.2393
    Cell Significance Index: -2.8200
  • Cell Name: centrocyte (CL0009111)
    Fold Change: -0.2433
    Cell Significance Index: -0.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2451
    Cell Significance Index: -6.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2495
    Cell Significance Index: -7.1200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2497
    Cell Significance Index: -6.3800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2502
    Cell Significance Index: -6.2500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2512
    Cell Significance Index: -7.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2653
    Cell Significance Index: -7.6100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2673
    Cell Significance Index: -6.8100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.2725
    Cell Significance Index: -3.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2744
    Cell Significance Index: -7.4700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2826
    Cell Significance Index: -7.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2836
    Cell Significance Index: -8.1700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2871
    Cell Significance Index: -2.9000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.2876
    Cell Significance Index: -2.4500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2989
    Cell Significance Index: -4.1900
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.3080
    Cell Significance Index: -2.7800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3109
    Cell Significance Index: -6.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3137
    Cell Significance Index: -8.2500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3245
    Cell Significance Index: -4.1000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3278
    Cell Significance Index: -7.9400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3312
    Cell Significance Index: -7.0300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3319
    Cell Significance Index: -7.1700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3323
    Cell Significance Index: -6.9400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3365
    Cell Significance Index: -6.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SLAMF1 is a member of the SLAM (Signaling Lymphocytic Activation Molecule) family, which comprises a group of receptors that interact with various ligands, including SLAMF2, SLAMF3, and SLAMF4. These receptors are characterized by their unique extracellular and transmembrane domains, which facilitate interactions with other cells and molecules. SLAMF1 is predominantly expressed on the surface of immune cells, including T cells, dendritic cells, and natural killer cells, where it serves as a bridge between the innate and adaptive immune systems. **Pathways and Functions:** SLAMF1 is involved in various signaling pathways that regulate immune cell activation, proliferation, and differentiation. Some of the key pathways and functions of SLAMF1 include: 1. **Adaptive Immune Response:** SLAMF1 interacts with its ligands, such as SLAMF2, to activate T cells and promote their proliferation and differentiation into effector cells. 2. **Negative Regulation of Immune Responses:** SLAMF1 also plays a crucial role in regulating the activity of immune cells, including T cells and dendritic cells, by inhibiting the production of pro-inflammatory cytokines, such as IL-6, IL-12, and TNF-α. 3. **Cell Adhesion and Migration:** SLAMF1 facilitates the adhesion and migration of immune cells, including T cells and dendritic cells, to sites of inflammation and infection. 4. **Apoptosis and Cell Survival:** SLAMF1 has been shown to regulate the expression of anti-apoptotic and pro-apoptotic proteins, influencing the survival and death of immune cells. **Clinical Significance:** SLAMF1 has been implicated in various immune-related disorders, including: 1. **Autoimmune Diseases:** SLAMF1 has been shown to contribute to the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, by promoting the activation and proliferation of autoreactive T cells. 2. **Cancer:** SLAMF1 has been identified as a potential target for cancer immunotherapy, as it can modulate the activity of immune cells and influence tumor growth and progression. 3. **Infectious Diseases:** SLAMF1 has been shown to play a role in the regulation of the innate immune response, influencing the activation and function of immune cells, such as natural killer cells and dendritic cells, in response to pathogens. In conclusion, SLAMF1 is a complex receptor that plays a pivotal role in regulating various aspects of the immune response. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of further research into the mechanisms and clinical significance of SLAMF1. As an expert immunologist, it is essential to continue studying SLAMF1 to unravel its full potential and to explore its therapeutic applications in the treatment of immune-related diseases.

Genular Protein ID: 1500653949

Symbol: SLAF1_HUMAN

Name: Signaling lymphocytic activation molecule

UniProtKB Accession Codes:

Q13291 Q5W172 Q9HBE8 W0HKK7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7617038

Title: A novel receptor involved in T-cell activation.

PubMed ID: 7617038

DOI: 10.1038/376260a0

PubMed ID: 25710480

Title: Expression of CD150 in tumors of the central nervous system: identification of a novel isoform.

PubMed ID: 25710480

DOI: 10.1371/journal.pone.0118302

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12629654

Title: Absence of SLAM mutations in EBV-associated lymphoproliferative disease patients.

PubMed ID: 12629654

DOI: 10.1002/jmv.10373

PubMed ID: 9091591

Title: Soluble and membrane-bound forms of signaling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B lymphocytes.

PubMed ID: 9091591

DOI: 10.1084/jem.185.6.993

PubMed ID: 9774102

Title: The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM.

PubMed ID: 9774102

DOI: 10.1038/26683

PubMed ID: 10229804

Title: CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis.

PubMed ID: 10229804

PubMed ID: 10972291

Title: SLAM (CDw150) is a cellular receptor for measles virus.

PubMed ID: 10972291

DOI: 10.1038/35022579

PubMed ID: 11313386

Title: CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A.

PubMed ID: 11313386

DOI: 10.4049/jimmunol.166.9.5480

PubMed ID: 11806999

Title: Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation.

PubMed ID: 11806999

DOI: 10.1182/blood.v99.3.957

PubMed ID: 12458214

Title: Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors.

PubMed ID: 12458214

DOI: 10.1074/jbc.m206649200

PubMed ID: 16317102

Title: SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines in monocyte-derived dendritic cells.

PubMed ID: 16317102

DOI: 10.1182/blood-2005-06-2265

PubMed ID: 20231852

Title: CD150 regulates JNK1/2 activation in normal and Hodgkin's lymphoma B cells.

PubMed ID: 20231852

DOI: 10.1038/icb.2010.14

PubMed ID: 20818396

Title: SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages.

PubMed ID: 20818396

DOI: 10.1038/ni.1931

PubMed ID: 11689425

Title: Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.

PubMed ID: 11689425

DOI: 10.1093/emboj/20.21.5840

PubMed ID: 11823424

Title: A 'three-pronged' binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.

PubMed ID: 11823424

DOI: 10.1093/emboj/21.3.314

PubMed ID: 12545174

Title: SAP couples Fyn to SLAM immune receptors.

PubMed ID: 12545174

DOI: 10.1038/ncb920

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 335
  • Mass: 37231
  • Checksum: BFB0F27EA31D8C04
  • Sequence:
    • MDPKGLLSLT FVLFLSLAFG ASYGTGGRMM NCPKILRQLG SKVLLPLTYE RINKSMNKSI 
HIVVTMAKSL ENSVENKIVS LDPSEAGPPR YLGDRYKFYL ENLTLGIRES RKEDEGWYLM 
TLEKNVSVQR FCLQLRLYEQ VSTPEIKVLN KTQENGTCTL ILGCTVEKGD HVAYSWSEKA 
GTHPLNPANS SHLLSLTLGP QHADNIYICT VSNPISNNSQ TFSPWPGCRT DPSETKPWAV 
YAGLLGGVIM ILIMVVILQL RRRGKTNHYQ TTVEKKSLTI YAQVQKPGPL QKKLDSFPAQ 
DPCTTIYVAA TEPVPESVQE TNSITVYASV TLPES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.