Details for: SRP9

Gene ID: 6726

Symbol: SRP9

Ensembl ID: ENSG00000143742

Description: signal recognition particle 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 431.5144
    Cell Significance Index: -67.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 264.0715
    Cell Significance Index: -66.9800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 225.4656
    Cell Significance Index: -92.8800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 196.0719
    Cell Significance Index: -92.5700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 186.0398
    Cell Significance Index: -75.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 171.2335
    Cell Significance Index: -88.0800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 138.2071
    Cell Significance Index: -92.7400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 80.1001
    Cell Significance Index: -76.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 71.6571
    Cell Significance Index: -88.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.7960
    Cell Significance Index: -93.9000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.2371
    Cell Significance Index: -59.5700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.1273
    Cell Significance Index: -61.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.6806
    Cell Significance Index: 149.3700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.6298
    Cell Significance Index: 44.9500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.4071
    Cell Significance Index: 57.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.6176
    Cell Significance Index: 160.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.5687
    Cell Significance Index: 95.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.3216
    Cell Significance Index: 36.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.1060
    Cell Significance Index: 1696.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.7586
    Cell Significance Index: 339.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.7292
    Cell Significance Index: 321.8600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.6673
    Cell Significance Index: 16.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4262
    Cell Significance Index: 437.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3560
    Cell Significance Index: 323.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.2886
    Cell Significance Index: 21.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.1473
    Cell Significance Index: 275.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.0803
    Cell Significance Index: 97.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.0706
    Cell Significance Index: 60.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.0372
    Cell Significance Index: 106.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.9883
    Cell Significance Index: 148.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8296
    Cell Significance Index: 808.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7660
    Cell Significance Index: 287.2300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.7456
    Cell Significance Index: 22.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.5950
    Cell Significance Index: 18.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5435
    Cell Significance Index: 109.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4692
    Cell Significance Index: 94.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4512
    Cell Significance Index: 67.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2093
    Cell Significance Index: 239.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1859
    Cell Significance Index: 32.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.1630
    Cell Significance Index: 26.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7185
    Cell Significance Index: 92.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7157
    Cell Significance Index: 37.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6847
    Cell Significance Index: 137.3600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.6162
    Cell Significance Index: 3.6200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6132
    Cell Significance Index: 31.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4636
    Cell Significance Index: 166.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4432
    Cell Significance Index: 84.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3761
    Cell Significance Index: 10.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3498
    Cell Significance Index: 21.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3473
    Cell Significance Index: 59.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2726
    Cell Significance Index: 7.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2086
    Cell Significance Index: 13.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1855
    Cell Significance Index: 3.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1264
    Cell Significance Index: 95.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1173
    Cell Significance Index: 3.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0579
    Cell Significance Index: 42.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0267
    Cell Significance Index: 0.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0027
    Cell Significance Index: 5.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0269
    Cell Significance Index: -19.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0282
    Cell Significance Index: -52.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0375
    Cell Significance Index: -57.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0450
    Cell Significance Index: -28.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0502
    Cell Significance Index: -4.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0594
    Cell Significance Index: -80.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0754
    Cell Significance Index: -47.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0758
    Cell Significance Index: -7.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0993
    Cell Significance Index: -56.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1171
    Cell Significance Index: -53.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.1251
    Cell Significance Index: -86.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1465
    Cell Significance Index: -30.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1736
    Cell Significance Index: -9.7400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1810
    Cell Significance Index: -1.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1963
    Cell Significance Index: -56.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1967
    Cell Significance Index: -4.1900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2108
    Cell Significance Index: -24.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2852
    Cell Significance Index: -7.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3366
    Cell Significance Index: -8.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3491
    Cell Significance Index: -39.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3811
    Cell Significance Index: -44.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4274
    Cell Significance Index: -29.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4302
    Cell Significance Index: -62.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4861
    Cell Significance Index: -38.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5382
    Cell Significance Index: -18.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6654
    Cell Significance Index: -17.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7196
    Cell Significance Index: -15.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7215
    Cell Significance Index: -55.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7545
    Cell Significance Index: -12.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8157
    Cell Significance Index: -54.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8625
    Cell Significance Index: -89.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8949
    Cell Significance Index: -12.2100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.9539
    Cell Significance Index: -16.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.9617
    Cell Significance Index: -17.7800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -1.1386
    Cell Significance Index: -7.1500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -1.2758
    Cell Significance Index: -8.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.3367
    Cell Significance Index: -34.3600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.3733
    Cell Significance Index: -16.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.4218
    Cell Significance Index: -85.3600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.4551
    Cell Significance Index: -20.4100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.4684
    Cell Significance Index: -43.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.4843
    Cell Significance Index: -67.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SRP9 is a small, acidic protein of approximately 9 kDa, which is encoded by the SRP9 gene (ENSG00000143742). It is highly expressed in various cell types, including mesodermal cells, mesenchymal stem cells, radial glial cells, and epithelial cells of the nephron. SRP9 has a unique structure, consisting of a single chain of 92 amino acids, with a highly conserved N-terminal domain that interacts with the SRP receptor complex. The C-terminal domain of SRP9 is less conserved and may play a role in protein binding or localization. **Pathways and Functions** SRP9 is involved in several key cellular pathways, including: 1. **Signal Recognition Particle (SRP) pathway**: SRP9 is a critical component of the SRP complex, which recognizes and binds to ribosomes on the ER membrane, facilitating the translocation of nascent polypeptide chains into the ER lumen. 2. **Protein synthesis**: SRP9 plays a role in regulating protein synthesis by controlling the translation of mRNAs into proteins. 3. **Endoplasmic reticulum targeting**: SRP9 is involved in the targeting of proteins to the ER for proper folding and assembly. 4. **Negative regulation of translational elongation**: SRP9 has been shown to inhibit the translation of certain mRNAs, suggesting a role in regulating protein synthesis. **Clinical Significance** Dysregulation of SRP9 has been implicated in various diseases, including: 1. **Immunodeficiency disorders**: Mutations in the SRP9 gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Cancer**: Altered expression of SRP9 has been observed in various types of cancer, including lung, breast, and colon cancer. 3. **Neurological disorders**: SRP9 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, SRP9 is a critical component of the SRP complex, which plays a pivotal role in protein synthesis, cell differentiation, and development. Dysregulation of SRP9 has been implicated in various diseases, highlighting the importance of this gene in maintaining proper cellular function. Further research is needed to fully elucidate the mechanisms of SRP9 and its role in disease pathogenesis.

Genular Protein ID: 2885027249

Symbol: SRP09_HUMAN

Name: Signal recognition particle 9 kDa protein

UniProtKB Accession Codes:

P49458 A8K0N0 Q6NVX0 Q8WTW0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 CarbonylDB 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7730321

Title: Human signal recognition particle (SRP) Alu-associated protein also binds Alu interspersed repeat sequence RNAs. Characterization of human SRP9.

PubMed ID: 7730321

DOI: 10.1074/jbc.270.17.10179

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11089964

Title: Structure and assembly of the Alu domain of the mammalian signal recognition particle.

PubMed ID: 11089964

DOI: 10.1038/35041507

PubMed ID: 34020957

Title: Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

PubMed ID: 34020957

DOI: 10.1126/sciadv.abg0942

Sequence Information:

  • Length: 86
  • Mass: 10112
  • Checksum: DB2CA071AF0E6F65
  • Sequence:
    • MPQYQTWEEF SRAAEKLYLA DPMKARVVLK YRHSDGNLCV KVTDDLVCLV YKTDQAQDVK 
KIEKFHSQLM RLMVAKEARN VTMETE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.