Details for: SREBF2

Gene ID: 6721

Symbol: SREBF2

Ensembl ID: ENSG00000198911

Description: sterol regulatory element binding transcription factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 371.2747
    Cell Significance Index: -57.7500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 227.2482
    Cell Significance Index: -57.6400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 129.6524
    Cell Significance Index: -53.4100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 125.3700
    Cell Significance Index: -59.1900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 116.7487
    Cell Significance Index: -47.4300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 49.9611
    Cell Significance Index: -47.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 47.5605
    Cell Significance Index: -58.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.9959
    Cell Significance Index: -56.2500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.4906
    Cell Significance Index: -50.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.9605
    Cell Significance Index: -59.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.1018
    Cell Significance Index: 109.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.7879
    Cell Significance Index: 105.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.3569
    Cell Significance Index: 188.3700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.3165
    Cell Significance Index: 41.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4394
    Cell Significance Index: 484.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1450
    Cell Significance Index: 430.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7617
    Cell Significance Index: 1590.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4199
    Cell Significance Index: 509.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3342
    Cell Significance Index: 102.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0574
    Cell Significance Index: 171.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0348
    Cell Significance Index: 112.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9592
    Cell Significance Index: 172.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9015
    Cell Significance Index: 40.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8062
    Cell Significance Index: 557.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6845
    Cell Significance Index: 84.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6593
    Cell Significance Index: 44.3300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.5338
    Cell Significance Index: 5.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4902
    Cell Significance Index: 10.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4870
    Cell Significance Index: 57.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4861
    Cell Significance Index: 29.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4464
    Cell Significance Index: 23.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4337
    Cell Significance Index: 12.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3927
    Cell Significance Index: 739.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3888
    Cell Significance Index: 212.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2601
    Cell Significance Index: 165.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2410
    Cell Significance Index: 4.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1918
    Cell Significance Index: 6.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1774
    Cell Significance Index: 78.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1690
    Cell Significance Index: 260.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1633
    Cell Significance Index: 222.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1406
    Cell Significance Index: 63.8200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1344
    Cell Significance Index: 3.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1322
    Cell Significance Index: 6.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1318
    Cell Significance Index: 243.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1168
    Cell Significance Index: 11.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0981
    Cell Significance Index: 4.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0959
    Cell Significance Index: 3.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0904
    Cell Significance Index: 4.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0789
    Cell Significance Index: 15.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0108
    Cell Significance Index: 0.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0059
    Cell Significance Index: 1.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0022
    Cell Significance Index: 0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0223
    Cell Significance Index: -16.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0248
    Cell Significance Index: -3.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0288
    Cell Significance Index: -1.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0410
    Cell Significance Index: -30.0300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0510
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0603
    Cell Significance Index: -44.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0998
    Cell Significance Index: -56.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1026
    Cell Significance Index: -2.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1048
    Cell Significance Index: -65.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1063
    Cell Significance Index: -13.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1471
    Cell Significance Index: -20.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1780
    Cell Significance Index: -51.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2346
    Cell Significance Index: -30.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2418
    Cell Significance Index: -18.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2418
    Cell Significance Index: -5.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2589
    Cell Significance Index: -26.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2721
    Cell Significance Index: -31.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2958
    Cell Significance Index: -62.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3306
    Cell Significance Index: -34.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3514
    Cell Significance Index: -18.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3994
    Cell Significance Index: -28.2500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4010
    Cell Significance Index: -5.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4300
    Cell Significance Index: -49.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4560
    Cell Significance Index: -29.4200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4978
    Cell Significance Index: -7.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5003
    Cell Significance Index: -12.8600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5013
    Cell Significance Index: -10.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5442
    Cell Significance Index: -17.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6005
    Cell Significance Index: -15.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6231
    Cell Significance Index: -39.2700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6252
    Cell Significance Index: -13.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6432
    Cell Significance Index: -50.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6446
    Cell Significance Index: -16.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7064
    Cell Significance Index: -20.2500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.7139
    Cell Significance Index: -9.0100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.7420
    Cell Significance Index: -6.1300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7683
    Cell Significance Index: -15.0000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7746
    Cell Significance Index: -4.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8130
    Cell Significance Index: -49.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8165
    Cell Significance Index: -17.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8356
    Cell Significance Index: -11.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9040
    Cell Significance Index: -26.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9718
    Cell Significance Index: -30.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9859
    Cell Significance Index: -34.2600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.0083
    Cell Significance Index: -15.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0162
    Cell Significance Index: -33.2700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.0393
    Cell Significance Index: -15.3400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.0703
    Cell Significance Index: -18.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcriptional regulation**: SREBF2 acts as a transcription factor that regulates the expression of target genes by binding to SREs in their promoter regions. 2. **Cholesterol homeostasis**: SREBF2 plays a crucial role in regulating cholesterol homeostasis by modulating the expression of genes involved in cholesterol biosynthesis, storage, and efflux. 3. **Lipid metabolism**: SREBF2 is involved in regulating lipid metabolism, including the expression of genes involved in fatty acid synthesis, storage, and degradation. 4. **Cellular localization**: SREBF2 is primarily localized to the nucleus, where it regulates gene expression. 5. **Interactions**: SREBF2 interacts with other transcription factors, such as SREBP1 and PPARα, to regulate gene expression. **Pathways and Functions** 1. **Cholesterol biosynthesis**: SREBF2 regulates the expression of genes involved in cholesterol biosynthesis, including HMG-CoA reductase and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase. 2. **Cholesterol storage**: SREBF2 regulates the expression of genes involved in cholesterol storage, including acetyl-CoA acetyltransferase (ACAT) and stearoyl-CoA desaturase (SCD). 3. **Cholesterol efflux**: SREBF2 regulates the expression of genes involved in cholesterol efflux, including ATP-binding cassette transporter A1 (ABCA1) and ABCG1. 4. **Lipid metabolism**: SREBF2 regulates the expression of genes involved in lipid metabolism, including fatty acid synthase (FASN) and adipose triglyceride lipase (ATGL). 5. **Cellular response to starvation**: SREBF2 regulates the expression of genes involved in cellular response to starvation, including peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and AMP-activated protein kinase (AMPK). **Clinical Significance** 1. **Atherosclerosis**: Dysregulation of SREBF2 has been implicated in atherosclerosis, a condition characterized by the buildup of cholesterol-rich plaques in the arteries. 2. **Metabolic syndrome**: SREBF2 dysregulation has been implicated in metabolic syndrome, a condition characterized by insulin resistance, obesity, and dyslipidemia. 3. **Neurodegenerative disorders**: SREBF2 dysregulation has been implicated in neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cancer**: SREBF2 dysregulation has been implicated in cancer, including breast cancer and colon cancer. 5. **Pharmacological targets**: SREBF2 is a potential target for pharmacological intervention in the treatment of diseases associated with its dysregulation, including atherosclerosis and metabolic syndrome.

Genular Protein ID: 1746848007

Symbol: SRBP2_HUMAN

Name: Class D basic helix-loop-helix protein 2

UniProtKB Accession Codes:

Q12772 Q05BD5 Q6GTH7 Q86V36 Q9UH04

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7903453

Title: SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.

PubMed ID: 7903453

DOI: 10.1073/pnas.90.24.11603

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8402897

Title: SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene.

PubMed ID: 8402897

DOI: 10.1016/s0092-8674(05)80095-9

PubMed ID: 11477106

Title: Direct demonstration of rapid degradation of nuclear sterol regulatory element-binding proteins by the ubiquitin-proteasome pathway.

PubMed ID: 11477106

DOI: 10.1074/jbc.m105200200

PubMed ID: 12202038

Title: Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.

PubMed ID: 12202038

DOI: 10.1016/s0092-8674(02)00872-3

PubMed ID: 12177166

Title: Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.

PubMed ID: 12177166

PubMed ID: 8626610

Title: Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane.

PubMed ID: 8626610

DOI: 10.1074/jbc.271.17.10379

PubMed ID: 8643593

Title: Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins.

PubMed ID: 8643593

DOI: 10.1073/pnas.93.11.5437

PubMed ID: 9651382

Title: Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning.

PubMed ID: 9651382

DOI: 10.1074/jbc.273.28.17801

PubMed ID: 10805775

Title: Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease.

PubMed ID: 10805775

DOI: 10.1073/pnas.97.10.5123

PubMed ID: 19706601

Title: The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage.

PubMed ID: 19706601

DOI: 10.1074/jbc.m109.041376

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28849786

Title: SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology.

PubMed ID: 28849786

DOI: 10.1038/nrendo.2017.91

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 32322062

Title: The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.

PubMed ID: 32322062

DOI: 10.1038/s41586-020-2183-2

PubMed ID: 35120642

Title: Directed mutational scanning reveals a balance between acidic and hydrophobic residues in strong human activation domains.

PubMed ID: 35120642

DOI: 10.1016/j.cels.2022.01.002

PubMed ID: 14645851

Title: The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor.

PubMed ID: 14645851

DOI: 10.1126/science.1088372

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1141
  • Mass: 123688
  • Checksum: 481B1D8E2A2306D2
  • Sequence:
    • MDDSGELGGL ETMETLTELG DELTLGDIDE MLQFVSNQVG EFPDLFSEQL CSSFPGSGGS 
GSSSGSSGSS SSSSNGRGSS SGAVDPSVQR SFTQVTLPSF SPSAASPQAP TLQVKVSPTS 
VPTTPRATPI LQPRPQPQPQ PQTQLQQQTV MITPTFSTTP QTRIIQQPLI YQNAATSFQV 
LQPQVQSLVT SSQVQPVTIQ QQVQTVQAQR VLTQTANGTL QTLAPATVQT VAAPQVQQVP 
VLVQPQIIKT DSLVLTTLKT DGSPVMAAVQ NPALTALTTP IQTAALQVPT LVGSSGTILT 
TMPVMMGQEK VPIKQVPGGV KQLEPPKEGE RRTTHNIIEK RYRSSINDKI IELKDLVMGT 
DAKMHKSGVL RKAIDYIKYL QQVNHKLRQE NMVLKLANQK NKLLKGIDLG SLVDNEVDLK 
IEDFNQNVLL MSPPASDSGS QAGFSPYSID SEPGSPLLDD AKVKDEPDSP PVALGMVDRS 
RILLCVLTFL CLSFNPLTSL LQWGGAHDSD QHPHSGSGRS VLSFESGSGG WFDWMMPTLL 
LWLVNGVIVL SVFVKLLVHG EPVIRPHSRS SVTFWRHRKQ ADLDLARGDF AAAAGNLQTC 
LAVLGRALPT SRLDLACSLS WNVIRYSLQK LRLVRWLLKK VFQCRRATPA TEAGFEDEAK 
TSARDAALAY HRLHQLHITG KLPAGSACSD VHMALCAVNL AECAEEKIPP STLVEIHLTA 
AMGLKTRCGG KLGFLASYFL SRAQSLCGPE HSAVPDSLRW LCHPLGQKFF MERSWSVKSA 
AKESLYCAQR NPADPIAQVH QAFCKNLLER AIESLVKPQA KKKAGDQEEE SCEFSSALEY 
LKLLHSFVDS VGVMSPPLSR SSVLKSALGP DIICRWWTSA ITVAISWLQG DDAAVRSHFT 
KVERIPKALE VTESPLVKAI FHACRAMHAS LPGKADGQQS SFCHCERASG HLWSSLNVSG 
ATSDPALNHV VQLLTCDLLL SLRTALWQKQ ASASQAVGET YHASGAELAG FQRDLGSLRR 
LAHSFRPAYR KVFLHEATVR LMAGASPTRT HQLLEHSLRR RTTQSTKHGE VDAWPGQRER 
ATAILLACRH LPLSFLSSPG QRAVLLAEAA RTLEKVGDRR SCNDCQQMIV KLGGGTAIAA 
S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.