TMF1 | ENSG00000144747 | NCBI 7110

Details for: TMF1

Associated with

Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Membrane trafficking
(R-HSA-199991)
Retrograde transport at the trans-golgi-network
(R-HSA-6811440)
Vesicle-mediated transport
(R-HSA-5653656)
Acrosome assembly
(GO:0001675)
Androgen receptor signaling pathway
(GO:0030521)
Cytosol
(GO:0005829)
Defense response to bacterium
(GO:0042742)
Dna binding
(GO:0003677)
Endoplasmic reticulum
(GO:0005783)
Epithelial cell apoptotic process
(GO:1904019)
Flagellated sperm motility
(GO:0030317)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Leydig cell differentiation
(GO:0033327)
Luteinizing hormone secretion
(GO:0032275)
Negative regulation of epithelial cell apoptotic process
(GO:1904036)
Negative regulation of gene expression
(GO:0010629)
Nuclear androgen receptor binding
(GO:0050681)
Nuclear receptor coactivator activity
(GO:0030374)
Nucleus
(GO:0005634)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of testosterone secretion
(GO:2000845)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of proteasomal protein catabolic process
(GO:0061136)
Spermatid nucleus differentiation
(GO:0007289)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

ciliated epithelial cell CL0000067

CSI 57.1

rCSI 50.21%

PRS 19.36
lung ciliated cell CL1000271

CSI 47.97

rCSI 55.47%

PRS 19.62
extravillous trophoblast CL0008036

CSI 20.61

rCSI 25.5%

PRS 23.27
CD4-positive helper T cell CL0000492

CSI 19.41

rCSI 14.68%

PRS 35.72
CD14-positive, CD16-positive monocyte CL0002397

CSI 17.41

rCSI 22.81%

PRS 37
stromal cell CL0000499

CSI 13.12

rCSI 36.92%

PRS 32.02
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 11.95

rCSI 27.24%

PRS 26.68
ciliated cell CL0000064

CSI 9.72

rCSI 15.75%

PRS 26.34
peripheral nervous system neuron CL2000032

CSI 9.24

rCSI 12.59%

PRS 22.93
multi-ciliated epithelial cell CL0005012

CSI 8.96

rCSI 8.94%

PRS 22.61
adventitial cell CL0002503

CSI 8.77

rCSI 20.94%

PRS 38.01
colon goblet cell CL0009039

CSI 7.83

rCSI 18.6%

PRS 38.09
mesenchymal cell CL0008019

CSI 7.76

rCSI 19.7%

PRS 25.73
activated CD4-positive, alpha-beta T cell CL0000896

CSI 7.63

rCSI 7.05%

PRS 45.32
memory T cell CL0000813

CSI 6.9

rCSI 13.3%

PRS 55.45
effector CD8-positive, alpha-beta T cell CL0001050

CSI 6.23

rCSI 4.74%

PRS 34.81
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 6.17

rCSI 8.4%

PRS 55.12
CD8-positive, alpha-beta memory T cell CL0000909

CSI 6.15

rCSI 6.42%

PRS 62.17
T follicular helper cell CL0002038

CSI 5.94

rCSI 4.45%

PRS 40.12
fallopian tube secretory epithelial cell CL4030006

CSI 5.57

rCSI 5.36%

PRS 27.26
immature B cell CL0000816

CSI 5.31

rCSI 3.94%

PRS 37.86
regular ventricular cardiac myocyte CL0002131

CSI 4.92

rCSI 30.74%

PRS 21.08
hepatic stellate cell CL0000632

CSI 4.79

rCSI 17.93%

PRS 22.21
lung macrophage CL1001603

CSI 4.73

rCSI 10.56%

PRS 30.9
epithelial cell of lung CL0000082

CSI 4.69

rCSI 3.89%

PRS 25.15
sncg GABAergic cortical interneuron CL4023015

CSI 4.55

rCSI 7.32%

PRS 17.54
regular atrial cardiac myocyte CL0002129

CSI 4.41

rCSI 14.19%

PRS 27.2
epithelial cell CL0000066

CSI 4.27

rCSI 6.57%

PRS 33.39
pro-B cell CL0000826

CSI 4.19

rCSI 3.47%

PRS 26.81
epithelial cell of lower respiratory tract CL0002632

CSI 4.05

rCSI 3.14%

PRS 25.71
astrocyte of the cerebral cortex CL0002605

CSI 4.02

rCSI 9.02%

PRS 16.71
neuroblast (sensu Vertebrata) CL0000031

CSI 3.9

rCSI 5.01%

PRS 25.2
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 3.78

rCSI 5.36%

PRS 24.5
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 3.5

rCSI 2.07%

PRS 36.94
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 3.48

rCSI 3.42%

PRS 39.91
precursor B cell CL0000817

CSI 3.41

rCSI 2.98%

PRS 34.49
CD14-positive monocyte CL0001054

CSI 3.31

rCSI 4.12%

PRS 35.98
lung pericyte CL0009089

CSI 3.24

rCSI 8.56%

PRS 31.44
deuterosomal cell CL4033044

CSI 3.23

rCSI 10.92%

PRS 39.23
melanocyte CL0000148

CSI 3.22

rCSI 2.38%

PRS 22.61
granulocyte CL0000094

CSI 3.19

rCSI 4.87%

PRS 33.77
pulmonary capillary endothelial cell CL4028001

CSI 3.13

rCSI 5.96%

PRS 40.88
acinar cell of salivary gland CL0002623

CSI 2.89

rCSI 67.24%

PRS 47.22
CD4-positive, alpha-beta thymocyte CL0000810

CSI 2.88

rCSI 2.31%

PRS 44.98
unswitched memory B cell CL0000970

CSI 2.88

rCSI 2.42%

PRS 40.64
hematopoietic precursor cell CL0008001

CSI 2.87

rCSI 2.95%

PRS 41.11
CD8-positive, alpha-beta thymocyte CL0000811

CSI 2.85

rCSI 4.45%

PRS 54.02
fibroblast of cardiac tissue CL0002548

CSI 2.85

rCSI 13.65%

PRS 22.92
promonocyte CL0000559

CSI 2.76

rCSI 4.73%

PRS 35.01
cerebellar granule cell CL0001031

CSI 2.63

rCSI 3.86%

PRS 24.35
bronchus fibroblast of lung CL2000093

CSI 2.5

rCSI 2.03%

PRS 27.49
naive T cell CL0000898

CSI 2.44

rCSI 1.7%

PRS 36.56
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 2.42

rCSI 1.81%

PRS 62.9
pulmonary artery endothelial cell CL1001568

CSI 2.41

rCSI 3.28%

PRS 38.37
neural crest cell CL0011012

CSI 2.38

rCSI 1.88%

PRS 18.22
pancreatic D cell CL0000173

CSI 2.32

rCSI 2.28%

PRS 28.29
secretory cell CL0000151

CSI 2.29

rCSI 2.39%

PRS 27.07
plasmablast CL0000980

CSI 2.24

rCSI 1.77%

PRS 31.69
forebrain radial glial cell CL0013000

CSI 2.22

rCSI 7.14%

PRS 35.41
fibroblast of lung CL0002553

CSI 2.19

rCSI 2.04%

PRS 26.4
enterocyte CL0000584

CSI 2.19

rCSI 3.54%

PRS 37.95
microcirculation associated smooth muscle cell CL0008035

CSI 2.18

rCSI 6.32%

PRS 29.44
renal alpha-intercalated cell CL0005011

CSI 2.17

rCSI 2.9%

PRS 33.36
interstitial cell of Cajal CL0002088

CSI 2.15

rCSI 2.74%

PRS 30.29
respiratory goblet cell CL0002370

CSI 2.13

rCSI 23.19%

PRS 47.25
goblet cell CL0000160

CSI 2.13

rCSI 2.01%

PRS 27.63
inflammatory macrophage CL0000863

CSI 2.11

rCSI 3.61%

PRS 50.6
memory B cell CL0000787

CSI 2.1

rCSI 2.07%

PRS 70.15
common dendritic progenitor CL0001029

CSI 2.1

rCSI 2.63%

PRS 33.93
skin fibroblast CL0002620

CSI 2.06

rCSI 1.78%

PRS 37.89
CD1c-positive myeloid dendritic cell CL0002399

CSI 2.06

rCSI 2.48%

PRS 31.72
cerebral cortex GABAergic interneuron CL0010011

CSI 2.05

rCSI 6.06%

PRS 30.62
type B pancreatic cell CL0000169

CSI 2.04

rCSI 4.51%

PRS 24.34
lamp5 GABAergic cortical interneuron CL4023011

CSI 2.01

rCSI 3.37%

PRS 16.07
colon epithelial cell CL0011108

CSI 2

rCSI 2.09%

PRS 24.66
interneuron CL0000099

CSI 1.99

rCSI 4%

PRS 19.62
intestine goblet cell CL0019031

CSI 1.98

rCSI 1.76%

PRS 26.58
innate lymphoid cell CL0001065

CSI 1.98

rCSI 4.09%

PRS 36.7
perivascular cell CL4033054

CSI 1.98

rCSI 2.71%

PRS 29.78
hematopoietic stem cell CL0000037

CSI 1.97

rCSI 1.31%

PRS 30.85
myofibroblast cell CL0000186

CSI 1.96

rCSI 2.71%

PRS 34.63
mature T cell CL0002419

CSI 1.94

rCSI 1.51%

PRS 38.54
activated CD8-positive, alpha-beta T cell CL0000906

CSI 1.94

rCSI 1.91%

PRS 60.15
transit amplifying cell of colon CL0009011

CSI 1.91

rCSI 2.24%

PRS 30.07
nasal mucosa goblet cell CL0002480

CSI 1.91

rCSI 2.21%

PRS 37.15
cerebral cortex neuron CL0010012

CSI 1.9

rCSI 7.75%

PRS 26.8
P/D1 enteroendocrine cell CL0002268

CSI 1.87

rCSI 10.19%

PRS 53.49
activated type II NK T cell CL0000931

CSI 1.87

rCSI 2.1%

PRS 40.92
hematopoietic multipotent progenitor cell CL0000837

CSI 1.87

rCSI 4.49%

PRS 40.73
class switched memory B cell CL0000972

CSI 1.86

rCSI 1.39%

PRS 42.74
neural progenitor cell CL0011020

CSI 1.86

rCSI 8.17%

PRS 23.65
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 1.85

rCSI 1.23%

PRS 55.62
retinal rod cell CL0000604

CSI 1.84

rCSI 3.24%

PRS 25.66
Mueller cell CL0000636

CSI 1.84

rCSI 4.19%

PRS 22.59
BEST4+ enteroycte CL4030026

CSI 1.83

rCSI 2.27%

PRS 28.26
mesodermal cell CL0000222

CSI 1.83

rCSI 2.19%

PRS 25.54
brush cell of tracheobronchial tree CL0002075

CSI 1.82

rCSI 5.41%

PRS 35.82
ependymal cell CL0000065

CSI 1.79

rCSI 3.62%

PRS 14.68
vascular associated smooth muscle cell CL0000359

CSI 1.78

rCSI 5.78%

PRS 30.9
CD4-positive, alpha-beta memory T cell CL0000897

CSI 1.78

rCSI 1.28%

PRS 35.99

mesenchymal stem cell CL0000134

CSI 0.1

rCSI 1.1%

PRS 44.3%
eosinophil CL0000771

CSI 0.2

rCSI 1.2%

PRS 59.4%
megakaryocyte CL0000556

CSI 0.2

rCSI 1.0%

PRS 42.7%
intestinal crypt stem cell of colon CL0009043

CSI 0.2

rCSI 1.8%

PRS 45.8%
tracheobronchial serous cell CL0019001

CSI 0.2

rCSI 1.1%

PRS 44.6%
vein endothelial cell of respiratory system CL4033008

CSI 0.3

rCSI 1.7%

PRS 47.5%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.3

rCSI 0.5%

PRS 15.7%
erythroblast CL0000765

CSI 0.3

rCSI 0.7%

PRS 39.1%
cytotoxic T cell CL0000910

CSI 0.3

rCSI 1.6%

PRS 37.9%
myeloid dendritic cell CL0000782

CSI 0.3

rCSI 0.5%

PRS 39.3%
amacrine cell CL0000561

CSI 0.3

rCSI 0.9%

PRS 20.7%
eye photoreceptor cell CL0000287

CSI 0.4

rCSI 3.9%

PRS 55.5%
enterocyte of epithelium of large intestine CL0002071

CSI 0.4

rCSI 1.8%

PRS 42.6%
mucus secreting cell CL0000319

CSI 0.4

rCSI 0.6%

PRS 33.8%
cerebral cortex pyramidal neuron CL4023111

CSI 0.4

rCSI 2.2%

PRS 55.1%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 0.4

rCSI 2.2%

PRS 53.1%
central nervous system neuron CL2000029

CSI 0.4

rCSI 2.9%

PRS 17.0%
myeloid lineage restricted progenitor cell CL0000839

CSI 0.4

rCSI 2.3%

PRS 48.7%
melanocyte of skin CL1000458

CSI 0.5

rCSI 0.7%

PRS 14.9%
retinal blood vessel endothelial cell CL0002585

CSI 0.5

rCSI 0.8%

PRS 28.9%
fraction A pre-pro B cell CL0002045

CSI 0.5

rCSI 0.6%

PRS 49.3%
helper T cell CL0000912

CSI 0.5

rCSI 0.8%

PRS 36.0%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 0.6

rCSI 1.1%

PRS 42.6%
basophil CL0000767

CSI 0.6

rCSI 1.2%

PRS 48.7%
alveolar adventitial fibroblast CL4028006

CSI 0.6

rCSI 0.9%

PRS 26.6%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.6

rCSI 2.2%

PRS 16.7%
pancreatic stellate cell CL0002410

CSI 0.6

rCSI 3.4%

PRS 37.7%
T-helper 17 cell CL0000899

CSI 0.6

rCSI 0.5%

PRS 45.3%
syncytiotrophoblast cell CL0000525

CSI 0.6

rCSI 1.7%

PRS 45.1%
acinar cell CL0000622

CSI 0.6

rCSI 0.9%

PRS 34.4%
granulocyte monocyte progenitor cell CL0000557

CSI 0.6

rCSI 0.5%

PRS 29.5%
respiratory basal cell CL0002633

CSI 0.6

rCSI 0.6%

PRS 31.1%
common lymphoid progenitor CL0000051

CSI 0.6

rCSI 0.8%

PRS 47.2%
intestinal crypt stem cell of small intestine CL0009017

CSI 0.6

rCSI 1.7%

PRS 34.0%
enteroendocrine cell of small intestine CL0009006

CSI 0.6

rCSI 1.4%

PRS 39.1%
kidney connecting tubule epithelial cell CL1000768

CSI 0.6

rCSI 1.6%

PRS 20.2%
basal cell of epidermis CL0002187

CSI 0.6

rCSI 1.1%

PRS 19.7%
mucous neck cell CL0000651

CSI 0.6

rCSI 0.9%

PRS 40.0%
large pre-B-II cell CL0000957

CSI 0.6

rCSI 1.8%

PRS 41.7%
cardiac neuron CL0010022

CSI 0.6

rCSI 2.0%

PRS 22.6%
pancreatic epsilon cell CL0005019

CSI 0.6

rCSI 3.0%

PRS 52.0%
serous secreting cell of bronchus submucosal gland CL4033005

CSI 0.7

rCSI 3.7%

PRS 65.4%
indirect pathway medium spiny neuron CL4023029

CSI 0.7

rCSI 15.7%

PRS 15.8%
tracheal goblet cell CL1000329

CSI 0.7

rCSI 1.4%

PRS 47.5%
cardiac muscle cell CL0000746

CSI 0.7

rCSI 1.0%

PRS 20.7%
glycinergic amacrine cell CL4030028

CSI 0.7

rCSI 1.8%

PRS 26.4%
Hofbauer cell CL3000001

CSI 0.7

rCSI 1.3%

PRS 33.5%
enterocyte of epithelium of small intestine CL1000334

CSI 0.7

rCSI 10.9%

PRS 56.4%
mammary gland epithelial cell CL0002327

CSI 0.7

rCSI 2.5%

PRS 43.0%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 0.7

rCSI 4.2%

PRS 16.9%
retina horizontal cell CL0000745

CSI 0.7

rCSI 1.1%

PRS 24.3%
pancreatic PP cell CL0002275

CSI 0.7

rCSI 2.8%

PRS 42.5%
paneth cell of epithelium of small intestine CL1000343

CSI 0.7

rCSI 2.0%

PRS 40.0%
T-helper 1 cell CL0000545

CSI 0.7

rCSI 1.3%

PRS 55.9%
tracheobronchial smooth muscle cell CL0019019

CSI 0.7

rCSI 1.3%

PRS 33.7%
parietal epithelial cell CL1000452

CSI 0.7

rCSI 2.0%

PRS 22.1%
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 0.7

rCSI 0.5%

PRS 32.8%
luminal cell of prostate epithelium CL0002340

CSI 0.7

rCSI 4.0%

PRS 43.2%
follicular B cell CL0000843

CSI 0.8

rCSI 2.7%

PRS 67.2%
renal interstitial pericyte CL1001318

CSI 0.8

rCSI 2.1%

PRS 24.7%
squamous epithelial cell CL0000076

CSI 0.8

rCSI 1.8%

PRS 31.9%
corneal epithelial cell CL0000575

CSI 0.8

rCSI 2.3%

PRS 43.8%
transitional stage B cell CL0000818

CSI 0.8

rCSI 2.7%

PRS 60.7%
intermediate monocyte CL0002393

CSI 0.8

rCSI 1.3%

PRS 27.0%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 0.8

rCSI 1.0%

PRS 44.2%
direct pathway medium spiny neuron CL4023026

CSI 0.8

rCSI 20.0%

PRS 14.9%
common myeloid progenitor CL0000049

CSI 0.8

rCSI 0.7%

PRS 26.6%
mature B cell CL0000785

CSI 0.9

rCSI 0.7%

PRS 33.0%
club cell CL0000158

CSI 0.9

rCSI 1.3%

PRS 29.2%
antibody secreting cell CL0000946

CSI 0.9

rCSI 3.9%

PRS 74.7%
retinal pigment epithelial cell CL0002586

CSI 0.9

rCSI 1.8%

PRS 27.3%
foveolar cell of stomach CL0002179

CSI 0.9

rCSI 1.9%

PRS 40.4%
small pre-B-II cell CL0000954

CSI 0.9

rCSI 0.9%

PRS 49.8%
lung neuroendocrine cell CL1000223

CSI 0.9

rCSI 1.3%

PRS 30.0%
duct epithelial cell CL0000068

CSI 0.9

rCSI 1.3%

PRS 28.1%
type L enteroendocrine cell CL0002279

CSI 0.9

rCSI 1.7%

PRS 48.0%
VIP GABAergic cortical interneuron CL4023016

CSI 0.9

rCSI 1.1%

PRS 15.9%
lung goblet cell CL1000143

CSI 0.9

rCSI 10.5%

PRS 66.8%
Langerhans cell CL0000453

CSI 0.9

rCSI 1.4%

PRS 43.9%
intestinal epithelial cell CL0002563

CSI 0.9

rCSI 1.0%

PRS 27.2%
stromal cell of ovary CL0002132

CSI 0.9

rCSI 2.6%

PRS 41.7%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 1.0

rCSI 1.2%

PRS 30.3%
glial cell CL0000125

CSI 1.0

rCSI 3.7%

PRS 24.5%
lung secretory cell CL1000272

CSI 1.0

rCSI 2.4%

PRS 24.6%
enteric smooth muscle cell CL0002504

CSI 1.0

rCSI 1.4%

PRS 29.2%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 1.0

rCSI 3.1%

PRS 18.4%
rod bipolar cell CL0000751

CSI 1.0

rCSI 1.8%

PRS 21.9%
endothelial cell of placenta CL0009092

CSI 1.0

rCSI 4.9%

PRS 35.3%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 1.0

rCSI 2.4%

PRS 15.7%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.0

rCSI 2.6%

PRS 24.4%
placental villous trophoblast CL2000060

CSI 1.0

rCSI 1.6%

PRS 24.8%
respiratory suprabasal cell CL4033048

CSI 1.1

rCSI 1.4%

PRS 30.3%
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 1.1

rCSI 1.8%

PRS 47.4%
conjunctival epithelial cell CL1000432

CSI 1.1

rCSI 1.6%

PRS 26.6%
elicited macrophage CL0000861

CSI 1.1

rCSI 1.0%

PRS 31.4%
pulmonary ionocyte CL0017000

CSI 1.1

rCSI 1.3%

PRS 32.6%
medium spiny neuron CL1001474

CSI 1.1

rCSI 9.3%

PRS 15.6%
keratocyte CL0002363

CSI 1.1

rCSI 2.6%

PRS 37.4%
glandular epithelial cell CL0000150

CSI 1.1

rCSI 2.9%

PRS 48.3%
sst GABAergic cortical interneuron CL4023017

CSI 1.1

rCSI 1.4%

PRS 16.7%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary TATA element modulatory factor 1 ([TMF1](/details-gene/7110)) is a multifunctional protein-coding gene located on chromosome 3. Initially identified for its potential role in modulating transcription ([Link](https://doi.org/10.1073/pnas.89.20.9372)), subsequent research has revealed its critical involvement in intracellular membrane trafficking, particularly retrograde transport from the Golgi apparatus ([Link](https://doi.org/10.1016/j.yexcr.2007.07.010)). It also functions as a nuclear receptor coactivator, specifically for the androgen receptor, where it is known as ARA160 ([Link](https://doi.org/10.1074/jbc.274.32.22373)). **Overall**, expression data highlights its exceptional significance in [ciliated epithelial cells](/details-cell/CL0000067), suggesting a primary role in processes unique to these cells. Additionally, notable expression in immune cells, such as [CD4-positive helper T cells](/details-cell/CL0000492), and reproductive tissues, like [extravillous trophoblasts](/details-cell/CL0008036), points to a diverse set of biological functions ranging from motility and secretion to immune regulation and hormonal signaling. ## Cellular Roles and Expression Landscape The expression profile of [TMF1](/details-gene/7110) reveals a highly specific and prominent role in ciliated epithelial tissues. **Overall**, it demonstrates the highest significance in [ciliated epithelial cell](/details-cell/CL0000067) (CSI: 57.10) and its subtypes, including [lung ciliated cell](/details-cell/CL1000271) (CSI: 47.97) and [ciliated columnar cell of tracheobronchial tree](/details-cell/CL0002145) (CSI: 11.95). This strong, tissue-specific signature suggests that [TMF1](/details-gene/7110) is a key operational component for the specialized functions of these cells, such as mucociliary clearance. Beyond its primary association with ciliated epithelia, [TMF1](/details-gene/7110) shows significant expression in several other distinct cellular contexts. It is a notable marker in cells of the reproductive system, particularly [extravillous trophoblast](/details-cell/CL0008036) (CSI: 20.61), which is consistent with its known function as an androgen receptor coactivator. Furthermore, [TMF1](/details-gene/7110) is expressed in key immune cell populations, including [CD14-positive, CD16-positive monocytes](/details-cell/CL0002397) (CSI: 17.41) and [CD4-positive helper T cells](/details-cell/CL0000492) (CSI: 19.41), indicating a potential role in modulating immune responses. Its presence in [stromal cells](/details-cell/CL0000499) and [mesenchymal cells](/details-cell/CL0008019) suggests a broader role in tissue structure and support. ## Pathways and Molecular Function The functions of [TMF1](/details-gene/7110) are distributed between the nucleus and the cytoplasm, reflecting its dual roles in transcriptional regulation and protein trafficking. Its localization to the [Golgi apparatus](/details-ontology/GO:0005794) and [endoplasmic reticulum](/details-ontology/GO:0005783) is central to its function in [Vesicle-mediated transport](/details-pathway/R-HSA-5653656). Specifically, it is involved in [Intra-golgi and retrograde golgi-to-er traffic](/details-pathway/R-HSA-6811442), a process essential for protein sorting, modification, and quality control. This function, confirmed to be Rab6-dependent ([Link](https://doi.org/10.1016/j.yexcr.2007.07.010)), is likely critical for the maintenance and function of the complex cellular machinery in highly active cells like the [ciliated epithelial cells](/details-cell/CL0000067) where it is most prominently expressed. In the [nucleus](/details-ontology/GO:0005634), [TMF1](/details-gene/7110) participates in the [regulation of gene expression](/details-ontology/GO:0010629). It acts as a [nuclear receptor coactivator](/details-ontology/GO:0030374), binding the androgen receptor ([Nuclear androgen receptor binding](/details-ontology/GO:0050681)) to modulate the [androgen receptor signaling pathway](/details-ontology/GO:0030521). This role is directly linked to biological processes such as [spermatid nucleus differentiation](/details-ontology/GO:0007289) and the regulation of hormone secretion. Additionally, [TMF1](/details-gene/7110) has been shown to mediate the proteasomal degradation of the transcription factor Stat3 ([Link](https://doi.org/10.1038/sj.onc.1208149)), linking it to the [regulation of proteasomal protein catabolic process](/details-ontology/GO:0061136) and the control of cytokine signaling pathways, which aligns with its expression in immune cells. ## Research Directions The diverse functions and specific expression patterns of [TMF1](/details-gene/7110) suggest several avenues for future investigation, particularly concerning its role in human health and disease. Based on the available data, the following testable hypotheses can be proposed: 1. Given its exceptionally high expression in [ciliated epithelial cells](/details-cell/CL0000067) and its established role in Golgi trafficking, [TMF1](/details-gene/7110) is hypothesized to be essential for ciliogenesis or ciliary maintenance. It may regulate the transport of critical structural or signaling proteins required for the formation and function of cilia, and its dysfunction could contribute to the pathology of ciliopathies affecting the respiratory tract. 2. Considering its function in mediating Stat3 degradation and its expression in [CD4-positive helper T cells](/details-cell/CL0000492) and [monocytes](/details-cell/CL0002397), [TMF1](/details-gene/7110) may function as a crucial negative regulator of inflammatory signaling. It is hypothesized that [TMF1](/details-gene/7110) dampens pro-inflammatory responses by targeting STAT3 for degradation following cytokine stimulation, thereby preventing excessive inflammation. To test the first hypothesis regarding the role of [TMF1](/details-gene/7110) in ciliogenesis, a key experiment would involve using CRISPR-Cas9 to knock out the gene in primary human bronchial epithelial cells. These cells would then be cultured at an air-liquid interface to induce differentiation into a mature, ciliated epithelium. The impact of [TMF1](/details-gene/7110) loss could be assessed by quantifying ciliary number and length via immunofluorescence microscopy and measuring ciliary beat frequency using high-speed video analysis. From a therapeutic perspective, [TMF1](/details-gene/7110) presents a complex but potentially valuable target. Its role in promoting the degradation of STAT3, a well-known oncogenic driver, suggests that strategies to **activate** or enhance [TMF1](/details-gene/7110) function could be beneficial in cancers characterized by hyperactive STAT3 signaling. Conversely, its function as an androgen receptor coactivator (ARA160) suggests that **inhibition** of [TMF1](/details-gene/7110) could be a viable strategy in androgen-dependent prostate cancer. However, its high expression in critical tissues like the respiratory epithelium raises concerns about potential on-target toxicity, indicating that tissue-specific targeting approaches would be necessary for clinical development.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

TATA element modulatory factor
Q6PII6_HUMAN

Genular Protein ID: 1592143362

Symbol: TMF1_HUMAN

Name: TATA element modulatory factor

UniProtKB Accession Codes:

P82094 B7ZLJ2 Q17R87 Q59GK0

Database IDs:

Citations:

PubMed ID: 1409643

Title: Cloning and chromosomal mapping of a human immunodeficiency virus 1 'TATA' element modulatory factor.

PubMed ID: 1409643

DOI: 10.1073/pnas.89.20.9372

PubMed ID: 10428808

Title: Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells.

PubMed ID: 10428808

DOI: 10.1074/jbc.274.32.22373

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12044884

Title: A putative nuclear receptor coactivator (TMF/ARA160) associates with hbrm/hSNF2 alpha and BRG-1/hSNF2 beta and localizes in the Golgi apparatus.

PubMed ID: 12044884

DOI: 10.1016/s0014-5793(02)02803-x

PubMed ID: 15467733

Title: TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3.

PubMed ID: 15467733

DOI: 10.1038/sj.onc.1208149

PubMed ID: 17698061

Title: Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic.

PubMed ID: 17698061

DOI: 10.1016/j.yexcr.2007.07.010

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 1093
Mass: 122842
Checksum: 566BBE3EC36EF11C
Sequence:

MSWFNASQLS SFAKQALSQA QKSIDRVLDI QEEEPSIWAE TIPYGEPGIS SPVSGGWDTS 
TWGLKSNTEP QSPPIASPKA ITKPVRRTVV DESENFFSAF LSPTDVQTIQ KSPVVSKPPA 
KSQRPEEEVK SSLHESLHIG QSRTPETTES QVKDSSLCVS GETLAAGTSS PKTEGKHEET 
VNKESDMKVP TVSLKVSESV IDVKTTMESI SNTSTQSLTA ETKDIALEPK EQKHEDRQSN 
TPSPPVSTFS SGTSTTSDIE VLDHESVISE SSASSRQETT DSKSSLHLMQ TSFQLLSASA 
CPEYNRLDDF QKLTESCCSS DAFERIDSFS VQSLDSRSVS EINSDDELSG KGYALVPIIV 
NSSTPKSKTV ESAEGKSEEV NETLVIPTEE AEMEESGRSA TPVNCEQPDI LVSSTPINEG 
QTVLDKVAEQ CEPAESQPEA LSEKEDVCKT VEFLNEKLEK REAQLLSLSK EKALLEEAFD 
NLKDEMFRVK EESSSISSLK DEFTQRIAEA EKKVQLACKE RDAAKKEIKN IKEELATRLN 
SSETADLLKE KDEQIRGLME EGEKLSKQQL HNSNIIKKLR AKDKENENMV AKLNKKVKEL 
EEELQHLKQV LDGKEEVEKQ HRENIKKLNS MVERQEKDLG RLQVDMDELE EKNRSIQAAL 
DSAYKELTDL HKANAAKDSE AQEAALSREM KAKEELSAAL EKAQEEARQQ QETLAIQVGD 
LRLALQRTEQ AAARKEDYLR HEIGELQQRL QEAENRNQEL SQSVSSTTRP LLRQIENLQA 
TLGSQTSSWE KLEKNLSDRL GESQTLLAAA VERERAATEE LLANKIQMSS MESQNSLLRQ 
ENSRFQAQLE SEKNRLCKLE DENNRYQVEL ENLKDEYVRT LEETRKEKTL LNSQLEMERM 
KVEQERKKAI FTQETIKEKE RKPFSVSSTP TMSRSSSISG VDMAGLQTSF LSQDESHDHS 
FGPMPISANG SNLYDAVRMG AGSSIIENLQ SQLKLREGEI THLQLEIGNL EKTRSIMAEE 
LVKLTNQNDE LEEKVKEIPK LRTQLRDLDQ RYNTILQMYG EKAEEAEELR LDLEDVKNMY 
KTQIDELLRQ SLS

Genular Protein ID: 449504758

Symbol: Q6PII6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PII6

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 533
Mass: 58382
Checksum: 51F5A8BA05E087FA
Sequence:

MSWFNASQLS SFAKQALSQA QKSIDRVLDI QEEEPSIWAE TIPYGEPGIS SPVSGGWDTS 
TWGLKSNTEP QSPPIASPKA ITKPVRRTVV DESENFFSAF LSPTDVQTIQ KSPVVSKPPA 
KSQRPEEEVK SSLHESLHIG QSRTPETTES QVKDSSLCVS GETLAAGTSS PKTEGKHEET 
VNKESDMKVP TVSLKVSESV IDVKTTMESI SNTSTQSLTA ETKDIALEPK EQKHEDRQSN 
TPSPPVSTFS SGTSTTSDIE VLDHESVISE SSASSRQETT DSKSSLHLMQ TSFQLLSASA 
CPEYNRLDDF QKLTESCCSS DAFERIDSFS VQSLDSRSVS EINSDDELSG KGYALVPIIV 
NSSTPKSKTV ESAEGKSEEV NETLVIPTEE AEMEESGRSA TPVNCEQPDI LVSSTPINEG 
QTVLDKVAEQ CEPAESQPEA LSEKEDVCKT VEFLNEKLEK REAQLLSLSK EKALLEEAFD 
NLKDEMFRVK EESSSISSLK DEFTQRIAEA EKKVQLACKE RDAAKKEIKK KKK

	Overall overall
	Acute kidney failure MONDO0002492
	Amyotrophic lateral sclerosis MONDO0004976
	Atherosclerosis MONDO0005311
	Basal cell carcinoma MONDO0020804
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Colon UBERON0001155
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Duodenum UBERON0002114
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Pancreas UBERON0001264
	\|— Pancreas Healthy UBERON0001264_PATO0000461
	Parkinson disease MONDO0005180
	Placenta UBERON0001987
	\|— Placenta Healthy UBERON0001987_PATO0000461
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Primary motor cortex UBERON0001384
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	Small cell lung carcinoma MONDO0008433
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952
	Vascular dementia MONDO0004648

Details for: TMF1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Cloning and chromosomal mapping of a human immunodeficiency virus 1 'TATA' element modulatory factor. PubMed ID: 1409643

Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells. PubMed ID: 10428808

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A putative nuclear receptor coactivator (TMF/ARA160) associates with hbrm/hSNF2 alpha and BRG-1/hSNF2 beta and localizes in the Golgi apparatus. PubMed ID: 12044884

TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3. PubMed ID: 15467733

Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic. PubMed ID: 17698061

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

PubMed ID: 1409643

PubMed ID: 10428808

PubMed ID: 16641997

PubMed ID: 15489334

PubMed ID: 12044884

PubMed ID: 15467733

PubMed ID: 17698061

PubMed ID: 18691976

PubMed ID: 18669648

PubMed ID: 19413330

PubMed ID: 19690332

PubMed ID: 20068231

PubMed ID: 21269460

PubMed ID: 21406692

PubMed ID: 23186163

PubMed ID: 24275569

PubMed ID: 15489334