Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 288.7906
Cell Significance Index: -44.9200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 182.1849
Cell Significance Index: -46.2100 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 138.9740
Cell Significance Index: -57.2500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 127.4808
Cell Significance Index: -51.7900 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 123.3790
Cell Significance Index: -58.2500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 112.0367
Cell Significance Index: -57.6300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 55.8580
Cell Significance Index: -53.3300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 42.7104
Cell Significance Index: -52.6600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 18.6945
Cell Significance Index: -50.0800 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 14.3385
Cell Significance Index: -44.0400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 13.8037
Cell Significance Index: -54.4700 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.0205
Cell Significance Index: 74.3100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.8121
Cell Significance Index: 94.3900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.7815
Cell Significance Index: 114.9400 - Cell Name: perivascular cell (CL4033054)
Fold Change: 1.7803
Cell Significance Index: 8.2200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.7585
Cell Significance Index: 47.1200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.6541
Cell Significance Index: 227.1500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.4528
Cell Significance Index: 87.2200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.3502
Cell Significance Index: 166.0200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.2559
Cell Significance Index: 136.6100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8942
Cell Significance Index: 161.2000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.8850
Cell Significance Index: 104.3700 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.7886
Cell Significance Index: 101.0900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.7131
Cell Significance Index: 19.4100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.7038
Cell Significance Index: 33.0800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6081
Cell Significance Index: 332.1100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5837
Cell Significance Index: 40.3700 - Cell Name: peg cell (CL4033014)
Fold Change: 0.5830
Cell Significance Index: 13.4700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5307
Cell Significance Index: 14.1700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5145
Cell Significance Index: 14.8300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.4723
Cell Significance Index: 13.5400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4514
Cell Significance Index: 199.5600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4121
Cell Significance Index: 81.7900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2991
Cell Significance Index: 8.0000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2797
Cell Significance Index: 6.0600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2585
Cell Significance Index: 51.8500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2284
Cell Significance Index: 10.6500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2244
Cell Significance Index: 10.1700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1768
Cell Significance Index: 33.6400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1680
Cell Significance Index: 11.8800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1666
Cell Significance Index: 16.4800 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.1604
Cell Significance Index: 3.1300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1347
Cell Significance Index: 10.3400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.1253
Cell Significance Index: 3.6800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1237
Cell Significance Index: 85.5600 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.1083
Cell Significance Index: 1.2300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1031
Cell Significance Index: 93.0600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0922
Cell Significance Index: 3.2400 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0620
Cell Significance Index: 1.6300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0457
Cell Significance Index: 86.0400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0324
Cell Significance Index: 11.6100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0041
Cell Significance Index: 3.0400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0011
Cell Significance Index: 0.1800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0035
Cell Significance Index: -6.4300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0073
Cell Significance Index: -11.2500 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0180
Cell Significance Index: -2.3300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0210
Cell Significance Index: -15.5400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0243
Cell Significance Index: -11.0100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0321
Cell Significance Index: -43.6300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0359
Cell Significance Index: -27.1400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0380
Cell Significance Index: -3.8900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0428
Cell Significance Index: -27.2000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0514
Cell Significance Index: -32.0800 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0546
Cell Significance Index: -0.3300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0669
Cell Significance Index: -37.7200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1447
Cell Significance Index: -30.4800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1558
Cell Significance Index: -11.6100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1694
Cell Significance Index: -48.7400 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.2083
Cell Significance Index: -1.7500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2306
Cell Significance Index: -3.8600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2356
Cell Significance Index: -27.0000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2774
Cell Significance Index: -40.3300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3046
Cell Significance Index: -18.7200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3139
Cell Significance Index: -36.5800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3305
Cell Significance Index: -17.1700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3877
Cell Significance Index: -44.2500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4297
Cell Significance Index: -44.7400 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.5465
Cell Significance Index: -11.4400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5670
Cell Significance Index: -44.9100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.5993
Cell Significance Index: -33.6300 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.7023
Cell Significance Index: -35.4900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.7256
Cell Significance Index: -45.7300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.7658
Cell Significance Index: -51.4900 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.8436
Cell Significance Index: -21.5500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.8491
Cell Significance Index: -23.7300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8539
Cell Significance Index: -52.3500 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.9113
Cell Significance Index: -14.1000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.9212
Cell Significance Index: -23.6800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.9256
Cell Significance Index: -40.9400 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.9432
Cell Significance Index: -13.2300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.9548
Cell Significance Index: -33.1800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.9872
Cell Significance Index: -31.6200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.0434
Cell Significance Index: -54.7800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.1365
Cell Significance Index: -43.0400 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -1.1549
Cell Significance Index: -14.7900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.1558
Cell Significance Index: -15.7700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.1908
Cell Significance Index: -25.3600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.2433
Cell Significance Index: -31.0800 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.2727
Cell Significance Index: -11.7200 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -1.2894
Cell Significance Index: -22.7900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1414451461
Symbol: TLN1_HUMAN
Name: Talin-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10610730
Title: Characterization of the human talin (TLN) gene: genomic structure, chromosomal localization, and expression pattern.
PubMed ID: 10610730
PubMed ID: 10470851
Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10470851
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 28251419
Title: Transcriptome profile of the human placenta.
PubMed ID: 28251419
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10320340
Title: Molecular interactions of N-RAP, a nebulin-related protein of striated muscle myotendon junctions and intercalated disks.
PubMed ID: 10320340
DOI: 10.1021/bi982395t
PubMed ID: 12422220
Title: Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions.
PubMed ID: 12422220
DOI: 10.1038/nature01082
PubMed ID: 12473654
Title: Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha.
PubMed ID: 12473654
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18342854
Title: Identification of a repeated domain within mammalian alpha-synemin that interacts directly with talin.
PubMed ID: 18342854
PubMed ID: 18088087
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21768292
Title: Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition.
PubMed ID: 21768292
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25121749
Title: HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells.
PubMed ID: 25121749
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27895300
Title: THSD1 (thrombospondin type 1 domain containing protein 1) mutation in the pathogenesis of intracranial aneurysm and subarachnoid emorrhage.
PubMed ID: 27895300
PubMed ID: 29069646
Title: The Intracranial Aneurysm Gene THSD1 Connects Endosome Dynamics to Nascent Focal Adhesion Assembly.
PubMed ID: 29069646
DOI: 10.1159/000484298
PubMed ID: 36880935
Title: TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity.
PubMed ID: 36880935
PubMed ID: 15070891
Title: Structural basis for amplifying vinculin activation by talin.
PubMed ID: 15070891
Sequence Information:
- Length: 2541
- Mass: 269767
- Checksum: E21575E9199BBC5C
- Sequence:
MVALSLKISI GNVVKTMQFE PSTMVYDACR IIRERIPEAP AGPPSDFGLF LSDDDPKKGI WLEAGKALDY YMLRNGDTME YRKKQRPLKI RMLDGTVKTI MVDDSKTVTD MLMTICARIG ITNHDEYSLV RELMEEKKEE ITGTLRKDKT LLRDEKKMEK LKQKLHTDDE LNWLDHGRTL REQGVEEHET LLLRRKFFYS DQNVDSRDPV QLNLLYVQAR DDILNGSHPV SFDKACEFAG FQCQIQFGPH NEQKHKAGFL DLKDFLPKEY VKQKGERKIF QAHKNCGQMS EIEAKVRYVK LARSLKTYGV SFFLVKEKMK GKNKLVPRLL GITKECVMRV DEKTKEVIQE WNLTNIKRWA ASPKSFTLDF GDYQDGYYSV QTTEGEQIAQ LIAGYIDIIL KKKKSKDHFG LEGDEESTML EDSVSPKKST VLQQQYNRVG KVEHGSVALP AIMRSGASGP ENFQVGSMPP AQQQITSGQM HRGHMPPLTS AQQALTGTIN SSMQAVQAAQ ATLDDFDTLP PLGQDAASKA WRKNKMDESK HEIHSQVDAI TAGTASVVNL TAGDPAETDY TAVGCAVTTI SSNLTEMSRG VKLLAALLED EGGSGRPLLQ AAKGLAGAVS ELLRSAQPAS AEPRQNLLQA AGNVGQASGE LLQQIGESDT DPHFQDALMQ LAKAVASAAA ALVLKAKSVA QRTEDSGLQT QVIAAATQCA LSTSQLVACT KVVAPTISSP VCQEQLVEAG RLVAKAVEGC VSASQAATED GQLLRGVGAA ATAVTQALNE LLQHVKAHAT GAGPAGRYDQ ATDTILTVTE NIFSSMGDAG EMVRQARILA QATSDLVNAI KADAEGESDL ENSRKLLSAA KILADATAKM VEAAKGAAAH PDSEEQQQRL REAAEGLRMA TNAAAQNAIK KKLVQRLEHA AKQAAASATQ TIAAAQHAAS TPKASAGPQP LLVQSCKAVA EQIPLLVQGV RGSQAQPDSP SAQLALIAAS QSFLQPGGKM VAAAKASVPT IQDQASAMQL SQCAKNLGTA LAELRTAAQK AQEACGPLEM DSALSVVQNL EKDLQEVKAA ARDGKLKPLP GETMEKCTQD LGNSTKAVSS AIAQLLGEVA QGNENYAGIA ARDVAGGLRS LAQAARGVAA LTSDPAVQAI VLDTASDVLD KASSLIEEAK KAAGHPGDPE SQQRLAQVAK AVTQALNRCV SCLPGQRDVD NALRAVGDAS KRLLSDSLPP STGTFQEAQS RLNEAAAGLN QAATELVQAS RGTPQDLARA SGRFGQDFST FLEAGVEMAG QAPSQEDRAQ VVSNLKGISM SSSKLLLAAK ALSTDPAAPN LKSQLAAAAR AVTDSINQLI TMCTQQAPGQ KECDNALREL ETVRELLENP VQPINDMSYF GCLDSVMENS KVLGEAMTGI SQNAKNGNLP EFGDAISTAS KALCGFTEAA AQAAYLVGVS DPNSQAGQQG LVEPTQFARA NQAIQMACQS LGEPGCTQAQ VLSAATIVAK HTSALCNSCR LASARTTNPT AKRQFVQSAK EVANSTANLV KTIKALDGAF TEENRAQCRA ATAPLLEAVD NLSAFASNPE FSSIPAQISP EGRAAMEPIV ISAKTMLESA GGLIQTARAL AVNPRDPPSW SVLAGHSRTV SDSIKKLITS MRDKAPGQLE CETAIAALNS CLRDLDQASL AAVSQQLAPR EGISQEALHT QMLTAVQEIS HLIEPLANAA RAEASQLGHK VSQMAQYFEP LTLAAVGAAS KTLSHPQQMA LLDQTKTLAE SALQLLYTAK EAGGNPKQAA HTQEALEEAV QMMTEAVEDL TTTLNEAASA AGVVGGMVDS ITQAINQLDE GPMGEPEGSF VDYQTTMVRT AKAIAVTVQE MVTKSNTSPE ELGPLANQLT SDYGRLASEA KPAAVAAENE EIGSHIKHRV QELGHGCAAL VTKAGALQCS PSDAYTKKEL IECARRVSEK VSHVLAALQA GNRGTQACIT AASAVSGIIA DLDTTIMFAT AGTLNREGTE TFADHREGIL KTAKVLVEDT KVLVQNAAGS QEKLAQAAQS SVATITRLAD VVKLGAASLG AEDPETQVVL INAVKDVAKA LGDLISATKA AAGKVGDDPA VWQLKNSAKV MVTNVTSLLK TVKAVEDEAT KGTRALEATT EHIRQELAVF CSPEPPAKTS TPEDFIRMTK GITMATAKAV AAGNSCRQED VIATANLSRR AIADMLRACK EAAYHPEVAP DVRLRALHYG RECANGYLEL LDHVLLTLQK PSPELKQQLT GHSKRVAGSV TELIQAAEAM KGTEWVDPED PTVIAENELL GAAAAIEAAA KKLEQLKPRA KPKEADESLN FEEQILEAAK SIAAATSALV KAASAAQREL VAQGKVGAIP ANALDDGQWS QGLISAARMV AAATNNLCEA ANAAVQGHAS QEKLISSAKQ VAASTAQLLV ACKVKADQDS EAMKRLQAAG NAVKRASDNL VKAAQKAAAF EEQENETVVV KEKMVGGIAQ IIAAQEEMLR KERELEEARK KLAQIRQQQY KFLPSELRDE H
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.