Details for: TLE1

Gene ID: 7088

Symbol: TLE1

Ensembl ID: ENSG00000196781

Description: TLE family member 1, transcriptional corepressor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 239.5445
    Cell Significance Index: -37.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 155.7107
    Cell Significance Index: -39.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 83.5270
    Cell Significance Index: -39.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 82.4109
    Cell Significance Index: -33.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.1456
    Cell Significance Index: -33.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.7449
    Cell Significance Index: -39.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.3597
    Cell Significance Index: -38.4700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.2486
    Cell Significance Index: -22.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.9910
    Cell Significance Index: -39.4300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.4444
    Cell Significance Index: 41.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.2153
    Cell Significance Index: 59.3600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.7058
    Cell Significance Index: 21.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6694
    Cell Significance Index: 75.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5845
    Cell Significance Index: 314.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5312
    Cell Significance Index: 249.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3735
    Cell Significance Index: 247.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3406
    Cell Significance Index: 268.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2597
    Cell Significance Index: 65.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2227
    Cell Significance Index: 68.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1771
    Cell Significance Index: 144.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0635
    Cell Significance Index: 47.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0217
    Cell Significance Index: 38.6900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.9854
    Cell Significance Index: 13.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8155
    Cell Significance Index: 7.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7917
    Cell Significance Index: 22.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7702
    Cell Significance Index: 36.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7410
    Cell Significance Index: 34.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7044
    Cell Significance Index: 96.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6850
    Cell Significance Index: 374.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6030
    Cell Significance Index: 17.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5950
    Cell Significance Index: 40.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5340
    Cell Significance Index: 68.9900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5079
    Cell Significance Index: 17.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4324
    Cell Significance Index: 191.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4311
    Cell Significance Index: 29.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3855
    Cell Significance Index: 38.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3753
    Cell Significance Index: 238.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2618
    Cell Significance Index: 6.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2530
    Cell Significance Index: 7.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2463
    Cell Significance Index: 5.6900
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.2113
    Cell Significance Index: 0.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1984
    Cell Significance Index: 10.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1938
    Cell Significance Index: 69.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1870
    Cell Significance Index: 35.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1551
    Cell Significance Index: 26.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1197
    Cell Significance Index: 108.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1114
    Cell Significance Index: 151.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1099
    Cell Significance Index: 76.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1041
    Cell Significance Index: 7.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0837
    Cell Significance Index: 2.3400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0798
    Cell Significance Index: 1.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0741
    Cell Significance Index: 1.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0706
    Cell Significance Index: 9.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0512
    Cell Significance Index: 1.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0465
    Cell Significance Index: 21.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0419
    Cell Significance Index: 77.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0384
    Cell Significance Index: 2.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0360
    Cell Significance Index: 67.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0041
    Cell Significance Index: 6.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0167
    Cell Significance Index: -12.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0193
    Cell Significance Index: -14.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0206
    Cell Significance Index: -0.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0208
    Cell Significance Index: -3.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0213
    Cell Significance Index: -13.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0473
    Cell Significance Index: -2.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0476
    Cell Significance Index: -36.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0520
    Cell Significance Index: -29.3100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0636
    Cell Significance Index: -1.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0660
    Cell Significance Index: -4.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0939
    Cell Significance Index: -10.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0957
    Cell Significance Index: -20.1600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1004
    Cell Significance Index: -2.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1102
    Cell Significance Index: -31.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1157
    Cell Significance Index: -13.4800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1381
    Cell Significance Index: -15.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1400
    Cell Significance Index: -1.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1401
    Cell Significance Index: -14.3200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1477
    Cell Significance Index: -2.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1587
    Cell Significance Index: -3.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2010
    Cell Significance Index: -5.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2056
    Cell Significance Index: -5.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2089
    Cell Significance Index: -6.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2486
    Cell Significance Index: -18.5300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2733
    Cell Significance Index: -3.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2910
    Cell Significance Index: -22.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3019
    Cell Significance Index: -31.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3095
    Cell Significance Index: -36.5000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.3392
    Cell Significance Index: -2.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3432
    Cell Significance Index: -7.4400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3449
    Cell Significance Index: -5.9100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3824
    Cell Significance Index: -5.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3948
    Cell Significance Index: -31.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4238
    Cell Significance Index: -25.9800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4287
    Cell Significance Index: -7.5800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5188
    Cell Significance Index: -8.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5334
    Cell Significance Index: -14.5200
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.5693
    Cell Significance Index: -1.5300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.5747
    Cell Significance Index: -4.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6049
    Cell Significance Index: -15.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6510
    Cell Significance Index: -41.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TLE1 is a transcriptional corepressor that belongs to the Groucho/TLE family of proteins. It is characterized by its ability to interact with transcription factors, such as β-catenin and TCF/LEF, and repress gene expression. TLE1 is highly expressed in various cell types, including astrocytes, glandular epithelial cells, and vascular smooth muscle cells. Its expression is also observed in specific tissues, such as the cerebral cortex and adrenal glands. **Pathways and Functions:** TLE1 is integral to several signaling pathways, including Wnt/β-catenin, Notch, and Wnt/β-catenin-independent pathways. It functions as a corepressor in the Wnt/β-catenin pathway, regulating the transcription of target genes. TLE1 also interacts with TCF/LEF transcription factors, which are essential for Wnt signaling. In addition, TLE1 has been shown to regulate other signaling pathways, such as Notch and Wnt-independent pathways, which are involved in cell adhesion, migration, and differentiation. **Functions:** 1. **Wnt/β-catenin pathway regulation**: TLE1 acts as a corepressor in the Wnt/β-catenin pathway, regulating the transcription of target genes. 2. **Notch signaling regulation**: TLE1 interacts with Notch1 intracellular domain, regulating its transcriptional activity. 3. **Cell adhesion and migration**: TLE1 regulates the expression of genes involved in cell adhesion and migration, such as cadherins and integrins. 4. **Differentiation and morphogenesis**: TLE1 is involved in regulating the expression of genes involved in differentiation and morphogenesis, such as those involved in the development of the cerebral cortex and adrenal glands. **Clinical Significance:** TLE1's dysregulation has been implicated in various diseases, including cancer, neurological disorders, and cardiovascular diseases. For example: 1. **Cancer**: TLE1 has been shown to be overexpressed in various types of cancer, including colorectal, breast, and lung cancer, where it promotes tumor progression and metastasis. 2. **Neurological disorders**: TLE1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it regulates the expression of genes involved in neuronal survival and function. 3. **Cardiovascular diseases**: TLE1 has been shown to regulate the expression of genes involved in cardiovascular development and function, where it plays a role in the development of cardiovascular diseases, such as atherosclerosis. In conclusion, TLE1 is a transcriptional corepressor that plays a critical role in regulating Wnt signaling and other cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of TLE1's function and its potential as a therapeutic target.

Genular Protein ID: 476456720

Symbol: TLE1_HUMAN

Name: Transducin-like enhancer protein 1

UniProtKB Accession Codes:

Q04724 A8K495 Q5T3G4 Q969V9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1303260

Title: Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins.

PubMed ID: 1303260

DOI: 10.1038/ng1092-119

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10748198

Title: Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.

PubMed ID: 10748198

DOI: 10.1074/jbc.m910211199

PubMed ID: 8687460

Title: Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif.

PubMed ID: 8687460

DOI: 10.1006/bbrc.1996.0959

PubMed ID: 8649374

Title: The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain.

PubMed ID: 8649374

DOI: 10.1128/mcb.16.6.2670

PubMed ID: 9334241

Title: The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3.

PubMed ID: 9334241

DOI: 10.1074/jbc.272.42.26604

PubMed ID: 9874198

Title: Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development.

PubMed ID: 9874198

DOI: 10.1046/j.1432-1327.1998.2580339.x

PubMed ID: 9751710

Title: Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.

PubMed ID: 9751710

DOI: 10.1073/pnas.95.20.11590

PubMed ID: 9854018

Title: Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms.

PubMed ID: 9854018

DOI: 10.1042/bj3370013

PubMed ID: 10660609

Title: Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats.

PubMed ID: 10660609

DOI: 10.1074/jbc.275.6.4383

PubMed ID: 11731482

Title: Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis.

PubMed ID: 11731482

DOI: 10.1101/gad.932601

PubMed ID: 12397081

Title: A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression.

PubMed ID: 12397081

DOI: 10.1074/jbc.m111660200

PubMed ID: 14651967

Title: Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma.

PubMed ID: 14651967

DOI: 10.1016/j.bbrc.2003.11.025

PubMed ID: 12441302

Title: Six3 and Six6 activity is modulated by members of the groucho family.

PubMed ID: 12441302

DOI: 10.1242/dev.00185

PubMed ID: 18254933

Title: The Groucho/TLE/Grg family of transcriptional co-repressors.

PubMed ID: 18254933

DOI: 10.1186/gb-2008-9-1-205

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21429299

Title: EphrinB1 interacts with the transcriptional co-repressor Groucho/xTLE4.

PubMed ID: 21429299

DOI: 10.5483/bmbrep.2011.44.3.199

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22304967

Title: XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.

PubMed ID: 22304967

DOI: 10.1016/j.molcel.2011.12.032

PubMed ID: 12057191

Title: Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor.

PubMed ID: 12057191

DOI: 10.1016/s0969-2126(02)00768-2

Sequence Information:

  • Length: 770
  • Mass: 83201
  • Checksum: 695FD1A37410EFE5
  • Sequence:
    • MFPQSRHPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH 
YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH QQQVAQAVER AKQVTMAELN 
AIIGQQQLQA QHLSHGHGPP VPLTPHPSGL QPPGIPPLGG SAGLLALSSA LSGQSHLAIK 
DDKKHHDAEH HRDREPGTSN SLLVPDSLRG TDKRRNGPEF SNDIKKRKVD DKDSSHYDSD 
GDKSDDNLVV DVSNEDPSSP RASPAHSPRE NGIDKNRLLK KDASSSPAST ASSASSTSLK 
SKEMSLHEKA STPVLKSSTP TPRSDMPTPG TSATPGLRPG LGKPPAIDPL VNQAAAGLRT 
PLAVPGPYPA PFGMVPHAGM NGELTSPGAA YASLHNMSPQ MSAAAAAAAV VAYGRSPMVG 
FDPPPHMRVP TIPPNLAGIP GGKPAYSFHV TADGQMQPVP FPPDALIGPG IPRHARQINT 
LNHGEVVCAV TISNPTRHVY TGGKGCVKVW DISHPGNKSP VSQLDCLNRD NYIRSCKLLP 
DGCTLIVGGE ASTLSIWDLA APTPRIKAEL TSSAPACYAL AISPDSKVCF SCCSDGNIAV 
WDLHNQTLVR QFQGHTDGAS CIDISNDGTK LWTGGLDNTV RSWDLREGRQ LQQHDFTSQI 
FSLGYCPTGE WLAVGMESSN VEVLHVNKPD KYQLHLHESC VLSLKFAYCG KWFVSTGKDN 
LLNAWRTPYG ASIFQSKESS SVLSCDISVD DKYIVTGSGD KKATVYEVIY

Genular Protein ID: 570479175

Symbol: Q59EF7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59EF7

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 Pfam 3 RefSeq 3 SAM 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 636
  • Mass: 68167
  • Checksum: 43EDDF601FE5A627
  • Sequence:
    • FSSAGLKLEI DRRIELPGNR APAAARAMFP QSRHPTPHQA AGQPFKFTIP ESLDRIKEEF 
QFLQAQYHSL KLECEKLASE KTEMQRHYVM YYEMSYGLNI EMHKQTEIAK RLNTICAQVI 
PFLSQEHQQQ VAQAVERAKQ VTMAELNAII GQQQLQAQHL SHGHGPPVPL TPHPSGLQPP 
GIPPLGGSAG LLALSSALSG QSHLAIKDDK KHHDAEHHRD REPGTSNSLL VPDSLRGTDK 
RRNGPEFSND IKKRKVDDKD SSHYDSDGDK SDDNLVVDVS NEDPSSPRAS PAHSPRENGI 
DKNRLLKKDA SSSPASTASS ASSTSLKSKE MSLHEKASTP VLKSSTPTPR SDMPTPGTSA 
TPGLRPGLGK PPAIDPLVNQ AAGLRTPLAV PGPYPAPFGM VPHAGMNGEL TSPGAAYASL 
HNMSPQMSAA AAAAAVVAYG RSPMVGFDPP PHMRVPTIPP NLAGIPGGKP AYSFHVTADG 
QMQPVPFPPD ALIGPGIPRH ARQINTLNHG EVVCAVTISN PTRHVYTGGK GCVKVWDISH 
PGNKSPVSQL DCLNRDNYIR SCKLLPDGCT LIVGGEASTL SIWDLAAPTP RIKAELTSSA 
PACYALAISP DSKVCFSCCS DGNIAVWDLY NQTLVR

Genular Protein ID: 1409467347

Symbol: B4DEF9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DEF9

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 755
  • Mass: 81713
  • Checksum: 97133F07AC2F34D7
  • Sequence:
    • MFPQSRHPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH 
YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH QQQVAQAVER AKQVTMAELN 
AIIGQQQLQA QHLSHGHGPP VPLTPHPSGL QPPGIPPLGG SAGLLALSSA LSGQSHLAIK 
DDKKHHDAEH HRDREPGTSN SLLVPDSLRG TDKRRNGPEF SNDIKKRKVD DKDSSHYDSD 
GDKSDDNLVV DVSNEDPSSP RASPAHSPRE NGIDKNRLLK KDASSSPAST ASSASSTSLK 
SKEMSLHEKA STPVLKSSTP TPRSDMPTPG TSATPGLRPA AGLRTPLAVP GPYPAPFGMV 
PHAGMNGELT SPGAAYASLH NMSPQMSAAA AAAAVVAYGR SPMVGFDPPP HMRVPTIPPN 
LAGIPGGKPA YSFHVTADGQ MQPVPFPPDA LIGPGIPRHA RQINTLNHGE VVCAVTISNP 
TRHVYTGGKG CVKVWDISHP GNKSPVSQLD CLNRDNYIRS CKLLPDGCTL IVGGEASTLS 
IWDLAAPTPR IKAELTSSAP ACYALAISPD SKVCFSCCSD GNIAVWDLHN QTLVRQFQGH 
TDGASCIDIS NDGTKLWTGG PDNTVRSWDL REGRQLQQHD FTSQIFSLGY CPTGEWLAVG 
MESSNVEVLH VNKPDKYQLH LHESCVLSLK FAYCGKWFVS TGKDNLLNAW RTPYGASIFQ 
SKESSSVLSC DISVDDKYIV TGSGDKKATV YEVIY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.