Details for: SMARCA4

Gene ID: 6597

Symbol: SMARCA4

Ensembl ID: ENSG00000127616

Description: SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 331.8649
    Cell Significance Index: -51.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 196.1810
    Cell Significance Index: -49.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 119.6533
    Cell Significance Index: -48.6100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 119.1414
    Cell Significance Index: -49.0800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 109.5871
    Cell Significance Index: -56.3700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 87.1655
    Cell Significance Index: -58.4900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 51.1237
    Cell Significance Index: -48.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.0624
    Cell Significance Index: -55.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.4229
    Cell Significance Index: -54.7100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.7031
    Cell Significance Index: -45.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.3055
    Cell Significance Index: -56.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.6364
    Cell Significance Index: -21.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.3894
    Cell Significance Index: 278.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.2534
    Cell Significance Index: 155.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.9842
    Cell Significance Index: 68.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.6762
    Cell Significance Index: 94.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6097
    Cell Significance Index: 322.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6087
    Cell Significance Index: 319.2600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.5053
    Cell Significance Index: 18.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4918
    Cell Significance Index: 41.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4136
    Cell Significance Index: 507.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2691
    Cell Significance Index: 81.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2498
    Cell Significance Index: 135.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0882
    Cell Significance Index: 65.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0418
    Cell Significance Index: 169.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9619
    Cell Significance Index: 95.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9489
    Cell Significance Index: 111.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9305
    Cell Significance Index: 167.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9160
    Cell Significance Index: 500.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8883
    Cell Significance Index: 614.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8750
    Cell Significance Index: 53.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8665
    Cell Significance Index: 24.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8651
    Cell Significance Index: 106.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8280
    Cell Significance Index: 43.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7141
    Cell Significance Index: 15.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5942
    Cell Significance Index: 30.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5743
    Cell Significance Index: 26.9900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5685
    Cell Significance Index: 6.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5282
    Cell Significance Index: 23.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4925
    Cell Significance Index: 67.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4870
    Cell Significance Index: 25.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4785
    Cell Significance Index: 61.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4597
    Cell Significance Index: 30.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4371
    Cell Significance Index: 4.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4054
    Cell Significance Index: 18.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3913
    Cell Significance Index: 173.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3808
    Cell Significance Index: 7.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3696
    Cell Significance Index: 16.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3664
    Cell Significance Index: 28.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3479
    Cell Significance Index: 9.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2552
    Cell Significance Index: 6.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2507
    Cell Significance Index: 5.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2438
    Cell Significance Index: 46.4100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.2131
    Cell Significance Index: 2.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1905
    Cell Significance Index: 6.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1841
    Cell Significance Index: 6.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1817
    Cell Significance Index: 13.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1097
    Cell Significance Index: 206.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0954
    Cell Significance Index: 16.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0470
    Cell Significance Index: 29.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0413
    Cell Significance Index: 63.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0273
    Cell Significance Index: 50.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0242
    Cell Significance Index: 21.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0124
    Cell Significance Index: 0.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0091
    Cell Significance Index: 12.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0081
    Cell Significance Index: 3.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0052
    Cell Significance Index: 3.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0086
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0178
    Cell Significance Index: -13.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0189
    Cell Significance Index: -11.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0245
    Cell Significance Index: -3.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0406
    Cell Significance Index: -30.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0473
    Cell Significance Index: -0.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0714
    Cell Significance Index: -1.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0767
    Cell Significance Index: -43.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1099
    Cell Significance Index: -2.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1136
    Cell Significance Index: -11.6100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1510
    Cell Significance Index: -4.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1518
    Cell Significance Index: -2.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1561
    Cell Significance Index: -32.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1684
    Cell Significance Index: -48.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1947
    Cell Significance Index: -13.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1977
    Cell Significance Index: -28.7400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2757
    Cell Significance Index: -5.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2859
    Cell Significance Index: -32.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3989
    Cell Significance Index: -41.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4654
    Cell Significance Index: -6.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4709
    Cell Significance Index: -10.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4770
    Cell Significance Index: -12.2600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4983
    Cell Significance Index: -12.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5045
    Cell Significance Index: -12.6100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5121
    Cell Significance Index: -58.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5717
    Cell Significance Index: -45.2800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.6525
    Cell Significance Index: -5.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7164
    Cell Significance Index: -22.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7227
    Cell Significance Index: -44.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8198
    Cell Significance Index: -21.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8887
    Cell Significance Index: -26.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9193
    Cell Significance Index: -27.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9287
    Cell Significance Index: -24.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SMARCA4 is a 239-kilobase gene located on chromosome 2q32.1. It encodes a protein called BRG1 (Brahma-Related Gene 1), which is a subunit of the SWI/SNF chromatin remodeling complex. The BRG1 protein is a 250-kilodalton protein that contains a RING finger domain and two bromodomains, which are essential for its function in chromatin remodeling. SMARCA4 is expressed in a wide range of cell types, including neurons, epithelial cells, and immune cells. **Pathways and Functions** SMARCA4 plays a critical role in various cellular processes, including: 1. **Chromatin remodeling**: SMARCA4 is involved in the remodeling of chromatin to facilitate transcriptional activation and repression of various genes. This process involves the removal of histone H3 and H4 from chromatin, allowing for the binding of transcription factors and other regulatory proteins. 2. **Gene expression regulation**: SMARCA4 regulates the expression of genes involved in development, cell growth, and differentiation. It also plays a role in the regulation of cytokine signaling, immune responses, and nervous system development. 3. **DNA repair**: SMARCA4 is involved in the repair of DNA double-strand breaks, which are critical for maintaining genome stability. **Clinical Significance** Mutations in SMARCA4 have been associated with a range of clinical disorders, including: 1. **Cancer**: SMARCA4 mutations have been identified in various types of cancer, including breast, lung, and prostate cancer. 2. **Neurological disorders**: SMARCA4 mutations have been associated with neurological disorders, including epilepsy, intellectual disability, and schizophrenia. 3. **Infertility**: SMARCA4 mutations have been identified in individuals with infertility, suggesting a role for this gene in reproductive biology. 4. **Genetic disorders**: SMARCA4 mutations have been associated with genetic disorders, including Kabuki syndrome and Weaver syndrome. In summary, SMARCA4 is a critical gene involved in chromatin remodeling, gene expression regulation, and DNA repair. Mutations in this gene have been associated with a range of clinical disorders, highlighting its importance in human health and disease.

Genular Protein ID: 501722277

Symbol: SMCA4_HUMAN

Name: Transcription activator BRG1

UniProtKB Accession Codes:

P51532 B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 3 CORUM 1 CPTAC 1 CTD 1 CarbonylDB 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 21 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 12 EMDB 4 Ensembl 12 EvolutionaryTrace 1 ExpressionAtlas 1 GO 62 Gene3D 5 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 19 PIR 1 PRINTS 1 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 7 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 8 RefSeq 10 SIGNOR 1 SMART 7 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8232556

Title: BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription.

PubMed ID: 8232556

DOI: 10.1038/366170a0

PubMed ID: 8208605

Title: Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor.

PubMed ID: 8208605

DOI: 10.1093/nar/22.10.1815

PubMed ID: 11085541

Title: BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines.

PubMed ID: 11085541

PubMed ID: 18386774

Title: Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines.

PubMed ID: 18386774

DOI: 10.1002/humu.20730

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 9590696

Title: Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex.

PubMed ID: 9590696

DOI: 10.1038/30032

PubMed ID: 10204490

Title: Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.

PubMed ID: 10204490

DOI: 10.1016/s1074-7613(00)80034-5

PubMed ID: 11839798

Title: BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation.

PubMed ID: 11839798

DOI: 10.1128/mcb.22.5.1307-1316.2002

PubMed ID: 12917342

Title: BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation.

PubMed ID: 12917342

DOI: 10.1128/mcb.23.17.6210-6220.2003

PubMed ID: 15075294

Title: TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival.

PubMed ID: 15075294

DOI: 10.1101/gad.1180204

PubMed ID: 16051670

Title: hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes.

PubMed ID: 16051670

DOI: 10.1210/me.2005-0097

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18765789

Title: Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.

PubMed ID: 18765789

DOI: 10.1101/gad.471408

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19571879

Title: Telomerase modulates Wnt signalling by association with target gene chromatin.

PubMed ID: 19571879

DOI: 10.1038/nature08137

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20137775

Title: Germline nonsense mutation and somatic inactivation of SMARCA4/BRG1 in a family with rhabdoid tumor predisposition syndrome.

PubMed ID: 20137775

DOI: 10.1016/j.ajhg.2010.01.013

PubMed ID: 20460684

Title: Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway.

PubMed ID: 20460684

DOI: 10.1074/jbc.m109.087783

PubMed ID: 20418909

Title: ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1.

PubMed ID: 20418909

DOI: 10.1038/onc.2010.102

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23071114

Title: Novel evolutionary-conserved role for the activity-dependent neuroprotective protein (ADNP) family that is important for erythropoiesis.

PubMed ID: 23071114

DOI: 10.1074/jbc.m112.387027

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 28649782

Title: Heterozygous variants in ACTL6A, encoding a component of the BAF complex, are associated with intellectual disability.

PubMed ID: 28649782

DOI: 10.1002/humu.23282

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 22952240

Title: SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions.

PubMed ID: 22952240

DOI: 10.1074/jbc.r111.309302

PubMed ID: 26601204

Title: Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics.

PubMed ID: 26601204

DOI: 10.1126/sciadv.1500447

PubMed ID: 29374058

Title: Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.

PubMed ID: 29374058

DOI: 10.1074/jbc.ra117.001065

PubMed ID: 32459350

Title: HRP2-DPF3a-BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription.

PubMed ID: 32459350

DOI: 10.1093/nar/gkaa441

PubMed ID: 17274598

Title: Solution structure of human Brg1 bromodomain and its specific binding to acetylated histone tails.

PubMed ID: 17274598

DOI: 10.1021/bi0611208

PubMed ID: 17582821

Title: Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex.

PubMed ID: 17582821

DOI: 10.1002/cbic.200600562

PubMed ID: 29567837

Title: The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators.

PubMed ID: 29567837

DOI: 10.1074/jbc.ra117.000678

PubMed ID: 22426308

Title: Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome.

PubMed ID: 22426308

DOI: 10.1038/ng.2219

PubMed ID: 37399313

Title: SMARCA4 mutation causes human otosclerosis and a similar phenotype in mice.

PubMed ID: 37399313

DOI: 10.1136/jmg-2023-109264

Sequence Information:

  • Length: 1647
  • Mass: 184646
  • Checksum: ABDA5EDBF10D7D28
  • Sequence:
    • MSTPDPPLGG TPRPGPSPGP GPSPGAMLGP SPGPSPGSAH SMMGPSPGPP SAGHPIPTQG 
PGGYPQDNMH QMHKPMESMH EKGMSDDPRY NQMKGMGMRS GGHAGMGPPP SPMDQHSQGY 
PSPLGGSEHA SSPVPASGPS SGPQMSSGPG GAPLDGADPQ ALGQQNRGPT PFNQNQLHQL 
RAQIMAYKML ARGQPLPDHL QMAVQGKRPM PGMQQQMPTL PPPSVSATGP GPGPGPGPGP 
GPGPAPPNYS RPHGMGGPNM PPPGPSGVPP GMPGQPPGGP PKPWPEGPMA NAAAPTSTPQ 
KLIPPQPTGR PSPAPPAVPP AASPVMPPQT QSPGQPAQPA PMVPLHQKQS RITPIQKPRG 
LDPVEILQER EYRLQARIAH RIQELENLPG SLAGDLRTKA TIELKALRLL NFQRQLRQEV 
VVCMRRDTAL ETALNAKAYK RSKRQSLREA RITEKLEKQQ KIEQERKRRQ KHQEYLNSIL 
QHAKDFKEYH RSVTGKIQKL TKAVATYHAN TEREQKKENE RIEKERMRRL MAEDEEGYRK 
LIDQKKDKRL AYLLQQTDEY VANLTELVRQ HKAAQVAKEK KKKKKKKKAE NAEGQTPAIG 
PDGEPLDETS QMSDLPVKVI HVESGKILTG TDAPKAGQLE AWLEMNPGYE VAPRSDSEES 
GSEEEEEEEE EEQPQAAQPP TLPVEEKKKI PDPDSDDVSE VDARHIIENA KQDVDDEYGV 
SQALARGLQS YYAVAHAVTE RVDKQSALMV NGVLKQYQIK GLEWLVSLYN NNLNGILADE 
MGLGKTIQTI ALITYLMEHK RINGPFLIIV PLSTLSNWAY EFDKWAPSVV KVSYKGSPAA 
RRAFVPQLRS GKFNVLLTTY EYIIKDKHIL AKIRWKYMIV DEGHRMKNHH CKLTQVLNTH 
YVAPRRLLLT GTPLQNKLPE LWALLNFLLP TIFKSCSTFE QWFNAPFAMT GEKVDLNEEE 
TILIIRRLHK VLRPFLLRRL KKEVEAQLPE KVEYVIKCDM SALQRVLYRH MQAKGVLLTD 
GSEKDKKGKG GTKTLMNTIM QLRKICNHPY MFQHIEESFS EHLGFTGGIV QGLDLYRASG 
KFELLDRILP KLRATNHKVL LFCQMTSLMT IMEDYFAYRG FKYLRLDGTT KAEDRGMLLK 
TFNEPGSEYF IFLLSTRAGG LGLNLQSADT VIIFDSDWNP HQDLQAQDRA HRIGQQNEVR 
VLRLCTVNSV EEKILAAAKY KLNVDQKVIQ AGMFDQKSSS HERRAFLQAI LEHEEQDESR 
HCSTGSGSAS FAHTAPPPAG VNPDLEEPPL KEEDEVPDDE TVNQMIARHE EEFDLFMRMD 
LDRRREEARN PKRKPRLMEE DELPSWIIKD DAEVERLTCE EEEEKMFGRG SRHRKEVDYS 
DSLTEKQWLK AIEEGTLEEI EEEVRQKKSS RKRKRDSDAG SSTPTTSTRS RDKDDESKKQ 
KKRGRPPAEK LSPNPPNLTK KMKKIVDAVI KYKDSSSGRQ LSEVFIQLPS RKELPEYYEL 
IRKPVDFKKI KERIRNHKYR SLNDLEKDVM LLCQNAQTFN LEGSLIYEDS IVLQSVFTSV 
RQKIEKEDDS EGEESEEEEE GEEEGSESES RSVKVKIKLG RKEKAQDRLK GGRRRPSRGS 
RAKPVVSDDD SEEEQEEDRS GSGSEED

Genular Protein ID: 1780817937

Symbol: B3KNW7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KNW7

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 3 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 4 SAM 1 SMART 3 SUPFAM 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 737
  • Mass: 85658
  • Checksum: EBB9F488435C396E
  • Sequence:
    • MIVDEGHRMK NHHCKLTQVL NTHYVAPRRL LLTGTPLQNK LPELWALLNF LLPTIFKSCS 
TFEQWFNAPF AMTGEKVDLN EEETILIIRR LHKVLRPFLL RRLKKEVEAQ LPEKVEYVIK 
CDMSALQRVL YRHMQAKGVL LTDGSEKDKK GKGGTKTLMN TIMQLRKICN HPYMFQHIEE 
SFSEHLGFTG GIVQGLDLYR ASGKFELLDR ILPKLRATNH KVLLFCQMTS LMTIMEDYFA 
YRGFKYLRLD GTTKAEDRGM LLKTFNEPGS EYFIFLLSTR AGGLGLNLQS ADTVIIFDSD 
WNPHQDLQAQ DRAHRIGQQN EVRVLRLCTV NSVEEKILAA AKYKLNVDQK VIQAGMFDQK 
SSSHERRAFL QAILEHEEQD EEEDEVPDDE TVNQMIARHE EEFDLFMRMD LDRRREEARN 
PKRKPRLMEE DELPSWIIKD DAEVERLTCE EEEEKMFGRG SRHRKEVDYS DSLTEKQWLK 
AIEEGTLEEI EEEVRQKKSS RKRKRDSDAG SSTPTTSTRS RDKDDESKKQ KKRGRPPAEK 
LSPNPPNLTK KMKKIVDAVI KYKDSSSGRQ LSEVFIQLPS RKELPEYYEL IRKPVDFKKI 
KERIRNHKYR SLNDLEKDVM LLCQNAQTFN LEGSLIYEDS IVLQSVFTSV RQKIEKEDDS 
EGEESEEEEE GEEEGSESES RSVKVKIKLG RKEKAQDRLK GGRRRPSRGS RAKPVVSDDD 
SEEEQEEDRS GSGSEED

Genular Protein ID: 4155594752

Symbol: Q9HBD4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9HBD4

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 GO 9 Gene3D 5 GeneTree 1 HGNC 1 IntAct 1 InterPro 15 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 11 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 7 PharmGKB 1 Proteomes 2 ProteomicsDB 2 RefSeq 4 SAM 1 SMART 7 SUPFAM 3 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11085541

Title: BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines.

PubMed ID: 11085541

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 1679
  • Mass: 188149
  • Checksum: C11A4EEF8086A175
  • Sequence:
    • MSTPDPPLGG TPRPGPSPGP GPSPGAMLGP SPGPSPGSAH SMMGPSPGPP SAGHPIPTQG 
PGGYPQDNMH QMHKPMESMH EKGMSDDPRY NQMKGMGMRS GGHAGMGPPP SPMDQHSQGY 
PSPLGGSEHA SSPVPASGPS SGPQMSSGPG GAPLDGADPQ ALGQQNRGPT PFNQNQLHQL 
RAQIMAYKML ARGQPLPDHL QMAVQGKRPM PGMQQQMPTL PPPSVSATGP GPGPGPGPGP 
GPGPAPPNYS RPHGMGGPNM PPPGPSGVPP GMPGQPPGGP PKPWPEGPMA NAAAPTSTPQ 
KLIPPQPTGR PSPAPPAVPP AASPVMPPQT QSPGQPAQPA PMVPLHQKQS RITPIQKPRG 
LDPVEILQER EYRLQARIAH RIQELENLPG SLAGDLRTKA TIELKALRLL NFQRQLRQEV 
VVCMRRDTAL ETALNAKAYK RSKRQSLREA RITEKLEKQQ KIEQERKRRQ KHQEYLNSIL 
QHAKDFKEYH RSVTGKIQKL TKAVATYHAN TEREQKKENE RIEKERMRRL MAEDEEGYRK 
LIDQKKDKRL AYLLQQTDEY VANLTELVRQ HKAAQVAKEK KKKKKKKKAE NAEGQTPAIG 
PDGEPLDETS QMSDLPVKVI HVESGKILTG TDAPKAGQLE AWLEMNPGYE VAPRSDSEES 
GSEEEEEEEE EEQPQAAQPP TLPVEEKKKI PDPDSDDVSE VDARHIIENA KQDVDDEYGV 
SQALARGLQS YYAVAHAVTE RVDKQSALMV NGVLKQYQIK GLEWLVSLYN NNLNGILADE 
MGLGKTIQTI ALITYLMEHK RINGPFLIIV PLSTLSNWAY EFDKWAPSVV KVSYKGSPAA 
RRAFVPQLRS GKFNVLLTTY EYIIKDKHIL AKIRWKYMIV DEGHRMKNHH CKLTQVLNTH 
YVAPRRLLLT GTPLQNKLPE LWALLNFLLP TIFKSCSTFE QWFNAPFAMT GEKVDLNEEE 
TILIIRRLHK VLRPFLLRRL KKEVEAQLPE KVEYVIKCDM SALQRVLYRH MQAKGVLLTD 
GSEKDKKGKG GTKTLMNTIM QLRKICNHPY MFQHIEESFS EHLGFTGGIV QGLDLYRASG 
KFELLDRILP KLRATNHKVL LFCQMTSLMT IMEDYFAYRG FKYLRLDGTT KAEDRGMLLK 
TFNEPGSEYF IFLLSTRAGG LGLNLQSADT VIIFDSDWNP HQDLQAQDRA HRIGQQNEVR 
VLRLCTVNSV EEKILAAAKY KLNVDQKVIQ AGMFDQKSSS HERRAFLQAI LEHEEQDESR 
HCSTGSGSAS FAHTAPPPAG VNPDLEEPPL KEEDEVPDDE TVNQMIARHE EEFDLFMRMD 
LDRRREEARN PKRKPRLMEE DELPSWIIKD DAEVERLTCE EEEEKMFGRG SRHRKEVDYS 
DSLTEKQWLK KITGKDIHDT ASSVARGLQF QRGLQFCTRA SKAIEEGTLE EIEEEVRQKK 
SSRKRKRDSD AGSSTPTTST RSRDKDDESK KQKKRGRPPA EKLSPNPPNL TKKMKKIVDA 
VIKYKDSSSG RQLSEVFIQL PSRKELPEYY ELIRKPVDFK KIKERIRNHK YRSLNDLEKD 
VMLLCQNAQT FNLEGSLIYE DSIVLQSVFT SVRQKIEKED DSEGEESEEE EEGEEEGSES 
ESRSVKVKIK LGRKEKAQDR LKGGRRRPSR GSRAKPVVSD DDSEEEQEED RSGSGSEED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.