Details for: NR2F2

Gene ID: 7026

Symbol: NR2F2

Ensembl ID: ENSG00000185551

Description: nuclear receptor subfamily 2 group F member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.92
    Marker Score: 3735.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.35
    Marker Score: 21779
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.16
    Marker Score: 2248
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.02
    Marker Score: 5667
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.01
    Marker Score: 1700
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.93
    Marker Score: 5634
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.91
    Marker Score: 32726
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.68
    Marker Score: 3082
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.63
    Marker Score: 5485
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.59
    Marker Score: 3369
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.55
    Marker Score: 1384
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.44
    Marker Score: 2590
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.35
    Marker Score: 5403
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.31
    Marker Score: 3919
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.28
    Marker Score: 2461
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.2
    Marker Score: 921
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.12
    Marker Score: 16286
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.11
    Marker Score: 1388
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.1
    Marker Score: 5625
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.07
    Marker Score: 1209
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.98
    Marker Score: 19959
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.98
    Marker Score: 1417
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.96
    Marker Score: 8445.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.86
    Marker Score: 4699
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.84
    Marker Score: 1229
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.81
    Marker Score: 439
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.8
    Marker Score: 3959
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.79
    Marker Score: 2763
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.78
    Marker Score: 665
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.78
    Marker Score: 6997
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.77
    Marker Score: 23363
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.75
    Marker Score: 3504
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.72
    Marker Score: 366
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.7
    Marker Score: 1058
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.69
    Marker Score: 389
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.68
    Marker Score: 6502
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.65
    Marker Score: 816
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.62
    Marker Score: 3989
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.59
    Marker Score: 54960
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.57
    Marker Score: 59675.5
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.57
    Marker Score: 1658
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.57
    Marker Score: 5564
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.56
    Marker Score: 1651
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.55
    Marker Score: 339
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.54
    Marker Score: 794
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.52
    Marker Score: 1300
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.51
    Marker Score: 1527
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.5
    Marker Score: 3938
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.48
    Marker Score: 1340
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.42
    Marker Score: 1757
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.39
    Marker Score: 1341
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.38
    Marker Score: 390
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.35
    Marker Score: 1399
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.34
    Marker Score: 894
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.34
    Marker Score: 343
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.34
    Marker Score: 850
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.33
    Marker Score: 3024
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.33
    Marker Score: 553
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.32
    Marker Score: 310
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.31
    Marker Score: 11418
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.31
    Marker Score: 645
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.31
    Marker Score: 314
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.3
    Marker Score: 1069.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.28
    Marker Score: 1755
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.26
    Marker Score: 365
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.24
    Marker Score: 1309
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.24
    Marker Score: 1754
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.23
    Marker Score: 1064
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.23
    Marker Score: 2890
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.22
    Marker Score: 41473
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.22
    Marker Score: 310
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.21
    Marker Score: 1309
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.16
    Marker Score: 259
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.16
    Marker Score: 1039
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.15
    Marker Score: 2697
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.12
    Marker Score: 8345.5
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.12
    Marker Score: 513
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.11
    Marker Score: 7092
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.1
    Marker Score: 1827
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.1
    Marker Score: 270.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.06
    Marker Score: 1533
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.05
    Marker Score: 244
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251691
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.04
    Marker Score: 536
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.03
    Marker Score: 303
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.02
    Marker Score: 372
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.02
    Marker Score: 269
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.02
    Marker Score: 1941
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.02
    Marker Score: 380
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.01
    Marker Score: 1310
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.01
    Marker Score: 1083
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.01
    Marker Score: 381
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.01
    Marker Score: 1709
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.01
    Marker Score: 1077
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.01
    Marker Score: 1482
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1
    Marker Score: 553
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71711
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1
    Marker Score: 377
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47935
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.99
    Marker Score: 478

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Other Information

**Key Characteristics** NR2F2 is a member of the nuclear receptor subfamily 2 group F, which is characterized by the presence of a specific ligand-binding domain. The gene is primarily expressed in cells of mesodermal origin, including pericytes, fibroblasts, and smooth muscle cells. NR2F2 is activated by the binding of specific ligands, such as estradiol and retinoic acid, which triggers a transcriptional response that regulates the expression of target genes. **Pathways and Functions** NR2F2 is involved in various signaling pathways, including: 1. **Cell differentiation**: NR2F2 regulates the expression of genes involved in cell differentiation, including those involved in the development of the immune system. 2. **Intracellular signaling**: NR2F2 interacts with other transcription factors and signaling molecules to regulate the expression of target genes. 3. **Transcriptional regulation**: NR2F2 acts as a transcription factor to regulate the expression of genes involved in cell growth, survival, and differentiation. 4. **Endothelial cell function**: NR2F2 is involved in the regulation of endothelial cell function, including cell migration, proliferation, and differentiation. **Clinical Significance** Dysregulation of NR2F2 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: NR2F2 has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: NR2F2 has been shown to regulate the expression of genes involved in cancer cell growth and survival. 3. **Inflammation**: NR2F2 is involved in the regulation of inflammatory responses, including the expression of genes involved in immune cell function. 4. **Immunodeficiency**: NR2F2 has been implicated in the pathogenesis of immunodeficiency disorders, such as chronic lymphocytic leukemia. In conclusion, NR2F2 is a critical transcription factor that plays a significant role in the regulation of immune system function and development. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of further research into the molecular mechanisms underlying NR2F2 function. **Implications for Immunology** The study of NR2F2 has significant implications for our understanding of immune system function and regulation. Further research into the molecular mechanisms underlying NR2F2 function could lead to the development of new therapeutic strategies for immune-related disorders. Additionally, the identification of NR2F2 as a key regulator of immune cell function highlights the importance of considering the role of transcription factors in the regulation of immune responses. **Future Directions** Future research should focus on the following areas: 1. **Mechanistic studies**: Further studies are needed to elucidate the molecular mechanisms underlying NR2F2 function. 2. **Clinical studies**: Clinical studies are needed to investigate the role of NR2F2 in immune-related disorders. 3. **Therapeutic strategies**: Research should focus on developing new therapeutic strategies that target NR2F2 or its downstream targets. In conclusion, NR2F2 is a critical transcription factor that plays a significant role in the regulation of immune system function and development. Further research into the molecular mechanisms underlying NR2F2 function could lead to the development of new therapeutic strategies for immune-related disorders.

Genular Protein ID: 2083949566

Symbol: COT2_HUMAN

Name: COUP transcription factor 2

UniProtKB Accession Codes:

P24468 B4DQJ2 B6ZGU1 Q03754 Q3KQR7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1899293

Title: Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily.

PubMed ID: 1899293

DOI: 10.1126/science.1899293

PubMed ID: 18619963

Title: DNA-binding profiling of human hormone nuclear receptors via fluorescence correlation spectroscopy in a cell-free system.

PubMed ID: 18619963

DOI: 10.1016/j.febslet.2008.07.003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1820218

Title: The COUP-TFs compose a family of functionally related transcription factors.

PubMed ID: 1820218

PubMed ID: 9343308

Title: The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter.

PubMed ID: 9343308

DOI: 10.1677/jme.0.0190163

PubMed ID: 10318855

Title: Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2.

PubMed ID: 10318855

DOI: 10.1074/jbc.274.20.14331

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29478779

Title: Loss of function of the nuclear receptor NR2F2, encoding COUP-TF2, causes testis development and cardiac defects in 46,XX children.

PubMed ID: 29478779

DOI: 10.1016/j.ajhg.2018.01.021

PubMed ID: 18798693

Title: Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor.

PubMed ID: 18798693

DOI: 10.1371/journal.pbio.0060227

PubMed ID: 24702954

Title: Rare variants in NR2F2 cause congenital heart defects in humans.

PubMed ID: 24702954

DOI: 10.1016/j.ajhg.2014.03.007

Sequence Information:

  • Length: 414
  • Mass: 45571
  • Checksum: C24CB2E8C8A27E8C
  • Sequence:
    • MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS TPAQTAAGGQ 
GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK SFFKRSVRRN LSYTCRANRN 
CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ RGRMPPTQPT HGQFALTNGD PLNCHSYLSG 
YISLLLRAEP YPTSRFGSQC MQPNNIMGIE NICELAARML FSAVEWARNI PFFPDLQITD 
QVALLRLTWS ELFVLNAAQC SMPLHVAPLL AAAGLHASPM SADRVVAFMD HIRIFQEQVE 
KLKALHVDSA EYSCLKAIVL FTSDACGLSD VAHVESLQEK SQCALEEYVR SQYPNQPTRF 
GKLLLRLPSL RTVSSSVIEQ LFFVRLVGKT PIETLIRDML LSGSSFNWPY MAIQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.