Details for: NR2F2

Gene ID: 7026

Symbol: NR2F2

Ensembl ID: ENSG00000185551

Description: nuclear receptor subfamily 2 group F member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 113.8688
    Cell Significance Index: -46.2600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 109.1771
    Cell Significance Index: -51.5500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 77.1510
    Cell Significance Index: -51.7700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.4947
    Cell Significance Index: -46.3000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 10.7436
    Cell Significance Index: 137.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 6.2585
    Cell Significance Index: 217.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 5.8624
    Cell Significance Index: 805.0700
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 5.1853
    Cell Significance Index: 23.9500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.8678
    Cell Significance Index: 43.9400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.1711
    Cell Significance Index: 18.6300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 2.6022
    Cell Significance Index: 12.0200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.1323
    Cell Significance Index: 17.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2906
    Cell Significance Index: 462.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0786
    Cell Significance Index: 589.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0776
    Cell Significance Index: 117.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9769
    Cell Significance Index: 193.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9044
    Cell Significance Index: 24.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7777
    Cell Significance Index: 140.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6935
    Cell Significance Index: 85.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6579
    Cell Significance Index: 34.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5673
    Cell Significance Index: 34.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5587
    Cell Significance Index: 90.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5553
    Cell Significance Index: 501.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5240
    Cell Significance Index: 36.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4758
    Cell Significance Index: 12.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2096
    Cell Significance Index: 6.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1497
    Cell Significance Index: 2.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1455
    Cell Significance Index: 106.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1328
    Cell Significance Index: 3.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1160
    Cell Significance Index: 52.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1061
    Cell Significance Index: 3.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1018
    Cell Significance Index: 13.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0960
    Cell Significance Index: 18.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0928
    Cell Significance Index: 2.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0547
    Cell Significance Index: 5.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0185
    Cell Significance Index: 0.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0140
    Cell Significance Index: 6.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0105
    Cell Significance Index: 1.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0029
    Cell Significance Index: 0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0070
    Cell Significance Index: -13.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0186
    Cell Significance Index: -13.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0362
    Cell Significance Index: -66.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0410
    Cell Significance Index: -25.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0432
    Cell Significance Index: -66.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0442
    Cell Significance Index: -2.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0464
    Cell Significance Index: -1.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0464
    Cell Significance Index: -32.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0491
    Cell Significance Index: -66.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0509
    Cell Significance Index: -32.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0569
    Cell Significance Index: -43.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0744
    Cell Significance Index: -41.9800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0976
    Cell Significance Index: -0.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1280
    Cell Significance Index: -9.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1332
    Cell Significance Index: -6.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1360
    Cell Significance Index: -6.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1376
    Cell Significance Index: -16.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1389
    Cell Significance Index: -17.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1564
    Cell Significance Index: -32.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1714
    Cell Significance Index: -49.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1877
    Cell Significance Index: -37.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1980
    Cell Significance Index: -20.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2263
    Cell Significance Index: -32.8900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2523
    Cell Significance Index: -6.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2667
    Cell Significance Index: -5.6800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2889
    Cell Significance Index: -5.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3086
    Cell Significance Index: -24.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3226
    Cell Significance Index: -36.9600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3288
    Cell Significance Index: -6.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3486
    Cell Significance Index: -18.1100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3700
    Cell Significance Index: -42.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4228
    Cell Significance Index: -31.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4286
    Cell Significance Index: -22.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4346
    Cell Significance Index: -24.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4467
    Cell Significance Index: -52.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4674
    Cell Significance Index: -48.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5143
    Cell Significance Index: -14.0000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5184
    Cell Significance Index: -11.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6188
    Cell Significance Index: -37.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6328
    Cell Significance Index: -48.5600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.6780
    Cell Significance Index: -10.4900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6785
    Cell Significance Index: -27.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7025
    Cell Significance Index: -9.5900
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: -0.7116
    Cell Significance Index: -3.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7689
    Cell Significance Index: -51.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7795
    Cell Significance Index: -18.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8184
    Cell Significance Index: -51.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8358
    Cell Significance Index: -22.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8817
    Cell Significance Index: -24.6400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.9121
    Cell Significance Index: -14.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9917
    Cell Significance Index: -29.2100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.0913
    Cell Significance Index: -21.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.1446
    Cell Significance Index: -10.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.1807
    Cell Significance Index: -30.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2428
    Cell Significance Index: -54.9700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.3030
    Cell Significance Index: -28.5300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.3154
    Cell Significance Index: -14.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3179
    Cell Significance Index: -42.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3471
    Cell Significance Index: -49.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.3972
    Cell Significance Index: -27.2700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -1.4145
    Cell Significance Index: -17.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NR2F2 is a member of the nuclear receptor subfamily 2 group F, which is characterized by the presence of a specific ligand-binding domain. The gene is primarily expressed in cells of mesodermal origin, including pericytes, fibroblasts, and smooth muscle cells. NR2F2 is activated by the binding of specific ligands, such as estradiol and retinoic acid, which triggers a transcriptional response that regulates the expression of target genes. **Pathways and Functions** NR2F2 is involved in various signaling pathways, including: 1. **Cell differentiation**: NR2F2 regulates the expression of genes involved in cell differentiation, including those involved in the development of the immune system. 2. **Intracellular signaling**: NR2F2 interacts with other transcription factors and signaling molecules to regulate the expression of target genes. 3. **Transcriptional regulation**: NR2F2 acts as a transcription factor to regulate the expression of genes involved in cell growth, survival, and differentiation. 4. **Endothelial cell function**: NR2F2 is involved in the regulation of endothelial cell function, including cell migration, proliferation, and differentiation. **Clinical Significance** Dysregulation of NR2F2 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: NR2F2 has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: NR2F2 has been shown to regulate the expression of genes involved in cancer cell growth and survival. 3. **Inflammation**: NR2F2 is involved in the regulation of inflammatory responses, including the expression of genes involved in immune cell function. 4. **Immunodeficiency**: NR2F2 has been implicated in the pathogenesis of immunodeficiency disorders, such as chronic lymphocytic leukemia. In conclusion, NR2F2 is a critical transcription factor that plays a significant role in the regulation of immune system function and development. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of further research into the molecular mechanisms underlying NR2F2 function. **Implications for Immunology** The study of NR2F2 has significant implications for our understanding of immune system function and regulation. Further research into the molecular mechanisms underlying NR2F2 function could lead to the development of new therapeutic strategies for immune-related disorders. Additionally, the identification of NR2F2 as a key regulator of immune cell function highlights the importance of considering the role of transcription factors in the regulation of immune responses. **Future Directions** Future research should focus on the following areas: 1. **Mechanistic studies**: Further studies are needed to elucidate the molecular mechanisms underlying NR2F2 function. 2. **Clinical studies**: Clinical studies are needed to investigate the role of NR2F2 in immune-related disorders. 3. **Therapeutic strategies**: Research should focus on developing new therapeutic strategies that target NR2F2 or its downstream targets. In conclusion, NR2F2 is a critical transcription factor that plays a significant role in the regulation of immune system function and development. Further research into the molecular mechanisms underlying NR2F2 function could lead to the development of new therapeutic strategies for immune-related disorders.

Genular Protein ID: 2083949566

Symbol: COT2_HUMAN

Name: COUP transcription factor 2

UniProtKB Accession Codes:

P24468 B4DQJ2 B6ZGU1 Q03754 Q3KQR7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 33 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1899293

Title: Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily.

PubMed ID: 1899293

DOI: 10.1126/science.1899293

PubMed ID: 18619963

Title: DNA-binding profiling of human hormone nuclear receptors via fluorescence correlation spectroscopy in a cell-free system.

PubMed ID: 18619963

DOI: 10.1016/j.febslet.2008.07.003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1820218

Title: The COUP-TFs compose a family of functionally related transcription factors.

PubMed ID: 1820218

PubMed ID: 9343308

Title: The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter.

PubMed ID: 9343308

DOI: 10.1677/jme.0.0190163

PubMed ID: 10318855

Title: Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2.

PubMed ID: 10318855

DOI: 10.1074/jbc.274.20.14331

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29478779

Title: Loss of function of the nuclear receptor NR2F2, encoding COUP-TF2, causes testis development and cardiac defects in 46,XX children.

PubMed ID: 29478779

DOI: 10.1016/j.ajhg.2018.01.021

PubMed ID: 18798693

Title: Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor.

PubMed ID: 18798693

DOI: 10.1371/journal.pbio.0060227

PubMed ID: 24702954

Title: Rare variants in NR2F2 cause congenital heart defects in humans.

PubMed ID: 24702954

DOI: 10.1016/j.ajhg.2014.03.007

Sequence Information:

  • Length: 414
  • Mass: 45571
  • Checksum: C24CB2E8C8A27E8C
  • Sequence:
    • MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS TPAQTAAGGQ 
GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK SFFKRSVRRN LSYTCRANRN 
CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ RGRMPPTQPT HGQFALTNGD PLNCHSYLSG 
YISLLLRAEP YPTSRFGSQC MQPNNIMGIE NICELAARML FSAVEWARNI PFFPDLQITD 
QVALLRLTWS ELFVLNAAQC SMPLHVAPLL AAAGLHASPM SADRVVAFMD HIRIFQEQVE 
KLKALHVDSA EYSCLKAIVL FTSDACGLSD VAHVESLQEK SQCALEEYVR SQYPNQPTRF 
GKLLLRLPSL RTVSSSVIEQ LFFVRLVGKT PIETLIRDML LSGSSFNWPY MAIQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.