Details for: SPRR2D

Gene ID: 6703

Symbol: SPRR2D

Ensembl ID: ENSG00000163216

Description: small proline rich protein 2D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 4.8377
    Cell Significance Index: 41.5700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 4.2737
    Cell Significance Index: 54.0000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.1645
    Cell Significance Index: 7.7300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0391
    Cell Significance Index: 0.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0133
    Cell Significance Index: 1.7000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0114
    Cell Significance Index: 0.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0086
    Cell Significance Index: 0.2400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0054
    Cell Significance Index: -4.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0074
    Cell Significance Index: -5.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0102
    Cell Significance Index: -5.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0186
    Cell Significance Index: -8.2300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0214
    Cell Significance Index: -1.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0272
    Cell Significance Index: -4.6400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0273
    Cell Significance Index: -1.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0307
    Cell Significance Index: -4.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0352
    Cell Significance Index: -4.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0382
    Cell Significance Index: -4.4600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0458
    Cell Significance Index: -0.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0470
    Cell Significance Index: -9.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0595
    Cell Significance Index: -1.5900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0651
    Cell Significance Index: -2.3900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0653
    Cell Significance Index: -1.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0830
    Cell Significance Index: -4.3100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0875
    Cell Significance Index: -1.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0890
    Cell Significance Index: -5.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0896
    Cell Significance Index: -5.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0945
    Cell Significance Index: -1.2900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1026
    Cell Significance Index: -1.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1077
    Cell Significance Index: -5.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1158
    Cell Significance Index: -3.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1221
    Cell Significance Index: -5.7400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1250
    Cell Significance Index: -1.7800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1375
    Cell Significance Index: -1.4500
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.1510
    Cell Significance Index: -1.1500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1534
    Cell Significance Index: -1.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1553
    Cell Significance Index: -4.1600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1614
    Cell Significance Index: -1.6700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1714
    Cell Significance Index: -2.0400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1744
    Cell Significance Index: -4.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1806
    Cell Significance Index: -4.7500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1896
    Cell Significance Index: -3.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2006
    Cell Significance Index: -5.7500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2074
    Cell Significance Index: -2.2600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2119
    Cell Significance Index: -5.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2142
    Cell Significance Index: -5.8300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2194
    Cell Significance Index: -3.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2410
    Cell Significance Index: -5.7800
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.2453
    Cell Significance Index: -1.8700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2478
    Cell Significance Index: -4.9000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2539
    Cell Significance Index: -2.5900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2704
    Cell Significance Index: -3.7500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2743
    Cell Significance Index: -5.4700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2747
    Cell Significance Index: -4.6200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2769
    Cell Significance Index: -2.7400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2874
    Cell Significance Index: -5.7700
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.2881
    Cell Significance Index: -3.0900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.2968
    Cell Significance Index: -3.0100
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.3005
    Cell Significance Index: -3.1000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3015
    Cell Significance Index: -5.1200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3022
    Cell Significance Index: -5.2100
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.3073
    Cell Significance Index: -3.4900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3097
    Cell Significance Index: -4.4000
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.3198
    Cell Significance Index: -3.5500
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.3254
    Cell Significance Index: -3.0900
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.3278
    Cell Significance Index: -3.5800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3297
    Cell Significance Index: -4.1600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.3306
    Cell Significance Index: -3.4100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3326
    Cell Significance Index: -4.4200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.3360
    Cell Significance Index: -4.2200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3389
    Cell Significance Index: -4.4600
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.3398
    Cell Significance Index: -2.4700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3428
    Cell Significance Index: -3.8000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3429
    Cell Significance Index: -4.5000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3436
    Cell Significance Index: -4.8200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.3470
    Cell Significance Index: -4.5300
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.3491
    Cell Significance Index: -3.4700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3508
    Cell Significance Index: -4.1700
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: -0.3525
    Cell Significance Index: -2.8800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.3526
    Cell Significance Index: -3.7800
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.3538
    Cell Significance Index: -4.1100
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.3560
    Cell Significance Index: -4.4200
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.3575
    Cell Significance Index: -3.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3594
    Cell Significance Index: -6.0200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.3603
    Cell Significance Index: -4.3200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3652
    Cell Significance Index: -5.0500
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.3654
    Cell Significance Index: -3.4800
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -0.3680
    Cell Significance Index: -3.4300
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.3690
    Cell Significance Index: -3.6400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.3699
    Cell Significance Index: -4.5000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.3714
    Cell Significance Index: -4.1300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3719
    Cell Significance Index: -4.4000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3736
    Cell Significance Index: -5.3500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3748
    Cell Significance Index: -4.8000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.3752
    Cell Significance Index: -0.8500
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.3767
    Cell Significance Index: -3.7200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.3800
    Cell Significance Index: -4.1200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3802
    Cell Significance Index: -4.4100
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.3803
    Cell Significance Index: -4.3200
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.3811
    Cell Significance Index: -4.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Small proline-rich protein 2D**: SPRR2D is a member of the small proline-rich protein family, which is characterized by the presence of proline-rich sequences. 2. **Epithelial-specific expression**: SPRR2D is predominantly expressed in epithelial cells, including keratinocytes, stratified epithelial cells, and respiratory basal cells. 3. **Immune cell involvement**: SPRR2D is also expressed in T cells and leukocytes, indicating its role in immune function and potentially in the regulation of immune responses. 4. **Developmental biology**: SPRR2D is involved in the development of epithelial tissues, including the formation of the cornified envelope in the skin. **Pathways and Functions:** 1. **Formation of the cornified envelope**: SPRR2D is essential for the formation of the cornified envelope, a critical structure in the skin's barrier function. The gene's expression patterns suggest its involvement in the assembly of this complex structure. 2. **Epithelial development**: SPRR2D is involved in the development of epithelial tissues, including the skin and respiratory epithelium. The gene's expression in oligodendrocyte precursor cells and cerebral cortex GABAergic interneurons highlights its role in neural development. 3. **Immune function**: SPRR2D is expressed in immune cells, including T cells and leukocytes, suggesting its involvement in immune function and potentially in the regulation of immune responses. 4. **Cell-cell interactions**: SPRR2D may play a role in cell-cell interactions, including adhesion and signaling, through its interactions with other proteins and cell surface receptors. **Clinical Significance:** 1. **Skin disorders**: Abnormal expression of SPRR2D has been implicated in various skin disorders, including psoriasis and ichthyosis. 2. **Immune-mediated diseases**: SPRR2D's involvement in immune function suggests its potential role in immune-mediated diseases, such as autoimmune disorders and allergies. 3. **Cancer**: Alterations in SPRR2D expression have been observed in certain types of cancer, including skin cancer and lung cancer. 4. **Neurological disorders**: SPRR2D's expression in neural cells highlights its potential role in neurological disorders, including neurodegenerative diseases and psychiatric disorders. In conclusion, SPRR2D is a multifunctional gene that plays a critical role in epithelial development, immune function, and cell-cell interactions. Its clinical significance extends to various skin disorders, immune-mediated diseases, cancer, and neurological disorders. Further research is necessary to fully elucidate the mechanisms by which SPRR2D regulates these processes and to explore its therapeutic potential.

Genular Protein ID: 568913193

Symbol: SPR2D_HUMAN

Name: Small proline-rich protein 2D

UniProtKB Accession Codes:

P22532 A4QN03 A8K5K2 D3DV33 Q5T523 Q96RM3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 4 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3133554

Title: Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes.

PubMed ID: 3133554

DOI: 10.1128/mcb.8.5.2195-2203.1988

PubMed ID: 11279051

Title: Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function.

PubMed ID: 11279051

DOI: 10.1074/jbc.m100336200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 72
  • Mass: 7905
  • Checksum: 87B4502DD773D448
  • Sequence:
    • MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPSPK CPQPCPPQQC QQKYPPVTPS 
PPCQPKCPPK SK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.