Details for: TGIF1

Gene ID: 7050

Symbol: TGIF1

Ensembl ID: ENSG00000177426

Description: TGFB induced factor homeobox 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 238.5158
    Cell Significance Index: -37.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 136.1163
    Cell Significance Index: -34.5300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 84.9258
    Cell Significance Index: -34.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 81.2183
    Cell Significance Index: -38.3500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 79.3832
    Cell Significance Index: -32.2500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 69.7337
    Cell Significance Index: -35.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.9463
    Cell Significance Index: -32.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.6661
    Cell Significance Index: -37.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.2216
    Cell Significance Index: -32.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.7237
    Cell Significance Index: -38.3700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.6018
    Cell Significance Index: -26.4200
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 6.9721
    Cell Significance Index: 20.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.5926
    Cell Significance Index: -12.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.0058
    Cell Significance Index: 136.2600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.0818
    Cell Significance Index: 25.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.9330
    Cell Significance Index: 53.6600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.0447
    Cell Significance Index: 24.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.8298
    Cell Significance Index: 147.0000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.5613
    Cell Significance Index: 73.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.5039
    Cell Significance Index: 65.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.0060
    Cell Significance Index: 141.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.9105
    Cell Significance Index: 89.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.8659
    Cell Significance Index: 139.0700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.7758
    Cell Significance Index: 31.3800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.7544
    Cell Significance Index: 12.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2156
    Cell Significance Index: 537.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2007
    Cell Significance Index: 155.1300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1695
    Cell Significance Index: 24.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0542
    Cell Significance Index: 28.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0183
    Cell Significance Index: 35.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9081
    Cell Significance Index: 111.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8738
    Cell Significance Index: 788.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8216
    Cell Significance Index: 148.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7776
    Cell Significance Index: 22.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7650
    Cell Significance Index: 417.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7561
    Cell Significance Index: 34.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7108
    Cell Significance Index: 15.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6748
    Cell Significance Index: 133.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6701
    Cell Significance Index: 92.0200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5915
    Cell Significance Index: 6.4300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5549
    Cell Significance Index: 12.8200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.5472
    Cell Significance Index: 3.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4982
    Cell Significance Index: 23.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4875
    Cell Significance Index: 48.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4634
    Cell Significance Index: 29.9000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4148
    Cell Significance Index: 3.8200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2719
    Cell Significance Index: 3.8700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2524
    Cell Significance Index: 1.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2404
    Cell Significance Index: 7.7000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1796
    Cell Significance Index: 2.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1486
    Cell Significance Index: 28.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1307
    Cell Significance Index: 22.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1288
    Cell Significance Index: 3.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0750
    Cell Significance Index: 9.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0648
    Cell Significance Index: 119.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0647
    Cell Significance Index: 2.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0549
    Cell Significance Index: 34.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0432
    Cell Significance Index: 66.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0414
    Cell Significance Index: 77.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0346
    Cell Significance Index: 47.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0140
    Cell Significance Index: 0.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0085
    Cell Significance Index: 2.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0003
    Cell Significance Index: -0.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0007
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0195
    Cell Significance Index: -14.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0275
    Cell Significance Index: -17.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0282
    Cell Significance Index: -4.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0326
    Cell Significance Index: -23.9400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0395
    Cell Significance Index: -0.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0462
    Cell Significance Index: -9.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0496
    Cell Significance Index: -27.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0617
    Cell Significance Index: -28.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0813
    Cell Significance Index: -9.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0953
    Cell Significance Index: -34.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0984
    Cell Significance Index: -11.4700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1063
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1168
    Cell Significance Index: -24.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1212
    Cell Significance Index: -17.6200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1722
    Cell Significance Index: -8.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1815
    Cell Significance Index: -21.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1816
    Cell Significance Index: -4.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1905
    Cell Significance Index: -10.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2399
    Cell Significance Index: -12.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2626
    Cell Significance Index: -20.1500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2701
    Cell Significance Index: -30.8300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2752
    Cell Significance Index: -3.5300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2797
    Cell Significance Index: -1.6900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3290
    Cell Significance Index: -8.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3500
    Cell Significance Index: -36.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4057
    Cell Significance Index: -8.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4060
    Cell Significance Index: -32.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4280
    Cell Significance Index: -26.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4284
    Cell Significance Index: -11.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5006
    Cell Significance Index: -30.7700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5043
    Cell Significance Index: -5.2200
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.5106
    Cell Significance Index: -3.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5272
    Cell Significance Index: -7.9000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5327
    Cell Significance Index: -21.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5772
    Cell Significance Index: -38.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6565
    Cell Significance Index: -41.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional repressor:** TGIF1 is a transcriptional repressor, meaning it regulates the expression of target genes by binding to specific DNA sequences and inhibiting the recruitment of transcriptional co-activators. 2. **TGF-β signaling pathway modulation:** TGIF1 is a key regulator of the TGF-β signaling pathway, which is involved in various cellular processes, including cell growth, differentiation, and immune responses. 3. **Cell type specificity:** TGIF1 is significantly expressed in various cell types, including basal cells of the prostate epithelium, skeletal muscle satellite stem cells, and fibroblasts of mammary glands and connective tissue of the prostate. 4. **Diverse cellular functions:** TGIF1 is involved in various cellular functions, including DNA binding, transcriptional activity, and response to xenobiotic stimuli. **Pathways and Functions:** 1. **TGF-β signaling pathway:** TGIF1 modulates the TGF-β signaling pathway by inhibiting the transcriptional activity of Smad2/3:Smad4 heterotrimer, which is a key regulator of TGF-β-mediated gene expression. 2. **Chromatin regulation:** TGIF1 regulates chromatin structure and function by binding to specific DNA sequences and modifying chromatin architecture. 3. **Gene expression regulation:** TGIF1 regulates gene expression by binding to specific DNA sequences and inhibiting the recruitment of transcriptional co-activators. 4. **Cellular differentiation and proliferation:** TGIF1 regulates cellular differentiation and proliferation by modulating the TGF-β signaling pathway and other signaling pathways involved in cell growth and differentiation. **Clinical Significance:** 1. **Cancer:** TGIF1 has been implicated in the development and progression of various cancers, including prostate cancer, breast cancer, and bladder cancer. 2. **Autoimmune diseases:** TGIF1 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Inflammatory responses:** TGIF1 regulates inflammatory responses by modulating the TGF-β signaling pathway and other signaling pathways involved in inflammation. 4. **Regenerative medicine:** TGIF1 has been identified as a potential therapeutic target for regenerative medicine, as it regulates cellular differentiation and proliferation. In conclusion, the TGIF1 gene plays a critical role in various cellular processes, including growth factor signaling, transcriptional activity, and gene expression. Its dysregulation has been implicated in various diseases, including cancer, autoimmune diseases, and inflammatory responses. Further research is needed to fully understand the mechanisms by which TGIF1 regulates cellular processes and to explore its potential as a therapeutic target for regenerative medicine.

Genular Protein ID: 2025421965

Symbol: TGIF1_HUMAN

Name: Homeobox protein TGIF1

UniProtKB Accession Codes:

Q15583 A6NE42 A6NLU7 F8VZB6 Q6ICR0 Q8N5X9 Q9NRS0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 9 Ensembl 11 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 14 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8537382

Title: A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif.

PubMed ID: 8537382

DOI: 10.1074/jbc.270.52.31178

PubMed ID: 10764806

Title: Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription.

PubMed ID: 10764806

DOI: 10.1074/jbc.m908382199

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10835638

Title: Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination.

PubMed ID: 10835638

DOI: 10.1038/76074

PubMed ID: 15221788

Title: Molecular screening of SHH, ZIC2, SIX3, and TGIF genes in patients with features of holoprosencephaly spectrum: mutation review and genotype-phenotype correlations.

PubMed ID: 15221788

DOI: 10.1002/humu.20056

Sequence Information:

  • Length: 401
  • Mass: 43013
  • Checksum: 4D9C76AFB37A29F0
  • Sequence:
    • MVLAQSRVSA GVGSPHCSGS GGGGSDSFPW PASHPGNPQC SFSTAFLASP RLSRGTLAYL 
PPAPWSSLAT PSALLGSSCA PPPPPARCPQ PRALSPELGT KAGPRRPHRW ELPRSPSQGA 
QGPAPRRRLL ETMKGIVAAS GSETEDEDSM DIPLDLSSSA GSGKRRRRGN LPKESVQILR 
DWLYEHRYNA YPSEQEKALL SQQTHLSTLQ VCNWFINARR RLLPDMLRKD GKDPNQFTIS 
RRGAKISETS SVESVMGIKN FMPALEETPF HSCTAGPNPT LGRPLSPKPS SPGSVLARPS 
VICHTTVTAL KDVPFSLCQS VGVGQNTDIQ QIAAKNFTDT SLMYPEDTCK SGPSTNTQSG 
LFNTPPPTPP DLNQDFSGFQ LLVDVALKRA AEMELQAKLT A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.