Details for: TACR2

Gene ID: 6865

Symbol: TACR2

Ensembl ID: ENSG00000075073

Description: tachykinin receptor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 8.8313
    Cell Significance Index: -2.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 4.7233
    Cell Significance Index: -2.2300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.3284
    Cell Significance Index: 6.9900
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 1.0567
    Cell Significance Index: 12.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5326
    Cell Significance Index: 101.3600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.4801
    Cell Significance Index: 6.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4299
    Cell Significance Index: 9.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3228
    Cell Significance Index: 19.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2707
    Cell Significance Index: 26.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2418
    Cell Significance Index: 26.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2212
    Cell Significance Index: 199.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1552
    Cell Significance Index: 25.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1208
    Cell Significance Index: 8.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0976
    Cell Significance Index: 28.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0758
    Cell Significance Index: 1.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0635
    Cell Significance Index: 3.3000
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.0620
    Cell Significance Index: 0.7700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0613
    Cell Significance Index: 0.8500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0536
    Cell Significance Index: 3.3800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0397
    Cell Significance Index: 0.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0254
    Cell Significance Index: 1.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0215
    Cell Significance Index: 14.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0199
    Cell Significance Index: 3.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0134
    Cell Significance Index: 0.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0132
    Cell Significance Index: 0.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0124
    Cell Significance Index: 0.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0099
    Cell Significance Index: 1.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0089
    Cell Significance Index: 1.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0063
    Cell Significance Index: 2.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0054
    Cell Significance Index: 0.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0036
    Cell Significance Index: 0.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0035
    Cell Significance Index: 0.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0030
    Cell Significance Index: 0.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0016
    Cell Significance Index: 0.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0009
    Cell Significance Index: 0.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0010
    Cell Significance Index: -1.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0010
    Cell Significance Index: -0.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0019
    Cell Significance Index: -2.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0019
    Cell Significance Index: -0.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0031
    Cell Significance Index: -2.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0031
    Cell Significance Index: -2.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0033
    Cell Significance Index: -2.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0034
    Cell Significance Index: -2.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0040
    Cell Significance Index: -2.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0041
    Cell Significance Index: -0.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0049
    Cell Significance Index: -2.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0054
    Cell Significance Index: -0.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0061
    Cell Significance Index: -0.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0066
    Cell Significance Index: -0.7700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0080
    Cell Significance Index: -0.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0098
    Cell Significance Index: -0.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0100
    Cell Significance Index: -1.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0102
    Cell Significance Index: -1.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0109
    Cell Significance Index: -1.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0122
    Cell Significance Index: -0.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0125
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0146
    Cell Significance Index: -1.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0193
    Cell Significance Index: -2.2800
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0205
    Cell Significance Index: -0.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0214
    Cell Significance Index: -1.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0216
    Cell Significance Index: -2.2500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0229
    Cell Significance Index: -1.1600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0242
    Cell Significance Index: -1.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0243
    Cell Significance Index: -0.6800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0274
    Cell Significance Index: -0.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0287
    Cell Significance Index: -2.2700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0319
    Cell Significance Index: -1.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0340
    Cell Significance Index: -1.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0343
    Cell Significance Index: -2.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0349
    Cell Significance Index: -1.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0391
    Cell Significance Index: -2.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0398
    Cell Significance Index: -2.0900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0404
    Cell Significance Index: -0.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0445
    Cell Significance Index: -0.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0452
    Cell Significance Index: -2.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0452
    Cell Significance Index: -1.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0462
    Cell Significance Index: -1.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0478
    Cell Significance Index: -1.0000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0482
    Cell Significance Index: -0.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0489
    Cell Significance Index: -1.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0496
    Cell Significance Index: -1.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0531
    Cell Significance Index: -2.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0594
    Cell Significance Index: -0.8100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0594
    Cell Significance Index: -2.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0613
    Cell Significance Index: -1.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0656
    Cell Significance Index: -2.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0669
    Cell Significance Index: -1.9700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0686
    Cell Significance Index: -0.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0687
    Cell Significance Index: -1.9600
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0695
    Cell Significance Index: -0.7000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0702
    Cell Significance Index: -1.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0719
    Cell Significance Index: -1.9200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0719
    Cell Significance Index: -1.2400
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0724
    Cell Significance Index: -1.0300
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0726
    Cell Significance Index: -0.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0734
    Cell Significance Index: -1.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** TACR2 belongs to the class A/1 rhodopsin-like receptors, which are characterized by a seven-transmembrane domain structure. 2. **Ligand Binding:** TACR2 is activated by tachykinins, a family of neuropeptides, including substance P, neurokinin A, and neurokinin B. 3. **Signaling Pathways:** TACR2 activates Gq protein-coupled signaling pathways, leading to the activation of various downstream effectors, including phospholipase C, protein kinase C, and mitogen-activated protein kinases. 4. **Cellular Expression:** TACR2 is expressed in various cell types, including smooth muscle cells, immune cells, and neurons, highlighting its involvement in different physiological processes. **Pathways and Functions:** 1. **Neurotransmission:** TACR2 is involved in the regulation of neurotransmission, particularly in the central nervous system, where it modulates the release of neurotransmitters, such as acetylcholine and dopamine. 2. **Smooth Muscle Contraction:** TACR2 is activated by tachykinins, leading to the contraction of smooth muscle cells in various organs, including the intestine, uterus, and blood vessels. 3. **Vascular Permeability:** TACR2 modulates vascular permeability, influencing the regulation of blood flow and the response to inflammatory stimuli. 4. **Immune Regulation:** TACR2 is expressed on immune cells, including granulocytes and monocytes, and plays a role in regulating immune responses, including the release of cytokines and the activation of immune cells. 5. **Sperm Motility:** TACR2 is involved in the regulation of sperm motility, particularly in the context of flagellated sperm. **Clinical Significance:** 1. **Neurological Disorders:** Abnormalities in TACR2 expression and function have been implicated in various neurological disorders, including anxiety, depression, and Parkinson's disease. 2. **Cardiovascular Diseases:** TACR2 is involved in the regulation of blood pressure and vascular tone, making it a potential target for the treatment of cardiovascular diseases, such as hypertension and atherosclerosis. 3. **Pain Modulation:** TACR2 is activated by tachykinins, which are released in response to pain stimulation, highlighting its role in pain modulation and the development of analgesic therapies. 4. **Cancer:** TACR2 is expressed in various types of cancer, including breast, lung, and colon cancer, and has been implicated in the regulation of tumor growth and metastasis. In conclusion, TACR2 is a multifunctional receptor that plays a crucial role in regulating various physiological processes, including neurotransmission, smooth muscle contraction, vascular permeability, and immune regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying TACR2 function and its role in human disease.

Genular Protein ID: 1855169534

Symbol: NK2R_HUMAN

Name: Substance-K receptor

UniProtKB Accession Codes:

P21452 A8K7I1 Q4QRI5 Q8NGQ8 Q9UDE6 Q9UDE7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 ELM 1 EMBL 16 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2173708

Title: The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues.

PubMed ID: 2173708

DOI: 10.1016/s0021-9258(17)30526-4

PubMed ID: 1845990

Title:

PubMed ID: 1845990

DOI: 10.1016/s0021-9258(17)35323-1

PubMed ID: 1659296

Title: Molecular cloning of the human neurokinin-2 receptor cDNA by polymerase chain reaction and isolation of the gene.

PubMed ID: 1659296

DOI: 10.1111/j.1749-6632.1991.tb33132.x

PubMed ID: 1659297

Title: Cloning, expression of the human substance K receptor, and analysis of its role in mitogenesis.

PubMed ID: 1659297

DOI: 10.1111/j.1749-6632.1991.tb33144.x

PubMed ID: 1710456

Title: Isolation and characterisation of the human lung NK-2 receptor gene using rapid amplification of cDNA ends.

PubMed ID: 1710456

DOI: 10.1016/0006-291x(91)91940-e

PubMed ID: 1848773

Title: Cloning and expression of the human substance K receptor and analysis of its role in mitogenesis.

PubMed ID: 1848773

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 398
  • Mass: 44442
  • Checksum: 20AD618EF74263A7
  • Sequence:
    • MGTCDIVTEA NISSGPESNT TGITAFSMPS WQLALWATAY LALVLVAVTG NAIVIWIILA 
HRRMRTVTNY FIVNLALADL CMAAFNAAFN FVYASHNIWY FGRAFCYFQN LFPITAMFVS 
IYSMTAIAAD RYMAIVHPFQ PRLSAPSTKA VIAGIWLVAL ALASPQCFYS TVTMDQGATK 
CVVAWPEDSG GKTLLLYHLV VIALIYFLPL AVMFVAYSVI GLTLWRRAVP GHQAHGANLR 
HLQAMKKFVK TMVLVVLTFA ICWLPYHLYF ILGSFQEDIY CHKFIQQVYL ALFWLAMSST 
MYNPIIYCCL NHRFRSGFRL AFRCCPWVTP TKEDKLELTP TTSLSTRVNR CHTKETLFMA 
GDTAPSEATS GEAGRPQDGS GLWFGYGLLA PTKTHVEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.