Details for: SRPK1
Gene ID: 6732
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SRPK1
Ensembl ID: ENSG00000096063
Description: SRSF protein kinase 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 24.67rCSI 59.95%PRS 28.11
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CSI 20.17rCSI 23.69%PRS 47.68
-
CSI 20rCSI 71.98%PRS 27.87
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CSI 15.09rCSI 40.69%PRS 52.8
-
CSI 14.57rCSI 45.54%PRS 30.07
-
CSI 13.03rCSI 11.57%PRS 43.09
-
CSI 11.33rCSI 13.6%PRS 42.14
-
CSI 10.19rCSI 15.75%PRS 41.94
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CSI 10.03rCSI 9.67%PRS 35.02
-
CSI 9.8rCSI 43.03%PRS 63.22
-
CSI 9.56rCSI 9.54%PRS 38.45
-
CSI 9.36rCSI 55.1%PRS 30.33
-
CSI 9.34rCSI 18.55%PRS 43.41
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CSI 9.21rCSI 29.57%PRS 51.5
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CSI 8.16rCSI 22.87%PRS 58.59
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CSI 7.24rCSI 6.69%PRS 64.04
-
CSI 7rCSI 52.56%PRS 64.22
-
CSI 6.75rCSI 19.35%PRS 61.41
-
CSI 6.71rCSI 17.03%PRS 34.95
-
CSI 6.51rCSI 9.57%PRS 40.13
-
CSI 6.47rCSI 10.85%PRS 28.93
-
CSI 6.46rCSI 9.22%PRS 46.62
-
CSI 6.35rCSI 13.9%PRS 53.96
-
CSI 6.32rCSI 33.97%PRS 59.24
-
CSI 6.18rCSI 12.32%PRS 61.72
-
CSI 6.06rCSI 22.92%PRS 29.87
-
CSI 5.95rCSI 6.81%PRS 66.61
-
CSI 5.9rCSI 5.68%PRS 44.53
-
CSI 5.76rCSI 18.43%PRS 41
-
CSI 5.76rCSI 8.84%PRS 50.86
-
CSI 5.71rCSI 11.72%PRS 38.73
-
CSI 5.6rCSI 10.02%PRS 42.39
-
CSI 5.39rCSI 8.24%PRS 52.98
-
CSI 5.31rCSI 4.04%PRS 55.17
-
CSI 5.2rCSI 11.88%PRS 43.39
-
CSI 5.12rCSI 31.97%PRS 36.79
-
CSI 4.94rCSI 7.54%PRS 44.66
-
CSI 4.83rCSI 24.93%PRS 67.77
-
CSI 4.69rCSI 30.81%PRS 76.68
-
CSI 4.58rCSI 3.46%PRS 56.15
-
CSI 4.23rCSI 10.08%PRS 46.29
-
CSI 4.22rCSI 6.46%PRS 60.24
-
CSI 4.05rCSI 10.74%PRS 57.42
-
CSI 4.04rCSI 4.16%PRS 61.56
-
CSI 4.03rCSI 2.81%PRS 56.65
-
CSI 3.89rCSI 4.07%PRS 41.36
-
CSI 3.78rCSI 4.43%PRS 59.46
-
CSI 3.74rCSI 8.38%PRS 29.6
-
CSI 3.72rCSI 2.98%PRS 65.36
-
CSI 3.67rCSI 4.91%PRS 52.35
-
CSI 3.65rCSI 8.32%PRS 37.71
-
CSI 3.6rCSI 18.07%PRS 54.87
-
CSI 3.56rCSI 2.56%PRS 56.75
-
CSI 3.54rCSI 26.01%PRS 32.48
-
CSI 3.53rCSI 10.43%PRS 47.99
-
CSI 3.53rCSI 3.19%PRS 40.72
-
CSI 3.52rCSI 6.96%PRS 69.57
-
CSI 3.49rCSI 12.24%PRS 59.49
-
CSI 3.41rCSI 18.4%PRS 58.45
-
CSI 3.4rCSI 2.29%PRS 54.06
-
CSI 3.39rCSI 4.87%PRS 51.42
-
CSI 3.38rCSI 2.5%PRS 37.87
-
CSI 3.28rCSI 2.44%PRS 56.98
-
CSI 3.26rCSI 4.77%PRS 46.96
-
CSI 3.18rCSI 2.79%PRS 48.88
-
CSI 3.1rCSI 2.5%PRS 44.6
-
CSI 3.08rCSI 73.68%PRS 28.42
-
CSI 3.03rCSI 73.03%PRS 29.32
-
CSI 2.95rCSI 2.29%PRS 60.69
-
CSI 2.9rCSI 4.6%PRS 37.42
-
CSI 2.88rCSI 1.91%PRS 47.77
-
CSI 2.87rCSI 3%PRS 44.68
-
CSI 2.83rCSI 2.97%PRS 46.68
-
CSI 2.83rCSI 15.83%PRS 56.86
-
CSI 2.81rCSI 2.18%PRS 44.44
-
CSI 2.78rCSI 4.28%PRS 46.22
-
CSI 2.77rCSI 7.4%PRS 37.27
-
CSI 2.75rCSI 2.81%PRS 56.97
-
CSI 2.67rCSI 10.78%PRS 42.58
-
CSI 2.67rCSI 1.99%PRS 62.37
-
CSI 2.64rCSI 4.62%PRS 36.62
-
CSI 2.63rCSI 3.6%PRS 48.86
-
CSI 2.61rCSI 3.57%PRS 46.61
-
CSI 2.6rCSI 2.37%PRS 59
-
CSI 2.57rCSI 4.21%PRS 35.1
-
CSI 2.55rCSI 4.11%PRS 52.94
-
CSI 2.54rCSI 3.15%PRS 27.47
-
CSI 2.5rCSI 5.87%PRS 53.1
-
CSI 2.5rCSI 5.41%PRS 34.67
-
CSI 2.47rCSI 8.13%PRS 33.36
-
CSI 2.43rCSI 5.61%PRS 36.16
-
CSI 2.42rCSI 4.85%PRS 34.29
-
CSI 2.39rCSI 8.96%PRS 37.37
-
CSI 2.39rCSI 7.48%PRS 32.33
-
CSI 2.38rCSI 1.66%PRS 52.38
-
CSI 2.38rCSI 3.03%PRS 49.22
-
CSI 2.38rCSI 2.06%PRS 47.69
-
CSI 2.35rCSI 2.22%PRS 44.99
-
CSI 2.34rCSI 8.84%PRS 37.28
-
CSI 2.33rCSI 1.84%PRS 32.25
-
CSI 0.1rCSI 0.6%PRS 56.1%
-
CSI 0.2rCSI 1.0%PRS 65.4%
-
CSI 0.3rCSI 4.8%PRS 48.2%
-
CSI 0.3rCSI 2.7%PRS 32.1%
-
CSI 0.3rCSI 1.4%PRS 60.4%
-
CSI 0.3rCSI 1.9%PRS 54.6%
-
CSI 0.4rCSI 0.5%PRS 52.8%
-
CSI 0.4rCSI 2.5%PRS 74.7%
-
CSI 0.4rCSI 2.1%PRS 43.8%
-
CSI 0.6rCSI 1.6%PRS 35.8%
-
CSI 0.6rCSI 2.0%PRS 36.0%
-
CSI 0.6rCSI 2.3%PRS 64.2%
-
CSI 0.6rCSI 1.8%PRS 58.5%
-
CSI 0.6rCSI 0.9%PRS 22.7%
-
CSI 0.7rCSI 2.5%PRS 37.7%
-
CSI 0.7rCSI 4.5%PRS 79.1%
-
CSI 0.8rCSI 1.5%PRS 46.0%
-
CSI 0.8rCSI 8.6%PRS 64.4%
-
CSI 0.8rCSI 2.1%PRS 43.9%
-
CSI 0.8rCSI 1.3%PRS 35.1%
-
CSI 0.8rCSI 1.9%PRS 56.3%
-
CSI 0.8rCSI 1.8%PRS 63.5%
-
CSI 0.8rCSI 1.1%PRS 48.7%
-
CSI 0.8rCSI 0.9%PRS 43.6%
-
CSI 0.8rCSI 3.0%PRS 63.0%
-
CSI 0.9rCSI 17.7%PRS 38.1%
-
CSI 0.9rCSI 2.6%PRS 61.7%
-
CSI 0.9rCSI 1.5%PRS 30.9%
-
CSI 1.0rCSI 5.4%PRS 74.7%
-
CSI 1.0rCSI 1.6%PRS 53.2%
-
CSI 1.0rCSI 24.3%PRS 69.8%
-
CSI 1.0rCSI 0.8%PRS 42.8%
-
CSI 1.0rCSI 4.6%PRS 69.5%
-
CSI 1.0rCSI 3.3%PRS 32.9%
-
CSI 1.0rCSI 1.3%PRS 29.8%
-
CSI 1.0rCSI 4.6%PRS 42.8%
-
CSI 1.0rCSI 2.1%PRS 66.1%
-
CSI 1.0rCSI 1.1%PRS 49.8%
-
CSI 1.1rCSI 5.2%PRS 55.7%
-
CSI 1.1rCSI 2.3%PRS 59.0%
-
CSI 1.1rCSI 1.9%PRS 27.3%
-
CSI 1.1rCSI 2.6%PRS 61.8%
-
CSI 1.1rCSI 2.6%PRS 61.9%
-
CSI 1.1rCSI 2.1%PRS 67.3%
-
CSI 1.1rCSI 3.0%PRS 66.6%
-
CSI 1.1rCSI 1.4%PRS 28.9%
-
CSI 1.1rCSI 23.2%PRS 37.1%
-
CSI 1.2rCSI 2.7%PRS 49.8%
-
CSI 1.2rCSI 0.9%PRS 66.0%
-
CSI 1.2rCSI 3.2%PRS 36.7%
-
CSI 1.2rCSI 3.1%PRS 43.1%
-
CSI 1.2rCSI 3.2%PRS 52.4%
-
CSI 1.2rCSI 2.2%PRS 37.7%
-
CSI 1.2rCSI 2.7%PRS 58.5%
-
CSI 1.2rCSI 4.0%PRS 46.8%
-
CSI 1.2rCSI 1.5%PRS 51.6%
-
CSI 1.3rCSI 1.8%PRS 55.1%
-
CSI 1.3rCSI 1.8%PRS 53.9%
-
CSI 1.3rCSI 1.6%PRS 53.6%
-
CSI 1.3rCSI 2.3%PRS 60.2%
-
CSI 1.3rCSI 2.2%PRS 64.8%
-
CSI 1.3rCSI 2.9%PRS 41.4%
-
CSI 1.4rCSI 2.4%PRS 27.9%
-
CSI 1.4rCSI 2.0%PRS 43.6%
-
CSI 1.4rCSI 3.1%PRS 32.9%
-
CSI 1.4rCSI 3.2%PRS 49.4%
-
CSI 1.4rCSI 11.5%PRS 38.8%
-
CSI 1.4rCSI 42.4%PRS 68.8%
-
CSI 1.4rCSI 2.2%PRS 53.9%
-
CSI 1.4rCSI 2.1%PRS 57.5%
-
CSI 1.4rCSI 2.6%PRS 37.7%
-
CSI 1.4rCSI 4.2%PRS 61.6%
-
CSI 1.4rCSI 1.8%PRS 40.0%
-
CSI 1.5rCSI 5.6%PRS 52.9%
-
CSI 1.5rCSI 2.0%PRS 45.5%
-
CSI 1.5rCSI 16.8%PRS 69.5%
-
CSI 1.5rCSI 1.9%PRS 48.7%
-
CSI 1.5rCSI 4.0%PRS 40.3%
-
CSI 1.5rCSI 2.7%PRS 35.1%
-
CSI 1.6rCSI 3.8%PRS 40.2%
-
CSI 1.6rCSI 3.9%PRS 42.1%
-
CSI 1.6rCSI 1.7%PRS 59.1%
-
CSI 1.7rCSI 1.7%PRS 62.5%
-
CSI 1.7rCSI 2.4%PRS 41.1%
-
CSI 1.7rCSI 2.7%PRS 38.1%
-
CSI 1.7rCSI 6.9%PRS 41.6%
-
CSI 1.7rCSI 1.3%PRS 47.3%
-
CSI 1.8rCSI 1.5%PRS 49.0%
-
CSI 1.8rCSI 2.1%PRS 51.6%
-
CSI 1.8rCSI 2.6%PRS 61.5%
-
CSI 1.8rCSI 1.7%PRS 59.2%
-
CSI 1.8rCSI 2.3%PRS 42.1%
-
CSI 1.8rCSI 4.7%PRS 51.5%
-
CSI 1.8rCSI 1.7%PRS 51.3%
-
CSI 1.8rCSI 1.6%PRS 33.6%
-
CSI 1.8rCSI 5.2%PRS 46.5%
-
CSI 1.9rCSI 3.9%PRS 41.9%
-
CSI 1.9rCSI 5.6%PRS 55.8%
-
CSI 1.9rCSI 1.9%PRS 46.3%
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CSI 1.9rCSI 10.1%PRS 58.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2900902478
Symbol: SRPK1_HUMAN
Name: SRSF protein kinase 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8208298
Title: A serine kinase regulates intracellular localization of splicing factors in the cell cycle.
PubMed ID: 8208298
DOI: 10.1038/369678a0
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 11509566
Title: Cloning and characterization of an alternatively spliced form of SR protein kinase 1 that interacts specifically with scaffold attachment factor-B.
PubMed ID: 11509566
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12134018
Title: Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein.
PubMed ID: 12134018
PubMed ID: 15034300
Title: Identification of toposome, a novel multisubunit complex containing topoisomerase IIalpha.
PubMed ID: 15034300
PubMed ID: 9237760
Title: A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA.
PubMed ID: 9237760
DOI: 10.1038/41137
PubMed ID: 10049757
Title: SRPK1 and LBR protein kinases show identical substrate specificities.
PubMed ID: 10049757
PubMed ID: 10390541
Title: SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1.
PubMed ID: 10390541
PubMed ID: 14555757
Title: Processive phosphorylation of alternative splicing factor/splicing factor 2.
PubMed ID: 14555757
PubMed ID: 12565829
Title: Protein kinase CK2 phosphorylates and activates the SR protein-specific kinase 1.
PubMed ID: 12565829
PubMed ID: 16122776
Title: Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein.
PubMed ID: 16122776
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18155240
Title: Ordered multi-site phosphorylation of the splicing factor ASF/SF2 by SRPK1.
PubMed ID: 18155240
PubMed ID: 18687337
Title: Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1.
PubMed ID: 18687337
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19886675
Title: Allosteric interactions direct binding and phosphorylation of ASF/SF2 by SRPK1.
PubMed ID: 19886675
DOI: 10.1021/bi901107q
PubMed ID: 19674106
Title: The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2.
PubMed ID: 19674106
PubMed ID: 19240134
Title: Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones.
PubMed ID: 19240134
DOI: 10.1101/gad.1752109
PubMed ID: 19477182
Title: Regiospecific phosphorylation control of the SR protein ASF/SF2 by SRPK1.
PubMed ID: 19477182
PubMed ID: 19553338
Title: Arginine methylation of the ICP27 RGG box regulates the functional interactions of ICP27 with SRPK1 and Aly/REF during herpes simplex virus 1 infection.
PubMed ID: 19553338
DOI: 10.1128/jvi.00801-09
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20708644
Title: The ratio of SRPK1/SRPK1a regulates erythroid differentiation in K562 leukaemic cells.
PubMed ID: 20708644
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21157427
Title: Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin.
PubMed ID: 21157427
PubMed ID: 21205200
Title: Serine-arginine protein kinases: a small protein kinase family with a large cellular presence.
PubMed ID: 21205200
PubMed ID: 21205204
Title: Phosphorylation mechanism and structure of serine-arginine protein kinases.
PubMed ID: 21205204
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28076779
Title: Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation.
PubMed ID: 28076779
PubMed ID: 16209947
Title: Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2.
PubMed ID: 16209947
PubMed ID: 17223538
Title: SR protein kinase 1 is resilient to inactivation.
PubMed ID: 17223538
PubMed ID: 18342604
Title: A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1.
PubMed ID: 18342604
Sequence Information:
- Length: 655
- Mass: 74325
- Checksum: 900E980FE1C16B9A
- Sequence:
MERKVLALQA RKKRTKAKKD KAQRKSETQH RGSAPHSESD LPEQEEEILG SDDDEQEDPN DYCKGGYHLV KIGDLFNGRY HVIRKLGWGH FSTVWLSWDI QGKKFVAMKV VKSAEHYTET ALDEIRLLKS VRNSDPNDPN REMVVQLLDD FKISGVNGTH ICMVFEVLGH HLLKWIIKSN YQGLPLPCVK KIIQQVLQGL DYLHTKCRII HTDIKPENIL LSVNEQYIRR LAAEATEWQR SGAPPPSGSA VSTAPQPKPA DKMSKNKKKK LKKKQKRQAE LLEKRMQEIE EMEKESGPGQ KRPNKQEESE SPVERPLKEN PPNKMTQEKL EESSTIGQDQ TLMERDTEGG AAEINCNGVI EVINYTQNSN NETLRHKEDL HNANDCDVQN LNQESSFLSS QNGDSSTSQE TDSCTPITSE VSDTMVCQSS STVGQSFSEQ HISQLQESIR AEIPCEDEQE QEHNGPLDNK GKSTAGNFLV NPLEPKNAEK LKVKIADLGN ACWVHKHFTE DIQTRQYRSL EVLIGSGYNT PADIWSTACM AFELATGDYL FEPHSGEEYT RDEDHIALII ELLGKVPRKL IVAGKYSKEF FTKKGDLKHI TKLKPWGLFE VLVEKYEWSQ EEAAGFTDFL LPMLELIPEK RATAAECLRH PWLNS