Details for: VPS72

Gene ID: 6944

Symbol: VPS72

Ensembl ID: ENSG00000163159

Description: vacuolar protein sorting 72 homolog

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 165.8039
    Cell Significance Index: -25.7900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 93.2411
    Cell Significance Index: -23.6500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 80.5321
    Cell Significance Index: -33.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 62.4414
    Cell Significance Index: -29.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 61.5743
    Cell Significance Index: -25.0200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 55.4254
    Cell Significance Index: -28.5100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 44.1416
    Cell Significance Index: -29.6200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.3265
    Cell Significance Index: -25.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.4802
    Cell Significance Index: -28.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.1789
    Cell Significance Index: -21.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.5316
    Cell Significance Index: -29.7200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.4176
    Cell Significance Index: -16.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.1162
    Cell Significance Index: -6.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4974
    Cell Significance Index: 174.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3855
    Cell Significance Index: 1251.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2290
    Cell Significance Index: 73.7800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.1599
    Cell Significance Index: 12.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1252
    Cell Significance Index: 122.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0305
    Cell Significance Index: 21.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9322
    Cell Significance Index: 151.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.8396
    Cell Significance Index: 21.4500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.8274
    Cell Significance Index: 6.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7191
    Cell Significance Index: 24.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5332
    Cell Significance Index: 14.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3987
    Cell Significance Index: 54.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3860
    Cell Significance Index: 170.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3779
    Cell Significance Index: 10.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3762
    Cell Significance Index: 23.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3743
    Cell Significance Index: 204.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3555
    Cell Significance Index: 10.4400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3451
    Cell Significance Index: 4.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3296
    Cell Significance Index: 22.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3110
    Cell Significance Index: 14.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3041
    Cell Significance Index: 60.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3023
    Cell Significance Index: 60.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2954
    Cell Significance Index: 34.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2800
    Cell Significance Index: 19.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2791
    Cell Significance Index: 50.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2782
    Cell Significance Index: 14.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2665
    Cell Significance Index: 34.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2568
    Cell Significance Index: 31.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2124
    Cell Significance Index: 27.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2098
    Cell Significance Index: 9.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2054
    Cell Significance Index: 5.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1902
    Cell Significance Index: 4.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1864
    Cell Significance Index: 8.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1711
    Cell Significance Index: 118.3600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1490
    Cell Significance Index: 1.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1463
    Cell Significance Index: 52.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1393
    Cell Significance Index: 8.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1347
    Cell Significance Index: 10.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1173
    Cell Significance Index: 3.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1108
    Cell Significance Index: 21.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1099
    Cell Significance Index: 18.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1079
    Cell Significance Index: 3.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0737
    Cell Significance Index: 7.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0728
    Cell Significance Index: 3.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0461
    Cell Significance Index: 2.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0443
    Cell Significance Index: 1.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0361
    Cell Significance Index: 1.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0098
    Cell Significance Index: 15.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0058
    Cell Significance Index: 10.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0083
    Cell Significance Index: -5.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0088
    Cell Significance Index: -3.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0143
    Cell Significance Index: -19.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0145
    Cell Significance Index: -10.7700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0169
    Cell Significance Index: -12.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0187
    Cell Significance Index: -13.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0239
    Cell Significance Index: -0.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0257
    Cell Significance Index: -16.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0269
    Cell Significance Index: -2.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0320
    Cell Significance Index: -4.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0331
    Cell Significance Index: -18.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0561
    Cell Significance Index: -1.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0763
    Cell Significance Index: -16.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0848
    Cell Significance Index: -24.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0930
    Cell Significance Index: -10.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1277
    Cell Significance Index: -2.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1539
    Cell Significance Index: -2.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1664
    Cell Significance Index: -10.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2424
    Cell Significance Index: -18.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2525
    Cell Significance Index: -28.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2604
    Cell Significance Index: -14.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2755
    Cell Significance Index: -28.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2927
    Cell Significance Index: -3.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2942
    Cell Significance Index: -19.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3037
    Cell Significance Index: -24.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3606
    Cell Significance Index: -6.1800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.3858
    Cell Significance Index: -2.5100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4395
    Cell Significance Index: -6.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4477
    Cell Significance Index: -11.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4786
    Cell Significance Index: -29.3400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4840
    Cell Significance Index: -5.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4874
    Cell Significance Index: -13.0600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5097
    Cell Significance Index: -5.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5351
    Cell Significance Index: -23.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5833
    Cell Significance Index: -16.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5841
    Cell Significance Index: -12.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6276
    Cell Significance Index: -18.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** VPS72 is a member of the vacuolar protein sorting (VPS) family, which is involved in the sorting of proteins within the endomembrane system. The VPS72 protein is a histone chaperone that interacts with histones, facilitating their assembly and disassembly. This function is critical for chromatin remodeling and regulation of gene expression. VPS72 has been shown to interact with various proteins, including histone acetyltransferases and histone deacetylases, which are involved in chromatin modification and regulation of transcription. **Pathways and Functions** VPS72 is involved in several key cellular pathways, including: 1. **Chromatin Remodeling**: VPS72 interacts with histones and chromatin-modifying enzymes to regulate chromatin structure and gene expression. 2. **DNA- Templated Transcription**: VPS72 is required for the regulation of transcription initiation and elongation, ensuring accurate and efficient gene expression. 3. **Double-Strand Break Repair**: VPS72 plays a crucial role in the repair of double-strand breaks via homologous recombination, ensuring genome stability. 4. **Apoptosis Regulation**: VPS72 is involved in the regulation of the apoptotic process, ensuring that cells undergo programmed cell death in response to DNA damage or other forms of cellular stress. 5. **Cell Cycle Regulation**: VPS72 is required for the regulation of the cell cycle, ensuring that cells progress through the cell cycle in an orderly and coordinated manner. **Clinical Significance** Dysregulation of VPS72 has been implicated in various diseases, including: 1. **Cancer**: Altered expression of VPS72 has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative Diseases**: VPS72 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Immune System Disorders**: VPS72 is required for the regulation of immune responses, and dysregulation has been observed in autoimmune diseases, such as multiple sclerosis. In summary, VPS72 is a critical component of the endomembrane system, playing a significant role in protein sorting, chromatin remodeling, and regulation of cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 870570325

Symbol: VPS72_HUMAN

Name: Vacuolar protein sorting-associated protein 72 homolog

UniProtKB Accession Codes:

Q15906 A6NLK9 A6PW55 Q53GJ2 Q5U0R4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 3 Ensembl 2 ExpressionAtlas 1 GO 20 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7702631

Title: Molecular cloning of a novel human cDNA on chromosome 1q21 and its mouse homolog encoding a nuclear protein with DNA-binding ability.

PubMed ID: 7702631

DOI: 10.1006/bbrc.1995.1433

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14966270

Title: Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.

PubMed ID: 14966270

DOI: 10.1128/mcb.24.5.1884-1896.2004

PubMed ID: 15647280

Title: The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes.

PubMed ID: 15647280

DOI: 10.1074/jbc.m500001200

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 26974126

Title: Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1.

PubMed ID: 26974126

DOI: 10.1038/nsmb.3189

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 364
  • Mass: 40594
  • Checksum: 0AEB90B62B2BCA4A
  • Sequence:
    • MSLAGGRAPR KTAGNRLSGL LEAEEEDEFY QTTYGGFTEE SGDDEYQGDQ SDTEDEVDSD 
FDIDEGDEPS SDGEAEEPRR KRRVVTKAYK EPLKSLRPRK VNTPAGSSQK AREEKALLPL 
ELQDDGSDSR KSMRQSTAEH TRQTFLRVQE RQGQSRRRKG PHCERPLTQE ELLREAKITE 
ELNLRSLETY ERLEADKKKQ VHKKRKCPGP IITYHSVTVP LVGEPGPKEE NVDIEGLDPA 
PSVSALTPHA GTGPVNPPAR CSRTFITFSD DATFEEWFPQ GRPPKVPVRE VCPVTHRPAL 
YRDPVTDIPY ATARAFKIIR EAYKKYITAH GLPPTASALG PGPPPPEPLP GSGPRALRQK 
IVIK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.