Details for: TGFB1I1

Gene ID: 7041

Symbol: TGFB1I1

Ensembl ID: ENSG00000140682

Description: transforming growth factor beta 1 induced transcript 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 118.4221
    Cell Significance Index: -18.4200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.1198
    Cell Significance Index: -18.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 39.5316
    Cell Significance Index: -16.0600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 37.7974
    Cell Significance Index: -17.8500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 36.9859
    Cell Significance Index: -19.0300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 27.9126
    Cell Significance Index: -18.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.9365
    Cell Significance Index: -16.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.6372
    Cell Significance Index: -19.2800
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 10.5264
    Cell Significance Index: 55.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.8317
    Cell Significance Index: -20.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.8808
    Cell Significance Index: -19.2600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.9721
    Cell Significance Index: -12.2000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 2.7820
    Cell Significance Index: 12.8500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.9477
    Cell Significance Index: 12.0500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.8951
    Cell Significance Index: 24.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.8199
    Cell Significance Index: 346.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.7868
    Cell Significance Index: 245.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.4733
    Cell Significance Index: 76.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.2278
    Cell Significance Index: 25.7000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.9685
    Cell Significance Index: 5.6900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.9156
    Cell Significance Index: 16.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8743
    Cell Significance Index: 18.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7403
    Cell Significance Index: 21.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6828
    Cell Significance Index: 87.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6099
    Cell Significance Index: 550.7100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4916
    Cell Significance Index: 29.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4873
    Cell Significance Index: 53.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4527
    Cell Significance Index: 73.6300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4524
    Cell Significance Index: 5.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4295
    Cell Significance Index: 50.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2177
    Cell Significance Index: 21.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2047
    Cell Significance Index: 14.1600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1373
    Cell Significance Index: 60.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1068
    Cell Significance Index: 6.8900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0960
    Cell Significance Index: 0.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0941
    Cell Significance Index: 1.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0833
    Cell Significance Index: 3.9200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0569
    Cell Significance Index: 0.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0304
    Cell Significance Index: 1.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0215
    Cell Significance Index: 11.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0037
    Cell Significance Index: 6.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0024
    Cell Significance Index: 1.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0017
    Cell Significance Index: 0.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0023
    Cell Significance Index: -0.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0120
    Cell Significance Index: -0.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0122
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0123
    Cell Significance Index: -7.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0124
    Cell Significance Index: -9.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0131
    Cell Significance Index: -9.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0133
    Cell Significance Index: -24.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0150
    Cell Significance Index: -23.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0188
    Cell Significance Index: -25.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0210
    Cell Significance Index: -2.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0218
    Cell Significance Index: -16.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0233
    Cell Significance Index: -13.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0235
    Cell Significance Index: -14.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0300
    Cell Significance Index: -0.7500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0393
    Cell Significance Index: -0.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0456
    Cell Significance Index: -8.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0485
    Cell Significance Index: -17.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0501
    Cell Significance Index: -8.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0606
    Cell Significance Index: -17.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0616
    Cell Significance Index: -12.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0698
    Cell Significance Index: -10.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0701
    Cell Significance Index: -4.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0714
    Cell Significance Index: -9.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0734
    Cell Significance Index: -9.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0775
    Cell Significance Index: -15.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0846
    Cell Significance Index: -4.2800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0957
    Cell Significance Index: -10.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0960
    Cell Significance Index: -9.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0969
    Cell Significance Index: -19.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1325
    Cell Significance Index: -1.4400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1374
    Cell Significance Index: -5.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1543
    Cell Significance Index: -16.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1561
    Cell Significance Index: -4.2500
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.1609
    Cell Significance Index: -0.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1641
    Cell Significance Index: -19.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1834
    Cell Significance Index: -13.6700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1973
    Cell Significance Index: -3.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2207
    Cell Significance Index: -17.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2456
    Cell Significance Index: -8.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2548
    Cell Significance Index: -7.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2658
    Cell Significance Index: -6.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2704
    Cell Significance Index: -20.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2735
    Cell Significance Index: -12.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2876
    Cell Significance Index: -9.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2900
    Cell Significance Index: -18.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2982
    Cell Significance Index: -20.0500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3035
    Cell Significance Index: -4.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3260
    Cell Significance Index: -20.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3982
    Cell Significance Index: -22.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4274
    Cell Significance Index: -22.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4474
    Cell Significance Index: -9.2800
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.4514
    Cell Significance Index: -2.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4576
    Cell Significance Index: -20.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4687
    Cell Significance Index: -24.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4751
    Cell Significance Index: -12.7300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.4844
    Cell Significance Index: -6.7900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4867
    Cell Significance Index: -12.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TGFB1I1 is a non-coding RNA transcript that is induced by TGF-β1, a cytokine involved in various cellular processes, including differentiation, growth, and apoptosis. The transcript is specifically expressed in cells involved in epithelial and mesenchymal transitions, such as respiratory basal cells, uterine smooth muscle cells, and enteric smooth muscle cells. The expression pattern of TGFB1I1 suggests a role in regulating cellular differentiation and morphogenesis, particularly in the development of tissues and organs. **Pathways and Functions:** TGFB1I1 is involved in various signaling pathways that regulate cellular processes, including: 1. **Transforming Growth Factor Beta Receptor Signaling Pathway:** TGFB1I1 is a positive regulator of this pathway, which is crucial for cell growth, differentiation, and survival. 2. **Wnt Signaling Pathway:** TGFB1I1 interacts with Roundabout proteins, which are involved in Wnt signaling, regulating cell migration, differentiation, and proliferation. 3. **Epithelial to Mesenchymal Transition (EMT):** TGFB1I1 is a positive regulator of EMT, a process involved in tissue development, repair, and cancer progression. 4. **Cell Adhesion and Cytoskeleton:** TGFB1I1 regulates cell adhesion and cytoskeletal organization, which are essential for cell migration, differentiation, and survival. 5. **DNA-templated Transcription:** TGFB1I1 is a positive regulator of transcription coactivators, which are involved in regulating gene expression. **Clinical Significance:** TGFB1I1 has significant implications in various diseases and disorders, including: 1. **Cancer:** TGFB1I1 is involved in regulating EMT, which is a key process in cancer progression and metastasis. 2. **Developmental Disorders:** TGFB1I1 is essential for proper tissue development and morphogenesis, and its dysregulation can lead to developmental disorders, such as congenital anomalies. 3. **Autoimmune Diseases:** TGFB1I1 is involved in regulating immune responses and inflammation, and its dysregulation can contribute to autoimmune diseases, such as rheumatoid arthritis. 4. **Cardiovascular Diseases:** TGFB1I1 regulates cell adhesion and cytoskeletal organization, which are essential for maintaining vascular health and preventing cardiovascular diseases. In conclusion, TGFB1I1 is a key regulator of cellular differentiation and morphogenesis, and its dysregulation can lead to various diseases and disorders. Further research is necessary to fully understand the role of TGFB1I1 in human health and disease.

Genular Protein ID: 502670463

Symbol: TGFI1_HUMAN

Name: Transforming growth factor beta-1-induced transcript 1 protein

UniProtKB Accession Codes:

O43294 B2R8D5 Q9BPW3 Q9Y2V5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10075738

Title: Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate.

PubMed ID: 10075738

DOI: 10.1074/jbc.274.12.8316

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9422762

Title: Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions.

PubMed ID: 9422762

DOI: 10.1074/jbc.273.2.1003

PubMed ID: 9032249

Title: Induction of senescence-like phenotypes by forced expression of hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts.

PubMed ID: 9032249

DOI: 10.1128/mcb.17.3.1224

PubMed ID: 9756887

Title: Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase.

PubMed ID: 9756887

DOI: 10.1074/jbc.273.41.26516

PubMed ID: 9664039

Title: Recruitment of the LIM protein hic-5 to focal contacts of human platelets.

PubMed ID: 9664039

DOI: 10.1242/jcs.111.15.2181

PubMed ID: 10838081

Title: Phosphorylation of Hic-5 at tyrosine 60 by CAKbeta and Fyn.

PubMed ID: 10838081

DOI: 10.1016/s0014-5793(00)01597-0

PubMed ID: 10708479

Title: Molecular cloning of human Hic-5, a potential regulator involved in signal transduction and cellular senescence.

PubMed ID: 10708479

DOI: 10.1002/(sici)1098-2744(200003)27:3<177::aid-mc4>3.3.co;2-j

PubMed ID: 11311131

Title: Involvement of Hic-5 in platelet activation: integrin alphaIIbbeta3-dependent tyrosine phosphorylation and association with proline-rich tyrosine kinase 2.

PubMed ID: 11311131

DOI: 10.1042/bj3550691

PubMed ID: 11313252

Title: CrkL is an adapter for Wiskott-Aldrich syndrome protein and Syk.

PubMed ID: 11313252

DOI: 10.1182/blood.v97.9.2633

PubMed ID: 11532379

Title: Potential anti-androgenic activity of roxithromycin in skin.

PubMed ID: 11532379

DOI: 10.1016/s0923-1811(01)00129-3

PubMed ID: 11463817

Title: Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase.

PubMed ID: 11463817

DOI: 10.1128/mcb.21.16.5332-5345.2001

PubMed ID: 11489729

Title: Different expression of androgen receptor coactivators in human prostate.

PubMed ID: 11489729

DOI: 10.1016/s0090-4295(01)01117-7

PubMed ID: 12445807

Title: Transcriptional activation of the c-fos gene by a LIM protein, Hic-5.

PubMed ID: 12445807

DOI: 10.1016/s0006-291x(02)02644-x

PubMed ID: 12153727

Title: Hic-5 interacts with GIT1 with a different binding mode from paxillin.

PubMed ID: 12153727

DOI: 10.1093/oxfordjournals.jbchem.a003222

PubMed ID: 11856738

Title: Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator.

PubMed ID: 11856738

DOI: 10.1074/jbc.m111218200

PubMed ID: 12177201

Title: The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter.

PubMed ID: 12177201

DOI: 10.1523/jneurosci.22-16-07045.2002

PubMed ID: 12714604

Title: The use of phage display technique for the isolation of androgen receptor interacting peptides with (F/W)XXL(F/W) and FXXLY new signature motifs.

PubMed ID: 12714604

DOI: 10.1074/jbc.m211908200

PubMed ID: 12642630

Title: Expression of the LIM proteins paxillin and Hic-5 in human tissues.

PubMed ID: 12642630

DOI: 10.1177/002215540305100413

PubMed ID: 12631731

Title: Hic-5 communicates between focal adhesions and the nucleus through oxidant-sensitive nuclear export signal.

PubMed ID: 12631731

DOI: 10.1091/mbc.02-06-0099

PubMed ID: 12700349

Title: Inactivation of androgen receptor coregulator ARA55 inhibits androgen receptor activity and agonist effect of antiandrogens in prostate cancer cells.

PubMed ID: 12700349

DOI: 10.1073/pnas.0530097100

PubMed ID: 12772188

Title: Expression of androgen receptor coactivators in normal and cancer prostate tissues and cultured cell lines.

PubMed ID: 12772188

DOI: 10.1002/pros.10229

PubMed ID: 15211577

Title: Distinct LIM domains of Hic-5/ARA55 are required for nuclear matrix targeting and glucocorticoid receptor binding and coactivation.

PubMed ID: 15211577

DOI: 10.1002/jcb.20109

PubMed ID: 15687259

Title: Hic-5 regulates an epithelial program mediated by PPARgamma.

PubMed ID: 15687259

DOI: 10.1101/gad.1240705

PubMed ID: 15561701

Title: Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling.

PubMed ID: 15561701

DOI: 10.1074/jbc.m411575200

PubMed ID: 16330715

Title: Subcellular targeting of oxidants during endothelial cell migration.

PubMed ID: 16330715

DOI: 10.1083/jcb.200507004

PubMed ID: 16849583

Title: Hic-5/ARA55, a LIM domain-containing nuclear receptor coactivator expressed in prostate stromal cells.

PubMed ID: 16849583

DOI: 10.1158/0008-5472.can-05-2379

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16624805

Title: ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5.

PubMed ID: 16624805

DOI: 10.1074/jbc.m512418200

PubMed ID: 16803896

Title: Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter.

PubMed ID: 16803896

DOI: 10.1074/jbc.m603877200

PubMed ID: 16141357

Title: Mechanism of action of Hic-5/androgen receptor activator 55, a LIM domain-containing nuclear receptor coactivator.

PubMed ID: 16141357

DOI: 10.1210/me.2005-0065

PubMed ID: 17202804

Title: Gonadotropin-releasing hormone functionally antagonizes testosterone activation of the human androgen receptor in prostate cells through focal adhesion complexes involving Hic-5.

PubMed ID: 17202804

DOI: 10.1159/000098402

PubMed ID: 17233630

Title: Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets.

PubMed ID: 17233630

DOI: 10.1042/bj20061618

PubMed ID: 17166536

Title: Hic-5/ARA55 a prostate stroma-specific AR coactivator.

PubMed ID: 17166536

DOI: 10.1016/j.steroids.2006.11.010

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23145173

Title: Cbl-c ubiquitin ligase activity is increased via the interaction of its RING finger domain with a LIM domain of the paxillin homolog, Hic 5.

PubMed ID: 23145173

DOI: 10.1371/journal.pone.0049428

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 461
  • Mass: 49814
  • Checksum: D2C7C32C3FD2C496
  • Sequence:
    • MEDLDALLSD LETTTSHMPR SGAPKERPAE PLTPPPSYGH QPQTGSGESS GASGDKDHLY 
STVCKPRSPK PAAPAAPPFS SSSGVLGTGL CELDRLLQEL NATQFNITDE IMSQFPSSKV 
ASGEQKEDQS EDKKRPSLPS SPSPGLPKAS ATSATLELDR LMASLSDFRV QNHLPASGPT 
QPPVVSSTNE GSPSPPEPTG KGSLDTMLGL LQSDLSRRGV PTQAKGLCGS CNKPIAGQVV 
TALGRAWHPE HFVCGGCSTA LGGSSFFEKD GAPFCPECYF ERFSPRCGFC NQPIRHKMVT 
ALGTHWHPEH FCCVSCGEPF GDEGFHEREG RPYCRRDFLQ LFAPRCQGCQ GPILDNYISA 
LSALWHPDCF VCRECFAPFS GGSFFEHEGR PLCENHFHAR RGSLCATCGL PVTGRCVSAL 
GRRFHPDHFT CTFCLRPLTK GSFQERAGKP YCQPCFLKLF G

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.