Details for: ITPRID2

Gene ID: 6744

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ITPRID2

Ensembl ID: ENSG00000138434

Description: ITPR interacting domain containing 2

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • ionocyte CL0005006
    CSI 36.97
    rCSI 39.62%
    PRS 24.23
  • helper T cell CL0000912
    CSI 32.27
    rCSI 45.64%
    PRS 35.85
  • basal cell of epidermis CL0002187
    CSI 30.96
    rCSI 54.87%
    PRS 19.52
  • pulmonary ionocyte CL0017000
    CSI 29.04
    rCSI 35.35%
    PRS 32.46
  • melanocyte of skin CL1000458
    CSI 27.42
    rCSI 37.37%
    PRS 14.71
  • keratinocyte CL0000312
    CSI 26.16
    rCSI 21.93%
    PRS 30.82
  • luminal epithelial cell of mammary gland CL0002326
    CSI 21.97
    rCSI 39.92%
    PRS 39.45
  • suprabasal keratinocyte CL4033013
    CSI 18.51
    rCSI 30.21%
    PRS 15.49
  • neural crest cell CL0011012
    CSI 18.18
    rCSI 14.37%
    PRS 18.11
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 17.56
    rCSI 21.27%
    PRS 30.21
  • regulatory T cell CL0000815
    CSI 15.67
    rCSI 18.17%
    PRS 58.5
  • chondrocyte CL0000138
    CSI 11.67
    rCSI 18.56%
    PRS 22.1
  • type EC enteroendocrine cell CL0000577
    CSI 11.25
    rCSI 39.92%
    PRS 40.74
  • extravillous trophoblast CL0008036
    CSI 11.12
    rCSI 13.76%
    PRS 23.13
  • colon epithelial cell CL0011108
    CSI 9.74
    rCSI 10.2%
    PRS 24.52
  • enterocyte of epithelium of large intestine CL0002071
    CSI 9.49
    rCSI 49.84%
    PRS 42.38
  • pancreatic acinar cell CL0002064
    CSI 8.84
    rCSI 11.75%
    PRS 28.84
  • sncg GABAergic cortical interneuron CL4023015
    CSI 8.81
    rCSI 14.17%
    PRS 17.41
  • mesenchymal cell CL0008019
    CSI 7.91
    rCSI 20.1%
    PRS 25.61
  • cytotoxic T cell CL0000910
    CSI 7.59
    rCSI 43.51%
    PRS 37.71
  • ependymal cell CL0000065
    CSI 7.4
    rCSI 15.02%
    PRS 14.56
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 7.27
    rCSI 26.17%
    PRS 15.12
  • IgA plasma cell CL0000987
    CSI 6.94
    rCSI 7.1%
    PRS 45.11
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 6.57
    rCSI 20.54%
    PRS 18.24
  • cardiac neuron CL0010022
    CSI 6.13
    rCSI 19.62%
    PRS 22.41
  • secretory cell CL0000151
    CSI 5.7
    rCSI 5.95%
    PRS 26.9
  • ciliated epithelial cell CL0000067
    CSI 5.67
    rCSI 4.99%
    PRS 19.24
  • hematopoietic precursor cell CL0008001
    CSI 5.66
    rCSI 5.83%
    PRS 40.96
  • lung macrophage CL1001603
    CSI 5.65
    rCSI 12.63%
    PRS 30.75
  • endothelial cell of placenta CL0009092
    CSI 5.36
    rCSI 26.41%
    PRS 35.04
  • glioblast CL0000030
    CSI 5.18
    rCSI 8.26%
    PRS 22.39
  • plasmacytoid dendritic cell, human CL0001058
    CSI 5.16
    rCSI 3.61%
    PRS 27.82
  • mucous neck cell CL0000651
    CSI 5.04
    rCSI 7.26%
    PRS 39.88
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 5.01
    rCSI 6.56%
    PRS 36.81
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 4.96
    rCSI 18.76%
    PRS 16.6
  • choroid plexus epithelial cell CL0000706
    CSI 4.95
    rCSI 8.11%
    PRS 20.32
  • melanocyte CL0000148
    CSI 4.88
    rCSI 3.62%
    PRS 22.47
  • retinal bipolar neuron CL0000748
    CSI 4.62
    rCSI 8.65%
    PRS 19.26
  • parietal epithelial cell CL1000452
    CSI 4.55
    rCSI 12.16%
    PRS 21.87
  • retinal pigment epithelial cell CL0002586
    CSI 4.51
    rCSI 8.95%
    PRS 27.17
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 4.43
    rCSI 10.66%
    PRS 40.56
  • stromal cell CL0000499
    CSI 4.38
    rCSI 12.31%
    PRS 31.9
  • foveolar cell of stomach CL0002179
    CSI 4.31
    rCSI 9.18%
    PRS 40.28
  • enteroendocrine cell CL0000164
    CSI 4.3
    rCSI 5.88%
    PRS 28.96
  • astrocyte of the cerebral cortex CL0002605
    CSI 4.28
    rCSI 9.6%
    PRS 16.59
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 4.12
    rCSI 9.39%
    PRS 26.5
  • renal beta-intercalated cell CL0002201
    CSI 4.06
    rCSI 9.67%
    PRS 29.13
  • paneth cell CL0000510
    CSI 4
    rCSI 5.91%
    PRS 40.15
  • megakaryocyte CL0000556
    CSI 3.9
    rCSI 16.93%
    PRS 42.54
  • ciliated cell CL0000064
    CSI 3.88
    rCSI 6.29%
    PRS 26.17
  • blood vessel endothelial cell CL0000071
    CSI 3.87
    rCSI 8.04%
    PRS 25.95
  • lung pericyte CL0009089
    CSI 3.84
    rCSI 10.14%
    PRS 31.26
  • peptic cell CL0000155
    CSI 3.82
    rCSI 37.62%
    PRS 57.92
  • vascular leptomeningeal cell CL4023051
    CSI 3.63
    rCSI 6.37%
    PRS 20.44
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 3.55
    rCSI 8.63%
    PRS 15.63
  • tracheal goblet cell CL1000329
    CSI 3.54
    rCSI 7.72%
    PRS 47.28
  • double negative thymocyte CL0002489
    CSI 3.34
    rCSI 2.32%
    PRS 31.64
  • pro-B cell CL0000826
    CSI 3.27
    rCSI 2.71%
    PRS 26.68
  • acinar cell CL0000622
    CSI 3.25
    rCSI 4.76%
    PRS 34.15
  • regular ventricular cardiac myocyte CL0002131
    CSI 3.22
    rCSI 20.09%
    PRS 20.92
  • squamous epithelial cell CL0000076
    CSI 3.14
    rCSI 7.44%
    PRS 31.67
  • acinar cell of salivary gland CL0002623
    CSI 3.11
    rCSI 72.48%
    PRS 47.04
  • respiratory basal cell CL0002633
    CSI 3.11
    rCSI 3.22%
    PRS 30.88
  • intestinal tuft cell CL0019032
    CSI 3.05
    rCSI 4.66%
    PRS 29.89
  • Mueller cell CL0000636
    CSI 2.98
    rCSI 6.8%
    PRS 22.43
  • CD14-positive monocyte CL0001054
    CSI 2.97
    rCSI 3.7%
    PRS 35.76
  • conjunctival epithelial cell CL1000432
    CSI 2.92
    rCSI 4.46%
    PRS 26.41
  • Schwann cell CL0002573
    CSI 2.82
    rCSI 8.03%
    PRS 28.58
  • lung interstitial macrophage CL4033043
    CSI 2.69
    rCSI 6.03%
    PRS 47.37
  • goblet cell CL0000160
    CSI 2.65
    rCSI 2.5%
    PRS 27.47
  • midzonal region hepatocyte CL0019028
    CSI 2.6
    rCSI 6.11%
    PRS 36.26
  • transit amplifying cell CL0009010
    CSI 2.59
    rCSI 3.97%
    PRS 41.22
  • pulmonary artery endothelial cell CL1001568
    CSI 2.58
    rCSI 3.52%
    PRS 38.14
  • retinal blood vessel endothelial cell CL0002585
    CSI 2.58
    rCSI 4.12%
    PRS 28.74
  • periportal region hepatocyte CL0019026
    CSI 2.54
    rCSI 9.88%
    PRS 35.05
  • pancreatic D cell CL0000173
    CSI 2.53
    rCSI 2.49%
    PRS 28.13
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 2.51
    rCSI 3.13%
    PRS 15
  • pulmonary alveolar type 2 cell CL0002063
    CSI 2.48
    rCSI 3.85%
    PRS 37.32
  • pulmonary capillary endothelial cell CL4028001
    CSI 2.47
    rCSI 4.71%
    PRS 40.67
  • endothelial cell of uterus CL0009095
    CSI 2.47
    rCSI 18.02%
    PRS 59.22
  • L6b glutamatergic cortical neuron CL4023038
    CSI 2.42
    rCSI 7.56%
    PRS 16.81
  • fibroblast of lung CL0002553
    CSI 2.39
    rCSI 2.22%
    PRS 26.25
  • intestine goblet cell CL0019031
    CSI 2.29
    rCSI 2.03%
    PRS 26.49
  • mononuclear phagocyte CL0000113
    CSI 2.28
    rCSI 5.02%
    PRS 29.88
  • BEST4+ enteroycte CL4030026
    CSI 2.26
    rCSI 2.81%
    PRS 28.08
  • myeloid leukocyte CL0000766
    CSI 2.23
    rCSI 2.06%
    PRS 27.35
  • retinal cone cell CL0000573
    CSI 2.23
    rCSI 3.58%
    PRS 20.18
  • M cell of gut CL0000682
    CSI 2.21
    rCSI 2.35%
    PRS 42.27
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 2.21
    rCSI 12.99%
    PRS 16.77
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 2.2
    rCSI 3.12%
    PRS 24.34
  • stem cell CL0000034
    CSI 2.2
    rCSI 2.12%
    PRS 19.5
  • epithelial cell of proximal tubule CL0002306
    CSI 2.18
    rCSI 5.31%
    PRS 25.22
  • vein endothelial cell of respiratory system CL4033008
    CSI 2.18
    rCSI 14.93%
    PRS 47.38
  • cardiac endothelial cell CL0010008
    CSI 2.17
    rCSI 8.74%
    PRS 24.52
  • perivascular cell CL4033054
    CSI 2.16
    rCSI 2.96%
    PRS 29.61
  • Kupffer cell CL0000091
    CSI 2.16
    rCSI 4.93%
    PRS 25.65
  • myoepithelial cell CL0000185
    CSI 2.15
    rCSI 5.43%
    PRS 32.16
  • duct epithelial cell CL0000068
    CSI 2.14
    rCSI 3.14%
    PRS 27.87
  • retinal rod cell CL0000604
    CSI 2.13
    rCSI 3.75%
    PRS 25.49
  • transit amplifying cell of colon CL0009011
    CSI 2.13
    rCSI 2.5%
    PRS 29.97
  • eosinophil CL0000771
    CSI 0.1
    rCSI 0.6%
    PRS 59.2%
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.2
    rCSI 4.5%
    PRS 15.7%
  • intestinal crypt stem cell of colon CL0009043
    CSI 0.2
    rCSI 1.5%
    PRS 45.6%
  • ON midget ganglion cell CL4033046
    CSI 0.3
    rCSI 5.4%
    PRS 21.8%
  • enterocyte of epithelium of small intestine CL1000334
    CSI 0.3
    rCSI 4.2%
    PRS 56.2%
  • kidney connecting tubule epithelial cell CL1000768
    CSI 0.4
    rCSI 0.9%
    PRS 20.1%
  • prostate gland microvascular endothelial cell CL2000059
    CSI 0.4
    rCSI 8.8%
    PRS 62.1%
  • colon goblet cell CL0009039
    CSI 0.4
    rCSI 0.9%
    PRS 37.9%
  • vasa recta descending limb cell CL1001285
    CSI 0.4
    rCSI 3.2%
    PRS 69.3%
  • basal cell of epithelium of trachea CL1000348
    CSI 0.4
    rCSI 2.9%
    PRS 59.4%
  • direct pathway medium spiny neuron CL4023026
    CSI 0.4
    rCSI 9.8%
    PRS 14.8%
  • bronchial goblet cell CL1000312
    CSI 0.4
    rCSI 1.7%
    PRS 50.3%
  • OFF midget ganglion cell CL4033047
    CSI 0.5
    rCSI 9.2%
    PRS 23.1%
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 0.5
    rCSI 0.9%
    PRS 15.6%
  • amacrine cell CL0000561
    CSI 0.5
    rCSI 1.5%
    PRS 20.6%
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 0.5
    rCSI 3.2%
    PRS 52.9%
  • deuterosomal cell CL4033044
    CSI 0.6
    rCSI 1.9%
    PRS 39.1%
  • serous secreting cell of bronchus submucosal gland CL4033005
    CSI 0.6
    rCSI 3.1%
    PRS 65.2%
  • paneth cell of epithelium of small intestine CL1000343
    CSI 0.7
    rCSI 1.9%
    PRS 39.8%
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 0.7
    rCSI 2.2%
    PRS 18.2%
  • intrahepatic cholangiocyte CL0002538
    CSI 0.7
    rCSI 1.7%
    PRS 43.7%
  • microcirculation associated smooth muscle cell CL0008035
    CSI 0.7
    rCSI 2.1%
    PRS 29.3%
  • Hofbauer cell CL3000001
    CSI 0.7
    rCSI 1.4%
    PRS 33.3%
  • lung microvascular endothelial cell CL2000016
    CSI 0.7
    rCSI 14.4%
    PRS 59.2%
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 0.8
    rCSI 1.4%
    PRS 22.5%
  • syncytiotrophoblast cell CL0000525
    CSI 0.8
    rCSI 2.3%
    PRS 44.9%
  • pancreatic ductal cell CL0002079
    CSI 0.9
    rCSI 1.7%
    PRS 27.0%
  • myeloid dendritic cell CL0000782
    CSI 0.9
    rCSI 1.3%
    PRS 39.1%
  • mucus secreting cell CL0000319
    CSI 0.9
    rCSI 1.5%
    PRS 33.7%
  • promonocyte CL0000559
    CSI 0.9
    rCSI 1.6%
    PRS 34.9%
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 0.9
    rCSI 8.0%
    PRS 35.2%
  • intermediate monocyte CL0002393
    CSI 0.9
    rCSI 1.4%
    PRS 26.9%
  • basophil CL0000767
    CSI 1.0
    rCSI 2.1%
    PRS 48.5%
  • stratified epithelial cell CL0000079
    CSI 1.0
    rCSI 6.3%
    PRS 65.7%
  • mesodermal cell CL0000222
    CSI 1.0
    rCSI 1.2%
    PRS 25.4%
  • promyelocyte CL0000836
    CSI 1.1
    rCSI 1.5%
    PRS 35.7%
  • neural progenitor cell CL0011020
    CSI 1.1
    rCSI 4.6%
    PRS 23.5%
  • enteroendocrine cell of colon CL0009042
    CSI 1.1
    rCSI 5.1%
    PRS 56.4%
  • tracheobronchial serous cell CL0019001
    CSI 1.1
    rCSI 4.7%
    PRS 44.4%
  • intestinal epithelial cell CL0002563
    CSI 1.1
    rCSI 1.1%
    PRS 27.1%
  • regular atrial cardiac myocyte CL0002129
    CSI 1.1
    rCSI 3.5%
    PRS 27.0%
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.1
    rCSI 1.9%
    PRS 16.0%
  • serous secreting cell CL0000313
    CSI 1.1
    rCSI 5.6%
    PRS 70.2%
  • mammary gland epithelial cell CL0002327
    CSI 1.1
    rCSI 4.0%
    PRS 42.9%
  • multi-ciliated epithelial cell CL0005012
    CSI 1.2
    rCSI 1.2%
    PRS 22.5%
  • pulmonary alveolar type 1 cell CL0002062
    CSI 1.2
    rCSI 6.8%
    PRS 31.5%
  • placental villous trophoblast CL2000060
    CSI 1.2
    rCSI 1.8%
    PRS 24.7%
  • dendritic cell, human CL0001056
    CSI 1.2
    rCSI 1.8%
    PRS 31.4%
  • lung secretory cell CL1000272
    CSI 1.2
    rCSI 3.0%
    PRS 24.5%
  • enteroendocrine cell of small intestine CL0009006
    CSI 1.2
    rCSI 2.7%
    PRS 38.8%
  • corneal epithelial cell CL0000575
    CSI 1.2
    rCSI 3.5%
    PRS 43.5%
  • central nervous system neuron CL2000029
    CSI 1.3
    rCSI 9.3%
    PRS 16.8%
  • cardiac muscle cell CL0000746
    CSI 1.3
    rCSI 1.8%
    PRS 20.6%
  • hepatocyte CL0000182
    CSI 1.3
    rCSI 2.3%
    PRS 24.4%
  • common myeloid progenitor CL0000049
    CSI 1.3
    rCSI 1.1%
    PRS 26.4%
  • respiratory goblet cell CL0002370
    CSI 1.4
    rCSI 14.7%
    PRS 47.1%
  • lung ciliated cell CL1000271
    CSI 1.4
    rCSI 1.6%
    PRS 19.5%
  • respiratory suprabasal cell CL4033048
    CSI 1.4
    rCSI 1.8%
    PRS 30.2%
  • centrilobular region hepatocyte CL0019029
    CSI 1.4
    rCSI 3.7%
    PRS 37.7%
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 1.4
    rCSI 3.9%
    PRS 33.8%
  • granulocyte monocyte progenitor cell CL0000557
    CSI 1.5
    rCSI 1.3%
    PRS 29.4%
  • retinal ganglion cell CL0000740
    CSI 1.5
    rCSI 3.3%
    PRS 18.8%
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.5
    rCSI 4.0%
    PRS 24.2%
  • respiratory hillock cell CL4030023
    CSI 1.6
    rCSI 2.8%
    PRS 41.3%
  • epithelial cell of lung CL0000082
    CSI 1.6
    rCSI 1.3%
    PRS 25.0%
  • Langerhans cell CL0000453
    CSI 1.6
    rCSI 2.4%
    PRS 43.7%
  • endocardial cell CL0002350
    CSI 1.6
    rCSI 7.5%
    PRS 31.0%
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 1.6
    rCSI 1.1%
    PRS 32.6%
  • glandular epithelial cell CL0000150
    CSI 1.6
    rCSI 4.3%
    PRS 48.1%
  • inhibitory interneuron CL0000498
    CSI 1.7
    rCSI 3.8%
    PRS 21.3%
  • retina horizontal cell CL0000745
    CSI 1.7
    rCSI 2.5%
    PRS 24.1%
  • fallopian tube secretory epithelial cell CL4030006
    CSI 1.7
    rCSI 1.6%
    PRS 27.1%
  • innate lymphoid cell CL0001065
    CSI 1.7
    rCSI 3.5%
    PRS 36.6%
  • brush cell of tracheobronchial tree CL0002075
    CSI 1.7
    rCSI 5.1%
    PRS 35.6%
  • alveolar macrophage CL0000583
    CSI 1.8
    rCSI 2.9%
    PRS 30.7%
  • VIP GABAergic cortical interneuron CL4023016
    CSI 1.8
    rCSI 2.1%
    PRS 15.8%
  • cerebral cortex endothelial cell CL1001602
    CSI 1.8
    rCSI 3.1%
    PRS 20.2%
  • group 3 innate lymphoid cell CL0001071
    CSI 1.8
    rCSI 1.3%
    PRS 28.1%
  • type L enteroendocrine cell CL0002279
    CSI 1.8
    rCSI 3.4%
    PRS 47.8%
  • hematopoietic stem cell CL0000037
    CSI 1.8
    rCSI 1.2%
    PRS 30.8%
  • colonocyte CL1000347
    CSI 1.8
    rCSI 2.6%
    PRS 34.4%
  • adventitial cell CL0002503
    CSI 1.9
    rCSI 4.4%
    PRS 37.8%
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.9
    rCSI 1.4%
    PRS 24.7%
  • platelet CL0000233
    CSI 1.9
    rCSI 7.8%
    PRS 40.8%
  • enterocyte CL0000584
    CSI 1.9
    rCSI 3.1%
    PRS 37.8%
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 1.9
    rCSI 1.7%
    PRS 23.9%
  • interstitial cell of Cajal CL0002088
    CSI 1.9
    rCSI 2.4%
    PRS 30.2%
  • enteric smooth muscle cell CL0002504
    CSI 1.9
    rCSI 2.7%
    PRS 29.1%
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.0
    rCSI 2.5%
    PRS 16.6%
  • cerebellar granule cell CL0001031
    CSI 2.0
    rCSI 2.9%
    PRS 24.2%
  • elicited macrophage CL0000861
    CSI 2.0
    rCSI 1.8%
    PRS 31.2%
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 2.0
    rCSI 5.2%
    PRS 24.9%
  • small intestine goblet cell CL1000495
    CSI 2.0
    rCSI 4.4%
    PRS 34.6%
  • nasal mucosa goblet cell CL0002480
    CSI 2.0
    rCSI 2.3%
    PRS 37.0%
  • lung endothelial cell CL1001567
    CSI 2.0
    rCSI 4.7%
    PRS 54.8%
  • renal interstitial pericyte CL1001318
    CSI 2.0
    rCSI 5.6%
    PRS 24.5%
  • granulocyte CL0000094
    CSI 2.0
    rCSI 3.1%
    PRS 33.6%
  • hepatic stellate cell CL0000632
    CSI 2.1
    rCSI 7.8%
    PRS 22.1%
  • luminal cell of prostate epithelium CL0002340
    CSI 2.1
    rCSI 11.1%
    PRS 43.0%
  • club cell CL0000158
    CSI 2.1
    rCSI 3.0%
    PRS 29.1%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ITPRID2](/details-gene/6744) (ITPR Interacting Domain Containing 2) is a protein-coding gene located on chromosome 2q31.3. Functionally, it is associated with [actin filament binding](/details-go/GO:0051015) and [signaling receptor binding](/details-go/GO:0005102), and its protein product has been localized to the [cytosol](/details-go/GO:0005829), [nucleoplasm](/details-go/GO:0005654), and [plasma membrane](/details-go/GO:0005886). Also known as sperm-specific antigen 2, it has a clinical association with OMIM entry [118990](https://omim.org/entry/118990). Expression analysis reveals that **Overall**, [ITPRID2](/details-gene/6744) shows significant expression in a diverse range of cell types, including specialized epithelial cells such as [ionocytes](/details-cell/CL0005006) and epidermal cells, as well as in key lymphocyte populations, most notably [helper T cells](/details-cell/CL0000912). This broad but distinct expression pattern suggests multifaceted roles in cellular functions ranging from ion transport and tissue barrier integrity to immune regulation. ## Cellular Roles and Expression Landscape The expression profile of [ITPRID2](/details-gene/6744) highlights its importance in several distinct biological systems, primarily in epithelial barrier tissues and the adaptive immune system. **Overall**, the gene's highest significance score is observed in [ionocytes](/details-cell/CL0005006) (CSI: 36.97) and [pulmonary ionocytes](/details-cell/CL0017000) (CSI: 29.04), cell types crucial for ion and water transport across epithelial layers. This suggests a specialized function for [ITPRID2](/details-gene/6744) in maintaining electrolyte balance in tissues like the airways. A second major site of expression is the skin and other epithelial tissues. [ITPRID2](/details-gene/6744) is highly significant in [basal cells of the epidermis](/details-cell/CL0002187) (CSI: 30.96), [melanocytes of skin](/details-cell/CL1000458) (CSI: 27.42), [keratinocytes](/details-cell/CL0000312) (CSI: 26.16), and [suprabasal keratinocytes](/details-cell/CL4033013) (CSI: 18.51). This consistent high expression across different layers and cell types of the epidermis points towards a fundamental role in skin homeostasis, potentially related to cell structure, adhesion, or differentiation. Its significance extends to other epithelial contexts, such as [luminal epithelial cells of the mammary gland](/details-cell/CL0002326) and [colon epithelial cells](/details-cell/CL0011108). Within the immune system, [ITPRID2](/details-gene/6744) shows a notable presence in T lymphocyte populations. It is a significant marker in [helper T cells](/details-cell/CL0000912) (CSI: 32.27), [CD8-positive, alpha-beta memory T cells, CD45RO-positive](/details-cell/CL0001203) (CSI: 17.56), and [regulatory T cells](/details-cell/CL0000815) (CSI: 15.67). This pattern suggests an active role in T cell function, possibly related to signaling or cytoskeletal dynamics during immune activation. ## Pathways and Molecular Function The functional annotations for [ITPRID2](/details-gene/6744) provide insight into its molecular activities. Gene Ontology terms indicate it is involved in [protein binding](/details-go/GO:0005515), [signaling receptor binding](/details-go/GO:0005102), and, most notably, [actin filament binding](/details-go/GO:0051015). Its presence in the [cytosol](/details-go/GO:0005829), [nucleoplasm](/details-go/GO:0005654), and at the [plasma membrane](/details-go/GO:0005886) suggests it may act as an adapter or scaffolding protein that links membrane-proximal signals to the actin cytoskeleton. This functional profile aligns well with its cellular expression pattern. In epithelial cells like [keratinocytes](/details-cell/CL0000312), its actin-binding capacity could be critical for maintaining cell shape and the integrity of the epidermal barrier. In [T cells](/details-cell/CL0000912), the ability to bind both signaling receptors and actin filaments could be crucial for organizing the immunological synapse during antigen presentation. Research has identified the protein as an actin-interacting protein, also known as KRAP, and found its expression to be deregulated in human colon cancer cells, suggesting a role in maintaining normal cellular architecture that is lost during malignancy [Link](https://doi.org/10.1007/s10038-003-0106-3). ## Research Directions The diverse expression pattern and actin-modulating function of [ITPRID2](/details-gene/6744) raise several questions about its specific roles in tissue homeostasis and disease. Based on the available data, several testable hypotheses can be proposed: 1. **Hypothesis 1:** Given its high expression in multiple T cell subsets and its annotated role in [signaling receptor binding](/details-go/GO:0005102), [ITPRID2](/details-gene/6744) functions as a regulator of T cell receptor (TCR) signaling by linking the TCR complex to the actin cytoskeleton, thereby modulating T cell activation and immunological synapse stability. 2. **Hypothesis 2:** In the epidermis, [ITPRID2](/details-gene/6744) is essential for maintaining skin barrier integrity by cross-linking actin filaments at cell-cell adhesion junctions (e.g., adherens junctions) in [keratinocytes](/details-cell/CL0000312). 3. **Hypothesis 3:** Consistent with a previous study [Link](https://doi.org/10.1007/s10038-003-0106-3), the loss of [ITPRID2](/details-gene/6744) expression in [colon epithelial cells](/details-cell/CL0011108) is an early event in colorectal carcinogenesis that promotes cell motility and invasion through disorganization of the actin cytoskeleton. To investigate the most compelling of these, Hypothesis 1, a key experiment could be designed. **To test the role of [ITPRID2](/details-gene/6744) in TCR signaling, one could utilize CRISPR-Cas9 to knock out the gene in a human T cell line, such as Jurkat cells. Following TCR stimulation with anti-CD3/CD28 antibodies, the phosphorylation status of key downstream signaling molecules (e.g., ZAP-70, LAT, ERK) could be assessed by phosphoflow cytometry or Western blotting. Furthermore, co-immunoprecipitation of [ITPRID2](/details-gene/6744) followed by mass spectrometry could identify its specific binding partners within the TCR signalosome.** From a therapeutic standpoint, the role of [ITPRID2](/details-gene/6744) is context-dependent. Its reported downregulation in colon cancer suggests it may function as a tumor suppressor. In this scenario, it is not a direct drug target for inhibition. However, strategies aimed at restoring its expression or targeting downstream pathways dysregulated by its loss could hold therapeutic promise. Conversely, if its function in T cells is found to suppress immune responses, it could be a target for inhibition to enhance anti-tumor immunity.

Genular Protein ID: 4090490051

Symbol: ITPI2_HUMAN

Name: Sperm-specific antigen 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14673706

Title: Deregulated expression of KRAP, a novel gene encoding actin-interacting protein, in human colon cancer cells.

PubMed ID: 14673706

DOI: 10.1007/s10038-003-0106-3

PubMed ID: 11572484

Title: Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.

PubMed ID: 11572484

DOI: 10.1093/dnares/8.4.179

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1555770

Title: Human cleavage signal-1 protein; cDNA cloning, transcription and immunological analysis.

PubMed ID: 1555770

DOI: 10.1016/0378-1119(92)90377-2

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 1259
  • Mass: 138386
  • Checksum: D5843D9D6D5414D7
  • Sequence:
  • MDRPLSSSAE AEEELEWQVA SRRRKAWAKC RSSWQASETE DLSTEATTQD EEEDEEEDLP 
    GAQLPAAGGR GNVPNEKIAI WLKDCRTPLG ASLDEQSSST LKGVLVRNGG SFEDDLSLGA 
    EANHLHESDA QIENCNNILA KERRLQFHQK GRSMNSTGSG KSSGTVSSVS ELLELYEEDP 
    EEILYNLGFG RDEPDIASKI PSRFFNSSSF AKGIDIKVFL SAQMQRMEVE NPNYALTSRF 
    RQIEVLTTVA NAFSSLYSQV SGTPLQRIGS MSSVTSNKET DPPPPLTRSN TANRLMKTLS 
    KLNLCVDKTE KGESSSPSPS AEKGKILNVS VIEESGNKND QKSQKIMKKK ESSSMLATVK 
    EEVSGSSAAV TENADSDRIS DEANSNFNQG TENEQSKETQ SHESKLGEES GIVESKLDSD 
    FNISSHSELE NSSELKSVHI STPEKEPCAP LTIPSIRNIM TQQKDSFEME EVQSTEGEAP 
    HVPATYQLGL TKSKRDHLLR TASQHSDSSG FAEDSTDCLS LNHLQVQESL QAMGSSADSC 
    DSETTVTSLG EDLATPTAQD QPYFNESEEE SLVPLQKGLE KAAAVADKRK SGSQDFPQCN 
    TIENTGTKQS TCSPGDHIIE ITEVEEDLFP AETVELLREA SAESDVGKSS ESEFTQYTTH 
    HILKSLASIE AKCSDMSSEN TTGPPSSMDR VNTALQRAQM KVCSLSNQRM GRSLLKSKDL 
    LKQRYLFAKA GYPLRRSQSL PTTLLSPVRV VSSVNVRLSP GKETRCSPPS FTYKYTPEEE 
    QELEKRVMEH DGQSLVKSTI FISPSSVKKE EAPQSEAPRV EECHHGRTPT CSRLAPPPMS 
    QSTCSLHSIH SEWQERPLCE HTRTLSTHSV PNISGATCSA FASPFGCPYS HRHATYPYRV 
    CSVNPPSAIE MQLRRVLHDI RNSLQNLSQY PMMRGPDPAA APYSTQKSSV LPLYENTFQE 
    LQVMRRSLNL FRTQMMDLEL AMLRQQTMVY HHMTEEERFE VDQLQGLRNS VRMELQDLEL 
    QLEERLLGLE EQLRAVRMPS PFRSSALMGM CGSRSADNLS CPSPLNVMEP VTELMQEQSY 
    LKSELGLGLG EMGFEIPPGE SSESVFSQAT SESSSVCSGP SHANRRTGVP STASVGKSKT 
    PLVARKKVFR ASVALTPTAP SRTGSVQTPP DLESSEEVDA AEGAPEVVGP KSEVEEGHGK 
    LPSMPAAEEM HKNVEQDELQ QVIREIKESI VGEIRREIVS GLLAAVSSSK ASNSKQDYH

Genular Protein ID: 1357592374

Symbol: E9PHV5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 1237
  • Mass: 136138
  • Checksum: 64BFA619E2C53DDA
  • Sequence:
  • MDRPLSSSAE AEEELEWQVA SRRRKAWAKC RSSWQASETE DLSTEATTQD EEEDEEEDLP 
    GAQLPAAGGR GNVPNEKIAI WLKDCRTPLG ASLDEQSSST LKGVLVRNGG SFEDDLSLGA 
    EANHLHESDA QIENCNNILA KERRLQFHQK GRSMNSTGSG KSSGTVSSVS ELLELYEEDP 
    EEILYNLGFG RDEPDIASKI PSRFFNSSSF AKGIDIKVFL SAQMQRMEVE NPNYALTSRF 
    RQIEVLTTVA NAFSSLYSQV SGTPLQRIGS MSSVTSNKET DPPPPLTRSN TANRLMKTLS 
    KLNLCVDKTE KGESSSPSPS AEKGKILNVS VIEESGNKND QKSQKIMKKK ESSSMLATVK 
    EEVSGSSAAV TENADSDRIS DEANSNFNQG TENEQSKETQ SHESKLGEES GIVESKLDSD 
    FNISSHSELE NSSELKSVHI STPEKEPCAP LTIPSIRNIM TQQKDSFEME EVQSTEGEAP 
    HVPATYQLGL TKSKRDHLLR TASQHSDSSG FAEDSTDCLS LNHLQVQESL QAMGSSADSC 
    DSETTVTSLG EDLATPTAQD QPYFNESEEE SLVPLQKGLE KAAAVADKRK SGSQDFPQCN 
    TIENTGTKQS TCSPGDHIIE ITEVEEDLFP AETVELLREA SAESDVGKSS ESEFTQYTTH 
    HILKSLASIE AKCSDMSSEN TTGPPSSMDR VNTALQRAQM KVCSLSNQRM GRSLLKSKDL 
    LKQRYLFAKA GYPLRRSQSL PTTLLSPVRV VSSVNVRLSP GKETRCSPPS FTYKYTPEEE 
    QELEKRVMEH DGQSLVKSTI FISPSSVKKE EAPQSEAPRV EECHHGRTPT CSRLAPPPMS 
    QSTCSLHSIH SEWQERPLCE HTRTLSTHSV PNISGATCSA FASPFGCPYS HRHATYPYRV 
    CSVNPPSAIE MQLRRVLHDI RNSLQNLSQY PMMRGPDPAA APYSTQKSSV LPLYENTFQE 
    LQVMRRSLNL FRTQMMDLEL AMLRQQTMVY HHMTEEERFE VDQLQGLRNS VRMELQDLEL 
    QLEERLLGLE EQLRAVRMPS PFRSSALMVT ELMQEQSYLK SELGLGLGEM GFEIPPGESS 
    ESVFSQATSE SSSVCSGPSH ANRRTGVPST ASVGKSKTPL VARKKVFRAS VALTPTAPSR 
    TGSVQTPPDL ESSEEVDAAE GAPEVVGPKS EVEEGHGKLP SMPAAEEMHK NVEQDELQQV 
    IREIKESIVG EIRREIVSGL LAAVSSSKAS NSKQDYH

Genular Protein ID: 4274525900

Symbol: E7EUL7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 768
  • Mass: 84593
  • Checksum: C2DC1907B353BF31
  • Sequence:
  • MTTEDHLLRT ASQHSDSSGF AEDSTDCLSL NHLQVQESLQ AMGSSADSCD SETTVTSLGE 
    DLATPTAQDQ PYFNESEEES LVPLQKGLEK AAAVADKRKS GSQDFPQCNT IENTGTKQST 
    CSPGDHIIEI TEVEEDLFPA ETVELLREAS AESDVGKSSE SEFTQYTTHH ILKSLASIEA 
    KCSDMSSENT TGPPSSMDRV NTALQRAQMK VCSLSNQRMG RSLLKSKDLL KQRYLFAKAG 
    YPLRRSQSLP TTLLSPVRVV SSVNVRLSPG KETRCSPPSF TYKYTPEEEQ ELEKRVMEHD 
    GQSLVKSTIF ISPSSVKKEE APQSEAPRVE ECHHGRTPTC SRLAPPPMSQ STCSLHSIHS 
    EWQERPLCEH TRTLSTHSVP NISGATCSAF ASPFGCPYSH RHATYPYRVC SVNPPSAIEM 
    QLRRVLHDIR NSLQNLSQYP MMRGPDPAAA PYSTQKSSVL PLYENTFQEL QVMRRSLNLF 
    RTQMMDLELA MLRQQTMVYH HMTEEERFEV DQLQGLRNSV RMELQDLELQ LEERLLGLEE 
    QLRAVRMPSP FRSSALMGMC GSRSADNLSC PSPLNVMEPV TELMQEQSYL KSELGLGLGE 
    MGFEIPPGES SESVFSQATS ESSSVCSGPS HANRRTGVPS TASVGKSKTP LVARKKVFRA 
    SVALTPTAPS RTGSVQTPPD LESSEEVDAA EGAPEVVGPK SEVEEGHGKL PSMPAAEEMH 
    KNVEQDELQQ VIREIKESIV GEIRREIVSG LLAAVSSSKA SNSKQDYH