Details for: SRPK1

Gene ID: 6732

Symbol: SRPK1

Ensembl ID: ENSG00000096063

Description: SRSF protein kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 242.6947
    Cell Significance Index: -37.7500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 155.5728
    Cell Significance Index: -39.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 104.7186
    Cell Significance Index: -49.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 100.5029
    Cell Significance Index: -40.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 95.2302
    Cell Significance Index: -48.9900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 73.7681
    Cell Significance Index: -49.5000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 43.1530
    Cell Significance Index: -41.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.7248
    Cell Significance Index: -45.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.2648
    Cell Significance Index: -46.2500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.9455
    Cell Significance Index: -36.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.8194
    Cell Significance Index: -46.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.4438
    Cell Significance Index: -18.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.1556
    Cell Significance Index: 84.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.8059
    Cell Significance Index: 807.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.4435
    Cell Significance Index: 2206.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4054
    Cell Significance Index: 477.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.3815
    Cell Significance Index: 142.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0378
    Cell Significance Index: 408.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8228
    Cell Significance Index: 94.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5921
    Cell Significance Index: 287.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4531
    Cell Significance Index: 40.6100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4399
    Cell Significance Index: 13.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3963
    Cell Significance Index: 19.0500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.2382
    Cell Significance Index: 14.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1012
    Cell Significance Index: 135.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9994
    Cell Significance Index: 28.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9604
    Cell Significance Index: 42.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9406
    Cell Significance Index: 35.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8884
    Cell Significance Index: 318.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8734
    Cell Significance Index: 477.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8376
    Cell Significance Index: 22.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7998
    Cell Significance Index: 44.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7915
    Cell Significance Index: 48.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7155
    Cell Significance Index: 32.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6900
    Cell Significance Index: 477.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6800
    Cell Significance Index: 110.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6324
    Cell Significance Index: 29.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5519
    Cell Significance Index: 65.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5364
    Cell Significance Index: 58.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4742
    Cell Significance Index: 29.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4386
    Cell Significance Index: 20.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4083
    Cell Significance Index: 180.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3968
    Cell Significance Index: 51.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3492
    Cell Significance Index: 24.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3254
    Cell Significance Index: 7.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3131
    Cell Significance Index: 43.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3117
    Cell Significance Index: 59.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2946
    Cell Significance Index: 29.1500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2723
    Cell Significance Index: 6.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2483
    Cell Significance Index: 8.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2479
    Cell Significance Index: 6.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2287
    Cell Significance Index: 14.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2192
    Cell Significance Index: 14.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2179
    Cell Significance Index: 37.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2168
    Cell Significance Index: 16.6400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1810
    Cell Significance Index: 2.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1764
    Cell Significance Index: 5.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1272
    Cell Significance Index: 4.4700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.1199
    Cell Significance Index: 1.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1160
    Cell Significance Index: 2.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0840
    Cell Significance Index: 1.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0407
    Cell Significance Index: 62.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0380
    Cell Significance Index: 70.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0360
    Cell Significance Index: 67.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0347
    Cell Significance Index: 1.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0074
    Cell Significance Index: 4.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0068
    Cell Significance Index: 9.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0024
    Cell Significance Index: -0.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0030
    Cell Significance Index: -1.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0205
    Cell Significance Index: -12.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0211
    Cell Significance Index: -15.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0298
    Cell Significance Index: -21.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0333
    Cell Significance Index: -25.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0481
    Cell Significance Index: -27.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0483
    Cell Significance Index: -3.6000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0730
    Cell Significance Index: -1.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1117
    Cell Significance Index: -5.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1328
    Cell Significance Index: -15.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1521
    Cell Significance Index: -32.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1577
    Cell Significance Index: -16.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1829
    Cell Significance Index: -26.5800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1942
    Cell Significance Index: -2.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2146
    Cell Significance Index: -4.7000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2330
    Cell Significance Index: -6.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2503
    Cell Significance Index: -28.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2571
    Cell Significance Index: -13.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2692
    Cell Significance Index: -6.7300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3018
    Cell Significance Index: -34.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3080
    Cell Significance Index: -8.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4072
    Cell Significance Index: -42.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4559
    Cell Significance Index: -11.7200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4916
    Cell Significance Index: -2.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5163
    Cell Significance Index: -40.8900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5363
    Cell Significance Index: -13.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6165
    Cell Significance Index: -10.3200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.6205
    Cell Significance Index: -6.7600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6314
    Cell Significance Index: -9.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7370
    Cell Significance Index: -45.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7422
    Cell Significance Index: -24.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7424
    Cell Significance Index: -15.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SRPK1 is a member of the SRSF family of protein kinases, which are known to regulate various aspects of RNA processing, including splicing, maturation, and translation. SRPK1 is a serine/threonine kinase that phosphorylates specific serine and threonine residues on RNA-binding proteins, leading to changes in their activity and function. The kinase activity of SRPK1 is regulated by its phosphorylation status, which is controlled by various upstream kinases and phosphatases. **Pathways and Functions:** SRPK1 is involved in several key pathways, including: 1. **mRNA Processing:** SRPK1 regulates the alternative splicing of exons, leading to the production of diverse mRNAs with distinct protein products. This process is critical for the development and function of various tissues and cells. 2. **Viral Genome Replication:** SRPK1 has been shown to regulate the replication of various viruses, including SARS-CoV-2, by phosphorylating and modulating the activity of viral proteins. 3. **Innate Immune Response:** SRPK1 is involved in the regulation of the innate immune response, particularly in the context of viral infections. It phosphorylates and activates key immune proteins, leading to the production of pro-inflammatory cytokines and the activation of immune cells. 4. **Chromatin Remodeling:** SRPK1 has been shown to regulate chromatin remodeling, which is critical for the regulation of gene expression and the maintenance of genome stability. **Clinical Significance:** SRPK1 has been implicated in various diseases, including: 1. **Cancer:** SRPK1 has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer. Its overexpression has been associated with poor prognosis and increased tumor aggressiveness. 2. **Neurological Disorders:** SRPK1 has been implicated in the regulation of neurodegenerative diseases, including Alzheimer's and Parkinson's disease. Its dysregulation has been associated with impaired RNA processing and increased risk of disease. 3. **Viral Infections:** SRPK1 has been shown to play a critical role in the regulation of viral genome replication and the innate immune response. Its dysregulation has been associated with increased susceptibility to viral infections and impaired immune function. In conclusion, SRPK1 is a critical regulator of mRNA processing and immune response, with implications for various diseases, including cancer, neurological disorders, and viral infections. Further studies are needed to fully elucidate the mechanisms by which SRPK1 regulates these processes and to explore its potential as a therapeutic target.

Genular Protein ID: 2900902478

Symbol: SRPK1_HUMAN

Name: SRSF protein kinase 1

UniProtKB Accession Codes:

Q96SB4 B4DS61 Q12890 Q5R364 Q5R365 Q8IY12

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 3 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8208298

Title: A serine kinase regulates intracellular localization of splicing factors in the cell cycle.

PubMed ID: 8208298

DOI: 10.1038/369678a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11509566

Title: Cloning and characterization of an alternatively spliced form of SR protein kinase 1 that interacts specifically with scaffold attachment factor-B.

PubMed ID: 11509566

DOI: 10.1074/jbc.m104755200

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12134018

Title: Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein.

PubMed ID: 12134018

DOI: 10.1128/jvi.76.16.8124-8137.2002

PubMed ID: 15034300

Title: Identification of toposome, a novel multisubunit complex containing topoisomerase IIalpha.

PubMed ID: 15034300

PubMed ID: 9237760

Title: A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA.

PubMed ID: 9237760

DOI: 10.1038/41137

PubMed ID: 10049757

Title: SRPK1 and LBR protein kinases show identical substrate specificities.

PubMed ID: 10049757

DOI: 10.1006/bbrc.1999.0249

PubMed ID: 10390541

Title: SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1.

PubMed ID: 10390541

DOI: 10.1093/nar/27.14.2972

PubMed ID: 14555757

Title: Processive phosphorylation of alternative splicing factor/splicing factor 2.

PubMed ID: 14555757

DOI: 10.1073/pnas.1635129100

PubMed ID: 12565829

Title: Protein kinase CK2 phosphorylates and activates the SR protein-specific kinase 1.

PubMed ID: 12565829

DOI: 10.1016/s0006-291x(02)03055-3

PubMed ID: 16122776

Title: Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein.

PubMed ID: 16122776

DOI: 10.1016/j.virol.2005.07.030

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18155240

Title: Ordered multi-site phosphorylation of the splicing factor ASF/SF2 by SRPK1.

PubMed ID: 18155240

DOI: 10.1016/j.jmb.2007.08.029

PubMed ID: 18687337

Title: Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1.

PubMed ID: 18687337

DOI: 10.1016/j.jmb.2008.07.055

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19886675

Title: Allosteric interactions direct binding and phosphorylation of ASF/SF2 by SRPK1.

PubMed ID: 19886675

DOI: 10.1021/bi901107q

PubMed ID: 19674106

Title: The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2.

PubMed ID: 19674106

DOI: 10.1111/j.1742-4658.2009.07217.x

PubMed ID: 19240134

Title: Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones.

PubMed ID: 19240134

DOI: 10.1101/gad.1752109

PubMed ID: 19477182

Title: Regiospecific phosphorylation control of the SR protein ASF/SF2 by SRPK1.

PubMed ID: 19477182

DOI: 10.1016/j.jmb.2009.05.060

PubMed ID: 19553338

Title: Arginine methylation of the ICP27 RGG box regulates the functional interactions of ICP27 with SRPK1 and Aly/REF during herpes simplex virus 1 infection.

PubMed ID: 19553338

DOI: 10.1128/jvi.00801-09

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20708644

Title: The ratio of SRPK1/SRPK1a regulates erythroid differentiation in K562 leukaemic cells.

PubMed ID: 20708644

DOI: 10.1016/j.bbamcr.2010.07.008

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21157427

Title: Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin.

PubMed ID: 21157427

DOI: 10.1038/emboj.2010.333

PubMed ID: 21205200

Title: Serine-arginine protein kinases: a small protein kinase family with a large cellular presence.

PubMed ID: 21205200

DOI: 10.1111/j.1742-4658.2010.07987.x

PubMed ID: 21205204

Title: Phosphorylation mechanism and structure of serine-arginine protein kinases.

PubMed ID: 21205204

DOI: 10.1111/j.1742-4658.2010.07992.x

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28076779

Title: Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation.

PubMed ID: 28076779

DOI: 10.1016/j.celrep.2016.12.050

PubMed ID: 16209947

Title: Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2.

PubMed ID: 16209947

DOI: 10.1016/j.molcel.2005.08.025

PubMed ID: 17223538

Title: SR protein kinase 1 is resilient to inactivation.

PubMed ID: 17223538

DOI: 10.1016/j.str.2006.11.011

PubMed ID: 18342604

Title: A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1.

PubMed ID: 18342604

DOI: 10.1016/j.molcel.2007.12.017

Sequence Information:

  • Length: 655
  • Mass: 74325
  • Checksum: 900E980FE1C16B9A
  • Sequence:
    • MERKVLALQA RKKRTKAKKD KAQRKSETQH RGSAPHSESD LPEQEEEILG SDDDEQEDPN 
DYCKGGYHLV KIGDLFNGRY HVIRKLGWGH FSTVWLSWDI QGKKFVAMKV VKSAEHYTET 
ALDEIRLLKS VRNSDPNDPN REMVVQLLDD FKISGVNGTH ICMVFEVLGH HLLKWIIKSN 
YQGLPLPCVK KIIQQVLQGL DYLHTKCRII HTDIKPENIL LSVNEQYIRR LAAEATEWQR 
SGAPPPSGSA VSTAPQPKPA DKMSKNKKKK LKKKQKRQAE LLEKRMQEIE EMEKESGPGQ 
KRPNKQEESE SPVERPLKEN PPNKMTQEKL EESSTIGQDQ TLMERDTEGG AAEINCNGVI 
EVINYTQNSN NETLRHKEDL HNANDCDVQN LNQESSFLSS QNGDSSTSQE TDSCTPITSE 
VSDTMVCQSS STVGQSFSEQ HISQLQESIR AEIPCEDEQE QEHNGPLDNK GKSTAGNFLV 
NPLEPKNAEK LKVKIADLGN ACWVHKHFTE DIQTRQYRSL EVLIGSGYNT PADIWSTACM 
AFELATGDYL FEPHSGEEYT RDEDHIALII ELLGKVPRKL IVAGKYSKEF FTKKGDLKHI 
TKLKPWGLFE VLVEKYEWSQ EEAAGFTDFL LPMLELIPEK RATAAECLRH PWLNS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.