Details for: PRDX2

Gene ID: 7001

Symbol: PRDX2

Ensembl ID: ENSG00000167815

Description: peroxiredoxin 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 5.41
    Marker Score: 1587
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.04
    Marker Score: 4874
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.61
    Marker Score: 3409
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 3.59
    Marker Score: 14968.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.33
    Marker Score: 59123
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.26
    Marker Score: 1073
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.25
    Marker Score: 8708
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.24
    Marker Score: 1194
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.23
    Marker Score: 42538
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.15
    Marker Score: 6396
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.14
    Marker Score: 20454
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.1
    Marker Score: 107246
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.06
    Marker Score: 22804
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.97
    Marker Score: 4929
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.94
    Marker Score: 22955
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.89
    Marker Score: 1818
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.87
    Marker Score: 8196
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.83
    Marker Score: 5908
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.8
    Marker Score: 10785
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.79
    Marker Score: 4581.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.79
    Marker Score: 4297
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.79
    Marker Score: 6358
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.77
    Marker Score: 2471
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.73
    Marker Score: 23571
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.72
    Marker Score: 13054
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.72
    Marker Score: 3053
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.71
    Marker Score: 6380
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.7
    Marker Score: 7336
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.69
    Marker Score: 1926
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.68
    Marker Score: 2714
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.67
    Marker Score: 3775
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.66
    Marker Score: 1062
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.66
    Marker Score: 9431
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.63
    Marker Score: 2473.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.61
    Marker Score: 2789
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.58
    Marker Score: 3645
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.57
    Marker Score: 16445
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 2.56
    Marker Score: 1430
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.55
    Marker Score: 1512
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.54
    Marker Score: 2541
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.53
    Marker Score: 753
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.52
    Marker Score: 1792
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.52
    Marker Score: 28379.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.52
    Marker Score: 1257.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.5
    Marker Score: 2088
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.49
    Marker Score: 2122.5
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.47
    Marker Score: 1274
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.47
    Marker Score: 24847.5
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.46
    Marker Score: 3961
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.46
    Marker Score: 10561
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.45
    Marker Score: 24298
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.45
    Marker Score: 7704
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.45
    Marker Score: 2597
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.45
    Marker Score: 2599
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.44
    Marker Score: 4580
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.44
    Marker Score: 1626
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.43
    Marker Score: 1147
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.42
    Marker Score: 5919.5
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.41
    Marker Score: 810
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.4
    Marker Score: 8872.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.38
    Marker Score: 886
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.37
    Marker Score: 3645
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.36
    Marker Score: 5349.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.36
    Marker Score: 756
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.34
    Marker Score: 10074
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.33
    Marker Score: 3700.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.32
    Marker Score: 2498
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.31
    Marker Score: 2445
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.3
    Marker Score: 5469
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.3
    Marker Score: 5648
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.29
    Marker Score: 1186
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.28
    Marker Score: 1064
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.28
    Marker Score: 26463
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.27
    Marker Score: 11925
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.26
    Marker Score: 4010
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.26
    Marker Score: 2414.5
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.26
    Marker Score: 2938
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2.25
    Marker Score: 779.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.25
    Marker Score: 8832.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.24
    Marker Score: 1477
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.24
    Marker Score: 849
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 2.24
    Marker Score: 1107
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.2
    Marker Score: 1470
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.19
    Marker Score: 756
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.19
    Marker Score: 529
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.19
    Marker Score: 3219.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.19
    Marker Score: 115556
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.18
    Marker Score: 1855
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.18
    Marker Score: 12956
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.18
    Marker Score: 912
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.18
    Marker Score: 2291
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.17
    Marker Score: 14150
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.16
    Marker Score: 13799
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 2.16
    Marker Score: 1347.5
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.16
    Marker Score: 1692
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.15
    Marker Score: 622
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.15
    Marker Score: 5428
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.14
    Marker Score: 4197
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.13
    Marker Score: 4252
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.12
    Marker Score: 1981

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Other Information

**Key characteristics** PRDX2 is a small, cytosolic enzyme that belongs to the peroxiredoxin family. It is a thioredoxin peroxidase, which means it uses thioredoxin as a reducing agent to reduce hydrogen peroxide and other ROS. PRDX2 has a high affinity for hydrogen peroxide, allowing it to effectively neutralize this toxic molecule. The enzyme is also capable of reducing other ROS, such as superoxide radicals, and has been shown to play a role in regulating the activity of various signaling pathways. **Pathways and functions** PRDX2 has been implicated in several cellular pathways, including: 1. **Antioxidant activity**: PRDX2 catalyzes the reduction of hydrogen peroxide and other ROS, thereby protecting cells from oxidative damage. 2. **Cell redox homeostasis**: PRDX2 helps maintain cellular redox balance by regulating the levels of ROS and reactive nitrogen species (RNS). 3. **Apoptosis**: PRDX2 has been shown to regulate apoptosis by reducing ROS and modulating the activity of pro-apoptotic and anti-apoptotic proteins. 4. **Cell proliferation and differentiation**: PRDX2 has been implicated in regulating cell proliferation and differentiation in various cell types, including neurons and smooth muscle cells. 5. **Response to oxidative stress**: PRDX2 plays a crucial role in responding to oxidative stress by regulating the activity of various signaling pathways and enzymes involved in ROS detoxification. 6. **Regulation of signaling pathways**: PRDX2 has been shown to regulate the activity of various signaling pathways, including the MAPK cascade, NF-κB, and JAK/STAT pathways. **Clinical significance** PRDX2 has been implicated in several diseases, including: 1. **Alzheimer's disease**: PRDX2 has been shown to play a role in regulating the activity of various signaling pathways involved in neurodegeneration. 2. **Neurodegenerative diseases**: PRDX2 has been implicated in the pathogenesis of various neurodegenerative diseases, including Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cancer**: PRDX2 has been shown to regulate cell proliferation and differentiation in various cancer cell types, including breast, lung, and colon cancer. 4. **Cardiovascular disease**: PRDX2 has been implicated in the pathogenesis of cardiovascular disease, including atherosclerosis and heart failure. 5. **Neurodevelopmental disorders**: PRDX2 has been shown to play a role in regulating the activity of various signaling pathways involved in neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In conclusion, PRDX2 is a critical enzyme involved in maintaining cellular redox homeostasis and regulating various cellular processes, including apoptosis, cell proliferation, differentiation, and responses to oxidative stress. Its dysregulation has been implicated in several diseases, highlighting its potential as a therapeutic target for the treatment of various diseases.

Genular Protein ID: 3342656669

Symbol: PRDX2_HUMAN

Name: Peroxiredoxin-2

UniProtKB Accession Codes:

P32119 A8K0C0 P31945 P32118 P35701 Q6FHG4 Q92763 Q9UC23

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 7 CPTC 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 12 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 7 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PeroxiBase 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8144038

Title: The thiol-specific antioxidant protein from human brain: gene cloning and analysis of conserved cysteine regions.

PubMed ID: 8144038

DOI: 10.1016/0378-1119(94)90558-4

PubMed ID: 8026862

Title: Cloning and sequence analysis of candidate human natural killer-enhancing factor genes.

PubMed ID: 8026862

DOI: 10.1007/bf00188176

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8554614

Title: Thioredoxin-linked peroxidase from human red blood cell: evidence for the existence of thioredoxin and thioredoxin reductase in human red blood cell.

PubMed ID: 8554614

DOI: 10.1006/bbrc.1995.2856

PubMed ID: 8313871

Title: Plasma and red blood cell protein maps: update 1993.

PubMed ID: 8313871

DOI: 10.1002/elps.11501401183

PubMed ID: 9150948

Title: A two-dimensional gel database of human colon carcinoma proteins.

PubMed ID: 9150948

DOI: 10.1002/elps.1150180344

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 9497357

Title: Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha.

PubMed ID: 9497357

DOI: 10.1074/jbc.273.11.6297

PubMed ID: 11904290

Title: Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site.

PubMed ID: 11904290

DOI: 10.1074/jbc.m106585200

PubMed ID: 12853451

Title: Regeneration of peroxiredoxins during recovery after oxidative stress: only some overoxidized peroxiredoxins can be reduced during recovery after oxidative stress.

PubMed ID: 12853451

DOI: 10.1074/jbc.m305161200

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17141802

Title: Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors.

PubMed ID: 17141802

DOI: 10.1016/j.jmb.2006.10.097

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10873855

Title: Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7 A resolution.

PubMed ID: 10873855

DOI: 10.1016/s0969-2126(00)00147-7

PubMed ID: 27892488

Title: Transition steps in peroxide reduction and a molecular switch for peroxide robustness of prokaryotic peroxiredoxins.

PubMed ID: 27892488

DOI: 10.1038/srep37610

Sequence Information:

  • Length: 198
  • Mass: 21892
  • Checksum: 1AC781D908B32B46
  • Sequence:
    • MASGNARIGK PAPDFKATAV VDGAFKEVKL SDYKGKYVVL FFYPLDFTFV CPTEIIAFSN 
RAEDFRKLGC EVLGVSVDSQ FTHLAWINTP RKEGGLGPLN IPLLADVTRR LSEDYGVLKT 
DEGIAYRGLF IIDGKGVLRQ ITVNDLPVGR SVDEALRLVQ AFQYTDEHGE VCPAGWKPGS 
DTIKPNVDDS KEYFSKHN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.