SRP9 | ENSG00000143742 | NCBI 6726

Details for: SRP9

Associated with

Metabolism of proteins
(R-HSA-392499)
Translation
(R-HSA-72766)
7s rna binding
(GO:0008312)
Cytosol
(GO:0005829)
Negative regulation of translational elongation
(GO:0045900)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)
Signal recognition particle, endoplasmic reticulum targeting
(GO:0005786)
Signal recognition particle binding
(GO:0005047)
Signal recognition particle receptor complex
(GO:0005785)
Srp-dependent cotranslational protein targeting to membrane
(GO:0006614)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

ciliated epithelial cell CL0000067

CSI 81.26

rCSI 71.46%

PRS 3.88
megakaryocyte-erythroid progenitor cell CL0000050

CSI 79.42

rCSI 71.72%

PRS 4.73
fallopian tube secretory epithelial cell CL4030006

CSI 75.36

rCSI 72.55%

PRS 5.56
hematopoietic stem cell CL0000037

CSI 74.91

rCSI 49.79%

PRS 6.38
common myeloid progenitor CL0000049

CSI 71.32

rCSI 57.66%

PRS 5.26
neural crest cell CL0011012

CSI 70.07

rCSI 55.38%

PRS 3.71
epithelial cell of lung CL0000082

CSI 69.24

rCSI 57.4%

PRS 5.08
intestinal epithelial cell CL0002563

CSI 65.99

rCSI 68.97%

PRS 5.67
peripheral nervous system neuron CL2000032

CSI 65.29

rCSI 88.97%

PRS 4.84
stem cell CL0000034

CSI 64.43

rCSI 62.12%

PRS 3.04
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 64.2

rCSI 74.14%

PRS 4.87
mesodermal cell CL0000222

CSI 60.44

rCSI 72.55%

PRS 5.37
multi-ciliated epithelial cell CL0005012

CSI 60.23

rCSI 60.1%

PRS 4.59
keratinocyte CL0000312

CSI 59.43

rCSI 49.81%

PRS 6.46
fraction A pre-pro B cell CL0002045

CSI 58.42

rCSI 66.88%

PRS 11.15
transit amplifying cell of colon CL0009011

CSI 56.36

rCSI 66.19%

PRS 6.5
early lymphoid progenitor CL0000936

CSI 56.11

rCSI 49.28%

PRS 6.01
radial glial cell CL0000681

CSI 55.44

rCSI 77.02%

PRS 5.64
colon epithelial cell CL0011108

CSI 52.74

rCSI 55.24%

PRS 5.01
common dendritic progenitor CL0001029

CSI 51.64

rCSI 64.81%

PRS 6.82
enteric smooth muscle cell CL0002504

CSI 48.19

rCSI 68.77%

PRS 6.12
pancreatic D cell CL0000173

CSI 41.81

rCSI 41.12%

PRS 5.86
pancreatic A cell CL0000171

CSI 40.72

rCSI 42.66%

PRS 5.76
pro-B cell CL0000826

CSI 40.6

rCSI 33.62%

PRS 5.37
intestine goblet cell CL0019031

CSI 40.08

rCSI 35.57%

PRS 5.38
granulocyte monocyte progenitor cell CL0000557

CSI 40.04

rCSI 34.67%

PRS 5.96
enteroendocrine cell CL0000164

CSI 39.13

rCSI 53.47%

PRS 5.94
neuroblast (sensu Vertebrata) CL0000031

CSI 38.83

rCSI 49.83%

PRS 5.31
glioblast CL0000030

CSI 33.38

rCSI 53.24%

PRS 4.69
retinal cone cell CL0000573

CSI 33.02

rCSI 53.15%

PRS 4.15
promyelocyte CL0000836

CSI 31.98

rCSI 46.12%

PRS 7.47
mucous neck cell CL0000651

CSI 30.41

rCSI 43.83%

PRS 8.72
large pre-B-II cell CL0000957

CSI 30.16

rCSI 86.1%

PRS 9.55
pancreatic ductal cell CL0002079

CSI 29.44

rCSI 57.26%

PRS 5.48
common lymphoid progenitor CL0000051

CSI 28.77

rCSI 38.44%

PRS 10.3
intestinal tuft cell CL0019032

CSI 27.97

rCSI 42.74%

PRS 6.22
lung ciliated cell CL1000271

CSI 27.9

rCSI 32.26%

PRS 3.9
kidney epithelial cell CL0002518

CSI 27.21

rCSI 51.94%

PRS 13.18
mesenchymal cell CL0008019

CSI 27.07

rCSI 68.75%

PRS 5.5
interstitial cell of Cajal CL0002088

CSI 26.85

rCSI 34.18%

PRS 6.27
transit amplifying cell CL0009010

CSI 25.97

rCSI 39.72%

PRS 8.79
forebrain radial glial cell CL0013000

CSI 25.14

rCSI 80.67%

PRS 8.07
type B pancreatic cell CL0000169

CSI 24.55

rCSI 54.35%

PRS 5.04
myeloid leukocyte CL0000766

CSI 24.33

rCSI 22.45%

PRS 5.43
colon goblet cell CL0009039

CSI 24.24

rCSI 57.61%

PRS 8.19
goblet cell CL0000160

CSI 24.05

rCSI 22.72%

PRS 5.6
intrahepatic cholangiocyte CL0002538

CSI 23.23

rCSI 55.75%

PRS 10.22
epithelial cell CL0000066

CSI 23.14

rCSI 35.56%

PRS 7.77
promonocyte CL0000559

CSI 22.64

rCSI 38.79%

PRS 7.18
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 21.51

rCSI 49.02%

PRS 5.61
tracheal goblet cell CL1000329

CSI 21.48

rCSI 46.89%

PRS 11.02
microcirculation associated smooth muscle cell CL0008035

CSI 20.8

rCSI 60.22%

PRS 6.09
foveolar cell of stomach CL0002179

CSI 20.03

rCSI 42.63%

PRS 8.74
Mueller cell CL0000636

CSI 19.63

rCSI 44.81%

PRS 4.98
progenitor cell CL0011026

CSI 19.3

rCSI 41.04%

PRS 10.24
paneth cell CL0000510

CSI 18.57

rCSI 27.41%

PRS 8.5
luminal epithelial cell of mammary gland CL0002326

CSI 18.11

rCSI 32.91%

PRS 8.23
mature T cell CL0002419

CSI 17.37

rCSI 13.51%

PRS 7.73
mammary gland epithelial cell CL0002327

CSI 17.12

rCSI 60.06%

PRS 9.79
plasmablast CL0000980

CSI 17.05

rCSI 13.41%

PRS 6.39
double negative thymocyte CL0002489

CSI 16.36

rCSI 11.37%

PRS 6.28
cerebral cortex GABAergic interneuron CL0010011

CSI 16.3

rCSI 48.12%

PRS 6.82
pancreatic PP cell CL0002275

CSI 15.17

rCSI 60.38%

PRS 9.63
M cell of gut CL0000682

CSI 14.74

rCSI 15.67%

PRS 9.62
pulmonary ionocyte CL0017000

CSI 14.74

rCSI 17.94%

PRS 6.8
retina horizontal cell CL0000745

CSI 14.66

rCSI 22.35%

PRS 5.06
myeloid lineage restricted progenitor cell CL0000839

CSI 14.64

rCSI 75.57%

PRS 10.77
club cell CL0000158

CSI 14.29

rCSI 20.94%

PRS 6.36
duct epithelial cell CL0000068

CSI 13.97

rCSI 20.44%

PRS 5.68
double-positive, alpha-beta thymocyte CL0000809

CSI 13.94

rCSI 14.21%

PRS 7.75
lymphoid lineage restricted progenitor cell CL0000838

CSI 13.46

rCSI 52.39%

PRS 8.87
acinar cell CL0000622

CSI 13.45

rCSI 19.73%

PRS 7.05
respiratory suprabasal cell CL4033048

CSI 13.36

rCSI 17.13%

PRS 6.2
pancreatic epsilon cell CL0005019

CSI 13.35

rCSI 62.22%

PRS 13.53
P/D1 enteroendocrine cell CL0002268

CSI 13.33

rCSI 72.58%

PRS 13.86
enterocyte CL0000584

CSI 13.03

rCSI 21.01%

PRS 8.74
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 12.83

rCSI 16.12%

PRS 28.15
lung neuroendocrine cell CL1000223

CSI 12.73

rCSI 18.84%

PRS 6.18
precursor B cell CL0000817

CSI 12.66

rCSI 11.09%

PRS 7.24
type EC enteroendocrine cell CL0000577

CSI 12.22

rCSI 43.39%

PRS 8.85
group 3 innate lymphoid cell CL0001071

CSI 12.15

rCSI 9.13%

PRS 5.52
basal-myoepithelial cell of mammary gland CL0002324

CSI 12.1

rCSI 22.88%

PRS 12.07
enteroendocrine cell of colon CL0009042

CSI 11.89

rCSI 55.75%

PRS 14.95
hematopoietic multipotent progenitor cell CL0000837

CSI 11.82

rCSI 28.44%

PRS 8.4
muscle cell CL0000187

CSI 11.66

rCSI 23.94%

PRS 13.07
primitive red blood cell CL0002355

CSI 11.44

rCSI 61.7%

PRS 10.59
secretory cell CL0000151

CSI 11.24

rCSI 11.73%

PRS 5.49
transit amplifying cell of small intestine CL0009012

CSI 11.05

rCSI 48.53%

PRS 10.37
epithelial cell of proximal tubule CL0002306

CSI 11.05

rCSI 26.98%

PRS 5.51
choroid plexus epithelial cell CL0000706

CSI 10.97

rCSI 17.97%

PRS 4.21
ON-bipolar cell CL0000749

CSI 10.7

rCSI 15.9%

PRS 6.9
glandular epithelial cell CL0000150

CSI 10.69

rCSI 28.15%

PRS 10.52
bronchial goblet cell CL1000312

CSI 10.39

rCSI 41.53%

PRS 11.9
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 10.38

rCSI 20.69%

PRS 9.19
amacrine cell CL0000561

CSI 10.38

rCSI 30.07%

PRS 4.62
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 10.34

rCSI 6.97%

PRS 6.5
myofibroblast cell CL0000186

CSI 10.13

rCSI 14.03%

PRS 7.74
pancreatic stellate cell CL0002410

CSI 10.1

rCSI 58.77%

PRS 8.08
ionocyte CL0005006

CSI 9.64

rCSI 10.33%

PRS 4.95
renal alpha-intercalated cell CL0005011

CSI 9.63

rCSI 12.87%

PRS 7.32

renal interstitial pericyte CL1001318

CSI -15.4

rCSI -42.6%

PRS 6.0%
brush cell of tracheobronchial tree CL0002075

CSI -13.5

rCSI -40.1%

PRS 8.9%
lung interstitial macrophage CL4033043

CSI -10.1

rCSI -22.7%

PRS 13.3%
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI -10.0

rCSI -9.1%

PRS 8.4%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI -9.5

rCSI -11.3%

PRS 9.4%
squamous epithelial cell CL0000076

CSI -8.6

rCSI -20.3%

PRS 7.1%
alternatively activated macrophage CL0000890

CSI -8.1

rCSI -10.1%

PRS 8.3%
regular ventricular cardiac myocyte CL0002131

CSI -7.7

rCSI -47.9%

PRS 4.5%
CD14-positive, CD16-positive monocyte CL0002397

CSI -7.5

rCSI -9.8%

PRS 7.5%
brush cell CL0002204

CSI -6.1

rCSI -12.2%

PRS 15.5%
lung pericyte CL0009089

CSI -4.8

rCSI -12.8%

PRS 6.4%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI -3.3

rCSI -12.0%

PRS 2.9%
platelet CL0000233

CSI -3.3

rCSI -13.5%

PRS 15.2%
class switched memory B cell CL0000972

CSI -2.7

rCSI -2.0%

PRS 9.1%
mature astrocyte CL0002627

CSI -2.3

rCSI -9.6%

PRS 9.6%
endothelial cell of periportal hepatic sinusoid CL0019021

CSI -2.2

rCSI -9.9%

PRS 19.3%
central nervous system neuron CL2000029

CSI -2.1

rCSI -15.2%

PRS 2.7%
vascular leptomeningeal cell CL4023051

CSI -1.9

rCSI -3.3%

PRS 4.1%
effector CD4-positive, alpha-beta T cell CL0001044

CSI -1.9

rCSI -5.3%

PRS 7.8%
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI -1.8

rCSI -3.1%

PRS 11.6%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI -1.8

rCSI -2.2%

PRS 8.0%
Kupffer cell CL0000091

CSI -1.6

rCSI -3.6%

PRS 5.2%
GABAergic neuron CL0000617

CSI -1.4

rCSI -4.8%

PRS 4.5%
alveolar type 1 fibroblast cell CL4028004

CSI -1.3

rCSI -1.4%

PRS 6.2%
astrocyte of the cerebral cortex CL0002605

CSI -1.2

rCSI -2.7%

PRS 3.4%
Schwann cell CL0002573

CSI -1.2

rCSI -3.3%

PRS 7.1%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI -0.9

rCSI -2.1%

PRS 3.1%
alveolar adventitial fibroblast CL4028006

CSI -0.7

rCSI -1.1%

PRS 5.4%
collagen secreting cell CL0000667

CSI -0.7

rCSI -3.8%

PRS 27.2%
mononuclear phagocyte CL0000113

CSI -0.7

rCSI -1.4%

PRS 5.9%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI -0.6

rCSI -3.6%

PRS 3.5%
near-projecting glutamatergic cortical neuron CL4023012

CSI -0.6

rCSI -2.3%

PRS 3.4%
tracheobronchial smooth muscle cell CL0019019

CSI -0.2

rCSI -0.4%

PRS 7.1%
B-2 B cell CL0000822

CSI 0.1

rCSI 1.1%

PRS 33.5%
CD14-positive monocyte CL0001054

CSI 0.1

rCSI 0.1%

PRS 7.8%
cytotoxic T cell CL0000910

CSI 0.1

rCSI 0.6%

PRS 8.3%
Merkel cell CL0000242

CSI 0.1

rCSI 2.5%

PRS 38.8%
basophil CL0000767

CSI 0.2

rCSI 0.3%

PRS 11.8%
IgA plasma cell CL0000987

CSI 0.2

rCSI 0.2%

PRS 10.2%
IgM plasma cell CL0000986

CSI 0.2

rCSI 0.8%

PRS 28.8%
lamp5 GABAergic cortical interneuron CL4023011

CSI 0.2

rCSI 0.3%

PRS 3.2%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 0.2

rCSI 0.5%

PRS 3.0%
blood vessel smooth muscle cell CL0019018

CSI 0.2

rCSI 1.8%

PRS 5.7%
prostate gland microvascular endothelial cell CL2000059

CSI 0.2

rCSI 5.5%

PRS 20.3%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.2

rCSI 0.4%

PRS 3.2%
L6b glutamatergic cortical neuron CL4023038

CSI 0.2

rCSI 0.8%

PRS 3.4%
pulmonary alveolar type 1 cell CL0002062

CSI 0.3

rCSI 1.5%

PRS 7.9%
parietal cell CL0000162

CSI 0.3

rCSI 2.3%

PRS 35.1%
sncg GABAergic cortical interneuron CL4023015

CSI 0.4

rCSI 0.6%

PRS 3.6%
midbrain dopaminergic neuron CL2000097

CSI 0.4

rCSI 2.6%

PRS 9.5%
vasa recta ascending limb cell CL1001131

CSI 0.4

rCSI 2.0%

PRS 24.2%
enteroendocrine cell of small intestine CL0009006

CSI 0.5

rCSI 1.1%

PRS 8.4%
periportal region hepatocyte CL0019026

CSI 0.5

rCSI 2.0%

PRS 8.9%
helper T cell CL0000912

CSI 0.6

rCSI 0.8%

PRS 7.9%
macroglial cell CL0000126

CSI 0.6

rCSI 1.4%

PRS 9.2%
osteoblast CL0000062

CSI 0.6

rCSI 14.9%

PRS 44.8%
cord blood hematopoietic stem cell CL2000095

CSI 0.6

rCSI 11.9%

PRS 42.2%
follicular B cell CL0000843

CSI 0.7

rCSI 2.4%

PRS 26.1%
neural cell CL0002319

CSI 0.7

rCSI 2.6%

PRS 10.5%
vascular associated smooth muscle cell CL0000359

CSI 0.7

rCSI 2.3%

PRS 6.6%
intermediate monocyte CL0002393

CSI 0.7

rCSI 1.1%

PRS 5.3%
serous secreting cell CL0000313

CSI 0.7

rCSI 3.8%

PRS 26.4%
keratocyte CL0002363

CSI 0.8

rCSI 1.8%

PRS 8.4%
IgG plasma cell CL0000985

CSI 0.8

rCSI 1.0%

PRS 9.3%
cerebral cortex pyramidal neuron CL4023111

CSI 0.8

rCSI 5.2%

PRS 19.3%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 0.9

rCSI 1.2%

PRS 5.2%
follicular dendritic cell CL0000442

CSI 0.9

rCSI 14.2%

PRS 34.0%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 0.9

rCSI 10.9%

PRS 23.1%
retinal bipolar neuron CL0000748

CSI 1.0

rCSI 1.8%

PRS 4.1%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 1.0

rCSI 3.0%

PRS 3.7%
forebrain neuroblast CL1000042

CSI 1.0

rCSI 10.8%

PRS 59.5%
kidney loop of Henle epithelial cell CL1000909

CSI 1.0

rCSI 21.5%

PRS 42.9%
VIP GABAergic cortical interneuron CL4023016

CSI 1.0

rCSI 1.2%

PRS 3.2%
activated CD4-positive, alpha-beta T cell, human CL0001043

CSI 1.1

rCSI 2.5%

PRS 36.7%
acinar cell of salivary gland CL0002623

CSI 1.1

rCSI 25.0%

PRS 8.1%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 1.1

rCSI 6.7%

PRS 12.5%
kidney connecting tubule epithelial cell CL1000768

CSI 1.1

rCSI 2.9%

PRS 4.3%
dendritic cell, human CL0001056

CSI 1.2

rCSI 1.8%

PRS 6.2%
colon macrophage CL0009038

CSI 1.2

rCSI 5.5%

PRS 11.7%
B-1 B cell CL0000819

CSI 1.2

rCSI 32.0%

PRS 31.2%
lung endothelial cell CL1001567

CSI 1.3

rCSI 2.9%

PRS 14.1%
vasa recta descending limb cell CL1001285

CSI 1.3

rCSI 10.2%

PRS 24.4%
pulmonary capillary endothelial cell CL4028001

CSI 1.3

rCSI 2.5%

PRS 8.6%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 1.3

rCSI 4.1%

PRS 10.6%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 1.3

rCSI 6.6%

PRS 7.0%
stratified epithelial cell CL0000079

CSI 1.3

rCSI 8.2%

PRS 26.4%
inhibitory interneuron CL0000498

CSI 1.3

rCSI 3.1%

PRS 4.8%
lung microvascular endothelial cell CL2000016

CSI 1.4

rCSI 26.6%

PRS 19.5%
monocyte CL0000576

CSI 1.4

rCSI 2.5%

PRS 15.4%
parietal epithelial cell CL1000452

CSI 1.4

rCSI 3.7%

PRS 5.4%
mesenchymal lymphangioblast CL0005021

CSI 1.5

rCSI 38.2%

PRS 29.2%
BEST4+ enteroycte CL4030026

CSI 1.5

rCSI 1.8%

PRS 5.7%
odontoblast CL0000060

CSI 1.5

rCSI 34.9%

PRS 30.1%
lung macrophage CL1001603

CSI 1.6

rCSI 3.5%

PRS 6.1%
centrilobular region hepatocyte CL0019029

CSI 1.6

rCSI 4.1%

PRS 9.6%
alveolar macrophage CL0000583

CSI 1.6

rCSI 2.6%

PRS 6.3%
intraepithelial lymphocyte CL0002496

CSI 1.7

rCSI 4.5%

PRS 25.6%
Hofbauer cell CL3000001

CSI 1.7

rCSI 3.2%

PRS 6.7%
myelocyte CL0002193

CSI 1.7

rCSI 11.1%

PRS 18.6%
hair follicular keratinocyte CL2000092

CSI 1.7

rCSI 29.8%

PRS 22.8%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [SRP9](/details-gene/6726) encodes the 9 kDa protein component of the signal recognition particle (SRP), a universally conserved ribonucleoprotein complex. Functionally, [SRP9](/details-gene/6726) is integral to the process of co-translational protein targeting, where it binds to the 7S RNA scaffold of the SRP to facilitate the transport of nascent polypeptides to the endoplasmic reticulum membrane. Expression data indicates its high significance in cell types with substantial protein synthesis and secretory demands, such as various progenitor cells and specialized epithelial cells. This fundamental role in protein metabolism underscores its importance in cellular homeostasis and development. It has a clinical association listed under OMIM ID [600707](https://omim.org/entry/600707). ## Cellular Roles and Expression Landscape The expression profile of [SRP9](/details-gene/6726) highlights its role as a key component of the protein processing machinery in metabolically active cells. **Overall**, the gene shows the highest significance in cells characterized by high rates of proliferation or protein secretion. Top-ranked cell types include [ciliated epithelial cell](/details-cell/CL0000067) (CSI: 81.26), [fallopian tube secretory epithelial cell](/details-cell/CL4030006) (CSI: 75.36), and [epithelial cell of lung](/details-cell/CL0000082) (CSI: 69.24), all of which have demanding secretory functions. Concurrently, [SRP9](/details-gene/6726) is highly significant in multiple progenitor and stem cell populations, including [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050) (CSI: 79.42), [hematopoietic stem cell](/details-cell/CL0000037) (CSI: 74.91), and [common myeloid progenitor](/details-cell/CL0000049) (CSI: 71.32). This pattern suggests that [SRP9](/details-gene/6726) is critical for building the cellular machinery required for both cell division and the establishment of specialized secretory functions. Conversely, the gene's significance is markedly lower in terminally differentiated cells with more specialized roles that may not involve extensive protein secretion. These include various immune cells like [effector memory CD8-positive, alpha-beta T cell](/details-cell/CL0000913) (CSI: -10.00) and [alternatively activated macrophage](/details-cell/CL0000890) (CSI: -8.06), as well as structural cells like [renal interstitial pericyte](/details-cell/CL1001318) (CSI: -15.44) and [regular ventricular cardiac myocyte](/details-cell/CL0002131) (CSI: -7.66). This suggests that while essential, its expression levels are modulated to match the specific metabolic demands of a given cell type. ## Pathways and Molecular Function The functional annotations for [SRP9](/details-gene/6726) are highly consistent with its role as a core component of the signal recognition particle. Its primary molecular functions include [7s rna binding](/details-go/GO:0008312) and [signal recognition particle binding](/details-go/GO:0005047), which are essential for the structural integrity and function of the SRP complex ([Link](https://doi.org/10.1038/35041507)). This molecular role enables its involvement in the biological process of [Srp-dependent cotranslational protein targeting to membrane](/details-go/GO:0006614), a crucial step for directing newly synthesized proteins with a signal peptide to the endoplasmic reticulum. This process is a key part of the broader Reactome pathways of [Translation](/details-pathway/R-HSA-72766) and the overall [Metabolism of proteins](/details-pathway/R-HSA-392499). The SRP complex, including [SRP9](/details-gene/6726), recognizes the signal sequence on a nascent polypeptide, transiently arrests translation ([Negative regulation of translational elongation](/details-go/GO:0045900)), and docks with the SRP receptor on the ER membrane to ensure proper protein translocation ([Link](https://doi.org/10.1126/sciadv.abg0942)). This function directly explains its high expression in secretory and rapidly dividing cells that have a high flux of proteins entering the secretory pathway. ## Research Directions The ubiquitous and fundamental role of [SRP9](/details-gene/6726) in protein biogenesis makes it a critical factor in cellular health, with dysregulation potentially leading to proteotoxic stress and cellular dysfunction. **Proposed Hypotheses:** 1. Given its high significance in multiple stem and progenitor cell populations ([hematopoietic stem cell](/details-cell/CL0000037), [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050)), the precise level of [SRP9](/details-gene/6726) expression is critical for maintaining stem cell pluripotency and guiding lineage-specific differentiation. A reduction in [SRP9](/details-gene/6726) levels may impair the synthesis of key surface receptors and secreted factors, thereby disrupting signaling pathways essential for stem cell fate decisions. 2. In highly specialized secretory cells, such as [fallopian tube secretory epithelial cell](/details-cell/CL4030006), [SRP9](/details-gene/6726) may be a rate-limiting component of the secretory pathway. Conditions that increase secretory demand could induce transcriptional upregulation of [SRP9](/details-gene/6726) as part of a coordinated cellular response, while failure to do so could lead to ER stress and cell death. **Experimental Approach:** To test the first hypothesis regarding the role of [SRP9](/details-gene/6726) in hematopoiesis, one could employ a lentiviral-based shRNA or CRISPRi system to achieve partial knockdown of [SRP9](/details-gene/6726) in primary human CD34+ hematopoietic stem and progenitor cells (HSPCs). These modified cells could then be cultured in vitro in colony-forming unit (CFU) assays with lineage-specific cytokines. The resulting colonies (e.g., BFU-E, CFU-GM) could be quantified and phenotyped to determine if [SRP9](/details-gene/6726) knockdown skews differentiation towards or away from specific lineages. Furthermore, flow cytometry for key surface markers (e.g., CD38, CD90) on the HSPC population over time would reveal impacts on the maintenance of the primitive stem cell pool. **Therapeutic Potential:** As a core component of the essential protein translocation machinery, [SRP9](/details-gene/6726) is a poor candidate for direct therapeutic inhibition. Its systemic inactivation would likely lead to widespread cellular toxicity and lethality due to the catastrophic failure of protein synthesis. Therefore, it does not represent a viable drug target. However, understanding its regulation could provide insights into diseases characterized by proteotoxic stress or aberrant protein secretion, potentially revealing more suitable upstream regulatory nodes for therapeutic intervention.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Signal recognition particle 9 kDa protein

Genular Protein ID: 2885027249

Symbol: SRP09_HUMAN

Name: Signal recognition particle 9 kDa protein

UniProtKB Accession Codes:

P49458 A8K0N0 Q6NVX0 Q8WTW0

Database IDs:

Citations:

PubMed ID: 7730321

Title: Human signal recognition particle (SRP) Alu-associated protein also binds Alu interspersed repeat sequence RNAs. Characterization of human SRP9.

PubMed ID: 7730321

DOI: 10.1074/jbc.270.17.10179

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11089964

Title: Structure and assembly of the Alu domain of the mammalian signal recognition particle.

PubMed ID: 11089964

DOI: 10.1038/35041507

PubMed ID: 34020957

Title: Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

PubMed ID: 34020957

DOI: 10.1126/sciadv.abg0942

Sequence Information:

Length: 86
Mass: 10112
Checksum: DB2CA071AF0E6F65
Sequence:

MPQYQTWEEF SRAAEKLYLA DPMKARVVLK YRHSDGNLCV KVTDDLVCLV YKTDQAQDVK 
KIEKFHSQLM RLMVAKEARN VTMETE

	Overall overall
	Acute kidney failure MONDO0002492
	Adrenal gland UBERON0002369
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Ascending colon UBERON0001156
	Atherosclerosis MONDO0005311
	Axilla UBERON0009472
	Basal cell carcinoma MONDO0020804
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	\|— Colonic epithelium UBERON0000397
	Colorectal cancer MONDO0005575
	Colorectum UBERON0012652
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileal epithelium UBERON0008345
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Liver UBERON0002107
	\|— Liver Breast cancer UBERON0002107_MONDO0007254
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Nonpapillary renal cell carcinoma MONDO0007763
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Pancreas UBERON0001264
	\|— Pancreas Healthy UBERON0001264_PATO0000461
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Primary motor cortex UBERON0001384
	Prostate gland UBERON0002367
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Stomach UBERON0000945
	\|— Stomach Healthy UBERON0000945_PATO0000461
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	Trachea UBERON0003126
	Transverse colon UBERON0001157
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952

Details for: SRP9

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Human signal recognition particle (SRP) Alu-associated protein also binds Alu interspersed repeat sequence RNAs. Characterization of human SRP9. PubMed ID: 7730321

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structure and assembly of the Alu domain of the mammalian signal recognition particle. PubMed ID: 11089964

Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. PubMed ID: 34020957