SOS1 | ENSG00000115904 | NCBI 6654

Details for: SOS1

Gene ID: 6654

Symbol: SOS1

Ensembl ID: ENSG00000115904

Description: SOS Ras/Rac guanine nucleotide exchange factor 1

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Axon guidance
(R-HSA-422475)
Cell death signalling via nrage, nrif and nade
(R-HSA-204998)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Constitutive signaling by overexpressed erbb2
(R-HSA-9634285)
Cytokine signaling in immune system
(R-HSA-1280215)
Dap12 interactions
(R-HSA-2172127)
Dap12 signaling
(R-HSA-2424491)
Death receptor signaling
(R-HSA-73887)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signal transduction
(R-HSA-186763)
Erythropoietin activates ras
(R-HSA-9027284)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Flt3 signaling
(R-HSA-9607240)
Flt3 signaling in disease
(R-HSA-9682385)
G alpha (12/13) signalling events
(R-HSA-416482)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Grb2 events in egfr signaling
(R-HSA-179812)
Grb2 events in erbb2 signaling
(R-HSA-1963640)
Hemostasis
(R-HSA-109582)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Insulin receptor signalling cascade
(R-HSA-74751)
Integrin signaling
(R-HSA-354192)
Interleukin-2 family signaling
(R-HSA-451927)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Met activates ras signaling
(R-HSA-8851805)
Ncam signaling for neurite out-growth
(R-HSA-375165)
Nervous system development
(R-HSA-9675108)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet aggregation (plug formation)
(R-HSA-76009)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of kit signaling
(R-HSA-1433559)
Ret signaling
(R-HSA-8853659)
Rho gtpase cycle
(R-HSA-9012999)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Sars-cov infections
(R-HSA-9679506)
Shc1 events in egfr signaling
(R-HSA-180336)
Shc1 events in erbb2 signaling
(R-HSA-1250196)
Shc1 events in erbb4 signaling
(R-HSA-1250347)
Signaling by csf1 (m-csf) in myeloid cells
(R-HSA-9680350)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by egfrviii in cancer
(R-HSA-5637812)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 ecd mutants
(R-HSA-9665348)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb2 kd mutants
(R-HSA-9664565)
Signaling by erbb2 tmd/jmd mutants
(R-HSA-9665686)
Signaling by erbb4
(R-HSA-1236394)
Signaling by erythropoietin
(R-HSA-9006335)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr4 in disease
(R-HSA-5655291)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by flt3 fusion proteins
(R-HSA-9703465)
Signaling by flt3 itd and tkd mutants
(R-HSA-9703648)
Signaling by gpcr
(R-HSA-372790)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by interleukins
(R-HSA-449147)
Signaling by kit in disease
(R-HSA-9669938)
Signaling by ligand-responsive egfr variants in cancer
(R-HSA-5637815)
Signaling by ltk
(R-HSA-9842663)
Signaling by met
(R-HSA-6806834)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrk2 (trkb)
(R-HSA-9006115)
Signaling by ntrk3 (trkc)
(R-HSA-9034015)
Signaling by ntrks
(R-HSA-166520)
Signaling by pdgf
(R-HSA-186797)
Signaling by pdgfra extracellular domain mutants
(R-HSA-9673770)
Signaling by pdgfra transmembrane, juxtamembrane and kinase domain mutants
(R-HSA-9673767)
Signaling by pdgfr in disease
(R-HSA-9671555)
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain kit mutants
(R-HSA-9670439)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by robo receptors
(R-HSA-376176)
Signaling by scf-kit
(R-HSA-1433557)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signal transduction
(R-HSA-162582)
Tie2 signaling
(R-HSA-210993)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 486.6752
Cell Significance Index: -75.7000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 294.2714
Cell Significance Index: -74.6400
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 167.0601
Cell Significance Index: -68.8200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 162.2248
Cell Significance Index: -76.5900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 153.1542
Cell Significance Index: -62.2200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 65.7350
Cell Significance Index: -62.7600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 62.0582
Cell Significance Index: -76.5200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 26.4889
Cell Significance Index: -70.9600
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 20.8125
Cell Significance Index: -45.5500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 20.4887
Cell Significance Index: -62.9300
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 19.4448
Cell Significance Index: -76.7300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 3.3328
Cell Significance Index: 187.0200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 2.9936
Cell Significance Index: 569.7000
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.9652
Cell Significance Index: 588.4600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 2.9273
Cell Significance Index: 224.6400
Cell Name: preadipocyte (CL0002334)
Fold Change: 2.8626
Cell Significance Index: 55.8700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.7743
Cell Significance Index: 556.5300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.7052
Cell Significance Index: 970.3200
Cell Name: cortical interneuron (CL0008031)
Fold Change: 2.6342
Cell Significance Index: 63.1800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 2.5736
Cell Significance Index: 418.5700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 2.5474
Cell Significance Index: 156.5800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 2.2379
Cell Significance Index: 84.7400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 2.1200
Cell Significance Index: 142.5500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.0476
Cell Significance Index: 90.5700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.0260
Cell Significance Index: 56.6200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.8362
Cell Significance Index: 45.9000
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.7987
Cell Significance Index: 25.8700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.7226
Cell Significance Index: 1191.4400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.6740
Cell Significance Index: 43.0300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.3385
Cell Significance Index: 145.5900
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.2598
Cell Significance Index: 35.9500
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.9214
Cell Significance Index: 19.7000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.8267
Cell Significance Index: 101.6500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.6822
Cell Significance Index: 122.9800
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 0.6075
Cell Significance Index: 7.6500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5878
Cell Significance Index: 16.9400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.4921
Cell Significance Index: 307.2800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.4888
Cell Significance Index: 920.3700
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4777
Cell Significance Index: 431.3400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.3979
Cell Significance Index: 180.5800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3778
Cell Significance Index: 17.1300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.3361
Cell Significance Index: 213.4500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.3139
Cell Significance Index: 5.3800
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.2944
Cell Significance Index: 542.8800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2754
Cell Significance Index: 423.9100
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.2526
Cell Significance Index: 5.5300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2144
Cell Significance Index: 29.4400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2072
Cell Significance Index: 4.4900
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1868
Cell Significance Index: 102.0000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1450
Cell Significance Index: 64.1300
Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.1371
Cell Significance Index: 3.3400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1072
Cell Significance Index: 145.7300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1025
Cell Significance Index: 3.6000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0337
Cell Significance Index: 2.3300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0081
Cell Significance Index: -0.4200
Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0176
Cell Significance Index: -1.7400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0394
Cell Significance Index: -5.7200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0416
Cell Significance Index: -1.1100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0459
Cell Significance Index: -33.9900
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0588
Cell Significance Index: -0.3600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0617
Cell Significance Index: -45.2500
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.0665
Cell Significance Index: -0.5900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0974
Cell Significance Index: -73.7600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1083
Cell Significance Index: -61.0800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1447
Cell Significance Index: -17.0600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1860
Cell Significance Index: -9.6600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.2039
Cell Significance Index: -34.8200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2324
Cell Significance Index: -66.8600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2466
Cell Significance Index: -51.9500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2502
Cell Significance Index: -29.1600
Cell Name: odontoblast (CL0000060)
Fold Change: -0.2540
Cell Significance Index: -32.5600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2654
Cell Significance Index: -12.4800
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.2925
Cell Significance Index: -4.2000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3386
Cell Significance Index: -35.2600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3835
Cell Significance Index: -17.8800
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.4071
Cell Significance Index: -11.9600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.4542
Cell Significance Index: -46.4000
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.4680
Cell Significance Index: -6.9100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.4870
Cell Significance Index: -62.9200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.5338
Cell Significance Index: -37.7500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5422
Cell Significance Index: -62.1200
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5662
Cell Significance Index: -64.6300
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.5875
Cell Significance Index: -37.9000
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.8145
Cell Significance Index: -21.8300
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.8253
Cell Significance Index: -17.1200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8270
Cell Significance Index: -65.5000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.8717
Cell Significance Index: -54.9400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.8925
Cell Significance Index: -66.5200
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.9269
Cell Significance Index: -9.3500
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.9907
Cell Significance Index: -19.5900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.0227
Cell Significance Index: -32.7600
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -1.0473
Cell Significance Index: -13.0600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.0532
Cell Significance Index: -14.3700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.1197
Cell Significance Index: -35.6600
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.1472
Cell Significance Index: -37.5600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.2249
Cell Significance Index: -75.1000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.2371
Cell Significance Index: -64.9500
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.2641
Cell Significance Index: -26.8300
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.2805
Cell Significance Index: -27.2700
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -1.2902
Cell Significance Index: -13.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Guanine Nucleotide Exchange Factor (GEF) activity**: SOS1 is a GEF that activates Ras and Rac GTPases by facilitating the exchange of GDP for GTP. 2. **Signaling pathway involvement**: SOS1 is involved in numerous signaling pathways, including the Ras/Raf/MAPK pathway, the PI3K/Akt pathway, and the MAPK/ERK pathway. 3. **Cell type specificity**: SOS1 is expressed in various cell types, including epithelial cells, neuronal cells, and immune cells. 4. **Overexpression and aberrant signaling**: SOS1 overexpression has been implicated in various diseases, including cancer, where aberrant signaling can lead to uncontrolled cell growth and tumor formation. **Pathways and Functions** 1. **Ras/Raf/MAPK pathway**: SOS1 activates Ras GTPases, which in turn regulate the Raf/MAPK pathway, influencing cell growth, differentiation, and survival. 2. **PI3K/Akt pathway**: SOS1 also activates the PI3K/Akt pathway, which regulates cell survival, metabolism, and proliferation. 3. **MAPK/ERK pathway**: SOS1 influences the MAPK/ERK pathway, which regulates cell growth, differentiation, and survival. 4. **Immune system regulation**: SOS1 is involved in the regulation of immune responses, including the activation of immune cells and the production of cytokines. **Clinical Significance** 1. **Cancer**: SOS1 overexpression has been implicated in various cancers, including breast cancer, lung cancer, and colon cancer. 2. **Neurological disorders**: SOS1 mutations have been associated with neurological disorders, including epilepsy and cancer. 3. **Immune system dysregulation**: SOS1 alterations have been linked to immune system dysregulation, including autoimmune diseases and immunodeficiency disorders. 4. **Therapeutic targets**: SOS1 is a potential therapeutic target for cancer and neurological disorders, where inhibition of SOS1 activity may lead to improved treatment outcomes. In conclusion, the SOS1 gene is a critical component of various signaling pathways, influencing cell growth, differentiation, and survival. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and immune system dysregulation. Further research is necessary to fully understand the SOS1 gene's role in human disease and to develop effective therapeutic strategies targeting this gene. **Recommendations** 1. **Further research**: Conduct in-depth studies to elucidate the SOS1 gene's role in human disease and its interactions with other signaling pathways. 2. **Therapeutic targeting**: Develop therapeutic strategies targeting SOS1 activity to improve treatment outcomes for cancer and neurological disorders. 3. **Immunological applications**: Investigate the potential of SOS1 as a therapeutic target for immune system dysregulation disorders. By advancing our understanding of the SOS1 gene and its role in signaling pathways, we can uncover new therapeutic targets and improve treatment outcomes for various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Son of sevenless homolog 1

Genular Protein ID: 3797935316

Symbol: SOS1_HUMAN

Name: Son of sevenless homolog 1

UniProtKB Accession Codes:

Q07889 A8K2G3 B4DXG2

Database IDs:

Citations:

PubMed ID: 8493579

Title: Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

PubMed ID: 8493579

DOI: 10.1126/science.8493579

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 7664271

Title: Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein.

PubMed ID: 7664271

PubMed ID: 10026169

Title: Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.

PubMed ID: 10026169

DOI: 10.1074/jbc.274.9.5542

PubMed ID: 12486104

Title: Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.

PubMed ID: 12486104

DOI: 10.1084/jem.20021405

PubMed ID: 17339331

Title: An activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the epidermal growth factor receptor pathway during Caenorhabditis elegans vulval development.

PubMed ID: 17339331

DOI: 10.1128/mcb.01630-06

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22827337

Title: RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation.

PubMed ID: 22827337

DOI: 10.1042/bj20120938

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9374522

Title: The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains.

PubMed ID: 9374522

DOI: 10.1074/jbc.272.48.30340

PubMed ID: 9790532

Title: Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein.

PubMed ID: 9790532

DOI: 10.1016/s0092-8674(00)81756-0

PubMed ID: 11868160

Title: A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1.

PubMed ID: 11868160

DOI: 10.1086/339689

PubMed ID: 17143285

Title: Germline gain-of-function mutations in SOS1 cause Noonan syndrome.

PubMed ID: 17143285

DOI: 10.1038/ng1926

PubMed ID: 17143282

Title: Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome.

PubMed ID: 17143282

DOI: 10.1038/ng1939

PubMed ID: 19020799

Title: PTPN11, SOS1, KRAS, and RAF1 gene analysis, and genotype-phenotype correlation in Korean patients with Noonan syndrome.

PubMed ID: 19020799

DOI: 10.1007/s10038-008-0343-6

PubMed ID: 19438935

Title: SOS1: a new player in the Noonan-like/multiple giant cell lesion syndrome.

PubMed ID: 19438935

DOI: 10.1111/j.1399-0004.2009.01149.x

PubMed ID: 20683980

Title: Noonan syndrome associated with both a new Jnk-activating familial SOS1 and a de novo RAF1 mutations.

PubMed ID: 20683980

DOI: 10.1002/ajmg.a.33564

PubMed ID: 20673819

Title: Two cases of Noonan syndrome with severe respiratory and gastroenteral involvement and the SOS1 mutation F623I.

PubMed ID: 20673819

DOI: 10.1016/j.ejmg.2010.07.011

PubMed ID: 19953625

Title: Tumor spectrum in children with Noonan syndrome and SOS1 or RAF1 mutations.

PubMed ID: 19953625

DOI: 10.1002/gcc.20735

PubMed ID: 21387466

Title: SOS1 mutations in Noonan syndrome: molecular spectrum, structural insights on pathogenic effects, and genotype-phenotype correlations.

PubMed ID: 21387466

DOI: 10.1002/humu.21492

Sequence Information:

Length: 1333
Mass: 152464
Checksum: C6B99CCA11A8DE45
Sequence:

MQAQQLPYEF FSEENAPKWR GLLVPALKKV QGQVHPTLES NDDALQYVEE LILQLLNMLC 
QAQPRSASDV EERVQKSFPH PIDKWAIADA QSAIEKRKRR NPLSLPVEKI HPLLKEVLGY 
KIDHQVSVYI VAVLEYISAD ILKLVGNYVR NIRHYEITKQ DIKVAMCADK VLMDMFHQDV 
EDINILSLTD EEPSTSGEQT YYDLVKAFMA EIRQYIRELN LIIKVFREPF VSNSKLFSAN 
DVENIFSRIV DIHELSVKLL GHIEDTVEMT DEGSPHPLVG SCFEDLAEEL AFDPYESYAR 
DILRPGFHDR FLSQLSKPGA ALYLQSIGEG FKEAVQYVLP RLLLAPVYHC LHYFELLKQL 
EEKSEDQEDK ECLKQAITAL LNVQSGMEKI CSKSLAKRRL SESACRFYSQ QMKGKQLAIK 
KMNEIQKNID GWEGKDIGQC CNEFIMEGTL TRVGAKHERH IFLFDGLMIC CKSNHGQPRL 
PGASNAEYRL KEKFFMRKVQ INDKDDTNEY KHAFEIILKD ENSVIFSAKS AEEKNNWMAA 
LISLQYRSTL ERMLDVTMLQ EEKEEQMRLP SADVYRFAEP DSEENIIFEE NMQPKAGIPI 
IKAGTVIKLI ERLTYHMYAD PNFVRTFLTT YRSFCKPQEL LSLIIERFEI PEPEPTEADR 
IAIENGDQPL SAELKRFRKE YIQPVQLRVL NVCRHWVEHH FYDFERDAYL LQRMEEFIGT 
VRGKAMKKWV ESITKIIQRK KIARDNGPGH NITFQSSPPT VEWHISRPGH IETFDLLTLH 
PIEIARQLTL LESDLYRAVQ PSELVGSVWT KEDKEINSPN LLKMIRHTTN LTLWFEKCIV 
ETENLEERVA VVSRIIEILQ VFQELNNFNG VLEVVSAMNS SPVYRLDHTF EQIPSRQKKI 
LEEAHELSED HYKKYLAKLR SINPPCVPFF GIYLTNILKT EEGNPEVLKR HGKELINFSK 
RRKVAEITGE IQQYQNQPYC LRVESDIKRF FENLNPMGNS MEKEFTDYLF NKSLEIEPRN 
PKPLPRFPKK YSYPLKSPGV RPSNPRPGTM RHPTPLQQEP RKISYSRIPE SETESTASAP 
NSPRTPLTPP PASGASSTTD VCSVFDSDHS SPFHSSNDTV FIQVTLPHGP RSASVSSISL 
TKGTDEVPVP PPVPPRRRPE SAPAESSPSK IMSKHLDSPP AIPPRQPTSK AYSPRYSISD 
RTSISDPPES PPLLPPREPV RTPDVFSSSP LHLQPPPLGK KSDHGNAFFP NSPSPFTPPP 
PQTPSPHGTR RHLPSPPLTQ EVDLHSIAGP PVPPRQSTSQ HIPKLPPKTY KREHTHPSMH 
RDGPPLLENA HSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SOS1

Associated with

Cells (max top 100)

Other Information

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. PubMed ID: 8493579

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein. PubMed ID: 7664271

Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck. PubMed ID: 10026169

Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. PubMed ID: 12486104

An activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the epidermal growth factor receptor pathway during Caenorhabditis elegans vulval development. PubMed ID: 17339331

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation. PubMed ID: 22827337

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains. PubMed ID: 9374522

Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein. PubMed ID: 9790532

A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1. PubMed ID: 11868160

Germline gain-of-function mutations in SOS1 cause Noonan syndrome. PubMed ID: 17143285

Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. PubMed ID: 17143282

PTPN11, SOS1, KRAS, and RAF1 gene analysis, and genotype-phenotype correlation in Korean patients with Noonan syndrome. PubMed ID: 19020799

SOS1: a new player in the Noonan-like/multiple giant cell lesion syndrome. PubMed ID: 19438935

Noonan syndrome associated with both a new Jnk-activating familial SOS1 and a de novo RAF1 mutations. PubMed ID: 20683980

Two cases of Noonan syndrome with severe respiratory and gastroenteral involvement and the SOS1 mutation F623I. PubMed ID: 20673819

Tumor spectrum in children with Noonan syndrome and SOS1 or RAF1 mutations. PubMed ID: 19953625

SOS1 mutations in Noonan syndrome: molecular spectrum, structural insights on pathogenic effects, and genotype-phenotype correlations. PubMed ID: 21387466