Details for: ST13

Gene ID: 6767

Symbol: ST13

Ensembl ID: ENSG00000100380

Description: ST13 Hsp70 interacting protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 558.1013
    Cell Significance Index: -86.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 300.4612
    Cell Significance Index: -76.2100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 262.7640
    Cell Significance Index: -108.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 228.6270
    Cell Significance Index: -107.9400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 209.3178
    Cell Significance Index: -107.6700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 161.2614
    Cell Significance Index: -108.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 79.6379
    Cell Significance Index: -98.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 29.4192
    Cell Significance Index: -78.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 27.6682
    Cell Significance Index: -109.1800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 26.8016
    Cell Significance Index: -82.3200
  • Cell Name: theca cell (CL0000503)
    Fold Change: 20.9650
    Cell Significance Index: 123.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.3478
    Cell Significance Index: -33.5900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.7357
    Cell Significance Index: 45.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.0527
    Cell Significance Index: 132.8600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.7378
    Cell Significance Index: 60.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.4024
    Cell Significance Index: 152.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.2212
    Cell Significance Index: 579.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.9849
    Cell Significance Index: 114.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.7269
    Cell Significance Index: 78.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.7143
    Cell Significance Index: 174.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.5563
    Cell Significance Index: 437.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.3317
    Cell Significance Index: 600.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.0965
    Cell Significance Index: 400.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.0225
    Cell Significance Index: 82.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.9416
    Cell Significance Index: 1606.4800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.9316
    Cell Significance Index: 31.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.8518
    Cell Significance Index: 365.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.8386
    Cell Significance Index: 132.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.7561
    Cell Significance Index: 194.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.5056
    Cell Significance Index: 186.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.4182
    Cell Significance Index: 1069.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.3861
    Cell Significance Index: 125.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.1420
    Cell Significance Index: 97.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9944
    Cell Significance Index: 395.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.9004
    Cell Significance Index: 224.1200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.8026
    Cell Significance Index: 16.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.7832
    Cell Significance Index: 115.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.4373
    Cell Significance Index: 245.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.2860
    Cell Significance Index: 14.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2712
    Cell Significance Index: 27.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2089
    Cell Significance Index: 242.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2078
    Cell Significance Index: 32.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2053
    Cell Significance Index: 62.6100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.1617
    Cell Significance Index: 26.8400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.9405
    Cell Significance Index: 16.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8275
    Cell Significance Index: 81.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8087
    Cell Significance Index: 290.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5957
    Cell Significance Index: 35.7600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.5752
    Cell Significance Index: 3.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5228
    Cell Significance Index: 85.0400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3333
    Cell Significance Index: 9.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2927
    Cell Significance Index: 55.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2353
    Cell Significance Index: 172.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2156
    Cell Significance Index: 7.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1476
    Cell Significance Index: 2.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1437
    Cell Significance Index: 108.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0992
    Cell Significance Index: 6.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0535
    Cell Significance Index: 100.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0148
    Cell Significance Index: 0.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0105
    Cell Significance Index: -7.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0323
    Cell Significance Index: -59.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0377
    Cell Significance Index: -3.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0430
    Cell Significance Index: -66.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0587
    Cell Significance Index: -36.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0588
    Cell Significance Index: -37.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0633
    Cell Significance Index: -86.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1197
    Cell Significance Index: -67.4800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1323
    Cell Significance Index: -1.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1496
    Cell Significance Index: -67.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1795
    Cell Significance Index: -14.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2142
    Cell Significance Index: -45.1100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2714
    Cell Significance Index: -3.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3224
    Cell Significance Index: -92.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4461
    Cell Significance Index: -64.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4542
    Cell Significance Index: -52.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4936
    Cell Significance Index: -27.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5128
    Cell Significance Index: -16.4300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5527
    Cell Significance Index: -14.1200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5538
    Cell Significance Index: -63.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6473
    Cell Significance Index: -75.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6885
    Cell Significance Index: -19.2400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7266
    Cell Significance Index: -4.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8235
    Cell Significance Index: -22.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8288
    Cell Significance Index: -55.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.9359
    Cell Significance Index: -71.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.0041
    Cell Significance Index: -13.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0041
    Cell Significance Index: -104.5500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.2655
    Cell Significance Index: -23.3900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.3484
    Cell Significance Index: -36.0700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.5310
    Cell Significance Index: -22.9400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.5857
    Cell Significance Index: -16.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6896
    Cell Significance Index: -103.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.7125
    Cell Significance Index: -44.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.8454
    Cell Significance Index: -81.6300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -1.9753
    Cell Significance Index: -14.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.1148
    Cell Significance Index: -62.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -2.1382
    Cell Significance Index: -108.0600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -2.1856
    Cell Significance Index: -13.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.1934
    Cell Significance Index: -83.0600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.1979
    Cell Significance Index: -37.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ST13 is a protein-coding gene that belongs to the Hsp70-interacting protein family. The protein encoded by ST13 interacts with Hsp70, a molecular chaperone that plays a central role in protein folding and stress response. This interaction is essential for regulating protein folding, refolding, and degradation. ST13 is also involved in various cellular processes, including protein dimerization, binding to other proteins, and regulation of the heat shock response. The gene's expression is tightly regulated and is significantly upregulated in response to stress and heat shock. **Pathways and Functions** ST13 is involved in several cellular pathways, including: 1. **Cellular responses to stimuli**: ST13 plays a crucial role in regulating cellular responses to various stimuli, including heat shock, stress, and bacterium. 2. **Cellular responses to stress**: ST13 interacts with Hsp70 to regulate protein folding and stress response, ensuring cellular homeostasis. 3. **Chaperone cofactor-dependent protein refolding**: ST13 is involved in the refolding of proteins that have become misfolded due to stress or heat shock. 4. **Protein-macromolecule adaptor activity**: ST13 interacts with other proteins and macromolecules to regulate various cellular processes. 5. **Protein binding and dimerization**: ST13 binds to other proteins and regulates protein dimerization, which is essential for various cellular processes. **Clinical Significance** ST13 is a gene of interest in various diseases and conditions, including: 1. **Protein misfolding diseases**: ST13 plays a crucial role in regulating protein folding and stress response, making it a potential target for treating protein misfolding diseases, such as Alzheimer's and Parkinson's. 2. **Cancer**: ST13 is significantly expressed in various types of cancer, including prostate, breast, and ovarian cancer, suggesting its potential role in cancer development and progression. 3. **Neurological disorders**: ST13 is involved in regulating protein folding and stress response in the brain, making it a potential target for treating neurological disorders, such as neurodegenerative diseases. 4. **Regenerative medicine**: ST13 is expressed in stem cells and satellite stem cells, suggesting its potential role in regenerative medicine and tissue repair. In conclusion, ST13 is a gene that plays a crucial role in regulating protein folding, stress response, and cellular homeostasis. Its significance in various diseases and conditions makes it an area of interest for further research and potential therapeutic applications.

Genular Protein ID: 3887528383

Symbol: F10A1_HUMAN

Name: Hsc70-interacting protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8721986

Title: Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein.

PubMed ID: 8721986

DOI: 10.1210/mend.10.4.8721986

PubMed ID: 9387309

Title: Differential expression of HSU17714 gene in colorectal cancer and normal colonic mucosa.

PubMed ID: 9387309

PubMed ID: 9292708

Title: Characterization of colorectal-cancer-related cDNA clones obtained by subtractive hybridization screening.

PubMed ID: 9292708

DOI: 10.1007/bf01372549

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21728385

Title: G protein-coupled receptor kinase 5 phosphorylation of Hip regulates internalization of the chemokine receptor CXCR4.

PubMed ID: 21728385

DOI: 10.1021/bi2005202

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 369
  • Mass: 41332
  • Checksum: 98FCC65BEE14CDD7
  • Sequence:
  • MDPRKVNELR AFVKMCKQDP SVLHTEEMRF LREWVESMGG KVPPATQKAK SEENTKEEKP 
    DSKKVEEDLK ADEPSSEESD LEIDKEGVIE PDTDAPQEMG DENAEITEEM MDQANDKKVA 
    AIEALNDGEL QKAIDLFTDA IKLNPRLAIL YAKRASVFVK LQKPNAAIRD CDRAIEINPD 
    SAQPYKWRGK AHRLLGHWEE AAHDLALACK LDYDEDASAM LKEVQPRAQK IAEHRRKYER 
    KREEREIKER IERVKKAREE HERAQREEEA RRQSGAQYGS FPGGFPGGMP GNFPGGMPGM 
    GGGMPGMAGM PGLNEILSDP EVLAAMQDPE VMVAFQDVAQ NPANMSKYQS NPKVMNLISK 
    LSAKFGGQA

Genular Protein ID: 1631521508

Symbol: Q0IJ56_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 310
  • Mass: 35015
  • Checksum: 7DDA10A23B789C7B
  • Sequence:
  • MDPRKVNELR AFVKMCKQDP SVLHTEEMRF LREWVESMGG KVPPATQKAK SEENTKEEKP 
    DSKKVEEDLK ADEPSSEESD LEIDKEGVIE PDTDAPQEMG DENAEITEEM MDQANDKKVA 
    AIEALNDGEL QKAIDLFTDA IKLNPRLAIL YAKRASVFVK LQKPNAAIRD CDRAIEINPD 
    SAQPYKWRGK AHRLLGHWEE AAHDLALACK LDYDEDASAM LKEVQPRAQK IAEHRRKYER 
    KREEREIKER IERVKKAREE HERAQREEEA RRQSGAQYGS FPGGFPGGMP GNFPGGMPGM 
    GGGMPGMAGM

Genular Protein ID: 1943160505

Symbol: B4E0U6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 359
  • Mass: 40161
  • Checksum: 627894621FD421D1
  • Sequence:
  • MDPRKVNELR AFVKMCKQDP SVLHTEEMRF LREWVESMGG KVPPATQKAK SEENTKEDLK 
    ADEPSSEESD LEIDKEGVIE PDTDAPQEMG DENAEITEEM MDQANDKKVA AIEALNDGEL 
    QKAIDLFTDA IKLNPRLAIL YAKRASVFVK LQKPNAAIRD CDRAIEINPD SAQPYKWRGK 
    AHRLLGHWEE AAHDLALACK LDYDEDASAM LKEVQPRAQK IAEHRRKYER KREEREIKER 
    IERVKKAREE HERAQREEEA RRQSGAQYGS FPGGFPGGMP GNFPGGMPGM GGGMPGMAGM 
    PGLNEILSDP EVLAAMQDPE VMVAFQDVAQ NPANMSKYQS NPKVMNLISK LSAKFGGQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.