Details for: SRP68

Gene ID: 6730

Symbol: SRP68

Ensembl ID: ENSG00000167881

Description: signal recognition particle 68

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 167.1540
    Cell Significance Index: -26.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 101.5205
    Cell Significance Index: -25.7500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 64.4960
    Cell Significance Index: -30.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 62.5220
    Cell Significance Index: -25.4000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.8240
    Cell Significance Index: -25.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.4680
    Cell Significance Index: -28.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.4704
    Cell Significance Index: -25.3700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.5088
    Cell Significance Index: -29.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4959
    Cell Significance Index: 243.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1988
    Cell Significance Index: 71.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1216
    Cell Significance Index: 30.5300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0954
    Cell Significance Index: 119.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7633
    Cell Significance Index: 137.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7371
    Cell Significance Index: 38.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7140
    Cell Significance Index: 87.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6947
    Cell Significance Index: 137.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6516
    Cell Significance Index: 17.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5579
    Cell Significance Index: 76.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5536
    Cell Significance Index: 111.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5238
    Cell Significance Index: 27.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5198
    Cell Significance Index: 10.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5094
    Cell Significance Index: 278.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4929
    Cell Significance Index: 217.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4559
    Cell Significance Index: 58.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4541
    Cell Significance Index: 21.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4405
    Cell Significance Index: 75.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4314
    Cell Significance Index: 22.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4306
    Cell Significance Index: 32.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3207
    Cell Significance Index: 22.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3175
    Cell Significance Index: 20.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3124
    Cell Significance Index: 9.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2737
    Cell Significance Index: 35.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2636
    Cell Significance Index: 9.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2536
    Cell Significance Index: 6.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2534
    Cell Significance Index: 5.4900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2498
    Cell Significance Index: 2.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2476
    Cell Significance Index: 6.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2288
    Cell Significance Index: 14.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2282
    Cell Significance Index: 10.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2236
    Cell Significance Index: 5.8800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2226
    Cell Significance Index: 2.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2170
    Cell Significance Index: 77.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2155
    Cell Significance Index: 10.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2111
    Cell Significance Index: 146.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2084
    Cell Significance Index: 6.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1668
    Cell Significance Index: 19.6700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1666
    Cell Significance Index: 1.3300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0858
    Cell Significance Index: 9.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0670
    Cell Significance Index: 1.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0587
    Cell Significance Index: 5.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0241
    Cell Significance Index: 21.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0108
    Cell Significance Index: 20.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0040
    Cell Significance Index: 0.7700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0006
    Cell Significance Index: 0.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0049
    Cell Significance Index: -9.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0050
    Cell Significance Index: -3.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0054
    Cell Significance Index: -8.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0077
    Cell Significance Index: -4.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0129
    Cell Significance Index: -9.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0130
    Cell Significance Index: -8.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0137
    Cell Significance Index: -18.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0217
    Cell Significance Index: -1.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0310
    Cell Significance Index: -0.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0323
    Cell Significance Index: -14.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0332
    Cell Significance Index: -18.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0350
    Cell Significance Index: -3.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0353
    Cell Significance Index: -0.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0623
    Cell Significance Index: -9.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0668
    Cell Significance Index: -14.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0752
    Cell Significance Index: -1.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0822
    Cell Significance Index: -2.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0875
    Cell Significance Index: -25.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0998
    Cell Significance Index: -2.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1345
    Cell Significance Index: -2.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1382
    Cell Significance Index: -15.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1463
    Cell Significance Index: -3.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1488
    Cell Significance Index: -2.0300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1651
    Cell Significance Index: -2.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1700
    Cell Significance Index: -19.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1761
    Cell Significance Index: -11.8400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1816
    Cell Significance Index: -1.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1873
    Cell Significance Index: -6.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1892
    Cell Significance Index: -11.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2204
    Cell Significance Index: -12.3700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2324
    Cell Significance Index: -1.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2591
    Cell Significance Index: -6.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2657
    Cell Significance Index: -27.6700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2759
    Cell Significance Index: -2.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2953
    Cell Significance Index: -23.3900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3257
    Cell Significance Index: -5.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3527
    Cell Significance Index: -21.6300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3893
    Cell Significance Index: -4.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4099
    Cell Significance Index: -18.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4788
    Cell Significance Index: -18.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4822
    Cell Significance Index: -24.3700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4949
    Cell Significance Index: -2.9900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5153
    Cell Significance Index: -8.8300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5354
    Cell Significance Index: -12.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6094
    Cell Significance Index: -17.3900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6301
    Cell Significance Index: -23.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** * SRP68 is a small protein subunit of the SRP complex (approximately 10 kDa). * It is highly expressed in various cell types, including epithelial cells, germ cells, and immune cells. * SRP68 is involved in the targeting of proteins to the ER for proper folding and secretion. * It recognizes and binds to specific sequences on the ribosome-bound mRNA, preventing translation initiation until the ribosome is positioned at the ER membrane. * SRP68 is a homolog of the SRP54 subunit, which is also involved in the targeting of proteins to the ER. **Pathways and Functions** The SRP complex plays a crucial role in the targeting of proteins to the ER for proper folding and secretion. The SRP68 subunit is involved in the recognition and binding of specific sequences on the ribosome-bound mRNA, preventing translation initiation until the ribosome is positioned at the ER membrane. This ensures that proteins are correctly targeted to the ER for folding and secretion. The SRP complex also interacts with other proteins, such as chaperones and translocases, to facilitate protein transport across the ER membrane. In addition to its role in protein targeting, SRP68 has been implicated in various cellular processes, including: * Cell signaling: SRP68 has been shown to interact with signaling proteins, such as G-proteins and phospholipase C, to regulate cellular responses to stimuli. * Immune response: SRP68 has been found to be highly expressed in immune cells, such as T cells and B cells, and has been implicated in the regulation of immune responses. * Developmental biology: SRP68 has been shown to be involved in the development and differentiation of various cell types, including epithelial cells and germ cells. **Clinical Significance** Dysregulation of the SRP complex has been implicated in various diseases, including: * Cancer: Alterations in the expression and function of SRP68 have been found in various types of cancer, including lung, breast, and colon cancer. * Neurodegenerative diseases: SRP68 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. * Autoimmune diseases: SRP68 has been found to be highly expressed in autoimmune diseases, such as rheumatoid arthritis and lupus. * Developmental disorders: SRP68 has been implicated in the development and differentiation of various cell types, and dysregulation of the SRP complex has been found in developmental disorders, such as Down syndrome. In summary, SRP68 is a critical protein component of the SRP complex, which plays a crucial role in the targeting of proteins to the ER for proper folding and secretion. Its dysregulation has been implicated in various diseases, and further research is needed to fully understand its role in normal and pathological processes.

Genular Protein ID: 3067337321

Symbol: SRP68_HUMAN

Name: Signal recognition particle subunit SRP68

UniProtKB Accession Codes:

Q9UHB9 B3KUU5 B3KWY7 G3V1U4 Q8NCJ4 Q8WUK2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 EMBL 8 EMDB 3 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10618370

Title: Signal recognition particle components in the nucleolus.

PubMed ID: 10618370

DOI: 10.1073/pnas.97.1.55

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16672232

Title: Protein SRP68 of human signal recognition particle: identification of the RNA and SRP72 binding domains.

PubMed ID: 16672232

DOI: 10.1110/ps.051861406

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32273475

Title: Identification of biallelic germline variants of SRP68 in a sporadic case with severe congenital neutropenia.

PubMed ID: 32273475

DOI: 10.3324/haematol.2020.247825

PubMed ID: 24700861

Title: SRP RNA remodeling by SRP68 explains its role in protein translocation.

PubMed ID: 24700861

DOI: 10.1126/science.1249094

PubMed ID: 28369529

Title: Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation.

PubMed ID: 28369529

DOI: 10.1093/jmcb/mjx010

PubMed ID: 27899666

Title: Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction.

PubMed ID: 27899666

DOI: 10.1093/nar/gkw1124

PubMed ID: 34020957

Title: Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

PubMed ID: 34020957

DOI: 10.1126/sciadv.abg0942

Sequence Information:

  • Length: 627
  • Mass: 70730
  • Checksum: 6EF582892D300B2D
  • Sequence:
    • MAAEKQVPGG GGGGGSGGGG GSGGGGSGGG RGAGGEENKE NERPSAGSKA NKEFGDSLSL 
EILQIIKESQ QQHGLRHGDF QRYRGYCSRR QRRLRKTLNF KMGNRHKFTG KKVTEELLTD 
NRYLLLVLMD AERAWSYAMQ LKQEANTEPR KRFHLLSRLR KAVKHAEELE RLCESNRVDA 
KTKLEAQAYT AYLSGMLRFE HQEWKAAIEA FNKCKTIYEK LASAFTEEQA VLYNQRVEEI 
SPNIRYCAYN IGDQSAINEL MQMRLRSGGT EGLLAEKLEA LITQTRAKQA ATMSEVEWRG 
RTVPVKIDKV RIFLLGLADN EAAIVQAESE ETKERLFESM LSECRDAIQV VREELKPDQK 
QRDYILEGEP GKVSNLQYLH SYLTYIKLST AIKRNENMAK GLQRALLQQQ PEDDSKRSPR 
PQDLIRLYDI ILQNLVELLQ LPGLEEDKAF QKEIGLKTLV FKAYRCFFIA QSYVLVKKWS 
EALVLYDRVL KYANEVNSDA GAFKNSLKDL PDVQELITQV RSEKCSLQAA AILDANDAHQ 
TETSSSQVKD NKPLVERFET FCLDPSLVTK QANLVHFPPG FQPIPCKPLF FDLALNHVAF 
PPLEDKLEQK TKSGLTGYIK GIFGFRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.