Details for: TLE1

Gene ID: 7088

Symbol: TLE1

Ensembl ID: ENSG00000196781

Description: TLE family member 1, transcriptional corepressor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.35
    Marker Score: 50082
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.24
    Marker Score: 5501
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.22
    Marker Score: 2557
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.05
    Marker Score: 750
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.04
    Marker Score: 36144
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.87
    Marker Score: 1013
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.79
    Marker Score: 1711
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.79
    Marker Score: 4083
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.73
    Marker Score: 507
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.72
    Marker Score: 2535
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.72
    Marker Score: 960
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.66
    Marker Score: 1750
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.6
    Marker Score: 956
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.59
    Marker Score: 3062
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.51
    Marker Score: 1135.5
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.51
    Marker Score: 1487
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.51
    Marker Score: 881
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.5
    Marker Score: 648
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167747
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.46
    Marker Score: 2112
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.44
    Marker Score: 48928
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.43
    Marker Score: 5294
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.38
    Marker Score: 4529
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.38
    Marker Score: 8886
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.38
    Marker Score: 2131
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.35
    Marker Score: 15249
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.35
    Marker Score: 2700
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.35
    Marker Score: 4518
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.33
    Marker Score: 5222
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.31
    Marker Score: 1303
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.3
    Marker Score: 3258
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.29
    Marker Score: 1558
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.28
    Marker Score: 596
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.26
    Marker Score: 5429
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.25
    Marker Score: 1399.5
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.24
    Marker Score: 750
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.24
    Marker Score: 76403
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.21
    Marker Score: 1048
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.21
    Marker Score: 452
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2
    Marker Score: 1200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.2
    Marker Score: 1329
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.18
    Marker Score: 6327
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.17
    Marker Score: 658
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.17
    Marker Score: 2444
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.15
    Marker Score: 39679
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.14
    Marker Score: 553
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.14
    Marker Score: 429
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.13
    Marker Score: 1743
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.13
    Marker Score: 399
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.12
    Marker Score: 740
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.12
    Marker Score: 17540
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.12
    Marker Score: 1392
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.09
    Marker Score: 639
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.09
    Marker Score: 342
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.08
    Marker Score: 285
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.07
    Marker Score: 4622
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.07
    Marker Score: 1112
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.07
    Marker Score: 562
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.04
    Marker Score: 527
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.04
    Marker Score: 336
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.04
    Marker Score: 38429
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.02
    Marker Score: 1110
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.02
    Marker Score: 357
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.02
    Marker Score: 493
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1
    Marker Score: 1063
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71698
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47922
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.99
    Marker Score: 355
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.98
    Marker Score: 1049
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30393
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.98
    Marker Score: 10122
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.98
    Marker Score: 553
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.98
    Marker Score: 1419
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.96
    Marker Score: 6271
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.96
    Marker Score: 459
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.96
    Marker Score: 1609
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.95
    Marker Score: 2599
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.95
    Marker Score: 1026
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.95
    Marker Score: 570
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.95
    Marker Score: 272
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.95
    Marker Score: 790
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 487
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.94
    Marker Score: 3844
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2395
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.94
    Marker Score: 452.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 442
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.93
    Marker Score: 377
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.93
    Marker Score: 2040
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.93
    Marker Score: 5570
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.93
    Marker Score: 632
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.92
    Marker Score: 212
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.92
    Marker Score: 387
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.92
    Marker Score: 754
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.92
    Marker Score: 308
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.92
    Marker Score: 2613
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.91
    Marker Score: 813
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.91
    Marker Score: 262
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.91
    Marker Score: 630
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.91
    Marker Score: 596

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Other Information

**Key Characteristics:** TLE1 is a transcriptional corepressor that belongs to the Groucho/TLE family of proteins. It is characterized by its ability to interact with transcription factors, such as β-catenin and TCF/LEF, and repress gene expression. TLE1 is highly expressed in various cell types, including astrocytes, glandular epithelial cells, and vascular smooth muscle cells. Its expression is also observed in specific tissues, such as the cerebral cortex and adrenal glands. **Pathways and Functions:** TLE1 is integral to several signaling pathways, including Wnt/β-catenin, Notch, and Wnt/β-catenin-independent pathways. It functions as a corepressor in the Wnt/β-catenin pathway, regulating the transcription of target genes. TLE1 also interacts with TCF/LEF transcription factors, which are essential for Wnt signaling. In addition, TLE1 has been shown to regulate other signaling pathways, such as Notch and Wnt-independent pathways, which are involved in cell adhesion, migration, and differentiation. **Functions:** 1. **Wnt/β-catenin pathway regulation**: TLE1 acts as a corepressor in the Wnt/β-catenin pathway, regulating the transcription of target genes. 2. **Notch signaling regulation**: TLE1 interacts with Notch1 intracellular domain, regulating its transcriptional activity. 3. **Cell adhesion and migration**: TLE1 regulates the expression of genes involved in cell adhesion and migration, such as cadherins and integrins. 4. **Differentiation and morphogenesis**: TLE1 is involved in regulating the expression of genes involved in differentiation and morphogenesis, such as those involved in the development of the cerebral cortex and adrenal glands. **Clinical Significance:** TLE1's dysregulation has been implicated in various diseases, including cancer, neurological disorders, and cardiovascular diseases. For example: 1. **Cancer**: TLE1 has been shown to be overexpressed in various types of cancer, including colorectal, breast, and lung cancer, where it promotes tumor progression and metastasis. 2. **Neurological disorders**: TLE1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it regulates the expression of genes involved in neuronal survival and function. 3. **Cardiovascular diseases**: TLE1 has been shown to regulate the expression of genes involved in cardiovascular development and function, where it plays a role in the development of cardiovascular diseases, such as atherosclerosis. In conclusion, TLE1 is a transcriptional corepressor that plays a critical role in regulating Wnt signaling and other cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of TLE1's function and its potential as a therapeutic target.

Genular Protein ID: 476456720

Symbol: TLE1_HUMAN

Name: Transducin-like enhancer protein 1

UniProtKB Accession Codes:

Q04724 A8K495 Q5T3G4 Q969V9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1303260

Title: Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins.

PubMed ID: 1303260

DOI: 10.1038/ng1092-119

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10748198

Title: Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.

PubMed ID: 10748198

DOI: 10.1074/jbc.m910211199

PubMed ID: 8687460

Title: Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif.

PubMed ID: 8687460

DOI: 10.1006/bbrc.1996.0959

PubMed ID: 8649374

Title: The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain.

PubMed ID: 8649374

DOI: 10.1128/mcb.16.6.2670

PubMed ID: 9334241

Title: The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3.

PubMed ID: 9334241

DOI: 10.1074/jbc.272.42.26604

PubMed ID: 9874198

Title: Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development.

PubMed ID: 9874198

DOI: 10.1046/j.1432-1327.1998.2580339.x

PubMed ID: 9751710

Title: Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.

PubMed ID: 9751710

DOI: 10.1073/pnas.95.20.11590

PubMed ID: 9854018

Title: Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms.

PubMed ID: 9854018

DOI: 10.1042/bj3370013

PubMed ID: 10660609

Title: Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats.

PubMed ID: 10660609

DOI: 10.1074/jbc.275.6.4383

PubMed ID: 11731482

Title: Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis.

PubMed ID: 11731482

DOI: 10.1101/gad.932601

PubMed ID: 12397081

Title: A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression.

PubMed ID: 12397081

DOI: 10.1074/jbc.m111660200

PubMed ID: 14651967

Title: Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma.

PubMed ID: 14651967

DOI: 10.1016/j.bbrc.2003.11.025

PubMed ID: 12441302

Title: Six3 and Six6 activity is modulated by members of the groucho family.

PubMed ID: 12441302

DOI: 10.1242/dev.00185

PubMed ID: 18254933

Title: The Groucho/TLE/Grg family of transcriptional co-repressors.

PubMed ID: 18254933

DOI: 10.1186/gb-2008-9-1-205

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21429299

Title: EphrinB1 interacts with the transcriptional co-repressor Groucho/xTLE4.

PubMed ID: 21429299

DOI: 10.5483/bmbrep.2011.44.3.199

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22304967

Title: XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.

PubMed ID: 22304967

DOI: 10.1016/j.molcel.2011.12.032

PubMed ID: 12057191

Title: Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor.

PubMed ID: 12057191

DOI: 10.1016/s0969-2126(02)00768-2

Sequence Information:

  • Length: 770
  • Mass: 83201
  • Checksum: 695FD1A37410EFE5
  • Sequence:
    • MFPQSRHPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH 
YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH QQQVAQAVER AKQVTMAELN 
AIIGQQQLQA QHLSHGHGPP VPLTPHPSGL QPPGIPPLGG SAGLLALSSA LSGQSHLAIK 
DDKKHHDAEH HRDREPGTSN SLLVPDSLRG TDKRRNGPEF SNDIKKRKVD DKDSSHYDSD 
GDKSDDNLVV DVSNEDPSSP RASPAHSPRE NGIDKNRLLK KDASSSPAST ASSASSTSLK 
SKEMSLHEKA STPVLKSSTP TPRSDMPTPG TSATPGLRPG LGKPPAIDPL VNQAAAGLRT 
PLAVPGPYPA PFGMVPHAGM NGELTSPGAA YASLHNMSPQ MSAAAAAAAV VAYGRSPMVG 
FDPPPHMRVP TIPPNLAGIP GGKPAYSFHV TADGQMQPVP FPPDALIGPG IPRHARQINT 
LNHGEVVCAV TISNPTRHVY TGGKGCVKVW DISHPGNKSP VSQLDCLNRD NYIRSCKLLP 
DGCTLIVGGE ASTLSIWDLA APTPRIKAEL TSSAPACYAL AISPDSKVCF SCCSDGNIAV 
WDLHNQTLVR QFQGHTDGAS CIDISNDGTK LWTGGLDNTV RSWDLREGRQ LQQHDFTSQI 
FSLGYCPTGE WLAVGMESSN VEVLHVNKPD KYQLHLHESC VLSLKFAYCG KWFVSTGKDN 
LLNAWRTPYG ASIFQSKESS SVLSCDISVD DKYIVTGSGD KKATVYEVIY

Genular Protein ID: 570479175

Symbol: Q59EF7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59EF7

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 Pfam 3 RefSeq 3 SAM 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 636
  • Mass: 68167
  • Checksum: 43EDDF601FE5A627
  • Sequence:
    • FSSAGLKLEI DRRIELPGNR APAAARAMFP QSRHPTPHQA AGQPFKFTIP ESLDRIKEEF 
QFLQAQYHSL KLECEKLASE KTEMQRHYVM YYEMSYGLNI EMHKQTEIAK RLNTICAQVI 
PFLSQEHQQQ VAQAVERAKQ VTMAELNAII GQQQLQAQHL SHGHGPPVPL TPHPSGLQPP 
GIPPLGGSAG LLALSSALSG QSHLAIKDDK KHHDAEHHRD REPGTSNSLL VPDSLRGTDK 
RRNGPEFSND IKKRKVDDKD SSHYDSDGDK SDDNLVVDVS NEDPSSPRAS PAHSPRENGI 
DKNRLLKKDA SSSPASTASS ASSTSLKSKE MSLHEKASTP VLKSSTPTPR SDMPTPGTSA 
TPGLRPGLGK PPAIDPLVNQ AAGLRTPLAV PGPYPAPFGM VPHAGMNGEL TSPGAAYASL 
HNMSPQMSAA AAAAAVVAYG RSPMVGFDPP PHMRVPTIPP NLAGIPGGKP AYSFHVTADG 
QMQPVPFPPD ALIGPGIPRH ARQINTLNHG EVVCAVTISN PTRHVYTGGK GCVKVWDISH 
PGNKSPVSQL DCLNRDNYIR SCKLLPDGCT LIVGGEASTL SIWDLAAPTP RIKAELTSSA 
PACYALAISP DSKVCFSCCS DGNIAVWDLY NQTLVR

Genular Protein ID: 1409467347

Symbol: B4DEF9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DEF9

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 755
  • Mass: 81713
  • Checksum: 97133F07AC2F34D7
  • Sequence:
    • MFPQSRHPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH 
YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH QQQVAQAVER AKQVTMAELN 
AIIGQQQLQA QHLSHGHGPP VPLTPHPSGL QPPGIPPLGG SAGLLALSSA LSGQSHLAIK 
DDKKHHDAEH HRDREPGTSN SLLVPDSLRG TDKRRNGPEF SNDIKKRKVD DKDSSHYDSD 
GDKSDDNLVV DVSNEDPSSP RASPAHSPRE NGIDKNRLLK KDASSSPAST ASSASSTSLK 
SKEMSLHEKA STPVLKSSTP TPRSDMPTPG TSATPGLRPA AGLRTPLAVP GPYPAPFGMV 
PHAGMNGELT SPGAAYASLH NMSPQMSAAA AAAAVVAYGR SPMVGFDPPP HMRVPTIPPN 
LAGIPGGKPA YSFHVTADGQ MQPVPFPPDA LIGPGIPRHA RQINTLNHGE VVCAVTISNP 
TRHVYTGGKG CVKVWDISHP GNKSPVSQLD CLNRDNYIRS CKLLPDGCTL IVGGEASTLS 
IWDLAAPTPR IKAELTSSAP ACYALAISPD SKVCFSCCSD GNIAVWDLHN QTLVRQFQGH 
TDGASCIDIS NDGTKLWTGG PDNTVRSWDL REGRQLQQHD FTSQIFSLGY CPTGEWLAVG 
MESSNVEVLH VNKPDKYQLH LHESCVLSLK FAYCGKWFVS TGKDNLLNAW RTPYGASIFQ 
SKESSSVLSC DISVDDKYIV TGSGDKKATV YEVIY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.