Details for: TGIF1

Gene ID: 7050

Symbol: TGIF1

Ensembl ID: ENSG00000177426

Description: TGFB induced factor homeobox 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.8
    Marker Score: 6844
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.77
    Marker Score: 2962
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.23
    Marker Score: 1754
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.2
    Marker Score: 74955
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.13
    Marker Score: 887
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.1
    Marker Score: 3098
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.08
    Marker Score: 705
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.98
    Marker Score: 1129
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.95
    Marker Score: 19637
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.86
    Marker Score: 7325
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.86
    Marker Score: 7182
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.85
    Marker Score: 3037
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.84
    Marker Score: 459
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.83
    Marker Score: 459
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.76
    Marker Score: 4785
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.75
    Marker Score: 1020
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.75
    Marker Score: 1490
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.74
    Marker Score: 8552
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.71
    Marker Score: 3879
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.65
    Marker Score: 1736
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.58
    Marker Score: 1683
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.58
    Marker Score: 1056
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.56
    Marker Score: 1652
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.55
    Marker Score: 3672
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.53
    Marker Score: 2435
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.52
    Marker Score: 5616
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.5
    Marker Score: 2663
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.47
    Marker Score: 1903
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.47
    Marker Score: 1715
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.47
    Marker Score: 2555
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.46
    Marker Score: 568
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.41
    Marker Score: 8359
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.41
    Marker Score: 500
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.4
    Marker Score: 1498
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.39
    Marker Score: 6001
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.39
    Marker Score: 2895
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.37
    Marker Score: 589
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.36
    Marker Score: 34909
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.36
    Marker Score: 750
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.35
    Marker Score: 852
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.35
    Marker Score: 2462
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.34
    Marker Score: 3168
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.34
    Marker Score: 11639.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.32
    Marker Score: 2230.5
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.3
    Marker Score: 812.5
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.29
    Marker Score: 314
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.29
    Marker Score: 1215
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.29
    Marker Score: 17030
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.28
    Marker Score: 659
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.28
    Marker Score: 606
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.25
    Marker Score: 1434
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.21
    Marker Score: 443
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.21
    Marker Score: 41847
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.19
    Marker Score: 373
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.19
    Marker Score: 376
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.19
    Marker Score: 1594
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.18
    Marker Score: 379
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.17
    Marker Score: 1293
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.17
    Marker Score: 2657
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.16
    Marker Score: 228
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.15
    Marker Score: 6971
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.14
    Marker Score: 257
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.14
    Marker Score: 667
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.14
    Marker Score: 7417
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.13
    Marker Score: 711
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.13
    Marker Score: 264
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.12
    Marker Score: 1904
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.12
    Marker Score: 2122
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.11
    Marker Score: 283
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.11
    Marker Score: 416
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.09
    Marker Score: 1274
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.07
    Marker Score: 16802
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.07
    Marker Score: 395
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.06
    Marker Score: 329
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.05
    Marker Score: 1241
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.05
    Marker Score: 3285
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.04
    Marker Score: 711
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.04
    Marker Score: 3703
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.03
    Marker Score: 514
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.02
    Marker Score: 6661
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.02
    Marker Score: 294
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.02
    Marker Score: 464
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.01
    Marker Score: 721
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.01
    Marker Score: 1211
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1
    Marker Score: 241
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1
    Marker Score: 639
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1
    Marker Score: 303
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1
    Marker Score: 995
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1
    Marker Score: 6355
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71615
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47842
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.99
    Marker Score: 245
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.99
    Marker Score: 1189
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30377
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.98
    Marker Score: 1226.5
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.98
    Marker Score: 249
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.97
    Marker Score: 666
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.97
    Marker Score: 461
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.97
    Marker Score: 927
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.97
    Marker Score: 2503

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** 1. **Transcriptional repressor:** TGIF1 is a transcriptional repressor, meaning it regulates the expression of target genes by binding to specific DNA sequences and inhibiting the recruitment of transcriptional co-activators. 2. **TGF-β signaling pathway modulation:** TGIF1 is a key regulator of the TGF-β signaling pathway, which is involved in various cellular processes, including cell growth, differentiation, and immune responses. 3. **Cell type specificity:** TGIF1 is significantly expressed in various cell types, including basal cells of the prostate epithelium, skeletal muscle satellite stem cells, and fibroblasts of mammary glands and connective tissue of the prostate. 4. **Diverse cellular functions:** TGIF1 is involved in various cellular functions, including DNA binding, transcriptional activity, and response to xenobiotic stimuli. **Pathways and Functions:** 1. **TGF-β signaling pathway:** TGIF1 modulates the TGF-β signaling pathway by inhibiting the transcriptional activity of Smad2/3:Smad4 heterotrimer, which is a key regulator of TGF-β-mediated gene expression. 2. **Chromatin regulation:** TGIF1 regulates chromatin structure and function by binding to specific DNA sequences and modifying chromatin architecture. 3. **Gene expression regulation:** TGIF1 regulates gene expression by binding to specific DNA sequences and inhibiting the recruitment of transcriptional co-activators. 4. **Cellular differentiation and proliferation:** TGIF1 regulates cellular differentiation and proliferation by modulating the TGF-β signaling pathway and other signaling pathways involved in cell growth and differentiation. **Clinical Significance:** 1. **Cancer:** TGIF1 has been implicated in the development and progression of various cancers, including prostate cancer, breast cancer, and bladder cancer. 2. **Autoimmune diseases:** TGIF1 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Inflammatory responses:** TGIF1 regulates inflammatory responses by modulating the TGF-β signaling pathway and other signaling pathways involved in inflammation. 4. **Regenerative medicine:** TGIF1 has been identified as a potential therapeutic target for regenerative medicine, as it regulates cellular differentiation and proliferation. In conclusion, the TGIF1 gene plays a critical role in various cellular processes, including growth factor signaling, transcriptional activity, and gene expression. Its dysregulation has been implicated in various diseases, including cancer, autoimmune diseases, and inflammatory responses. Further research is needed to fully understand the mechanisms by which TGIF1 regulates cellular processes and to explore its potential as a therapeutic target for regenerative medicine.

Genular Protein ID: 2025421965

Symbol: TGIF1_HUMAN

Name: Homeobox protein TGIF1

UniProtKB Accession Codes:

Q15583 A6NE42 A6NLU7 F8VZB6 Q6ICR0 Q8N5X9 Q9NRS0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 9 EPD 1 Ensembl 11 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 14 SAM 1 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8537382

Title: A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif.

PubMed ID: 8537382

DOI: 10.1074/jbc.270.52.31178

PubMed ID: 10764806

Title: Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription.

PubMed ID: 10764806

DOI: 10.1074/jbc.m908382199

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10835638

Title: Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination.

PubMed ID: 10835638

DOI: 10.1038/76074

PubMed ID: 15221788

Title: Molecular screening of SHH, ZIC2, SIX3, and TGIF genes in patients with features of holoprosencephaly spectrum: mutation review and genotype-phenotype correlations.

PubMed ID: 15221788

DOI: 10.1002/humu.20056

Sequence Information:

  • Length: 401
  • Mass: 43013
  • Checksum: 4D9C76AFB37A29F0
  • Sequence:
    • MVLAQSRVSA GVGSPHCSGS GGGGSDSFPW PASHPGNPQC SFSTAFLASP RLSRGTLAYL 
PPAPWSSLAT PSALLGSSCA PPPPPARCPQ PRALSPELGT KAGPRRPHRW ELPRSPSQGA 
QGPAPRRRLL ETMKGIVAAS GSETEDEDSM DIPLDLSSSA GSGKRRRRGN LPKESVQILR 
DWLYEHRYNA YPSEQEKALL SQQTHLSTLQ VCNWFINARR RLLPDMLRKD GKDPNQFTIS 
RRGAKISETS SVESVMGIKN FMPALEETPF HSCTAGPNPT LGRPLSPKPS SPGSVLARPS 
VICHTTVTAL KDVPFSLCQS VGVGQNTDIQ QIAAKNFTDT SLMYPEDTCK SGPSTNTQSG 
LFNTPPPTPP DLNQDFSGFQ LLVDVALKRA AEMELQAKLT A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.