Details for: SOAT1

Gene ID: 6646

Symbol: SOAT1

Ensembl ID: ENSG00000057252

Description: sterol O-acyltransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 179.6262
    Cell Significance Index: -27.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 108.4988
    Cell Significance Index: -27.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 63.5852
    Cell Significance Index: -30.0200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.0389
    Cell Significance Index: -25.6100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 55.2115
    Cell Significance Index: -28.4000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 44.8122
    Cell Significance Index: -30.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.8240
    Cell Significance Index: -25.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.9854
    Cell Significance Index: -28.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 11.9641
    Cell Significance Index: 320.5800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.6160
    Cell Significance Index: -25.7600
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 8.8730
    Cell Significance Index: 11.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2123
    Cell Significance Index: -28.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.1758
    Cell Significance Index: -22.0400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.3694
    Cell Significance Index: -13.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7215
    Cell Significance Index: 119.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3858
    Cell Significance Index: 1251.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2826
    Cell Significance Index: 149.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1959
    Cell Significance Index: 237.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9647
    Cell Significance Index: 104.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9522
    Cell Significance Index: 154.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8095
    Cell Significance Index: 48.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7159
    Cell Significance Index: 16.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6091
    Cell Significance Index: 17.4600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5410
    Cell Significance Index: 10.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4514
    Cell Significance Index: 90.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3525
    Cell Significance Index: 6.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3436
    Cell Significance Index: 123.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3390
    Cell Significance Index: 64.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3226
    Cell Significance Index: 58.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3082
    Cell Significance Index: 580.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3046
    Cell Significance Index: 14.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3001
    Cell Significance Index: 163.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2625
    Cell Significance Index: 36.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2421
    Cell Significance Index: 6.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1834
    Cell Significance Index: 22.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1819
    Cell Significance Index: 3.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1785
    Cell Significance Index: 123.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1563
    Cell Significance Index: 15.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0982
    Cell Significance Index: 4.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0739
    Cell Significance Index: 2.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0661
    Cell Significance Index: 11.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0511
    Cell Significance Index: 23.1800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0377
    Cell Significance Index: 0.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0257
    Cell Significance Index: 16.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0120
    Cell Significance Index: 0.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0096
    Cell Significance Index: 0.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0022
    Cell Significance Index: 0.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0034
    Cell Significance Index: -5.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0044
    Cell Significance Index: -8.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0049
    Cell Significance Index: -0.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0061
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0083
    Cell Significance Index: -6.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0083
    Cell Significance Index: -5.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0121
    Cell Significance Index: -0.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0131
    Cell Significance Index: -1.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0155
    Cell Significance Index: -11.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0163
    Cell Significance Index: -1.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0189
    Cell Significance Index: -8.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0195
    Cell Significance Index: -26.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0229
    Cell Significance Index: -12.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0246
    Cell Significance Index: -18.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0513
    Cell Significance Index: -1.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0530
    Cell Significance Index: -6.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0555
    Cell Significance Index: -2.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0681
    Cell Significance Index: -19.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0712
    Cell Significance Index: -15.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0712
    Cell Significance Index: -3.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0817
    Cell Significance Index: -1.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1177
    Cell Significance Index: -7.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1219
    Cell Significance Index: -13.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1269
    Cell Significance Index: -16.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1828
    Cell Significance Index: -5.3700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2054
    Cell Significance Index: -23.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2057
    Cell Significance Index: -10.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2075
    Cell Significance Index: -5.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2077
    Cell Significance Index: -13.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2474
    Cell Significance Index: -17.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2505
    Cell Significance Index: -6.7000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2535
    Cell Significance Index: -4.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2567
    Cell Significance Index: -3.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2584
    Cell Significance Index: -15.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2685
    Cell Significance Index: -20.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2712
    Cell Significance Index: -16.6700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2824
    Cell Significance Index: -4.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3200
    Cell Significance Index: -21.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3309
    Cell Significance Index: -26.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3352
    Cell Significance Index: -9.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3778
    Cell Significance Index: -19.6800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3875
    Cell Significance Index: -5.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3923
    Cell Significance Index: -6.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4162
    Cell Significance Index: -13.3300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4333
    Cell Significance Index: -3.9900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4357
    Cell Significance Index: -15.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4486
    Cell Significance Index: -6.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4948
    Cell Significance Index: -25.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5268
    Cell Significance Index: -13.5400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5437
    Cell Significance Index: -7.8200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5621
    Cell Significance Index: -8.4700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6261
    Cell Significance Index: -21.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6304
    Cell Significance Index: -23.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SOAT1 is a membrane-bound enzyme that belongs to the O-acyltransferase family. It is primarily expressed in cells involved in lipid metabolism, such as macrophages, smooth muscle cells, and adrenal gland cells. The enzyme exhibits a wide range of substrate specificity, accepting various acyl-CoA derivatives and transferring them to cholesterol, resulting in the formation of cholesteryl esters. SOAT1 is also involved in the regulation of cholesterol esterification and the maturation of HDL particles. **Pathways and Functions:** SOAT1 is involved in several key pathways related to cholesterol homeostasis, including: 1. **Cholesterol efflux:** SOAT1 plays a crucial role in the transfer of cholesteryl esters from HDL particles to apolipoprotein A-I (apoA-I), facilitating the maturation and clearance of HDL particles. 2. **Cholesterol storage:** SOAT1 is involved in the esterification of cholesterol, which is essential for the storage of cholesterol in cells and the regulation of cholesterol levels. 3. **Cholesterol metabolic process:** SOAT1 is involved in the regulation of cholesterol esterification and the maturation of HDL particles, which is critical for maintaining cholesterol homeostasis. 4. **Lipid metabolism:** SOAT1 is involved in the regulation of lipid metabolism, including the transfer of cholesteryl esters to acyl-CoA, resulting in the formation of cholesteryl esters. **Clinical Significance:** Dysregulation of SOAT1 has been implicated in various diseases, including: 1. **Atherosclerosis:** SOAT1 deficiency has been linked to increased cholesterol levels and the development of atherosclerosis. 2. **Hyperlipidemia:** SOAT1 overexpression has been associated with increased cholesterol esterification and hyperlipidemia. 3. **Xanthomas:** SOAT1 deficiency has been linked to the development of xanthomas, a type of skin lesion characterized by the accumulation of cholesterol esters. In conclusion, SOAT1 is a critical enzyme involved in the regulation of cholesterol homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its role in lipid metabolism. Further research is necessary to elucidate the mechanisms by which SOAT1 regulates cholesterol homeostasis and to explore its potential as a therapeutic target for the treatment of cholesterol-related diseases.

Genular Protein ID: 2420283117

Symbol: SOAT1_HUMAN

Name: Cholesterol acyltransferase 1

UniProtKB Accession Codes:

P35610 A6NC40 A8K3P4 A9Z1V7 B4DU95 Q5T0X4 Q8N1E4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 48 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 1 EMBL 8 EMDB 7 Ensembl 3 ExpressionAtlas 1 GO 16 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PIRSF 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 20 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8407899

Title: Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells.

PubMed ID: 8407899

DOI: 10.1016/s0021-9258(19)36846-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9020103

Title: Functional expression of a cDNA to human acyl-coenzyme A:cholesterol acyltransferase in yeast. Species-dependent substrate specificity and inhibitor sensitivity.

PubMed ID: 9020103

DOI: 10.1074/jbc.272.7.3980

PubMed ID: 10438503

Title: Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains.

PubMed ID: 10438503

DOI: 10.1074/jbc.274.33.23276

PubMed ID: 11294643

Title: Differential modulation of ACAT1 and ACAT2 transcription and activity by long chain free fatty acids in cultured cells.

PubMed ID: 11294643

DOI: 10.1021/bi0022947

PubMed ID: 16154994

Title: The active site His-460 of human acyl-coenzyme A:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain.

PubMed ID: 16154994

DOI: 10.1074/jbc.m508384200

PubMed ID: 16647063

Title: A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2.

PubMed ID: 16647063

DOI: 10.1016/j.febslet.2006.04.035

PubMed ID: 18480028

Title: Identification of putative active site residues of ACAT enzymes.

PubMed ID: 18480028

DOI: 10.1194/jlr.m800131-jlr200

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23169578

Title: The UBIAD1 prenyltransferase links menaquione-4 synthesis to cholesterol metabolic enzymes.

PubMed ID: 23169578

DOI: 10.1002/humu.22230

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 32944968

Title: Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol.

PubMed ID: 32944968

DOI: 10.15252/embj.2020106057

PubMed ID: 32433614

Title: Structural basis for catalysis and substrate specificity of human ACAT1.

PubMed ID: 32433614

DOI: 10.1038/s41586-020-2290-0

PubMed ID: 32433613

Title: Structure of nevanimibe-bound tetrameric human ACAT1.

PubMed ID: 32433613

DOI: 10.1038/s41586-020-2295-8

Sequence Information:

  • Length: 550
  • Mass: 64735
  • Checksum: 5F5ACD525D541DEE
  • Sequence:
    • MVGEEKMSLR NRLSKSRENP EEDEDQRNPA KESLETPSNG RIDIKQLIAK KIKLTAEAEE 
LKPFFMKEVG SHFDDFVTNL IEKSASLDNG GCALTTFSVL EGEKNNHRAK DLRAPPEQGK 
IFIARRSLLD ELLEVDHIRT IYHMFIALLI LFILSTLVVD YIDEGRLVLE FSLLSYAFGK 
FPTVVWTWWI MFLSTFSVPY FLFQHWATGY SKSSHPLIRS LFHGFLFMIF QIGVLGFGPT 
YVVLAYTLPP ASRFIIIFEQ IRFVMKAHSF VRENVPRVLN SAKEKSSTVP IPTVNQYLYF 
LFAPTLIYRD SYPRNPTVRW GYVAMKFAQV FGCFFYVYYI FERLCAPLFR NIKQEPFSAR 
VLVLCVFNSI LPGVLILFLT FFAFLHCWLN AFAEMLRFGD RMFYKDWWNS TSYSNYYRTW 
NVVVHDWLYY YAYKDFLWFF SKRFKSAAML AVFAVSAVVH EYALAVCLSF FYPVLFVLFM 
FFGMAFNFIV NDSRKKPIWN VLMWTSLFLG NGVLLCFYSQ EWYARQHCPL KNPTFLDYVR 
PRSWTCRYVF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.