Details for: SPAG1

Gene ID: 6674

Symbol: SPAG1

Ensembl ID: ENSG00000104450

Description: sperm associated antigen 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 147.3526
    Cell Significance Index: -22.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 89.1212
    Cell Significance Index: -22.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 49.0576
    Cell Significance Index: -19.9300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.5500
    Cell Significance Index: -19.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.6179
    Cell Significance Index: -22.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.0113
    Cell Significance Index: -24.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8362
    Cell Significance Index: -23.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.7925
    Cell Significance Index: -14.7200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 4.5677
    Cell Significance Index: 75.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.0661
    Cell Significance Index: 93.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.0059
    Cell Significance Index: 104.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0667
    Cell Significance Index: 213.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9377
    Cell Significance Index: 8.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9359
    Cell Significance Index: 845.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.9163
    Cell Significance Index: 133.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8900
    Cell Significance Index: 53.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8075
    Cell Significance Index: 558.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7515
    Cell Significance Index: 410.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6685
    Cell Significance Index: 108.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6362
    Cell Significance Index: 28.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6065
    Cell Significance Index: 13.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5775
    Cell Significance Index: 21.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5160
    Cell Significance Index: 102.4000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4987
    Cell Significance Index: 10.6600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4952
    Cell Significance Index: 7.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3920
    Cell Significance Index: 140.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3899
    Cell Significance Index: 38.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3860
    Cell Significance Index: 26.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3828
    Cell Significance Index: 9.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3217
    Cell Significance Index: 24.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2920
    Cell Significance Index: 52.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1800
    Cell Significance Index: 13.4200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1732
    Cell Significance Index: 3.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1718
    Cell Significance Index: 4.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1689
    Cell Significance Index: 20.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1281
    Cell Significance Index: 8.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1276
    Cell Significance Index: 3.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0858
    Cell Significance Index: 1.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0804
    Cell Significance Index: 51.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0786
    Cell Significance Index: 14.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0641
    Cell Significance Index: 3.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0617
    Cell Significance Index: 1.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0523
    Cell Significance Index: 71.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0516
    Cell Significance Index: 79.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0474
    Cell Significance Index: 1.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0465
    Cell Significance Index: 87.5700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0457
    Cell Significance Index: 0.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0406
    Cell Significance Index: 17.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0352
    Cell Significance Index: 64.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0143
    Cell Significance Index: 0.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0121
    Cell Significance Index: 2.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0040
    Cell Significance Index: -2.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0058
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0102
    Cell Significance Index: -6.3500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0103
    Cell Significance Index: -0.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0188
    Cell Significance Index: -14.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0219
    Cell Significance Index: -16.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0220
    Cell Significance Index: -9.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0255
    Cell Significance Index: -14.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0522
    Cell Significance Index: -6.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0524
    Cell Significance Index: -2.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0588
    Cell Significance Index: -8.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0593
    Cell Significance Index: -12.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0603
    Cell Significance Index: -17.3600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0694
    Cell Significance Index: -0.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0793
    Cell Significance Index: -9.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0810
    Cell Significance Index: -10.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0883
    Cell Significance Index: -1.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0971
    Cell Significance Index: -11.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1070
    Cell Significance Index: -2.9900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1094
    Cell Significance Index: -12.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1230
    Cell Significance Index: -3.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1336
    Cell Significance Index: -15.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1343
    Cell Significance Index: -13.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1592
    Cell Significance Index: -10.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1790
    Cell Significance Index: -8.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1810
    Cell Significance Index: -2.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1876
    Cell Significance Index: -19.5300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1902
    Cell Significance Index: -2.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2124
    Cell Significance Index: -15.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2235
    Cell Significance Index: -13.7000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2323
    Cell Significance Index: -5.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2347
    Cell Significance Index: -14.7900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2516
    Cell Significance Index: -7.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2545
    Cell Significance Index: -6.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2617
    Cell Significance Index: -20.7300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2759
    Cell Significance Index: -2.9900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2968
    Cell Significance Index: -6.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3021
    Cell Significance Index: -6.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3029
    Cell Significance Index: -15.7800
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.3363
    Cell Significance Index: -3.2900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3408
    Cell Significance Index: -4.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3447
    Cell Significance Index: -6.9200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3488
    Cell Significance Index: -5.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3746
    Cell Significance Index: -19.6700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.4042
    Cell Significance Index: -5.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4101
    Cell Significance Index: -13.0600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.4213
    Cell Significance Index: -5.6200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4271
    Cell Significance Index: -7.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4376
    Cell Significance Index: -15.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** SPAG1 is highly expressed in ciliated cells of the tracheobronchial tree, as well as in neurons, muscle fibers, and neural progenitor cells. 2. **Protein Function:** The protein encoded by SPAG1 is involved in the assembly and function of the axonemal dynein complex, protein folding, stability, and hydrolysis. 3. **Cellular Processes:** SPAG1 is involved in various cellular processes, including axonemal dynein complex assembly, protein folding, stability, and hydrolysis. 4. **Disease Implication:** SPAG1 has been implicated in various diseases, including respiratory and neurological disorders. **Pathways and Functions:** 1. **Axonemal Dynein Complex Assembly:** SPAG1 plays a critical role in the assembly and function of the axonemal dynein complex, which is essential for motility and ciliary movement. 2. **Protein Folding:** SPAG1 is involved in protein folding, which is essential for maintaining protein stability and function. 3. **Protein Stability:** SPAG1 helps maintain protein stability by regulating protein degradation and turnover. 4. **Hydrolase Activity:** SPAG1 is involved in hydrolysis, which is essential for various cellular processes, including protein degradation and signal transduction. **Clinical Significance:** 1. **Respiratory Disorders:** SPAG1 has been implicated in respiratory disorders, including chronic obstructive pulmonary disease (COPD) and cystic fibrosis. 2. **Neurological Disorders:** SPAG1 has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cancer:** SPAG1 has been found to be overexpressed in certain types of cancer, including lung and breast cancer. 4. **Fertility:** SPAG1 plays a critical role in sperm function and fertility, making it an important gene for reproductive health. In conclusion, SPAG1 is a multifunctional gene that plays a critical role in various cellular processes, including axonemal dynein complex assembly, protein folding, stability, and hydrolysis. The significance of SPAG1 extends beyond its role in sperm function, as it has been implicated in various diseases, including respiratory and neurological disorders. Further research is needed to fully elucidate the functions and clinical significance of SPAG1.

Genular Protein ID: 3064095333

Symbol: SPAG1_HUMAN

Name: Sperm-associated antigen 1

UniProtKB Accession Codes:

Q07617 A6NP70 B3KQ58 G3XAM3 Q7Z5G1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 4 GO 9 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 4 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11517287

Title: Expression and function of the HSD-3.8 gene encoding a testis-specific protein.

PubMed ID: 11517287

DOI: 10.1093/molehr/7.9.811

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1299558

Title: Isolation and sequencing of the cDNA encoding the 75-kD human sperm protein related to infertility.

PubMed ID: 1299558

PubMed ID: 16983343

Title: Sperm-associated antigen 1 is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells.

PubMed ID: 16983343

DOI: 10.1038/sj.onc.1209961

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 24055112

Title: Mutations in SPAG1 cause primary ciliary dyskinesia associated with defective outer and inner dynein arms.

PubMed ID: 24055112

DOI: 10.1016/j.ajhg.2013.07.025

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 926
  • Mass: 103639
  • Checksum: 947E460842AD9615
  • Sequence:
    • MTTKDYPSLW GFGTTKTFKI PIEHLDFKYI EKCSDVKHLE KILCVLRSGE EGYYPELTEF 
CEKHLQALAP ESRALRKDKP AATAASFTAE EWEKIDGDIK SWVSEIKKEE DKMHFHETET 
FPAMKDNLPP VRGSNSCLHV GKEKYSKRPT KKKTPRDYAE WDKFDVEKEC LKIDEDYKEK 
TVIDKSHLSK IETRIDTAGL TEKEKDFLAT REKEKGNEAF NSGDYEEAVM YYTRSISALP 
TVVAYNNRAQ AEIKLQNWNS AFQDCEKVLE LEPGNVKALL RRATTYKHQN KLREATEDLS 
KVLDVEPDND LAKKTLSEVE RDLKNSEAAS ETQTKGKRMV IQEIENSEDE EGKSGRKHED 
GGGDKKPAEP AGAARAAQPC VMGNIQKKLT GKAEGGKRPA RGAPQRGQTP EAGADKRSPR 
RASAAAAAGG GATGHPGGGQ GAENPAGLKS QGNELFRSGQ FAEAAGKYSA AIALLEPAGS 
EIADDLSILY SNRAACYLKE GNCSGCIQDC NRALELHPFS MKPLLRRAMA YETLEQYGKA 
YVDYKTVLQI DCGLQLANDS VNRLSRILME LDGPNWREKL SPIPAVPASV PLQAWHPAKE 
MISKQAGDSS SHRQQGITDE KTFKALKEEG NQCVNDKNYK DALSKYSECL KINNKECAIY 
TNRALCYLKL CQFEEAKQDC DQALQLADGN VKAFYRRALA HKGLKNYQKS LIDLNKVILL 
DPSIIEAKME LEEVTRLLNL KDKTAPFNKE KERRKIEIQE VNEGKEEPGR PAGEVSMGCL 
ASEKGGKSSR SPEDPEKLPI AKPNNAYEFG QIINALSTRK DKEACAHLLA ITAPKDLPMF 
LSNKLEGDTF LLLIQSLKNN LIEKDPSLVY QHLLYLSKAE RFKMMLTLIS KGQKELIEQL 
FEDLSDTPNN HFTLEDIQAL KRQYEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.