Details for: SURF6

Gene ID: 6838

Symbol: SURF6

Ensembl ID: ENSG00000148296

Description: surfeit 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 114.8541
    Cell Significance Index: -17.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 69.0339
    Cell Significance Index: -17.5100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.1777
    Cell Significance Index: -18.7600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 45.6854
    Cell Significance Index: -18.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.7069
    Cell Significance Index: -18.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.6575
    Cell Significance Index: -19.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.7309
    Cell Significance Index: -20.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.0532
    Cell Significance Index: -19.9400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.9358
    Cell Significance Index: -15.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 4.7157
    Cell Significance Index: 117.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.1344
    Cell Significance Index: -6.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.6311
    Cell Significance Index: 15.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.6250
    Cell Significance Index: 46.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6068
    Cell Significance Index: 72.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5702
    Cell Significance Index: 170.7900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.2622
    Cell Significance Index: 20.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1992
    Cell Significance Index: 1082.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1229
    Cell Significance Index: 15.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1117
    Cell Significance Index: 129.5600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.9627
    Cell Significance Index: 7.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9012
    Cell Significance Index: 24.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7559
    Cell Significance Index: 136.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6845
    Cell Significance Index: 135.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6101
    Cell Significance Index: 83.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6084
    Cell Significance Index: 13.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5774
    Cell Significance Index: 30.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5198
    Cell Significance Index: 32.7600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5099
    Cell Significance Index: 7.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4585
    Cell Significance Index: 56.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4332
    Cell Significance Index: 236.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4072
    Cell Significance Index: 10.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4040
    Cell Significance Index: 28.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3827
    Cell Significance Index: 169.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3423
    Cell Significance Index: 65.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3126
    Cell Significance Index: 8.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3038
    Cell Significance Index: 14.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2977
    Cell Significance Index: 13.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2873
    Cell Significance Index: 36.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2728
    Cell Significance Index: 54.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2542
    Cell Significance Index: 5.3200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2474
    Cell Significance Index: 2.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2453
    Cell Significance Index: 24.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1757
    Cell Significance Index: 4.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1706
    Cell Significance Index: 27.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1599
    Cell Significance Index: 10.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1548
    Cell Significance Index: 8.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1314
    Cell Significance Index: 47.1200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1257
    Cell Significance Index: 1.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1127
    Cell Significance Index: 3.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1106
    Cell Significance Index: 5.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1081
    Cell Significance Index: 13.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1052
    Cell Significance Index: 7.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0558
    Cell Significance Index: 1.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0491
    Cell Significance Index: 5.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0405
    Cell Significance Index: 6.9100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0242
    Cell Significance Index: 0.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0235
    Cell Significance Index: 0.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0104
    Cell Significance Index: 16.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0080
    Cell Significance Index: 14.7200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0065
    Cell Significance Index: 4.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0041
    Cell Significance Index: 7.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0013
    Cell Significance Index: 0.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0002
    Cell Significance Index: -0.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0047
    Cell Significance Index: -6.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0160
    Cell Significance Index: -10.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0184
    Cell Significance Index: -13.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0233
    Cell Significance Index: -0.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0284
    Cell Significance Index: -15.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0300
    Cell Significance Index: -13.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0331
    Cell Significance Index: -3.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0400
    Cell Significance Index: -4.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0493
    Cell Significance Index: -0.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0730
    Cell Significance Index: -21.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0732
    Cell Significance Index: -5.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0934
    Cell Significance Index: -13.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1025
    Cell Significance Index: -21.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1329
    Cell Significance Index: -3.8100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1437
    Cell Significance Index: -1.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1731
    Cell Significance Index: -4.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1822
    Cell Significance Index: -18.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1878
    Cell Significance Index: -11.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1887
    Cell Significance Index: -4.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1982
    Cell Significance Index: -15.7000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2299
    Cell Significance Index: -2.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2620
    Cell Significance Index: -11.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2777
    Cell Significance Index: -8.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2833
    Cell Significance Index: -14.7600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2922
    Cell Significance Index: -6.2500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3025
    Cell Significance Index: -8.9100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3276
    Cell Significance Index: -13.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3285
    Cell Significance Index: -12.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3987
    Cell Significance Index: -11.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4016
    Cell Significance Index: -14.0700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4212
    Cell Significance Index: -8.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4215
    Cell Significance Index: -13.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4287
    Cell Significance Index: -11.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4295
    Cell Significance Index: -8.9100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4365
    Cell Significance Index: -3.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SURF6, also known as the Surfeit locus protein 6, is a human gene with an Ensembl ID of ENSG00000148296. Its expression is observed in a wide range of cell types, including pulmonary interstitial fibroblasts, proerythroblasts, pancreatic A cells, extravillous trophoblasts, Leydig cells, primordial germ cells, stem cells, cortical thymic epithelial cells, and absorptive cells. The SURF6 protein, encoded by this gene, exhibits a unique expression profile and is involved in various cellular processes, including DNA binding, RNA binding, and ribosomal biogenesis. **Pathways and Functions:** The SURF6 gene is involved in several critical pathways, including: 1. **DNA Binding**: SURF6 interacts with DNA, suggesting a role in regulating gene expression and transcription. 2. **RNA Binding**: The protein binds to RNA, potentially influencing RNA processing, splicing, and translation. 3. **Ribosomal Large Subunit Biogenesis**: SURF6 is involved in the assembly and maturation of the ribosomal large subunit, highlighting its importance in protein synthesis and cellular homeostasis. 4. **Ribosomal Small Subunit Biogenesis**: The protein also plays a role in the biogenesis of the ribosomal small subunit, underscoring its significance in protein synthesis and cellular function. **Clinical Significance:** While the clinical significance of SURF6 is still emerging, its dysregulation has been implicated in various diseases, including: 1. **Immunodeficiency Disorders**: Altered expression of SURF6 has been observed in immunodeficiency disorders, such as X-linked agammaglobulinemia and severe combined immunodeficiency (SCID). 2. **Cancer**: Aberrant expression of SURF6 has been linked to various types of cancer, including pancreatic cancer and ovarian cancer. 3. **Neurological Disorders**: Dysregulation of SURF6 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the SURF6 gene is a complex and multifaceted locus that plays a critical role in various cellular processes, including DNA binding, RNA binding, and ribosomal biogenesis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the clinical significance of SURF6. As an expert immunologist, I believe that a deeper understanding of SURF6's role in immunology and beyond will shed light on novel therapeutic strategies for the treatment of diseases associated with its dysregulation.

Genular Protein ID: 3834658463

Symbol: SURF6_HUMAN

Name: Surfeit locus protein 6

UniProtKB Accession Codes:

O75683 Q5T8U1 Q9BRK9 Q9BTZ5 Q9UK24

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 7 EMDB 4 Ensembl 2 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10675619

Title: Isolation and genomic analysis of the human surf-6 gene: a member of the Surfeit locus.

PubMed ID: 10675619

DOI: 10.1016/s0378-1119(99)00551-x

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11891058

Title: The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts.

PubMed ID: 11891058

DOI: 10.1016/s0378-1119(02)00379-7

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 361
  • Mass: 41450
  • Checksum: 34F63992E3E82797
  • Sequence:
    • MASLLAKDAY LQSLAKKICS HSAPEQQART RAGKTQGSET AGPPKKKRKK TQKKFRKREE 
KAAEHKAKSL GEKSPAASGA RRPEAAKEEA AWASSSAGNP ADGLATEPES VFALDVLRQR 
LHEKIQEARG QGSAKELSPA ALEKRRRRKQ ERDRKKRKRK ELRAKEKARK AEEATEAQEV 
VEATPEGACT EPREPPGLIF NKVEVSEDEP ASKAQRRKEK RQRVKGNLTP LTGRNYRQLL 
ERLQARQSRL DELRGQDEGK AQELEAKMKW TNLLYKAEGV KIRDDERLLQ EALKRKEKRR 
AQRQRRWEKR TAGVVEKMQQ RQDRRRQNLR RKKAARAERR LLRARKKGRI LPQDLERAGL 
V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.