Details for: TLL1

Gene ID: 7092

Symbol: TLL1

Ensembl ID: ENSG00000038295

Description: tolloid like 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 6.85
    Marker Score: 22957
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 5.32
    Marker Score: 12224.5
  • Cell Name: interneuron (CL0000099)
    Fold Change: 3.81
    Marker Score: 1741
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.95
    Marker Score: 935
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.84
    Marker Score: 15280
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.75
    Marker Score: 7859
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.7
    Marker Score: 1297
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.29
    Marker Score: 778
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.26
    Marker Score: 6484
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.16
    Marker Score: 20320
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.08
    Marker Score: 873
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.92
    Marker Score: 117962
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.89
    Marker Score: 1553
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.68
    Marker Score: 458
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1164
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168704
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.46
    Marker Score: 1457
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 864
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.35
    Marker Score: 432
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 849.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.25
    Marker Score: 2547
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.24
    Marker Score: 12753.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.21
    Marker Score: 729
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.18
    Marker Score: 1711
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 484
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4799
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 792
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 15936
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.01
    Marker Score: 2377
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71806
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48030
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.99
    Marker Score: 3829
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.95
    Marker Score: 299
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.95
    Marker Score: 537
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5217
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.88
    Marker Score: 395
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.87
    Marker Score: 4588
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5282
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.86
    Marker Score: 483
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.8
    Marker Score: 192
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.8
    Marker Score: 3250
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.78
    Marker Score: 381
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.77
    Marker Score: 334
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 498
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.68
    Marker Score: 618
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.64
    Marker Score: 795
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.62
    Marker Score: 241
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.62
    Marker Score: 5882
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.61
    Marker Score: 5135.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.57
    Marker Score: 273
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.56
    Marker Score: 119
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.54
    Marker Score: 249
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.54
    Marker Score: 155
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.53
    Marker Score: 331
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.52
    Marker Score: 1037
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.51
    Marker Score: 211.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.5
    Marker Score: 277
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.5
    Marker Score: 162
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.5
    Marker Score: 4295.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.49
    Marker Score: 172.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 472
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.49
    Marker Score: 187
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.48
    Marker Score: 430
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.48
    Marker Score: 276
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.47
    Marker Score: 403
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.45
    Marker Score: 201
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.44
    Marker Score: 1577
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.44
    Marker Score: 332
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.44
    Marker Score: 380
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.43
    Marker Score: 731
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.41
    Marker Score: 213
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.4
    Marker Score: 164
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.4
    Marker Score: 617
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.39
    Marker Score: 740
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.39
    Marker Score: 1059
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.37
    Marker Score: 96
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.37
    Marker Score: 619
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.36
    Marker Score: 92
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.36
    Marker Score: 178
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.35
    Marker Score: 488
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.34
    Marker Score: 127
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.33
    Marker Score: 133
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.32
    Marker Score: 589
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.32
    Marker Score: 119

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Other Information

**Key Characteristics:** TLL1 is a member of the tolloid-like protein family, which is characterized by its ability to bind to and process collagen. The protein is widely expressed in various cell types, including neuronal brush cells, macroglial cells, and interneurons. Its expression is also observed in the retina, where it may play a role in the development and maintenance of the retinal tissue. **Pathways and Functions:** TLL1 is involved in several key pathways, including: 1. **Anchoring fibril formation**: TLL1 is required for the formation of anchoring fibrils, which are critical for the integrity of the extracellular matrix in the skin. 2. **Collagen biosynthesis and modifying enzymes**: TLL1 is involved in the processing and modification of collagen, which is essential for the development and maintenance of connective tissue. 3. **Cell differentiation**: TLL1 plays a role in the differentiation of various cell types, including neuronal and glial cells. 4. **Extracellular matrix organization**: TLL1 is involved in the organization and regulation of the extracellular matrix, which is essential for tissue development and function. **Clinical Significance:** TLL1 has been implicated in several diseases and disorders, including: 1. **Neurological disorders**: TLL1 has been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer**: TLL1 has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer. 3. **Skin disorders**: TLL1 has been implicated in various skin disorders, including psoriasis and vitiligo. 4. **Eye diseases**: TLL1 has been linked to various eye diseases, including retinitis pigmentosa and age-related macular degeneration. **Conclusion:** In conclusion, TLL1 is a multifunctional protein that plays a critical role in various cellular processes, including cell differentiation, collagen biosynthesis, and degradation of the extracellular matrix. Its dysregulation has been implicated in several diseases and disorders, highlighting the importance of further research into the gene's functions and clinical significance. As an expert immunologist, it is essential to consider the potential implications of TLL1 in immunological disorders and to explore its role in the development of novel therapeutic strategies. **Recommendations for Future Research:** 1. **Investigate the role of TLL1 in immunological disorders**: Further research is needed to understand the role of TLL1 in immunological disorders, including autoimmune diseases and cancer. 2. **Examine the protein's interaction with other genes and pathways**: The protein's interaction with other genes and pathways may provide insights into its functions and potential therapeutic targets. 3. **Explore the use of TLL1 as a biomarker**: TLL1 may serve as a biomarker for various diseases and disorders, highlighting its potential as a diagnostic tool. 4. **Investigate the potential of TLL1 as a therapeutic target**: The protein's dysregulation has been implicated in several diseases and disorders, making it a potential target for therapeutic intervention.

Genular Protein ID: 2999535011

Symbol: TLL1_HUMAN

Name: Tolloid-like protein 1

UniProtKB Accession Codes:

O43897 B2RMU2 Q96AN3 Q9NQS4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 6 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 2 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10479448

Title: Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.

PubMed ID: 10479448

DOI: 10.1006/dbio.1999.9383

PubMed ID: 10896944

Title: Bone morphogenetic protein-1 processes probiglycan.

PubMed ID: 10896944

DOI: 10.1074/jbc.m004846200

PubMed ID: 11313359

Title: Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures.

PubMed ID: 11313359

DOI: 10.1074/jbc.m102352200

PubMed ID: 18824173

Title: Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.

PubMed ID: 18824173

DOI: 10.1016/j.jmb.2008.09.029

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 18830233

Title: Mutations in mammalian tolloid-like 1 gene detected in adult patients with ASD.

PubMed ID: 18830233

DOI: 10.1038/ejhg.2008.175

Sequence Information:

  • Length: 1013
  • Mass: 114709
  • Checksum: 0FDDB6E8E9032DCC
  • Sequence:
    • MGLGTLSPRM LVWLVASGIV FYGELWVCAG LDYDYTFDGN EEDKTETIDY KDPCKAAVFW 
GDIALDDEDL NIFQIDRTID LTQNPFGNLG HTTGGLGDHA MSKKRGALYQ LIDRIRRIGF 
GLEQNNTVKG KVPLQFSGQN EKNRVPRAAT SRTERIWPGG VIPYVIGGNF TGSQRAMFKQ 
AMRHWEKHTC VTFIERSDEE SYIVFTYRPC GCCSYVGRRG NGPQAISIGK NCDKFGIVVH 
ELGHVIGFWH EHTRPDRDNH VTIIRENIQP GQEYNFLKME PGEVNSLGER YDFDSIMHYA 
RNTFSRGMFL DTILPSRDDN GIRPAIGQRT RLSKGDIAQA RKLYRCPACG ETLQESNGNL 
SSPGFPNGYP SYTHCIWRVS VTPGEKIVLN FTTMDLYKSS LCWYDYIEVR DGYWRKSPLL 
GRFCGDKLPE VLTSTDSRMW IEFRSSSNWV GKGFAAVYEA ICGGEIRKNE GQIQSPNYPD 
DYRPMKECVW KITVSESYHV GLTFQSFEIE RHDNCAYDYL EVRDGTSENS PLIGRFCGYD 
KPEDIRSTSN TLWMKFVSDG TVNKAGFAAN FFKEEDECAK PDRGGCEQRC LNTLGSYQCA 
CEPGYELGPD RRSCEAACGG LLTKLNGTIT TPGWPKEYPP NKNCVWQVVA PTQYRISVKF 
EFFELEGNEV CKYDYVEIWS GLSSESKLHG KFCGAEVPEV ITSQFNNMRI EFKSDNTVSK 
KGFKAHFFSD KDECSKDNGG CQHECVNTMG SYMCQCRNGF VLHDNKHDCK EAECEQKIHS 
PSGLITSPNW PDKYPSRKEC TWEISATPGH RIKLAFSEFE IEQHQECAYD HLEVFDGETE 
KSPILGRLCG NKIPDPLVAT GNKMFVRFVS DASVQRKGFQ ATHSTECGGR LKAESKPRDL 
YSHAQFGDNN YPGQVDCEWL LVSERGSRLE LSFQTFEVEE EADCGYDYVE LFDGLDSTAV 
GLGRFCGSGP PEEIYSIGDS VLIHFHTDDT INKKGFHIRY KSIRYPDTTH TKK

Genular Protein ID: 3736269716

Symbol: B7ZLW3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZLW3

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 EMBL 2 GO 4 Gene3D 3 Genevisible 1 GenomeRNAi 1 InterPro 11 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 9 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 3 RefSeq 1 RuleBase 1 SMART 4 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1036
  • Mass: 117326
  • Checksum: E58ACD75248541B0
  • Sequence:
    • MGLGTLSPRM LVWLVASGIV FYGELWVCAG LDYDYTFDGN EEDKTETIDY KDPCKAAVFW 
GDIALDDEDL NIFQIDRTID LTQNPFGNLG HTTGGLGDHA MSKKRGALYQ LIDRIRRIGF 
GLEQNNTVKG KVPLQFSGQN EKNRVPRAAT SRTERIWPGG VIPYVIGGNF TGSQRAMFKQ 
AMRHWEKHTC VTFIERSDEE SYIVFTYRPC GCCSYVGRRG NGPQAISIGK NCDKFGIVVH 
ELGHVIGFWH EHTRPDRDNH VTIIRENIQP GQEYNFLKME PGEVNSLGER YDFDSIMHYA 
RNTFSRGMFL DTILPSRDDN GIRPAIGQRT RLSKGDIAQA RKLYRCPACG ETLQESNGNL 
SSPGFSNGYP SYTHCIWRVS VTPGEKIVLN FTTMDLYKSS LCWYDYIEVR DGYWRKSPLL 
GRFCGDKLPE VLTSTDSRMW IEFRSSSNWV GKGFAAVYEA ICGGEIRKNE GQIQSPNYPD 
DYRPMKECVW KITVSESYHV GLTFQSFEQE HQENPGIASK ARESLILIWK PIERHDNCAY 
DYLEVRDGTS ENSPLIGRFC GYDKPEDIRS TSNTLWMKFV SDGTVNKAGF AANFFKEEDE 
CAKPDRGGCE QRCLNTLGSY QCACEPGYEL GPDRRSCEAA CGGLLTKLNG TITTPGWPKE 
YPPNKNCVWQ VVAPTQYRIS VKFEFFELEG NEVCKYDYVE IWSGLSSESK LHGKFCGAEV 
PEVITSQFNN MRIEFKSDNT VSKKGFKAHF FSDKDECSKD NGGCQHECVN TMGSYMCQCR 
NGFVLHDNKH DCKEAECEQK IHSPSGLITS PNWPDKYPSR KECTWEISAT PGHRIKLAFS 
EFEIEQHQEC AYDHLEVFDG ETEKSPILGR LCGNKIPDPL VATGNKMFVR FVSDASVQRK 
GFQATHSTEC GGRLKAESKP RDLYSHAQFG DNNYPGQVDC EWLLVSERGS RLELSFQTFE 
VEEEADCGYD YVELFDGLDS TAVGLGRFCG SGPPEEIYSI GDSVLIHFHT DDTINKKGFH 
IRYKSIRYPD TTHTKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.