Details for: TLE1
Gene ID: 7088
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: TLE1
Ensembl ID: ENSG00000196781
Description: TLE family member 1, transcriptional corepressor
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 15.24rCSI 21.6%PRS 60.02
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CSI 13.99rCSI 11.06%PRS 50.52
-
CSI 13.95rCSI 10.48%PRS 69.33
-
CSI 13.37rCSI 23.93%PRS 62.78
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CSI 12.73rCSI 10.54%PRS 66.07
-
CSI 10.95rCSI 25.98%PRS 67.19
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CSI 9.95rCSI 8.74%PRS 69.17
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CSI 9.87rCSI 15.08%PRS 64.37
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CSI 9.17rCSI 54.95%PRS 70.38
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CSI 9.01rCSI 7.83%PRS 74.41
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CSI 7.76rCSI 27.92%PRS 43.44
-
CSI 7.64rCSI 22.14%PRS 53.16
-
CSI 6.59rCSI 10.79%PRS 52.7
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CSI 5.26rCSI 6.75%PRS 60.74
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CSI 5.24rCSI 23.06%PRS 53.77
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CSI 5.01rCSI 3.88%PRS 65.95
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CSI 4.93rCSI 25.88%PRS 73.08
-
CSI 4.38rCSI 8.36%PRS 78.18
-
CSI 4.04rCSI 5.19%PRS 55.94
-
CSI 4.03rCSI 5.14%PRS 70.04
-
CSI 3.98rCSI 4.6%PRS 56.65
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CSI 3.75rCSI 23.99%PRS 64.85
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CSI 3.64rCSI 4.84%PRS 70.23
-
CSI 3.62rCSI 4.95%PRS 69.69
-
CSI 3.58rCSI 2.68%PRS 88.45
-
CSI 3.54rCSI 3.49%PRS 85.51
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CSI 3.35rCSI 5.92%PRS 44.21
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CSI 3.32rCSI 2.46%PRS 56.18
-
CSI 3.3rCSI 21.91%PRS 60.53
-
CSI 3.03rCSI 4.82%PRS 74.75
-
CSI 2.93rCSI 4.51%PRS 59.13
-
CSI 2.82rCSI 2.29%PRS 64.1
-
CSI 2.78rCSI 5.58%PRS 52.63
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CSI 2.72rCSI 2.62%PRS 54.47
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CSI 2.66rCSI 3.64%PRS 65.21
-
CSI 2.59rCSI 3.79%PRS 68.68
-
CSI 2.56rCSI 1.91%PRS 79.92
-
CSI 2.55rCSI 4.77%PRS 51.79
-
CSI 2.52rCSI 8.55%PRS 57.03
-
CSI 2.51rCSI 4.34%PRS 53.72
-
CSI 2.47rCSI 59.21%PRS 44.11
-
CSI 2.44rCSI 58.78%PRS 44.92
-
CSI 2.43rCSI 12.43%PRS 68.28
-
CSI 2.42rCSI 3.6%PRS 65.08
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CSI 2.4rCSI 55.87%PRS 81.82
-
CSI 2.39rCSI 2.09%PRS 72.95
-
CSI 2.38rCSI 2.9%PRS 71.21
-
CSI 2.37rCSI 5.42%PRS 55.21
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CSI 2.37rCSI 9.23%PRS 83.48
-
CSI 2.37rCSI 10.07%PRS 56.77
-
CSI 2.34rCSI 2.25%PRS 84.16
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CSI 2.26rCSI 3.13%PRS 64.41
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CSI 2.24rCSI 2.88%PRS 68.51
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CSI 2.21rCSI 5.37%PRS 43.64
-
CSI 2.21rCSI 3.87%PRS 55.55
-
CSI 2.14rCSI 4.9%PRS 63.71
-
CSI 2.13rCSI 1.68%PRS 70.39
-
CSI 2.11rCSI 1.57%PRS 77.07
-
CSI 2.09rCSI 3.33%PRS 67.86
-
CSI 2.07rCSI 11.14%PRS 75.55
-
CSI 2.07rCSI 3.15%PRS 60.1
-
CSI 2.07rCSI 1.83%PRS 61.69
-
CSI 2.06rCSI 4.83%PRS 67.88
-
CSI 2.06rCSI 1.81%PRS 51.61
-
CSI 2.02rCSI 1.6%PRS 84.32
-
CSI 1.99rCSI 2.72%PRS 55.33
-
CSI 1.98rCSI 7.71%PRS 67.94
-
CSI 1.98rCSI 2.07%PRS 64.05
-
CSI 1.98rCSI 5.02%PRS 57.82
-
CSI 1.95rCSI 1.63%PRS 67.98
-
CSI 1.93rCSI 3.05%PRS 66.15
-
CSI 1.93rCSI 4.01%PRS 60.83
-
CSI 1.93rCSI 2.58%PRS 72.58
-
CSI 1.89rCSI 4.54%PRS 73.44
-
CSI 1.88rCSI 1.56%PRS 63.11
-
CSI 1.87rCSI 4.88%PRS 66.72
-
CSI 1.86rCSI 2.09%PRS 79.94
-
CSI 1.86rCSI 2.68%PRS 74.23
-
CSI 1.85rCSI 2.53%PRS 56.75
-
CSI 1.85rCSI 2.57%PRS 62.18
-
CSI 1.8rCSI 4.19%PRS 80.81
-
CSI 1.79rCSI 3.56%PRS 61.08
-
CSI 1.79rCSI 1.73%PRS 63.72
-
CSI 1.78rCSI 4.26%PRS 71.9
-
CSI 1.78rCSI 2.21%PRS 43.25
-
CSI 1.76rCSI 6.59%PRS 55.56
-
CSI 1.72rCSI 2.07%PRS 61.75
-
CSI 1.7rCSI 5.52%PRS 63.68
-
CSI 1.69rCSI 1.66%PRS 66.36
-
CSI 1.68rCSI 5.48%PRS 63.68
-
CSI 1.67rCSI 9.15%PRS 62.2
-
CSI 1.67rCSI 3.39%PRS 42.76
-
CSI 1.67rCSI 4.4%PRS 81.31
-
CSI 1.67rCSI 3%PRS 56.81
-
CSI 1.63rCSI 4.62%PRS 61.57
-
CSI 1.6rCSI 4.5%PRS 60.33
-
CSI 1.59rCSI 6.42%PRS 62.41
-
CSI 1.58rCSI 1.66%PRS 60.17
-
CSI 1.56rCSI 1.83%PRS 65.99
-
CSI 1.55rCSI 4.58%PRS 66.6
-
CSI 0.1rCSI 3.9%PRS 82.4%
-
CSI 0.2rCSI 1.3%PRS 50.1%
-
CSI 0.2rCSI 2.5%PRS 75.6%
-
CSI 0.2rCSI 1.7%PRS 79.2%
-
CSI 0.2rCSI 1.7%PRS 76.1%
-
CSI 0.3rCSI 3.5%PRS 77.9%
-
CSI 0.3rCSI 1.4%PRS 76.2%
-
CSI 0.4rCSI 3.7%PRS 60.4%
-
CSI 0.4rCSI 3.1%PRS 56.4%
-
CSI 0.5rCSI 6.1%PRS 88.2%
-
CSI 0.5rCSI 2.6%PRS 72.3%
-
CSI 0.5rCSI 3.9%PRS 56.9%
-
CSI 0.5rCSI 3.1%PRS 77.3%
-
CSI 0.5rCSI 2.9%PRS 82.1%
-
CSI 0.6rCSI 4.0%PRS 58.8%
-
CSI 0.6rCSI 4.9%PRS 59.9%
-
CSI 0.7rCSI 3.7%PRS 68.6%
-
CSI 0.7rCSI 1.6%PRS 49.6%
-
CSI 0.7rCSI 4.7%PRS 88.8%
-
CSI 0.7rCSI 2.3%PRS 49.2%
-
CSI 0.8rCSI 6.5%PRS 50.7%
-
CSI 0.8rCSI 5.8%PRS 56.9%
-
CSI 0.8rCSI 2.7%PRS 48.5%
-
CSI 0.8rCSI 2.2%PRS 75.9%
-
CSI 0.8rCSI 2.8%PRS 76.1%
-
CSI 0.8rCSI 3.1%PRS 54.3%
-
CSI 0.8rCSI 4.1%PRS 60.7%
-
CSI 0.8rCSI 2.0%PRS 50.8%
-
CSI 0.9rCSI 1.9%PRS 59.9%
-
CSI 0.9rCSI 6.7%PRS 69.8%
-
CSI 0.9rCSI 1.0%PRS 54.0%
-
CSI 0.9rCSI 1.2%PRS 46.4%
-
CSI 0.9rCSI 6.7%PRS 79.3%
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CSI 0.9rCSI 2.5%PRS 54.5%
-
CSI 0.9rCSI 2.7%PRS 76.5%
-
CSI 1.0rCSI 2.5%PRS 60.7%
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CSI 1.0rCSI 2.8%PRS 65.0%
-
CSI 1.0rCSI 1.2%PRS 79.7%
-
CSI 1.0rCSI 2.2%PRS 74.6%
-
CSI 1.0rCSI 2.6%PRS 85.9%
-
CSI 1.0rCSI 4.2%PRS 75.6%
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CSI 1.0rCSI 9.5%PRS 73.2%
-
CSI 1.1rCSI 3.4%PRS 68.4%
-
CSI 1.1rCSI 2.1%PRS 66.7%
-
CSI 1.1rCSI 1.9%PRS 71.8%
-
CSI 1.1rCSI 1.8%PRS 69.1%
-
CSI 1.1rCSI 2.4%PRS 71.6%
-
CSI 1.1rCSI 1.7%PRS 62.1%
-
CSI 1.1rCSI 5.0%PRS 63.4%
-
CSI 1.2rCSI 1.9%PRS 53.1%
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CSI 1.2rCSI 1.9%PRS 45.1%
-
CSI 1.2rCSI 2.8%PRS 70.9%
-
CSI 1.2rCSI 1.9%PRS 56.0%
-
CSI 1.2rCSI 2.3%PRS 76.9%
-
CSI 1.2rCSI 2.4%PRS 64.8%
-
CSI 1.2rCSI 1.7%PRS 75.4%
-
CSI 1.2rCSI 3.4%PRS 75.4%
-
CSI 1.2rCSI 5.8%PRS 58.1%
-
CSI 1.2rCSI 6.5%PRS 57.7%
-
CSI 1.3rCSI 2.3%PRS 84.6%
-
CSI 1.3rCSI 3.6%PRS 59.1%
-
CSI 1.3rCSI 3.5%PRS 70.7%
-
CSI 1.3rCSI 3.9%PRS 62.2%
-
CSI 1.3rCSI 1.7%PRS 65.4%
-
CSI 1.3rCSI 3.2%PRS 64.3%
-
CSI 1.3rCSI 3.0%PRS 61.7%
-
CSI 1.3rCSI 3.4%PRS 62.7%
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CSI 1.3rCSI 1.5%PRS 67.5%
-
CSI 1.3rCSI 4.3%PRS 60.7%
-
CSI 1.4rCSI 1.7%PRS 72.7%
-
CSI 1.4rCSI 3.4%PRS 56.9%
-
CSI 1.4rCSI 1.5%PRS 63.4%
-
CSI 1.4rCSI 2.1%PRS 56.9%
-
CSI 1.4rCSI 2.3%PRS 56.1%
-
CSI 1.5rCSI 3.3%PRS 45.8%
-
CSI 1.5rCSI 2.2%PRS 53.2%
-
CSI 1.5rCSI 2.3%PRS 76.7%
-
CSI 1.5rCSI 1.8%PRS 44.9%
-
CSI 1.5rCSI 7.3%PRS 62.0%
-
CSI 1.5rCSI 2.2%PRS 65.8%
-
CSI 1.5rCSI 2.1%PRS 70.0%
-
CSI 1.5rCSI 2.0%PRS 64.1%
-
CSI 1.5rCSI 4.0%PRS 72.4%
-
CSI 1.5rCSI 2.3%PRS 68.9%
-
CSI 1.6rCSI 1.9%PRS 60.5%
-
CSI 1.6rCSI 3.8%PRS 62.2%
-
CSI 1.6rCSI 4.6%PRS 66.6%
-
CSI 1.6rCSI 1.8%PRS 66.0%
-
CSI 1.6rCSI 1.7%PRS 60.2%
-
CSI 1.6rCSI 6.4%PRS 62.4%
-
CSI 1.6rCSI 4.5%PRS 60.3%
-
CSI 1.6rCSI 4.6%PRS 61.6%
-
CSI 1.7rCSI 3.0%PRS 56.8%
-
CSI 1.7rCSI 4.4%PRS 81.3%
-
CSI 1.7rCSI 3.4%PRS 42.8%
-
CSI 1.7rCSI 9.2%PRS 62.2%
-
CSI 1.7rCSI 5.5%PRS 63.7%
-
CSI 1.7rCSI 1.7%PRS 66.4%
-
CSI 1.7rCSI 5.5%PRS 63.7%
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CSI 1.7rCSI 2.1%PRS 61.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 476456720
Symbol: TLE1_HUMAN
Name: Transducin-like enhancer protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1303260
Title: Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins.
PubMed ID: 1303260
DOI: 10.1038/ng1092-119
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10748198
Title: Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.
PubMed ID: 10748198
PubMed ID: 8687460
Title: Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif.
PubMed ID: 8687460
PubMed ID: 8649374
Title: The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain.
PubMed ID: 8649374
PubMed ID: 9334241
Title: The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3.
PubMed ID: 9334241
PubMed ID: 9874198
Title: Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development.
PubMed ID: 9874198
PubMed ID: 9751710
Title: Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.
PubMed ID: 9751710
PubMed ID: 9854018
Title: Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms.
PubMed ID: 9854018
DOI: 10.1042/bj3370013
PubMed ID: 10660609
Title: Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats.
PubMed ID: 10660609
PubMed ID: 11731482
Title: Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis.
PubMed ID: 11731482
DOI: 10.1101/gad.932601
PubMed ID: 12397081
Title: A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression.
PubMed ID: 12397081
PubMed ID: 14651967
Title: Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma.
PubMed ID: 14651967
PubMed ID: 12441302
Title: Six3 and Six6 activity is modulated by members of the groucho family.
PubMed ID: 12441302
DOI: 10.1242/dev.00185
PubMed ID: 18254933
Title: The Groucho/TLE/Grg family of transcriptional co-repressors.
PubMed ID: 18254933
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21429299
Title: EphrinB1 interacts with the transcriptional co-repressor Groucho/xTLE4.
PubMed ID: 21429299
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22304967
Title: XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.
PubMed ID: 22304967
PubMed ID: 12057191
Title: Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor.
PubMed ID: 12057191
Sequence Information:
- Length: 770
- Mass: 83201
- Checksum: 695FD1A37410EFE5
- Sequence:
MFPQSRHPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH QQQVAQAVER AKQVTMAELN AIIGQQQLQA QHLSHGHGPP VPLTPHPSGL QPPGIPPLGG SAGLLALSSA LSGQSHLAIK DDKKHHDAEH HRDREPGTSN SLLVPDSLRG TDKRRNGPEF SNDIKKRKVD DKDSSHYDSD GDKSDDNLVV DVSNEDPSSP RASPAHSPRE NGIDKNRLLK KDASSSPAST ASSASSTSLK SKEMSLHEKA STPVLKSSTP TPRSDMPTPG TSATPGLRPG LGKPPAIDPL VNQAAAGLRT PLAVPGPYPA PFGMVPHAGM NGELTSPGAA YASLHNMSPQ MSAAAAAAAV VAYGRSPMVG FDPPPHMRVP TIPPNLAGIP GGKPAYSFHV TADGQMQPVP FPPDALIGPG IPRHARQINT LNHGEVVCAV TISNPTRHVY TGGKGCVKVW DISHPGNKSP VSQLDCLNRD NYIRSCKLLP DGCTLIVGGE ASTLSIWDLA APTPRIKAEL TSSAPACYAL AISPDSKVCF SCCSDGNIAV WDLHNQTLVR QFQGHTDGAS CIDISNDGTK LWTGGLDNTV RSWDLREGRQ LQQHDFTSQI FSLGYCPTGE WLAVGMESSN VEVLHVNKPD KYQLHLHESC VLSLKFAYCG KWFVSTGKDN LLNAWRTPYG ASIFQSKESS SVLSCDISVD DKYIVTGSGD KKATVYEVIY
Genular Protein ID: 570479175
Symbol: Q59EF7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 636
- Mass: 68167
- Checksum: 43EDDF601FE5A627
- Sequence:
FSSAGLKLEI DRRIELPGNR APAAARAMFP QSRHPTPHQA AGQPFKFTIP ESLDRIKEEF QFLQAQYHSL KLECEKLASE KTEMQRHYVM YYEMSYGLNI EMHKQTEIAK RLNTICAQVI PFLSQEHQQQ VAQAVERAKQ VTMAELNAII GQQQLQAQHL SHGHGPPVPL TPHPSGLQPP GIPPLGGSAG LLALSSALSG QSHLAIKDDK KHHDAEHHRD REPGTSNSLL VPDSLRGTDK RRNGPEFSND IKKRKVDDKD SSHYDSDGDK SDDNLVVDVS NEDPSSPRAS PAHSPRENGI DKNRLLKKDA SSSPASTASS ASSTSLKSKE MSLHEKASTP VLKSSTPTPR SDMPTPGTSA TPGLRPGLGK PPAIDPLVNQ AAGLRTPLAV PGPYPAPFGM VPHAGMNGEL TSPGAAYASL HNMSPQMSAA AAAAAVVAYG RSPMVGFDPP PHMRVPTIPP NLAGIPGGKP AYSFHVTADG QMQPVPFPPD ALIGPGIPRH ARQINTLNHG EVVCAVTISN PTRHVYTGGK GCVKVWDISH PGNKSPVSQL DCLNRDNYIR SCKLLPDGCT LIVGGEASTL SIWDLAAPTP RIKAELTSSA PACYALAISP DSKVCFSCCS DGNIAVWDLY NQTLVR
Genular Protein ID: 1409467347
Symbol: B4DEF9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 755
- Mass: 81713
- Checksum: 97133F07AC2F34D7
- Sequence:
MFPQSRHPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH QQQVAQAVER AKQVTMAELN AIIGQQQLQA QHLSHGHGPP VPLTPHPSGL QPPGIPPLGG SAGLLALSSA LSGQSHLAIK DDKKHHDAEH HRDREPGTSN SLLVPDSLRG TDKRRNGPEF SNDIKKRKVD DKDSSHYDSD GDKSDDNLVV DVSNEDPSSP RASPAHSPRE NGIDKNRLLK KDASSSPAST ASSASSTSLK SKEMSLHEKA STPVLKSSTP TPRSDMPTPG TSATPGLRPA AGLRTPLAVP GPYPAPFGMV PHAGMNGELT SPGAAYASLH NMSPQMSAAA AAAAVVAYGR SPMVGFDPPP HMRVPTIPPN LAGIPGGKPA YSFHVTADGQ MQPVPFPPDA LIGPGIPRHA RQINTLNHGE VVCAVTISNP TRHVYTGGKG CVKVWDISHP GNKSPVSQLD CLNRDNYIRS CKLLPDGCTL IVGGEASTLS IWDLAAPTPR IKAELTSSAP ACYALAISPD SKVCFSCCSD GNIAVWDLHN QTLVRQFQGH TDGASCIDIS NDGTKLWTGG PDNTVRSWDL REGRQLQQHD FTSQIFSLGY CPTGEWLAVG MESSNVEVLH VNKPDKYQLH LHESCVLSLK FAYCGKWFVS TGKDNLLNAW RTPYGASIFQ SKESSSVLSC DISVDDKYIV TGSGDKKATV YEVIY