Details for: SRP54

Gene ID: 6729

Symbol: SRP54

Ensembl ID: ENSG00000100883

Description: signal recognition particle 54

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 377.4465
    Cell Significance Index: -58.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 237.6171
    Cell Significance Index: -60.2700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 137.2141
    Cell Significance Index: -56.5300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 136.6594
    Cell Significance Index: -64.5200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 125.8809
    Cell Significance Index: -51.1400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 113.7086
    Cell Significance Index: -58.4900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 96.3157
    Cell Significance Index: -64.6300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 54.2135
    Cell Significance Index: -51.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 51.4009
    Cell Significance Index: -63.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.7066
    Cell Significance Index: -55.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.3277
    Cell Significance Index: -64.4300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.8804
    Cell Significance Index: -36.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.9843
    Cell Significance Index: -24.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.1234
    Cell Significance Index: 1917.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9709
    Cell Significance Index: 26.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.8287
    Cell Significance Index: 48.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4711
    Cell Significance Index: 68.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4042
    Cell Significance Index: 84.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1645
    Cell Significance Index: 231.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9807
    Cell Significance Index: 120.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9510
    Cell Significance Index: 171.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9031
    Cell Significance Index: 181.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8907
    Cell Significance Index: 169.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8809
    Cell Significance Index: 45.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8019
    Cell Significance Index: 437.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7039
    Cell Significance Index: 48.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5899
    Cell Significance Index: 27.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5383
    Cell Significance Index: 73.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5205
    Cell Significance Index: 230.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5101
    Cell Significance Index: 352.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4987
    Cell Significance Index: 178.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3811
    Cell Significance Index: 48.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3724
    Cell Significance Index: 22.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3448
    Cell Significance Index: 34.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3253
    Cell Significance Index: 18.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2719
    Cell Significance Index: 32.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2568
    Cell Significance Index: 11.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2403
    Cell Significance Index: 41.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2246
    Cell Significance Index: 16.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2075
    Cell Significance Index: 15.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1931
    Cell Significance Index: 10.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1903
    Cell Significance Index: 5.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1758
    Cell Significance Index: 3.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1351
    Cell Significance Index: 254.3900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1317
    Cell Significance Index: 2.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1182
    Cell Significance Index: 19.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0622
    Cell Significance Index: 39.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0530
    Cell Significance Index: 97.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0457
    Cell Significance Index: 20.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0434
    Cell Significance Index: 3.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0429
    Cell Significance Index: 65.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0377
    Cell Significance Index: 1.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0106
    Cell Significance Index: -14.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0240
    Cell Significance Index: -1.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0257
    Cell Significance Index: -18.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0297
    Cell Significance Index: -22.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0328
    Cell Significance Index: -24.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0417
    Cell Significance Index: -26.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0482
    Cell Significance Index: -7.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0539
    Cell Significance Index: -6.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0852
    Cell Significance Index: -48.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0860
    Cell Significance Index: -5.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1014
    Cell Significance Index: -10.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1588
    Cell Significance Index: -33.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1625
    Cell Significance Index: -4.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1739
    Cell Significance Index: -4.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1810
    Cell Significance Index: -52.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2341
    Cell Significance Index: -26.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2590
    Cell Significance Index: -9.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2829
    Cell Significance Index: -4.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2863
    Cell Significance Index: -33.3600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3034
    Cell Significance Index: -5.2000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3211
    Cell Significance Index: -36.6500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3311
    Cell Significance Index: -2.7000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3557
    Cell Significance Index: -4.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3670
    Cell Significance Index: -10.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3678
    Cell Significance Index: -40.0100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4049
    Cell Significance Index: -6.8200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4088
    Cell Significance Index: -2.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4417
    Cell Significance Index: -23.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4588
    Cell Significance Index: -12.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5089
    Cell Significance Index: -52.9900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.5412
    Cell Significance Index: -7.6900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5549
    Cell Significance Index: -5.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5825
    Cell Significance Index: -39.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5937
    Cell Significance Index: -47.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6494
    Cell Significance Index: -28.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6505
    Cell Significance Index: -20.8400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6750
    Cell Significance Index: -19.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7800
    Cell Significance Index: -47.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8002
    Cell Significance Index: -30.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8039
    Cell Significance Index: -17.1200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.8062
    Cell Significance Index: -11.9000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8089
    Cell Significance Index: -21.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9727
    Cell Significance Index: -24.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.0501
    Cell Significance Index: -24.2600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.1366
    Cell Significance Index: -24.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.1406
    Cell Significance Index: -24.7100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.1650
    Cell Significance Index: -27.9400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3869
    Cell Significance Index: -40.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SRP54 is a small, highly conserved protein that belongs to the SRP family of proteins. It is characterized by its ability to bind to 7S RNA, a key component of the SRP complex, and its role in recognizing and binding to signal sequences on proteins. SRP54 is also involved in the regulation of protein targeting to the ER, and its dysfunction has been implicated in various diseases. The protein is highly expressed in cells that require efficient protein targeting to the ER, such as oogonial cells and acinar cells of the salivary gland. **Pathways and Functions** SRP54 plays a central role in the SRP-dependent cotranslational protein targeting pathway, which involves the recognition and binding of signal sequences on proteins to the SRP complex. The SRP complex then facilitates the translocation of the protein across the ER membrane, where it is folded and assembled into its final form. SRP54 is involved in the following pathways: 1. **Signal recognition and binding**: SRP54 binds to 7S RNA and recognizes signal sequences on proteins, facilitating their binding to the SRP complex. 2. **Protein targeting to ER**: SRP54 is involved in the translocation of proteins across the ER membrane, where they are folded and assembled into their final form. 3. **Regulation of protein synthesis**: SRP54 regulates the synthesis of proteins by controlling the rate of translocation across the ER membrane. **Clinical Significance** Dysregulation of SRP54 has been implicated in various diseases, including: 1. **Neurological disorders**: Mutations in the SRP54 gene have been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: SRP54 has been implicated in the development and progression of cancer, including breast cancer and lung cancer. 3. **Immunodeficiency**: SRP54 has been shown to play a role in the regulation of immune cell development and function, and its dysfunction has been implicated in immunodeficiency disorders. In conclusion, SRP54 is a critical component of the SRP complex that plays a central role in protein targeting to the ER. Its dysfunction has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis. Further research is needed to fully understand the role of SRP54 in human disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 3370847117

Symbol: SRP54_HUMAN

Name: Signal recognition particle subunit SRP54

UniProtKB Accession Codes:

P61011 B2R759 B4DUW6 P13624

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 EMDB 2 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8722571

Title: Sequence of the highly conserved gene encoding the human 54kDa subunit of signal recognition particle.

PubMed ID: 8722571

DOI: 10.3109/10425179609010204

PubMed ID: 9511762

Title: Protein SRP54 of human signal recognition particle: cloning, expression, and comparative analysis of functional sites.

PubMed ID: 9511762

DOI: 10.1016/s0378-1119(97)00627-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14729963

Title: Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo.

PubMed ID: 14729963

DOI: 10.1128/mcb.24.3.1174-1187.2004

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10497032

Title: Crystal structure of the conserved subdomain of human protein SRP54M at 2.1 A resolution: evidence for the mechanism of signal peptide binding.

PubMed ID: 10497032

DOI: 10.1006/jmbi.1999.3090

PubMed ID: 12244299

Title: Induced structural changes of 7SL RNA during the assembly of human signal recognition particle.

PubMed ID: 12244299

DOI: 10.1038/nsb843

PubMed ID: 28972538

Title: Mutations in signal recognition particle SRP54 cause syndromic neutropenia with Shwachman-Diamond-like features.

PubMed ID: 28972538

DOI: 10.1172/jci92876

PubMed ID: 29914977

Title: Mutations in the SRP54 gene cause severe congenital neutropenia as well as Shwachman-Diamond-like syndrome.

PubMed ID: 29914977

DOI: 10.1182/blood-2017-12-820308

PubMed ID: 34020957

Title: Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

PubMed ID: 34020957

DOI: 10.1126/sciadv.abg0942

Sequence Information:

  • Length: 504
  • Mass: 55705
  • Checksum: 7D7630A43BC5EC2C
  • Sequence:
    • MVLADLGRKI TSALRSLSNA TIINEEVLNA MLKEVCTALL EADVNIKLVK QLRENVKSAI 
DLEEMASGLN KRKMIQHAVF KELVKLVDPG VKAWTPTKGK QNVIMFVGLQ GSGKTTTCSK 
LAYYYQRKGW KTCLICADTF RAGAFDQLKQ NATKARIPFY GSYTEMDPVI IASEGVEKFK 
NENFEIIIVD TSGRHKQEDS LFEEMLQVAN AIQPDNIVYV MDASIGQACE AQAKAFKDKV 
DVASVIVTKL DGHAKGGGAL SAVAATKSPI IFIGTGEHID DFEPFKTQPF ISKLLGMGDI 
EGLIDKVNEL KLDDNEALIE KLKHGQFTLR DMYEQFQNIM KMGPFSQILG MIPGFGTDFM 
SKGNEQESMA RLKKLMTIMD SMNDQELDST DGAKVFSKQP GRIQRVARGS GVSTRDVQEL 
LTQYTKFAQM VKKMGGIKGL FKGGDMSKNV SQSQMAKLNQ QMAKMMDPRV LHHMGGMAGL 
QSMMRQFQQG AAGNMKGMMG FNNM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.