Details for: SP3

Gene ID: 6670

Symbol: SP3

Ensembl ID: ENSG00000172845

Description: Sp3 transcription factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 313.1565
    Cell Significance Index: -48.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 196.9695
    Cell Significance Index: -49.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 114.6736
    Cell Significance Index: -54.1400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 112.3180
    Cell Significance Index: -45.6300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 111.6161
    Cell Significance Index: -45.9800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 99.6335
    Cell Significance Index: -51.2500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 80.7425
    Cell Significance Index: -54.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 47.9920
    Cell Significance Index: -45.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 42.1589
    Cell Significance Index: -51.9800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.2634
    Cell Significance Index: -48.9300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.7297
    Cell Significance Index: -42.1700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.3653
    Cell Significance Index: -52.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.7114
    Cell Significance Index: -27.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.7830
    Cell Significance Index: 74.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.5082
    Cell Significance Index: 497.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.3887
    Cell Significance Index: 32.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.3655
    Cell Significance Index: 132.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5800
    Cell Significance Index: 316.9500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.4369
    Cell Significance Index: 30.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3543
    Cell Significance Index: 147.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1833
    Cell Significance Index: 71.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0502
    Cell Significance Index: 29.3500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9715
    Cell Significance Index: 18.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9389
    Cell Significance Index: 152.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9277
    Cell Significance Index: 114.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8471
    Cell Significance Index: 303.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8244
    Cell Significance Index: 148.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8187
    Cell Significance Index: 50.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7348
    Cell Significance Index: 100.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7103
    Cell Significance Index: 491.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6012
    Cell Significance Index: 59.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5395
    Cell Significance Index: 238.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5390
    Cell Significance Index: 486.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5325
    Cell Significance Index: 40.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4580
    Cell Significance Index: 29.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3924
    Cell Significance Index: 11.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3691
    Cell Significance Index: 201.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3537
    Cell Significance Index: 16.0300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3248
    Cell Significance Index: 38.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2868
    Cell Significance Index: 36.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2402
    Cell Significance Index: 16.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1625
    Cell Significance Index: 103.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1531
    Cell Significance Index: 6.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1348
    Cell Significance Index: 3.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1105
    Cell Significance Index: 2.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0819
    Cell Significance Index: 154.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0472
    Cell Significance Index: 21.4000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0421
    Cell Significance Index: 1.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0369
    Cell Significance Index: 2.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0257
    Cell Significance Index: 4.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0239
    Cell Significance Index: 36.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0153
    Cell Significance Index: 28.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0143
    Cell Significance Index: 0.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0097
    Cell Significance Index: 13.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0066
    Cell Significance Index: 0.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0195
    Cell Significance Index: -14.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0389
    Cell Significance Index: -2.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0434
    Cell Significance Index: -31.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0449
    Cell Significance Index: -28.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0556
    Cell Significance Index: -42.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0641
    Cell Significance Index: -36.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0799
    Cell Significance Index: -1.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0906
    Cell Significance Index: -17.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1045
    Cell Significance Index: -4.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1469
    Cell Significance Index: -15.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1561
    Cell Significance Index: -44.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1575
    Cell Significance Index: -33.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1667
    Cell Significance Index: -24.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1679
    Cell Significance Index: -2.8100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1870
    Cell Significance Index: -2.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1899
    Cell Significance Index: -9.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2055
    Cell Significance Index: -5.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2061
    Cell Significance Index: -15.3600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2104
    Cell Significance Index: -4.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2174
    Cell Significance Index: -7.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2266
    Cell Significance Index: -29.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2528
    Cell Significance Index: -29.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2952
    Cell Significance Index: -33.8200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3388
    Cell Significance Index: -38.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3509
    Cell Significance Index: -9.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3600
    Cell Significance Index: -22.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3755
    Cell Significance Index: -13.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4080
    Cell Significance Index: -7.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4155
    Cell Significance Index: -43.2600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4469
    Cell Significance Index: -2.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5358
    Cell Significance Index: -14.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5759
    Cell Significance Index: -45.6100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.6245
    Cell Significance Index: -3.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6426
    Cell Significance Index: -20.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6825
    Cell Significance Index: -35.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7294
    Cell Significance Index: -44.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7427
    Cell Significance Index: -17.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7619
    Cell Significance Index: -20.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8337
    Cell Significance Index: -23.7900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.9647
    Cell Significance Index: -16.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9827
    Cell Significance Index: -32.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9928
    Cell Significance Index: -31.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.9994
    Cell Significance Index: -20.9200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.0061
    Cell Significance Index: -9.2700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.0214
    Cell Significance Index: -14.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional regulation:** SP3 is a transcription factor that binds to specific DNA sequences, thereby modulating the expression of target genes. It can act as both a repressor and an activator, depending on the context and the presence of other regulatory elements. 2. **Cell-type specificity:** SP3 is expressed in a variety of cell types, including neural progenitor cells, immune cells, and cells of the kidney and liver. Its expression patterns suggest a role in the development and maintenance of these tissues. 3. **Chromatin remodeling:** SP3 is associated with chromatin remodeling complexes, which are essential for the regulation of gene expression. This interaction allows SP3 to modulate chromatin structure and facilitate the recruitment of other transcriptional regulators. 4. **Post-translational modifications:** SP3 undergoes various post-translational modifications, including phosphorylation and sumoylation, which can affect its activity and interaction with other proteins. **Pathways and Functions:** 1. **Cell differentiation:** SP3 plays a critical role in the regulation of cell differentiation, particularly in the development of the nervous system and immune system. It modulates the expression of genes involved in cell fate determination and terminal differentiation. 2. **Chromatin remodeling:** SP3 is involved in chromatin remodeling, which is essential for the regulation of gene expression. It interacts with chromatin remodeling complexes to modulate chromatin structure and facilitate the recruitment of other transcriptional regulators. 3. **DNA repair:** SP3 is also involved in the regulation of DNA repair, particularly in the context of nucleotide excision repair (NER). It modulates the expression of genes involved in NER and interacts with other DNA repair proteins. 4. **Metabolism:** SP3 regulates the expression of genes involved in cellular metabolism, including those involved in glucose and lipid metabolism. **Clinical Significance:** 1. **Cancer:** Mutations in the SP3 gene have been implicated in various types of cancer, including breast, lung, and colon cancer. These mutations can lead to the overexpression of SP3, resulting in the activation of oncogenic pathways. 2. **Neurological disorders:** SP3 has been implicated in the regulation of gene expression in the nervous system, and its dysregulation has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Immune system disorders:** SP3 is also involved in the regulation of immune system function, and its dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Developmental disorders:** SP3 is involved in the regulation of embryonic development, and its dysregulation has been linked to various developmental disorders, including birth defects and congenital abnormalities. In conclusion, the SP3 transcription factor plays a complex and multifaceted role in the regulation of gene expression across various cellular contexts. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, immune system disorders, and developmental disorders. Further research is needed to fully understand the mechanisms by which SP3 regulates gene expression and to identify potential therapeutic targets for the treatment of these diseases.

Genular Protein ID: 80791634

Symbol: SP3_HUMAN

Name: Transcription factor Sp3

UniProtKB Accession Codes:

Q02447 A0AVL9 B4E2B7 Q69B26 Q69B27 Q8TD56 Q8WWU4 Q9BQR1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 37 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12297010

Title: AUA as a translation initiation site in vitro for the human transcription factor Sp3.

PubMed ID: 12297010

DOI: 10.5483/bmbrep.2002.35.3.273

PubMed ID: 15474306

Title: Human transcription factor Sp3: genomic structure, identification of a processed pseudogene, and transcript analysis.

PubMed ID: 15474306

DOI: 10.1016/j.gene.2004.06.055

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12411611

Title: 5' genomic structure of human Sp3.

PubMed ID: 12411611

DOI: 10.1093/oxfordjournals.molbev.a004026

PubMed ID: 1341900

Title: Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression.

PubMed ID: 1341900

DOI: 10.1128/mcb.12.10.4251-4261.1992

PubMed ID: 1454515

Title: Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes.

PubMed ID: 1454515

DOI: 10.1093/nar/20.21.5519

PubMed ID: 9278495

Title: Sp3 is a transcriptional activator of the human alpha2(I) collagen gene.

PubMed ID: 9278495

DOI: 10.1093/nar/25.18.3712

PubMed ID: 10391891

Title: Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene.

PubMed ID: 10391891

DOI: 10.1074/jbc.274.28.19573

PubMed ID: 11812829

Title: Transcription factor Sp3 is regulated by acetylation.

PubMed ID: 11812829

DOI: 10.1093/nar/29.24.4994

PubMed ID: 12176973

Title: The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2.

PubMed ID: 12176973

DOI: 10.1074/jbc.c200378200

PubMed ID: 12419227

Title: SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization.

PubMed ID: 12419227

DOI: 10.1016/s1097-2765(02)00682-2

PubMed ID: 12837748

Title: Acetylated SP3 is a transcriptional activator.

PubMed ID: 12837748

DOI: 10.1074/jbc.m305961200

PubMed ID: 15247228

Title: Complexity of translationally controlled transcription factor Sp3 isoform expression.

PubMed ID: 15247228

DOI: 10.1074/jbc.m404989200

PubMed ID: 15494207

Title: Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism.

PubMed ID: 15494207

DOI: 10.1016/j.cellsig.2004.06.007

PubMed ID: 15554904

Title: Sp3 is involved in the regulation of SOCS3 gene expression.

PubMed ID: 15554904

DOI: 10.1042/bj20041101

PubMed ID: 16781829

Title: The modification of Sp3 isoforms by SUMOylation has differential effects on the SRC1A promoter.

PubMed ID: 16781829

DOI: 10.1016/j.gene.2006.04.015

PubMed ID: 17548428

Title: Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1.

PubMed ID: 17548428

DOI: 10.1096/fj.07-8621com

PubMed ID: 18187045

Title: Nuclear organization and chromatin dynamics -- Sp1, Sp3 and histone deacetylases.

PubMed ID: 18187045

DOI: 10.1016/j.advenzreg.2007.11.016

PubMed ID: 18617891

Title: SUMO-modified Sp3 represses transcription by provoking local heterochromatic gene silencing.

PubMed ID: 18617891

DOI: 10.1038/embor.2008.127

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21746878

Title: Cooperative transcriptional activation by Klf4, Meis2, and Pbx1.

PubMed ID: 21746878

DOI: 10.1128/mcb.01456-10

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

Sequence Information:

  • Length: 781
  • Mass: 81925
  • Checksum: DCFD4363509DB49D
  • Sequence:
    • MTAPEKPVKQ EEMAALDVDS GGGGGGGGGH GEYLQQQQQH GNGAVAAAAA AQDTQPSPLA 
LLAATCSKIG PPSPGDDEEE AAAAAGAPAA AGATGDLASA QLGGAPNRWE VLSATPTTIK 
DEAGNLVQIP SAATSSGQYV LPLQNLQNQQ IFSVAPGSDS SNGTVSSVQY QVIPQIQSAD 
GQQVQIGFTG SSDNGGINQE SSQIQIIPGS NQTLLASGTP SANIQNLIPQ TGQVQVQGVA 
IGGSSFPGQT QVVANVPLGL PGNITFVPIN SVDLDSLGLS GSSQTMTAGI NADGHLINTG 
QAMDSSDNSE RTGERVSPDI NETNTDTDLF VPTSSSSQLP VTIDSTGILQ QNTNSLTTSS 
GQVHSSDLQG NYIQSPVSEE TQAQNIQVST AQPVVQHLQL QESQQPTSQA QIVQGITPQT 
IHGVQASGQN ISQQALQNLQ LQLNPGTFLI QAQTVTPSGQ VTWQTFQVQG VQNLQNLQIQ 
NTAAQQITLT PVQTLTLGQV AAGGAFTSTP VSLSTGQLPN LQTVTVNSID SAGIQLHPGE 
NADSPADIRI KEEEPDPEEW QLSGDSTLNT NDLTHLRVQV VDEEGDQQHQ EGKRLRRVAC 
TCPNCKEGGG RGTNLGKKKQ HICHIPGCGK VYGKTSHLRA HLRWHSGERP FVCNWMYCGK 
RFTRSDELQR HRRTHTGEKK FVCPECSKRF MRSDHLAKHI KTHQNKKGIH SSSTVLASVE 
AARDDTLITA GGTTLILANI QQGSVSGIGT VNTSATSNQD ILTNTEIPLQ LVTVSGNETM 
E

Genular Protein ID: 1061429014

Symbol: B7ZLN9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZLN9

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 778
  • Mass: 81551
  • Checksum: 35BF141527E5D3FF
  • Sequence:
    • MTAPEKPVKQ EEMAALDVDS GGGGGGGGGH GEYLQQQQQH GNGAVAAAAA AQPSPLALLA 
ATCSKIGPPS PGDDEEEAAA AAGAPAAAGA TGDLASAQLG GAPNRWEVLS ATPTTIKDEA 
GNLVQIPSAA TSSGQYVLPL QNLQNQQIFS VAPGSDSSNG AVSSVQYQVI PQIQSADGQQ 
VQIGFTGSSD NGGINQESSQ IQIIPGSNQT LLASGTPSAN IQNLIPQTGQ VQVQGVAIGG 
SSFPGQTQVV ANVPLGLPGN ITFVPINSVD LDSLGLSGSS QTMTAGINAD GHLINTGQAM 
DSSDNSERTG ERVSPDINET NTDTDLFVPT SSSSQLPVTI DSTGILQQNT NSLTTSSGQV 
HSSDLQGNYI QSPVSEETQA QNIQVSTAQP VVQHLQLQES QQPTSQAQIV QGITPQTIHG 
VQASGQNISQ QALQNLQLQL NPGTFLIQAQ TVTPSGQVTW QTFQVQGVQN LQNLQIQNTA 
AQQITLTPVQ TLTLGQVAAG GAFTSTPVSL STGQLPNLQT VTVNSIDSAG IQLHPGENAD 
SPADIRIKEE EPDPEEWQLS GDSTLNTNDL THLRVQVVDE EGDQQHQEGK RLRRVACTCP 
NCKEGGGRGT NLGKKKQHIC HIPGCGKVYG KTSHLRAHLR WHSGERPFVC NWMYCGKRFT 
RSDELQRHRR THTGEKKFVC PECSKRFMRS DHLAKHIKTH QNKKGIHSSS TVLASVEAAR 
DDTLITAGGT TLILANIQQG SVSGIGTVNT SATSNQDILT NTEIPLQLVT VSGNETME

Genular Protein ID: 3432211183

Symbol: Q59FX5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FX5

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 662
  • Mass: 70701
  • Checksum: 9E22C65605EE16EA
  • Sequence:
    • KDEAGNLVQI PSAATSSGQY VLPLQNLQNQ QIFSVAPGSD SSNGTVSSVQ YQVIPQIQSA 
DGQQVQIGFT GSSDNGGINQ ESSQIQIIPG SNQTLLASGT PSANIQNLIP QTGQVQVQGV 
AIGGSSFPGQ TQVVANVPLG LPGNITFVPI NSVDLDSLGL SGSSQTMTAG INADGHLINT 
GQAMDSSDNS ERTGERVSPD INETNTDTDL FVPTSSSSQL PVTIDSTGIL QQNTNSLTTS 
SGQVHSSDLQ GNYIQSPVSE ETQAQNIQVS TAQPVVQHLQ LQESQQPTSQ AQIVQGITPQ 
TIHGVQASGQ NISQQALQNL QLQLNPGTFL IQAQTVTPSG QVTWQTFQVQ RVQNLQNLQI 
QNTAAQQITL TPVQTLTLGQ VAAGGAFTST PVSLSTGQLP NLQTVTVNSI DSAGIQLHPG 
ENADSPADIR IKEEEPDPEE WQLSGDSTLN TNDLTHLRVQ VVDEEGDQQH QEGKRLRRVA 
CTCPNCKEGG GRGTNLGKKK QHICHIPGFG KVYGKTSHLR AHLRWHSGER PFVCNWMYCG 
KRFTRSDELQ RHRRTHTGEK KFVCPECSKR FMRSDHLAKH IKTHQNKKGI HSSSTVLASV 
EAARDDTLIT AGGTTLILAN IQQGSVSGIG TVNTSATSNQ DILTNTEIPL QLVTVSGNET 
ME

Genular Protein ID: 2790832610

Symbol: Q86TP0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86TP0

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 IntAct 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 359
  • Mass: 39178
  • Checksum: 2209579E16CE8961
  • Sequence:
    • CVQASGQNIS QQALQNLQLQ LNPGTFLIQA QTVTPSGQVT WQTFQVQGVQ NLQNLQIQNT 
AAQQITLTPV QTLTLGQVAA GGAFTSTPVS LSTGQLPNLQ TVTVNSIDSA GIQLHPGENA 
DSPADIRIKE EEPDPEEWQL SGDSTLNTND LTHLRVQVVD EEGDQQHQEG KRLRRVACTC 
PNCKEGGGRG TNLGKKKQHI CHIPGCGKVY GKTSHLRAHL RWHSGERPFV CNWMYCGKRF 
TRSDELQRHR RTHTGEKKFV CPECSKRFMR SDHLAKHIKT HQNKKGIHSS STVLASVEAA 
RDDTLITAGG TTLILANIQQ GSVSGIGTVN TSATSNQDIL TNTEIPLQLV TVSGNETME

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.