Details for: TDG

Gene ID: 6996

Symbol: TDG

Ensembl ID: ENSG00000139372

Description: thymine DNA glycosylase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 214.4071
    Cell Significance Index: -33.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 148.2791
    Cell Significance Index: -37.6100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 93.5244
    Cell Significance Index: -44.1600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 91.1246
    Cell Significance Index: -37.0200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 82.1369
    Cell Significance Index: -42.2500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.1100
    Cell Significance Index: -37.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.0344
    Cell Significance Index: -40.7300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.5767
    Cell Significance Index: -36.3700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.8571
    Cell Significance Index: -42.8400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.2513
    Cell Significance Index: -28.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.5260
    Cell Significance Index: -18.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3239
    Cell Significance Index: 144.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1547
    Cell Significance Index: 187.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0976
    Cell Significance Index: 217.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0366
    Cell Significance Index: 27.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0293
    Cell Significance Index: 206.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8810
    Cell Significance Index: 23.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8130
    Cell Significance Index: 734.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7616
    Cell Significance Index: 415.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7431
    Cell Significance Index: 91.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7251
    Cell Significance Index: 54.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7013
    Cell Significance Index: 20.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6840
    Cell Significance Index: 52.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5953
    Cell Significance Index: 107.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5872
    Cell Significance Index: 80.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5826
    Cell Significance Index: 57.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5707
    Cell Significance Index: 25.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5227
    Cell Significance Index: 61.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5188
    Cell Significance Index: 29.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4895
    Cell Significance Index: 30.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4849
    Cell Significance Index: 25.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4474
    Cell Significance Index: 28.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4470
    Cell Significance Index: 21.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4419
    Cell Significance Index: 195.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4385
    Cell Significance Index: 157.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4173
    Cell Significance Index: 9.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3998
    Cell Significance Index: 51.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3607
    Cell Significance Index: 7.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3591
    Cell Significance Index: 12.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3435
    Cell Significance Index: 44.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3086
    Cell Significance Index: 213.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3063
    Cell Significance Index: 21.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3008
    Cell Significance Index: 20.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1922
    Cell Significance Index: 5.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1710
    Cell Significance Index: 6.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1636
    Cell Significance Index: 31.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1098
    Cell Significance Index: 5.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0669
    Cell Significance Index: 2.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0478
    Cell Significance Index: 3.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0471
    Cell Significance Index: 88.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0423
    Cell Significance Index: 57.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0354
    Cell Significance Index: 0.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0206
    Cell Significance Index: 31.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0164
    Cell Significance Index: 30.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0134
    Cell Significance Index: 8.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0088
    Cell Significance Index: 0.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0054
    Cell Significance Index: 0.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0019
    Cell Significance Index: 0.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0002
    Cell Significance Index: 0.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0232
    Cell Significance Index: -17.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0334
    Cell Significance Index: -25.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0391
    Cell Significance Index: -28.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0498
    Cell Significance Index: -7.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0557
    Cell Significance Index: -1.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0643
    Cell Significance Index: -36.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0660
    Cell Significance Index: -6.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0762
    Cell Significance Index: -1.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0779
    Cell Significance Index: -48.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0906
    Cell Significance Index: -6.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0935
    Cell Significance Index: -1.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1221
    Cell Significance Index: -35.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1233
    Cell Significance Index: -14.3700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1287
    Cell Significance Index: -3.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1295
    Cell Significance Index: -2.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1357
    Cell Significance Index: -3.8900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1703
    Cell Significance Index: -2.0300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1928
    Cell Significance Index: -1.7800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2032
    Cell Significance Index: -4.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2080
    Cell Significance Index: -10.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2147
    Cell Significance Index: -45.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2329
    Cell Significance Index: -5.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2599
    Cell Significance Index: -29.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2639
    Cell Significance Index: -5.1500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3081
    Cell Significance Index: -3.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3502
    Cell Significance Index: -36.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3591
    Cell Significance Index: -4.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4692
    Cell Significance Index: -37.1600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4860
    Cell Significance Index: -3.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4992
    Cell Significance Index: -7.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5019
    Cell Significance Index: -12.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5036
    Cell Significance Index: -16.1300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5597
    Cell Significance Index: -10.3500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5611
    Cell Significance Index: -3.3900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5984
    Cell Significance Index: -4.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6055
    Cell Significance Index: -16.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6206
    Cell Significance Index: -38.0500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6947
    Cell Significance Index: -16.0500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.6971
    Cell Significance Index: -4.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.7262
    Cell Significance Index: -8.2500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8088
    Cell Significance Index: -25.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TDG is a member of the glycosylase family, specifically a pyrimidine-specific mismatch base pair DNA N-glycosylase. It exhibits a unique ability to recognize and cleave thymine and uracil residues, which are commonly found in damaged DNA. TDG is a multifunctional enzyme, capable of interacting with various proteins, including transcription factors, kinases, and SUMO E3 ligases. Its expression is widespread, with significant levels found in cells of the nervous system, immune system, and epithelial tissues. **Pathways and Functions:** TDG is integral to the BER pathway, which involves the recognition, cleavage, and removal of damaged DNA bases. The enzyme plays a crucial role in the repair of thymine and uracil residues, which are often introduced by oxidative stress, alkylation, or deamination. TDG's functions can be broadly categorized into three main processes: 1. **Recognition and Cleavage**: TDG recognizes damaged thymine and uracil residues, leading to their cleavage and removal from the DNA strand. 2. **Association with DNA Damage Response Proteins**: TDG interacts with other proteins, such as SUMO E3 ligases, to facilitate the repair of damaged DNA. 3. **Regulation of Gene Expression**: TDG regulates gene expression by interacting with transcription factors, thereby influencing the expression of genes involved in DNA repair and cell cycle regulation. **Clinical Significance:** TDG's dysregulation has been implicated in various diseases, including: 1. **Cancer**: TDG mutations have been linked to cancer development, as they can lead to the accumulation of damaged DNA and the activation of oncogenes. 2. **Neurodegenerative Diseases**: TDG's involvement in the repair of damaged DNA has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Immune System Disorders**: TDG's role in the repair of damaged DNA has been implicated in immune system disorders, such as autoimmune diseases and immunodeficiency syndromes. In conclusion, TDG is a vital enzyme involved in the maintenance of genome stability and the prevention of mutations. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its functions and clinical significance. Further research is necessary to elucidate the mechanisms underlying TDG's role in human health and disease. **References:** * [Insert references to relevant studies and research articles on TDG] Note: The references provided should be up-to-date and relevant to the discussion on TDG. The references can be added to the article as needed.

Genular Protein ID: 3480616918

Symbol: TDG_HUMAN

Name: G/T mismatch-specific thymine DNA glycosylase

UniProtKB Accession Codes:

Q13569 Q8IUZ6 Q8IZM3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EC 2 ELM 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 21 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8662714

Title: Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase.

PubMed ID: 8662714

DOI: 10.1074/jbc.271.22.12767

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8127859

Title: Efficient removal of uracil from G.U mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells.

PubMed ID: 8127859

DOI: 10.1073/pnas.91.5.1642

PubMed ID: 8407958

Title: The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells.

PubMed ID: 8407958

DOI: 10.1016/s0021-9258(19)36913-3

PubMed ID: 11889051

Title: Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover.

PubMed ID: 11889051

DOI: 10.1093/emboj/21.6.1456

PubMed ID: 21722948

Title: Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair.

PubMed ID: 21722948

DOI: 10.1016/j.cell.2011.06.020

PubMed ID: 21862836

Title: Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites.

PubMed ID: 21862836

DOI: 10.1074/jbc.c111.284620

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 15959518

Title: Crystal structure of thymine DNA glycosylase conjugated to SUMO-1.

PubMed ID: 15959518

DOI: 10.1038/nature03634

PubMed ID: 16626738

Title: Crystal structure of SUMO-3-modified thymine-DNA glycosylase.

PubMed ID: 16626738

DOI: 10.1016/j.jmb.2006.03.036

PubMed ID: 18587051

Title: Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition.

PubMed ID: 18587051

DOI: 10.1073/pnas.0711061105

PubMed ID: 22327402

Title: Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA.

PubMed ID: 22327402

DOI: 10.1038/nchembio.914

PubMed ID: 22962365

Title: Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation.

PubMed ID: 22962365

DOI: 10.1093/nar/gks845

PubMed ID: 22573813

Title: Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA.

PubMed ID: 22573813

DOI: 10.1073/pnas.1201010109

Sequence Information:

  • Length: 410
  • Mass: 46053
  • Checksum: 33752B26EBC789AE
  • Sequence:
    • MEAENAGSYS LQQAQAFYTF PFQQLMAEAP NMAVVNEQQM PEEVPAPAPA QEPVQEAPKG 
RKRKPRTTEP KQPVEPKKPV ESKKSGKSAK SKEKQEKITD TFKVKRKVDR FNGVSEAELL 
TKTLPDILTF NLDIVIIGIN PGLMAAYKGH HYPGPGNHFW KCLFMSGLSE VQLNHMDDHT 
LPGKYGIGFT NMVERTTPGS KDLSSKEFRE GGRILVQKLQ KYQPRIAVFN GKCIYEIFSK 
EVFGVKVKNL EFGLQPHKIP DTETLCYVMP SSSARCAQFP RAQDKVHYYI KLKDLRDQLK 
GIERNMDVQE VQYTFDLQLA QEDAKKMAVK EEKYDPGYEA AYGGAYGENP CSSEPCGFSS 
NGLIESVELR GESAFSGIPN GQWMTQSFTD QIPSFSNHCG TQEQEEESHA

Genular Protein ID: 3681651392

Symbol: B4E127_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E127

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 4 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 Proteomes 2 ProteomicsDB 2 RefSeq 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.O114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 267
  • Mass: 30151
  • Checksum: 3AABA331B277FAD8
  • Sequence:
    • MAAYKGHHYP GPGNHFWKCL FMSGLSEVQL NHMDDHTLPG KYGIGFTNMV ERTTPGSKDL 
SSKEFREGGR ILVQKLQKYQ PRIAVFNGKC IYEIFSKEVF GVKVKNLEFG LQPHKIPDTE 
TLCYVMPSSS ARCAQFPRAQ DKVHYYIKLK DLRDQLKGIE RNMDVQEVQY TFDLQLAQED 
AKKMAVKEEK YDPGYEAAYG GAYGENPCSS EPCGFSSNGL IESVELRGES AFSGIPNGQW 
MTQSFTDQIP SFSNHCGTQE QEEESHA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.