TFDP2 | ENSG00000114126 | NCBI 7029

Details for: TFDP2

Gene ID: 7029

Symbol: TFDP2

Ensembl ID: ENSG00000114126

Description: transcription factor Dp-2

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Activation of bh3-only proteins
(R-HSA-114452)
Activation of noxa and translocation to mitochondria
(R-HSA-111448)
Activation of puma and translocation to mitochondria
(R-HSA-139915)
Apoptosis
(R-HSA-109581)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
E2f mediated regulation of dna replication
(R-HSA-113510)
G0 and early g1
(R-HSA-1538133)
G1 phase
(R-HSA-69236)
G1/s-specific transcription
(R-HSA-69205)
G1/s transition
(R-HSA-69206)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Inhibition of replication initiation of damaged dna by rb1/e2f1
(R-HSA-113501)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Programmed cell death
(R-HSA-5357801)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by notch
(R-HSA-157118)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-HSA-2173796)
S phase
(R-HSA-69242)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g2 cell cycle arrest
(R-HSA-6804114)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-HSA-2173793)
Transcriptional regulation by e2f6
(R-HSA-8953750)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Transcription of e2f targets under negative control by dream complex
(R-HSA-1362277)
Transcription of e2f targets under negative control by p107 (rbl1) and p130 (rbl2) in complex with hdac1
(R-HSA-1362300)
Chromatin
(GO:0000785)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Heart development
(GO:0007507)
Mitotic spindle
(GO:0072686)
Negative regulation of dna-templated transcription
(GO:0045892)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Regulation of cell cycle
(GO:0051726)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Transcription factor binding
(GO:0008134)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 343.9193
Cell Significance Index: -53.5000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 214.0801
Cell Significance Index: -54.3000
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 139.0317
Cell Significance Index: -65.6400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 130.8777
Cell Significance Index: -53.1700
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 121.3293
Cell Significance Index: -62.4100
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 55.9103
Cell Significance Index: -53.3800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 48.9596
Cell Significance Index: -60.3700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 23.2636
Cell Significance Index: -62.3200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 20.2738
Cell Significance Index: -62.2700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 18.0383
Cell Significance Index: -71.1800
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 12.1905
Cell Significance Index: -26.6800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 5.2278
Cell Significance Index: 293.3600
Cell Name: cortical interneuron (CL0008031)
Fold Change: 2.6352
Cell Significance Index: 63.2000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.6253
Cell Significance Index: 941.6600
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 2.5105
Cell Significance Index: 17.0100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.4831
Cell Significance Index: 498.1000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.4353
Cell Significance Index: 107.7200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.3829
Cell Significance Index: 63.6300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 2.3545
Cell Significance Index: 144.7200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.3277
Cell Significance Index: 65.0500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 2.3247
Cell Significance Index: 88.0300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 2.2489
Cell Significance Index: 172.5800
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 2.1898
Cell Significance Index: 62.4900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.0883
Cell Significance Index: 414.4400
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.9343
Cell Significance Index: 17.1700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.8739
Cell Significance Index: 112.5000
Cell Name: preadipocyte (CL0002334)
Fold Change: 1.8210
Cell Significance Index: 35.5400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.7570
Cell Significance Index: 204.7600
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 1.4954
Cell Significance Index: 18.8300
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.2843
Cell Significance Index: 15.9300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.2205
Cell Significance Index: 82.0700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.1016
Cell Significance Index: 135.4500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.0473
Cell Significance Index: 30.1800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.0459
Cell Significance Index: 188.5500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.9920
Cell Significance Index: 17.0000
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.8489
Cell Significance Index: 4.8300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7922
Cell Significance Index: 35.9100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.7753
Cell Significance Index: 106.4700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.7605
Cell Significance Index: 52.5900
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.7362
Cell Significance Index: 402.0800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6947
Cell Significance Index: 307.1500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.5661
Cell Significance Index: 1065.9300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4139
Cell Significance Index: 373.7000
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.3726
Cell Significance Index: 0.8400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.3665
Cell Significance Index: 9.4200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.3281
Cell Significance Index: 208.4100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.3122
Cell Significance Index: 480.5800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2796
Cell Significance Index: 27.6600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.2728
Cell Significance Index: 9.4800
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.2587
Cell Significance Index: 477.0500
Cell Name: odontoblast (CL0000060)
Fold Change: 0.2443
Cell Significance Index: 31.3200
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.2031
Cell Significance Index: 5.3400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1990
Cell Significance Index: 90.3300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1799
Cell Significance Index: 34.2300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1699
Cell Significance Index: 7.9200
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.1361
Cell Significance Index: 2.0100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1201
Cell Significance Index: 6.2400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1102
Cell Significance Index: 18.8300
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1000
Cell Significance Index: 6.4500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0961
Cell Significance Index: 130.6400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0877
Cell Significance Index: 2.3500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0297
Cell Significance Index: 21.7900
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: -0.0097
Cell Significance Index: -0.0600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0172
Cell Significance Index: -0.6100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0190
Cell Significance Index: -11.8700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0439
Cell Significance Index: -32.5000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0686
Cell Significance Index: -1.4600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0697
Cell Significance Index: -52.7500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0732
Cell Significance Index: -3.4400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0814
Cell Significance Index: -6.0700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0877
Cell Significance Index: -49.4700
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0908
Cell Significance Index: -2.3200
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0963
Cell Significance Index: -12.4400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1266
Cell Significance Index: -14.9300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1526
Cell Significance Index: -7.9500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1632
Cell Significance Index: -16.6700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1861
Cell Significance Index: -39.1900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1862
Cell Significance Index: -27.0600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2103
Cell Significance Index: -60.5000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2208
Cell Significance Index: -6.0100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2497
Cell Significance Index: -26.0000
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2836
Cell Significance Index: -7.6000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3194
Cell Significance Index: -36.5900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3375
Cell Significance Index: -23.8700
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.3556
Cell Significance Index: -7.6000
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.3958
Cell Significance Index: -4.9400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4883
Cell Significance Index: -8.1700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5015
Cell Significance Index: -31.6100
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5089
Cell Significance Index: -58.0900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5230
Cell Significance Index: -41.4200
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.5744
Cell Significance Index: -9.6800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.5834
Cell Significance Index: -7.9600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.5978
Cell Significance Index: -31.3900
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.7068
Cell Significance Index: -10.1500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7222
Cell Significance Index: -23.1300
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.7353
Cell Significance Index: -9.2800
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.7537
Cell Significance Index: -18.3900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.7732
Cell Significance Index: -7.1200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7814
Cell Significance Index: -47.9100
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.8178
Cell Significance Index: -8.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** TFDP2 is a transcription factor that belongs to the E2F family, which is characterized by its ability to bind to specific DNA sequences and regulate the expression of target genes involved in cell cycle progression, apoptosis, and cellular responses to stress. TFDP2's expression is tightly regulated by the retinoblastoma protein (Rb) and the p53 tumor suppressor, which are key regulators of the cell cycle and apoptosis. TFDP2's involvement in the regulation of cell cycle and apoptosis has significant implications for our understanding of immune cell development, homeostasis, and the pathogenesis of immune-related disorders. **Pathways and Functions** TFDP2 plays a crucial role in regulating cell cycle progression, apoptosis, and cellular responses to stress. Its involvement in the regulation of cell cycle progression is mediated through its binding to specific DNA sequences, which activate the expression of target genes involved in cell cycle progression. TFDP2's role in apoptosis is mediated through its activation of pro-apoptotic proteins, such as Noxa and Puma, which are involved in the regulation of mitochondrial function and the induction of apoptosis. TFDP2's involvement in cellular responses to stress is mediated through its activation of stress response pathways, such as the unfolded protein response (UPR) and the endoplasmic reticulum stress response (ER stress response). **Clinical Significance** TFDP2's involvement in the regulation of cell cycle progression, apoptosis, and cellular responses to stress has significant implications for our understanding of immune cell development, homeostasis, and the pathogenesis of immune-related disorders. Dysregulation of TFDP2's expression and activity has been implicated in various immune-related disorders, including cancer, autoimmune diseases, and immunodeficiency diseases. For example, TFDP2's dysregulation has been implicated in the development of T-cell leukemia, a type of cancer that affects T-cells, a type of immune cell. Additionally, TFDP2's dysregulation has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, which are characterized by the dysregulation of immune cell function and the induction of inflammation. In conclusion, TFDP2 is a transcription factor that plays a crucial role in regulating cell cycle progression, apoptosis, and cellular responses to stress. Its involvement in the regulation of cell cycle progression and apoptosis has significant implications for our understanding of immune cell development, homeostasis, and the pathogenesis of immune-related disorders. Further research is needed to fully understand the role of TFDP2 in the regulation of immune cell function and the pathogenesis of immune-related disorders. **Relevance to Immunology** TFDP2's involvement in the regulation of cell cycle progression, apoptosis, and cellular responses to stress has significant implications for our understanding of immune cell development, homeostasis, and the pathogenesis of immune-related disorders. TFDP2's dysregulation has been implicated in various immune-related disorders, including cancer, autoimmune diseases, and immunodeficiency diseases. For example, TFDP2's dysregulation has been implicated in the development of T-cell leukemia, a type of cancer that affects T-cells, a type of immune cell. Additionally, TFDP2's dysregulation has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, which are characterized by the dysregulation of immune cell function and the induction of inflammation. In the context of immunology, TFDP2's involvement in the regulation of cell cycle progression and apoptosis has significant implications for our understanding of immune cell development, homeostasis, and the pathogenesis of immune-related disorders. TFDP2's dysregulation has been implicated in various immune-related disorders, including cancer, autoimmune diseases, and immunodeficiency diseases. Further research is needed to fully understand the role of TFDP2 in the regulation of immune cell function and the pathogenesis of immune-related disorders. **Potential Therapeutic Applications** TFDP2's dysregulation has been implicated in various immune-related disorders, including cancer, autoimmune diseases, and immunodeficiency diseases. Further research is needed to fully understand the role of TFDP2 in the regulation of immune cell function and the pathogenesis of immune-related disorders. However, potential therapeutic applications of TFDP2 include the development of targeted therapies aimed at restoring TFDP2's expression and activity in cells affected by TFDP2 dysregulation. Additionally, TFDP2's involvement in the regulation of cell cycle progression and apoptosis has significant implications for our understanding of immune cell development, homeostasis, and the pathogenesis of immune-related disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Transcription factor Dp-2

Genular Protein ID: 2788587794

Symbol: TFDP2_HUMAN

Name: Transcription factor Dp-2

UniProtKB Accession Codes:

Q14188 B7Z8C8 B7Z8L5 D3DNG1 E9PFC3 F8WAI2 Q13331 Q14187 Q6R754 Q8WU88 Q9UG28

Database IDs:

Citations:

PubMed ID: 7739537

Title: In vivo association of E2F and DP family proteins.

PubMed ID: 7739537

DOI: 10.1128/mcb.15.5.2536

PubMed ID: 7784053

Title: Cloning and characterization of human DP2, a novel dimerization partner of E2F.

PubMed ID: 7784053

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 8755520

Title: DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo.

PubMed ID: 8755520

DOI: 10.1073/pnas.93.15.7594

PubMed ID: 16360038

Title: Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.

PubMed ID: 16360038

DOI: 10.1016/j.cell.2005.09.044

PubMed ID: 17531812

Title: Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.

PubMed ID: 17531812

DOI: 10.1016/j.molcel.2007.04.015

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20176812

Title: Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes.

PubMed ID: 20176812

DOI: 10.1128/mcb.01619-09

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 10090723

Title: Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP.

PubMed ID: 10090723

DOI: 10.1101/gad.13.6.666

Sequence Information:

Length: 446
Mass: 49236
Checksum: 19A6C85BAD61DFF1
Sequence:

MTAKNVGLTS TNAEVRGFID QNLSPTKGNI SFVAFPVSNT NSPTKILPKT LGPINVNVGP 
QMIISTPQRL TSSGSVLIGS PYTPAPAMVT QTHIAEATGW VPGDRKRARK FIDSDFSESK 
RSKKGDKNGK GLRHFSMKVC EKVQRKGTTS YNEVADELVS EFTNSNNHLA ADSAYDQKNI 
RRRVYDALNV LMAMNIISKE KKEIKWIGLP TNSAQECQNL EIEKQRRIER IKQKRAQLQE 
LLLQQIAFKN LVQRNRQNEQ QNQGPPALNS TIQLPFIIIN TSRKTVIDCS ISSDKFEYLF 
NFDNTFEIHD DIEVLKRMGM SFGLESGKCS LEDLKLAKSL VPKALEGYIT DISTGPSWLN 
QGLLLNSTQS VSNLDLTTGA TLPQSSVNQG LCLDAEVALA TGQFLAPNSH QSSSAASHCS 
ESRGETPCSF NDEDEEDDEE DSSSPE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TFDP2

Associated with

Cells (max top 100)

Other Information

In vivo association of E2F and DP family proteins. PubMed ID: 7739537

Cloning and characterization of human DP2, a novel dimerization partner of E2F. PubMed ID: 7784053

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo. PubMed ID: 8755520

Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. PubMed ID: 16360038

Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. PubMed ID: 17531812

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. PubMed ID: 20176812

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. PubMed ID: 10090723