Details for: PRDX2

Gene ID: 7001

Symbol: PRDX2

Ensembl ID: ENSG00000167815

Description: peroxiredoxin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 343.1590
    Cell Significance Index: -87.0400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 269.5003
    Cell Significance Index: -111.0200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 232.3337
    Cell Significance Index: -109.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 207.3835
    Cell Significance Index: -106.6800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 164.0780
    Cell Significance Index: -110.1000
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 86.2772
    Cell Significance Index: -13.4200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 57.4798
    Cell Significance Index: -70.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 28.0787
    Cell Significance Index: -110.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 27.1123
    Cell Significance Index: -72.6300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.6849
    Cell Significance Index: -78.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 8.0562
    Cell Significance Index: 422.9800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 7.3908
    Cell Significance Index: 59.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 6.9527
    Cell Significance Index: 182.8200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 6.0068
    Cell Significance Index: 46.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 5.9822
    Cell Significance Index: 207.8800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 5.7323
    Cell Significance Index: 48.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.8453
    Cell Significance Index: 101.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.7134
    Cell Significance Index: 219.7600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.6085
    Cell Significance Index: 50.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 4.2887
    Cell Significance Index: 1233.9800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.9239
    Cell Significance Index: 57.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.8753
    Cell Significance Index: 2116.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.8277
    Cell Significance Index: 525.6500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.8257
    Cell Significance Index: 49.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.3945
    Cell Significance Index: 417.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.2321
    Cell Significance Index: 582.6500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.1305
    Cell Significance Index: 91.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.8086
    Cell Significance Index: 209.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.6077
    Cell Significance Index: 184.4300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.4105
    Cell Significance Index: 55.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.4025
    Cell Significance Index: 1062.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.3709
    Cell Significance Index: 26.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.0725
    Cell Significance Index: 337.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.9097
    Cell Significance Index: 89.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.7414
    Cell Significance Index: 223.2400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7049
    Cell Significance Index: 15.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.7037
    Cell Significance Index: 220.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.5307
    Cell Significance Index: 41.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.4196
    Cell Significance Index: 89.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3735
    Cell Significance Index: 71.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2829
    Cell Significance Index: 34.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1036
    Cell Significance Index: 23.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8566
    Cell Significance Index: 171.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8552
    Cell Significance Index: 100.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8097
    Cell Significance Index: 56.0000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.7864
    Cell Significance Index: 4.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6581
    Cell Significance Index: 112.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.6105
    Cell Significance Index: 447.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4748
    Cell Significance Index: 170.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.4009
    Cell Significance Index: 31.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2439
    Cell Significance Index: 46.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1999
    Cell Significance Index: 151.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1970
    Cell Significance Index: 8.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1721
    Cell Significance Index: 2.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1315
    Cell Significance Index: 4.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0657
    Cell Significance Index: 4.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0648
    Cell Significance Index: 3.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0369
    Cell Significance Index: 2.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0208
    Cell Significance Index: 2.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0205
    Cell Significance Index: 14.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0310
    Cell Significance Index: -22.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0469
    Cell Significance Index: -2.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0522
    Cell Significance Index: -98.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0709
    Cell Significance Index: -130.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0849
    Cell Significance Index: -130.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0971
    Cell Significance Index: -132.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1186
    Cell Significance Index: -74.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1377
    Cell Significance Index: -77.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1455
    Cell Significance Index: -92.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1616
    Cell Significance Index: -16.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1937
    Cell Significance Index: -7.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2086
    Cell Significance Index: -5.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2138
    Cell Significance Index: -24.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2295
    Cell Significance Index: -104.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2328
    Cell Significance Index: -49.0400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2640
    Cell Significance Index: -2.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5734
    Cell Significance Index: -66.8200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6165
    Cell Significance Index: -15.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6330
    Cell Significance Index: -35.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7153
    Cell Significance Index: -103.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7849
    Cell Significance Index: -25.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8168
    Cell Significance Index: -62.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.0156
    Cell Significance Index: -115.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0727
    Cell Significance Index: -111.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.1567
    Cell Significance Index: -30.9400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.1588
    Cell Significance Index: -7.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.2402
    Cell Significance Index: -35.5500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.4521
    Cell Significance Index: -25.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6484
    Cell Significance Index: -101.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.7433
    Cell Significance Index: -90.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.7591
    Cell Significance Index: -24.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.7929
    Cell Significance Index: -52.8100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -1.8311
    Cell Significance Index: -16.1300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -1.8319
    Cell Significance Index: -17.4300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -1.9828
    Cell Significance Index: -22.4000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -2.0637
    Cell Significance Index: -24.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.1544
    Cell Significance Index: -36.9200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -2.1984
    Cell Significance Index: -45.8500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -2.2115
    Cell Significance Index: -13.6100
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -2.2853
    Cell Significance Index: -12.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key characteristics** PRDX2 is a small, cytosolic enzyme that belongs to the peroxiredoxin family. It is a thioredoxin peroxidase, which means it uses thioredoxin as a reducing agent to reduce hydrogen peroxide and other ROS. PRDX2 has a high affinity for hydrogen peroxide, allowing it to effectively neutralize this toxic molecule. The enzyme is also capable of reducing other ROS, such as superoxide radicals, and has been shown to play a role in regulating the activity of various signaling pathways. **Pathways and functions** PRDX2 has been implicated in several cellular pathways, including: 1. **Antioxidant activity**: PRDX2 catalyzes the reduction of hydrogen peroxide and other ROS, thereby protecting cells from oxidative damage. 2. **Cell redox homeostasis**: PRDX2 helps maintain cellular redox balance by regulating the levels of ROS and reactive nitrogen species (RNS). 3. **Apoptosis**: PRDX2 has been shown to regulate apoptosis by reducing ROS and modulating the activity of pro-apoptotic and anti-apoptotic proteins. 4. **Cell proliferation and differentiation**: PRDX2 has been implicated in regulating cell proliferation and differentiation in various cell types, including neurons and smooth muscle cells. 5. **Response to oxidative stress**: PRDX2 plays a crucial role in responding to oxidative stress by regulating the activity of various signaling pathways and enzymes involved in ROS detoxification. 6. **Regulation of signaling pathways**: PRDX2 has been shown to regulate the activity of various signaling pathways, including the MAPK cascade, NF-κB, and JAK/STAT pathways. **Clinical significance** PRDX2 has been implicated in several diseases, including: 1. **Alzheimer's disease**: PRDX2 has been shown to play a role in regulating the activity of various signaling pathways involved in neurodegeneration. 2. **Neurodegenerative diseases**: PRDX2 has been implicated in the pathogenesis of various neurodegenerative diseases, including Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cancer**: PRDX2 has been shown to regulate cell proliferation and differentiation in various cancer cell types, including breast, lung, and colon cancer. 4. **Cardiovascular disease**: PRDX2 has been implicated in the pathogenesis of cardiovascular disease, including atherosclerosis and heart failure. 5. **Neurodevelopmental disorders**: PRDX2 has been shown to play a role in regulating the activity of various signaling pathways involved in neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In conclusion, PRDX2 is a critical enzyme involved in maintaining cellular redox homeostasis and regulating various cellular processes, including apoptosis, cell proliferation, differentiation, and responses to oxidative stress. Its dysregulation has been implicated in several diseases, highlighting its potential as a therapeutic target for the treatment of various diseases.

Genular Protein ID: 3342656669

Symbol: PRDX2_HUMAN

Name: Peroxiredoxin-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8144038

Title: The thiol-specific antioxidant protein from human brain: gene cloning and analysis of conserved cysteine regions.

PubMed ID: 8144038

DOI: 10.1016/0378-1119(94)90558-4

PubMed ID: 8026862

Title: Cloning and sequence analysis of candidate human natural killer-enhancing factor genes.

PubMed ID: 8026862

DOI: 10.1007/bf00188176

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8554614

Title: Thioredoxin-linked peroxidase from human red blood cell: evidence for the existence of thioredoxin and thioredoxin reductase in human red blood cell.

PubMed ID: 8554614

DOI: 10.1006/bbrc.1995.2856

PubMed ID: 8313871

Title: Plasma and red blood cell protein maps: update 1993.

PubMed ID: 8313871

DOI: 10.1002/elps.11501401183

PubMed ID: 9150948

Title: A two-dimensional gel database of human colon carcinoma proteins.

PubMed ID: 9150948

DOI: 10.1002/elps.1150180344

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 9497357

Title: Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha.

PubMed ID: 9497357

DOI: 10.1074/jbc.273.11.6297

PubMed ID: 11904290

Title: Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site.

PubMed ID: 11904290

DOI: 10.1074/jbc.m106585200

PubMed ID: 12853451

Title: Regeneration of peroxiredoxins during recovery after oxidative stress: only some overoxidized peroxiredoxins can be reduced during recovery after oxidative stress.

PubMed ID: 12853451

DOI: 10.1074/jbc.m305161200

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17141802

Title: Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors.

PubMed ID: 17141802

DOI: 10.1016/j.jmb.2006.10.097

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10873855

Title: Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7 A resolution.

PubMed ID: 10873855

DOI: 10.1016/s0969-2126(00)00147-7

PubMed ID: 27892488

Title: Transition steps in peroxide reduction and a molecular switch for peroxide robustness of prokaryotic peroxiredoxins.

PubMed ID: 27892488

DOI: 10.1038/srep37610

Sequence Information:

  • Length: 198
  • Mass: 21892
  • Checksum: 1AC781D908B32B46
  • Sequence:
  • MASGNARIGK PAPDFKATAV VDGAFKEVKL SDYKGKYVVL FFYPLDFTFV CPTEIIAFSN 
    RAEDFRKLGC EVLGVSVDSQ FTHLAWINTP RKEGGLGPLN IPLLADVTRR LSEDYGVLKT 
    DEGIAYRGLF IIDGKGVLRQ ITVNDLPVGR SVDEALRLVQ AFQYTDEHGE VCPAGWKPGS 
    DTIKPNVDDS KEYFSKHN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.