Details for: TCF19

Gene ID: 6941

Symbol: TCF19

Ensembl ID: ENSG00000137310

Description: transcription factor 19

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 21.6446
    Cell Significance Index: -5.4900
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 5.2075
    Cell Significance Index: -0.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.8582
    Cell Significance Index: -5.9900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.3368
    Cell Significance Index: -6.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.7361
    Cell Significance Index: 36.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.6574
    Cell Significance Index: -6.5400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.3544
    Cell Significance Index: -4.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6240
    Cell Significance Index: 37.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5811
    Cell Significance Index: 63.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5597
    Cell Significance Index: 91.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.4948
    Cell Significance Index: 12.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4373
    Cell Significance Index: 12.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4350
    Cell Significance Index: 26.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4282
    Cell Significance Index: 386.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4142
    Cell Significance Index: 48.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2628
    Cell Significance Index: 13.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2360
    Cell Significance Index: 3.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2339
    Cell Significance Index: 7.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2196
    Cell Significance Index: 7.6300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2195
    Cell Significance Index: 3.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2024
    Cell Significance Index: 20.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1948
    Cell Significance Index: 4.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1503
    Cell Significance Index: 17.5100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1319
    Cell Significance Index: 2.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1220
    Cell Significance Index: 22.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1148
    Cell Significance Index: 22.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0912
    Cell Significance Index: 40.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0684
    Cell Significance Index: 13.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0536
    Cell Significance Index: 29.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0446
    Cell Significance Index: 1.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0436
    Cell Significance Index: 5.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0409
    Cell Significance Index: 2.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0396
    Cell Significance Index: 5.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0352
    Cell Significance Index: 4.5100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0323
    Cell Significance Index: 0.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0321
    Cell Significance Index: 2.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0319
    Cell Significance Index: 1.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0258
    Cell Significance Index: 1.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0231
    Cell Significance Index: 0.5000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0157
    Cell Significance Index: 0.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0044
    Cell Significance Index: 0.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0028
    Cell Significance Index: 0.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0021
    Cell Significance Index: 0.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0002
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0027
    Cell Significance Index: -4.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0030
    Cell Significance Index: -5.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0031
    Cell Significance Index: -1.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0051
    Cell Significance Index: -3.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0057
    Cell Significance Index: -7.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0072
    Cell Significance Index: -0.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0086
    Cell Significance Index: -5.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0092
    Cell Significance Index: -0.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0099
    Cell Significance Index: -7.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0114
    Cell Significance Index: -0.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0121
    Cell Significance Index: -6.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0134
    Cell Significance Index: -6.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0134
    Cell Significance Index: -1.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0139
    Cell Significance Index: -0.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0142
    Cell Significance Index: -2.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0218
    Cell Significance Index: -2.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0231
    Cell Significance Index: -6.6500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0241
    Cell Significance Index: -0.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0247
    Cell Significance Index: -0.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0257
    Cell Significance Index: -3.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0280
    Cell Significance Index: -4.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0389
    Cell Significance Index: -2.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0399
    Cell Significance Index: -8.4000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0461
    Cell Significance Index: -0.7000
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0485
    Cell Significance Index: -0.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0493
    Cell Significance Index: -2.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0569
    Cell Significance Index: -4.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0587
    Cell Significance Index: -2.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0610
    Cell Significance Index: -6.3500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0650
    Cell Significance Index: -0.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0652
    Cell Significance Index: -3.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0701
    Cell Significance Index: -5.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0727
    Cell Significance Index: -2.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0748
    Cell Significance Index: -0.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0829
    Cell Significance Index: -6.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0871
    Cell Significance Index: -5.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0932
    Cell Significance Index: -2.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1054
    Cell Significance Index: -5.4900
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1068
    Cell Significance Index: -0.8500
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.1119
    Cell Significance Index: -1.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1224
    Cell Significance Index: -2.6800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1226
    Cell Significance Index: -1.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1284
    Cell Significance Index: -3.3000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1288
    Cell Significance Index: -1.4000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1299
    Cell Significance Index: -0.8800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1330
    Cell Significance Index: -1.8900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1340
    Cell Significance Index: -1.9200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1387
    Cell Significance Index: -2.2000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1397
    Cell Significance Index: -1.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1402
    Cell Significance Index: -4.1300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1419
    Cell Significance Index: -2.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1436
    Cell Significance Index: -5.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1501
    Cell Significance Index: -6.6400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1584
    Cell Significance Index: -3.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1628
    Cell Significance Index: -4.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** TCF19 acts as a transcription factor, binding to specific DNA sequences to regulate the expression of target genes. 2. **Diverse Cellular Expression:** TCF19 is expressed in a wide range of cell types, including mural cells, retinal ganglion cells, and intestinal epithelial cells, suggesting its involvement in various physiological processes. 3. **Metal Ion Binding:** TCF19 exhibits metal ion binding capabilities, which may contribute to its functional diversity and ability to interact with other proteins. 4. **Protein Binding:** TCF19 interacts with various proteins, including other transcription factors, to modulate gene expression and cellular processes. **Pathways and Functions:** 1. **Regulation of Gene Expression:** TCF19 regulates gene expression by binding to specific DNA sequences, thereby influencing the transcription of target genes. 2. **Metal Ion Homeostasis:** TCF19's metal ion binding capabilities may contribute to the regulation of metal ion homeostasis, which is essential for various cellular processes, including DNA synthesis and repair. 3. **Cellular Differentiation:** TCF19's involvement in regulating gene expression and cellular differentiation suggests its role in maintaining cellular homeostasis and promoting tissue development. 4. **Intestinal Epithelial Cell Function:** TCF19's expression in intestinal epithelial cells highlights its potential role in maintaining intestinal barrier function, regulating nutrient absorption, and modulating the immune response. **Clinical Significance:** 1. **Cancer Research:** TCF19's involvement in regulating gene expression and cellular differentiation makes it a potential target for cancer therapy. Aberrant TCF19 expression has been implicated in various cancers, including colorectal cancer and breast cancer. 2. **Intestinal Diseases:** TCF19's expression in intestinal epithelial cells suggests its potential role in maintaining intestinal barrier function and regulating the immune response. Dysregulation of TCF19 may contribute to intestinal diseases, such as inflammatory bowel disease (IBD). 3. **Neurological Disorders:** TCF19's expression in retinal ganglion cells and other neuronal cells highlights its potential role in maintaining neuronal homeostasis and regulating neural development. Dysregulation of TCF19 may contribute to neurological disorders, such as glaucoma and Alzheimer's disease. 4. **Developmental Biology:** TCF19's involvement in regulating gene expression and cellular differentiation suggests its role in maintaining developmental homeostasis and promoting tissue development. Understanding TCF19's function in developmental biology may provide insights into the molecular mechanisms underlying embryonic development and tissue patterning. In conclusion, TCF19 is a multifunctional transcription factor with diverse cellular expression and functional significance. Its involvement in regulating gene expression, metal ion homeostasis, and cellular differentiation highlights its importance in maintaining cellular homeostasis and promoting tissue development. Further research is needed to elucidate the clinical significance of TCF19 and its potential implications in human diseases.

Genular Protein ID: 448776660

Symbol: TCF19_HUMAN

Name: Transcription factor 19

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1868030

Title: A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor.

PubMed ID: 1868030

PubMed ID: 10777095

Title: Genetic polymorphisms in the cell growth regulated gene, SC1 telomeric of the HLA-C gene and lack of association of psoriasis vulgaris.

PubMed ID: 10777095

DOI: 10.1034/j.1399-0039.2000.550303.x

PubMed ID: 16702430

Title: Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.

PubMed ID: 16702430

DOI: 10.1534/genetics.106.057034

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

Sequence Information:

  • Length: 345
  • Mass: 37184
  • Checksum: B5730936A842B83A
  • Sequence:
  • MLPCFQLLRI GGGRGGDLYT FHPPAGAGCT YRLGHRADLC DVALRPQQEP GLISGIHAEL 
    HAEPRGDDWR VSLEDHSSQG TLVNNVRLPR GHRLELSDGD LLTFGPEGPP GTSPSEFYFM 
    FQQVRVKPQD FAAITIPRSR GEARVGAGFR PMLPSQGAPQ RPLSTFSPAP KATLILNSIG 
    SLSKLRPQPL TFSPSWGGPK SLPVPAPPGE MGTTPSAPPQ RNRRKSVHRV LAELDDESEP 
    PENPPPVLME PRKKLRVDKA PLTPTGNRRG RPRKYPVSAP MAPPAVGGGE PCAAPCCCLP 
    QEETVAWVQC DGCDVWFHVA CVGCSIQAAR EADFRCPGCR AGIQT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.