Details for: SMPD2

Gene ID: 6610

Symbol: SMPD2

Ensembl ID: ENSG00000135587

Description: sphingomyelin phosphodiesterase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.48
    Marker Score: 12893
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.25
    Marker Score: 1044
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.18
    Marker Score: 4042
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.06
    Marker Score: 2011
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71774
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47999
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2720
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5034
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5262
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.8
    Marker Score: 1395
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.77
    Marker Score: 6648
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 544
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.71
    Marker Score: 337
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 642
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 281
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2756
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.64
    Marker Score: 1341.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.62
    Marker Score: 1171.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.58
    Marker Score: 9046
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.57
    Marker Score: 261
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.56
    Marker Score: 4342.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.55
    Marker Score: 1249
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 426
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.53
    Marker Score: 424
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.52
    Marker Score: 498
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.5
    Marker Score: 1176
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.49
    Marker Score: 2371
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.49
    Marker Score: 725
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.47
    Marker Score: 4788
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.46
    Marker Score: 2952
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.45
    Marker Score: 415
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.45
    Marker Score: 538
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.44
    Marker Score: 138
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.44
    Marker Score: 442
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.44
    Marker Score: 1041
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.43
    Marker Score: 1354
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.43
    Marker Score: 138
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.43
    Marker Score: 1158
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.42
    Marker Score: 269
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.42
    Marker Score: 110
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.41
    Marker Score: 14323
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.41
    Marker Score: 170
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.4
    Marker Score: 267
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.4
    Marker Score: 266
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4
    Marker Score: 1178
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.4
    Marker Score: 195
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.39
    Marker Score: 351
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.39
    Marker Score: 560
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.39
    Marker Score: 281
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.39
    Marker Score: 190
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.39
    Marker Score: 374
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.39
    Marker Score: 192
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.38
    Marker Score: 136
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.38
    Marker Score: 357
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.38
    Marker Score: 240
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.38
    Marker Score: 208
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.37
    Marker Score: 1441
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.37
    Marker Score: 87
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.37
    Marker Score: 12508
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.37
    Marker Score: 566
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.37
    Marker Score: 398
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.36
    Marker Score: 635
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.36
    Marker Score: 124
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.36
    Marker Score: 171
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.35
    Marker Score: 165
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.35
    Marker Score: 442
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.35
    Marker Score: 461
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.35
    Marker Score: 309
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.34
    Marker Score: 1345
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.34
    Marker Score: 481
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.34
    Marker Score: 252
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.33
    Marker Score: 329
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.33
    Marker Score: 200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.33
    Marker Score: 345
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.33
    Marker Score: 106
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.33
    Marker Score: 122
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.33
    Marker Score: 75
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.32
    Marker Score: 325
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.32
    Marker Score: 113
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.32
    Marker Score: 236
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.32
    Marker Score: 70
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.32
    Marker Score: 76
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.32
    Marker Score: 4264
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.32
    Marker Score: 77
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.32
    Marker Score: 119
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.32
    Marker Score: 503
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.32
    Marker Score: 185
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.32
    Marker Score: 215
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.32
    Marker Score: 2015
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.31
    Marker Score: 67
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.31
    Marker Score: 210
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.31
    Marker Score: 193

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Other Information

**Key Characteristics** SMPD2 is a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide and phosphocholine. This enzyme is highly specific, with a substrate specificity for sphingomyelin and a low affinity for other sphingolipids. SMPD2 is composed of two catalytic domains, each with a serine residue that is essential for its enzymatic activity. The enzyme is also regulated by various post-translational modifications, including phosphorylation and ubiquitination. **Pathways and Functions** SMPD2 is involved in various cellular pathways, including: 1. **Ceramide biosynthesis**: SMPD2 is the rate-limiting enzyme in the ceramide biosynthetic pathway, which is essential for cell signaling, apoptosis, and lipid metabolism. 2. **Death receptor signaling**: SMPD2 is involved in the regulation of death receptor signaling, which is critical for apoptosis and immune responses. 3. **Glycosphingolipid catabolism**: SMPD2 is also involved in the catabolism of glycosphingolipids, which are essential for cell signaling and membrane structure. 4. **Sphingomyelin metabolism**: SMPD2 is the primary enzyme responsible for the breakdown of sphingomyelin, which is a key component of cellular membranes. **Clinical Significance** Dysregulation of SMPD2 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: SMPD2 has been linked to neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where it plays a role in the regulation of ceramide levels and apoptosis. 2. **Cancer**: SMPD2 has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer, where it contributes to tumor progression and metastasis. 3. **Inflammatory conditions**: SMPD2 has been implicated in inflammatory conditions, such as atherosclerosis and inflammatory bowel disease, where it regulates ceramide levels and immune responses. In conclusion, SMPD2 is a critical enzyme involved in various cellular processes, including cell signaling, apoptosis, and lipid metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of SMPD2 in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 3767844211

Symbol: NSMA_HUMAN

Name: N/A

UniProtKB Accession Codes:

O60906 Q5TED1 Q9BWR3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 32 ChEMBL 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 12 SAM 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9520418

Title: Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?

PubMed ID: 9520418

DOI: 10.1073/pnas.95.7.3638

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10608884

Title: Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C.

PubMed ID: 10608884

DOI: 10.1074/jbc.274.53.38131

PubMed ID: 14741383

Title: Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases.

PubMed ID: 14741383

DOI: 10.1016/s0014-5793(03)01523-0

Sequence Information:

  • Length: 423
  • Mass: 47646
  • Checksum: 3C1514CE21560501
  • Sequence:
    • MKPNFSLRLR IFNLNCWGIP YLSKHRADRM RRLGDFLNQE SFDLALLEEV WSEQDFQYLR 
QKLSPTYPAA HHFRSGIIGS GLCVFSKHPI QELTQHIYTL NGYPYMIHHG DWFSGKAVGL 
LVLHLSGMVL NAYVTHLHAE YNRQKDIYLA HRVAQAWELA QFIHHTSKKA DVVLLCGDLN 
MHPEDLGCCL LKEWTGLHDA YLETRDFKGS EEGNTMVPKN CYVSQQELKP FPFGVRIDYV 
LYKAVSGFYI SCKSFETTTG FDPHRGTPLS DHEALMATLF VRHSPPQQNP SSTHGPAERS 
PLMCVLKEAW TELGLGMAQA RWWATFASYV IGLGLLLLAL LCVLAAGGGA GEAAILLWTP 
SVGLVLWAGA FYLFHVQEVN GLYRAQAELQ HVLGRAREAQ DLGPEPQPAL LLGQQEGDRT 
KEQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.