Details for: SMPD2

Gene ID: 6610

Symbol: SMPD2

Ensembl ID: ENSG00000135587

Description: sphingomyelin phosphodiesterase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 52.2678
    Cell Significance Index: -8.1300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 24.6606
    Cell Significance Index: -6.2600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 22.8184
    Cell Significance Index: -9.4000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 19.5288
    Cell Significance Index: -9.2200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 17.9389
    Cell Significance Index: -9.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.7967
    Cell Significance Index: -8.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.9416
    Cell Significance Index: -7.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.1617
    Cell Significance Index: -8.5300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.0912
    Cell Significance Index: 34.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2157
    Cell Significance Index: 1097.7000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.0144
    Cell Significance Index: -2.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8114
    Cell Significance Index: 131.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7214
    Cell Significance Index: 84.0700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.6750
    Cell Significance Index: 10.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6660
    Cell Significance Index: 34.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5542
    Cell Significance Index: 38.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5511
    Cell Significance Index: 11.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5193
    Cell Significance Index: 51.3700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5021
    Cell Significance Index: 6.8500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4137
    Cell Significance Index: 3.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3673
    Cell Significance Index: 16.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3611
    Cell Significance Index: 10.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3584
    Cell Significance Index: 23.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3498
    Cell Significance Index: 9.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3026
    Cell Significance Index: 19.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2589
    Cell Significance Index: 12.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2269
    Cell Significance Index: 123.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2235
    Cell Significance Index: 26.3600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2071
    Cell Significance Index: 5.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2028
    Cell Significance Index: 38.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1955
    Cell Significance Index: 2.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1881
    Cell Significance Index: 33.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1779
    Cell Significance Index: 13.2600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1773
    Cell Significance Index: 2.4600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1723
    Cell Significance Index: 3.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1624
    Cell Significance Index: 20.9800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.1449
    Cell Significance Index: 0.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1277
    Cell Significance Index: 3.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1170
    Cell Significance Index: 4.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1158
    Cell Significance Index: 14.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1104
    Cell Significance Index: 5.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1019
    Cell Significance Index: 2.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1009
    Cell Significance Index: 44.6000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0885
    Cell Significance Index: 2.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0774
    Cell Significance Index: 10.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0718
    Cell Significance Index: 5.0800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0701
    Cell Significance Index: 48.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0660
    Cell Significance Index: 1.7700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0642
    Cell Significance Index: 0.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0637
    Cell Significance Index: 2.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0614
    Cell Significance Index: 12.1900
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.0545
    Cell Significance Index: 0.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0483
    Cell Significance Index: 9.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0229
    Cell Significance Index: 2.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0129
    Cell Significance Index: 2.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0094
    Cell Significance Index: 0.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0019
    Cell Significance Index: 0.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0003
    Cell Significance Index: 0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0020
    Cell Significance Index: -3.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0032
    Cell Significance Index: -4.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0050
    Cell Significance Index: -1.8100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0055
    Cell Significance Index: -0.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0061
    Cell Significance Index: -4.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0067
    Cell Significance Index: -9.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0085
    Cell Significance Index: -6.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0088
    Cell Significance Index: -5.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0123
    Cell Significance Index: -6.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0157
    Cell Significance Index: -9.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0172
    Cell Significance Index: -1.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0179
    Cell Significance Index: -8.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0239
    Cell Significance Index: -6.8900
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0241
    Cell Significance Index: -0.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0310
    Cell Significance Index: -4.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0456
    Cell Significance Index: -9.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0495
    Cell Significance Index: -2.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0601
    Cell Significance Index: -1.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0692
    Cell Significance Index: -5.3100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0757
    Cell Significance Index: -0.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0795
    Cell Significance Index: -8.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0938
    Cell Significance Index: -5.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0992
    Cell Significance Index: -4.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1026
    Cell Significance Index: -8.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1090
    Cell Significance Index: -2.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1149
    Cell Significance Index: -3.0200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1214
    Cell Significance Index: -2.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1227
    Cell Significance Index: -8.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1278
    Cell Significance Index: -7.1700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1312
    Cell Significance Index: -1.4200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1318
    Cell Significance Index: -1.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1338
    Cell Significance Index: -4.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1355
    Cell Significance Index: -8.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1365
    Cell Significance Index: -4.0200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1366
    Cell Significance Index: -2.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1368
    Cell Significance Index: -7.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1536
    Cell Significance Index: -6.8000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1622
    Cell Significance Index: -1.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1647
    Cell Significance Index: -5.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1682
    Cell Significance Index: -4.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SMPD2 is a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide and phosphocholine. This enzyme is highly specific, with a substrate specificity for sphingomyelin and a low affinity for other sphingolipids. SMPD2 is composed of two catalytic domains, each with a serine residue that is essential for its enzymatic activity. The enzyme is also regulated by various post-translational modifications, including phosphorylation and ubiquitination. **Pathways and Functions** SMPD2 is involved in various cellular pathways, including: 1. **Ceramide biosynthesis**: SMPD2 is the rate-limiting enzyme in the ceramide biosynthetic pathway, which is essential for cell signaling, apoptosis, and lipid metabolism. 2. **Death receptor signaling**: SMPD2 is involved in the regulation of death receptor signaling, which is critical for apoptosis and immune responses. 3. **Glycosphingolipid catabolism**: SMPD2 is also involved in the catabolism of glycosphingolipids, which are essential for cell signaling and membrane structure. 4. **Sphingomyelin metabolism**: SMPD2 is the primary enzyme responsible for the breakdown of sphingomyelin, which is a key component of cellular membranes. **Clinical Significance** Dysregulation of SMPD2 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: SMPD2 has been linked to neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where it plays a role in the regulation of ceramide levels and apoptosis. 2. **Cancer**: SMPD2 has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer, where it contributes to tumor progression and metastasis. 3. **Inflammatory conditions**: SMPD2 has been implicated in inflammatory conditions, such as atherosclerosis and inflammatory bowel disease, where it regulates ceramide levels and immune responses. In conclusion, SMPD2 is a critical enzyme involved in various cellular processes, including cell signaling, apoptosis, and lipid metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of SMPD2 in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 3767844211

Symbol: NSMA_HUMAN

Name: N/A

UniProtKB Accession Codes:

O60906 Q5TED1 Q9BWR3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 32 ChEMBL 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 12 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9520418

Title: Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?

PubMed ID: 9520418

DOI: 10.1073/pnas.95.7.3638

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10608884

Title: Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C.

PubMed ID: 10608884

DOI: 10.1074/jbc.274.53.38131

PubMed ID: 14741383

Title: Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases.

PubMed ID: 14741383

DOI: 10.1016/s0014-5793(03)01523-0

Sequence Information:

  • Length: 423
  • Mass: 47646
  • Checksum: 3C1514CE21560501
  • Sequence:
    • MKPNFSLRLR IFNLNCWGIP YLSKHRADRM RRLGDFLNQE SFDLALLEEV WSEQDFQYLR 
QKLSPTYPAA HHFRSGIIGS GLCVFSKHPI QELTQHIYTL NGYPYMIHHG DWFSGKAVGL 
LVLHLSGMVL NAYVTHLHAE YNRQKDIYLA HRVAQAWELA QFIHHTSKKA DVVLLCGDLN 
MHPEDLGCCL LKEWTGLHDA YLETRDFKGS EEGNTMVPKN CYVSQQELKP FPFGVRIDYV 
LYKAVSGFYI SCKSFETTTG FDPHRGTPLS DHEALMATLF VRHSPPQQNP SSTHGPAERS 
PLMCVLKEAW TELGLGMAQA RWWATFASYV IGLGLLLLAL LCVLAAGGGA GEAAILLWTP 
SVGLVLWAGA FYLFHVQEVN GLYRAQAELQ HVLGRAREAQ DLGPEPQPAL LLGQQEGDRT 
KEQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.