Details for: TNFRSF1B
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 130.3158
Cell Significance Index: -20.2700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 87.1696
Cell Significance Index: -22.1100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 63.2974
Cell Significance Index: -25.7200 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 54.9857
Cell Significance Index: -25.9600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 53.9868
Cell Significance Index: -27.7700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 27.6776
Cell Significance Index: -26.4300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 18.1109
Cell Significance Index: -22.3300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 7.4733
Cell Significance Index: -20.0200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 7.3385
Cell Significance Index: -22.5400 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.2513
Cell Significance Index: -15.8700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.7830
Cell Significance Index: -22.8200 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 5.4494
Cell Significance Index: 100.7200 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 5.1265
Cell Significance Index: 150.5600 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 4.4184
Cell Significance Index: 68.3600 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 2.2399
Cell Significance Index: 33.5600 - Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: 0.8009
Cell Significance Index: 13.7600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6050
Cell Significance Index: 36.3200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.5402
Cell Significance Index: 14.4500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5270
Cell Significance Index: 475.8500 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.5229
Cell Significance Index: 7.5200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4759
Cell Significance Index: 47.0800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4117
Cell Significance Index: 44.7800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3370
Cell Significance Index: 64.1300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2956
Cell Significance Index: 48.0800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.2355
Cell Significance Index: 12.2700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1689
Cell Significance Index: 7.9400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1449
Cell Significance Index: 92.0400 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.1191
Cell Significance Index: 2.1100 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0518
Cell Significance Index: 0.7800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0298
Cell Significance Index: 0.8600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0280
Cell Significance Index: 0.7000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0106
Cell Significance Index: 0.7300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0095
Cell Significance Index: 1.3100 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.0025
Cell Significance Index: 0.0400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0006
Cell Significance Index: -0.3900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0068
Cell Significance Index: -0.2400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0068
Cell Significance Index: -3.0000 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0088
Cell Significance Index: -4.8000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0103
Cell Significance Index: -19.4300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0126
Cell Significance Index: -0.8100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0141
Cell Significance Index: -2.7900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0149
Cell Significance Index: -27.5400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0157
Cell Significance Index: -24.1600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0159
Cell Significance Index: -9.9600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0160
Cell Significance Index: -11.8600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0199
Cell Significance Index: -11.2000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0206
Cell Significance Index: -27.9700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0256
Cell Significance Index: -19.3500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0322
Cell Significance Index: -6.7900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0338
Cell Significance Index: -4.3700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0358
Cell Significance Index: -4.1700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0374
Cell Significance Index: -27.4300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0442
Cell Significance Index: -1.1800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0526
Cell Significance Index: -18.8800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0527
Cell Significance Index: -23.9200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0572
Cell Significance Index: -1.2400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0580
Cell Significance Index: -2.6300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0629
Cell Significance Index: -11.3300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0775
Cell Significance Index: -22.3000 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0807
Cell Significance Index: -10.3400 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0825
Cell Significance Index: -1.3900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0861
Cell Significance Index: -14.7100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0903
Cell Significance Index: -18.1100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0942
Cell Significance Index: -9.6200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0957
Cell Significance Index: -11.7700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1388
Cell Significance Index: -7.0200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1518
Cell Significance Index: -22.0600 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.1556
Cell Significance Index: -0.9400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1710
Cell Significance Index: -20.1700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1822
Cell Significance Index: -20.8000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2161
Cell Significance Index: -22.5000 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.2318
Cell Significance Index: -3.3900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2345
Cell Significance Index: -26.8700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2437
Cell Significance Index: -14.9400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2444
Cell Significance Index: -18.7600 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: -0.2543
Cell Significance Index: -2.0600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2795
Cell Significance Index: -19.7700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2860
Cell Significance Index: -6.0900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2892
Cell Significance Index: -6.0000 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.3021
Cell Significance Index: -4.2400 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.3125
Cell Significance Index: -13.5900 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.3208
Cell Significance Index: -3.6500 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3266
Cell Significance Index: -4.8200 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3331
Cell Significance Index: -8.7600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3346
Cell Significance Index: -24.9400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3388
Cell Significance Index: -19.0100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3621
Cell Significance Index: -24.3500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3663
Cell Significance Index: -23.0900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3944
Cell Significance Index: -20.4900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4167
Cell Significance Index: -25.6100 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.4373
Cell Significance Index: -8.5500 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4375
Cell Significance Index: -12.5400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4853
Cell Significance Index: -25.4800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.4905
Cell Significance Index: -22.8700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.5042
Cell Significance Index: -22.3000 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.5165
Cell Significance Index: -10.0800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5236
Cell Significance Index: -16.7700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.5621
Cell Significance Index: -15.7100 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.5643
Cell Significance Index: -13.6700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5922
Cell Significance Index: -22.4300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2885709722
Symbol: TNR1B_HUMAN
Name: Tumor necrosis factor receptor superfamily member 1B
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2172983
Title: A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor.
PubMed ID: 2172983
PubMed ID: 2160731
Title: A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins.
PubMed ID: 2160731
PubMed ID: 8661109
Title: Physical mapping and genomic structure of the human TNFR2 gene.
PubMed ID: 8661109
PubMed ID: 14688072
Title: Identification and characterization of a novel spliced variant that encodes human soluble tumor necrosis factor receptor 2.
PubMed ID: 14688072
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2173696
Title: Purification and partial amino acid sequence analysis of two distinct tumor necrosis factor receptors from HL60 cells.
PubMed ID: 2173696
PubMed ID: 8015639
Title: Purification of two types of TNF inhibitors in the urine of the patient with chronic glomerulonephritis.
PubMed ID: 8015639
DOI: 10.1159/000187851
PubMed ID: 2153136
Title: Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors.
PubMed ID: 2153136
PubMed ID: 1966549
Title: Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences.
PubMed ID: 1966549
PubMed ID: 2166946
Title: Complementary DNA cloning of a receptor for tumor necrosis factor and demonstration of a shed form of the receptor.
PubMed ID: 2166946
PubMed ID: 11197692
Title: New single nucleotide polymorphisms in the coding region of human TNFR2: association with systemic lupus erythematosus.
PubMed ID: 11197692
PubMed ID: 1328224
Title: Biochemical properties of the 75-kDa tumor necrosis factor receptor. Characterization of ligand binding, internalization, and receptor phosphorylation.
PubMed ID: 1328224
PubMed ID: 8069916
Title: A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.
PubMed ID: 8069916
PubMed ID: 12370298
Title: Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis.
PubMed ID: 12370298
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25456591
Title: Identification of protein O-glycosylation site and corresponding glycans using liquid chromatography-tandem mass spectrometry via mapping accurate mass and retention time shift.
PubMed ID: 25456591
PubMed ID: 25609706
Title: Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2.
PubMed ID: 25609706
DOI: 10.1242/jcs.149385
PubMed ID: 10206649
Title: Structural basis for self-association and receptor recognition of human TRAF2.
PubMed ID: 10206649
DOI: 10.1038/19110
PubMed ID: 11762942
Title: Association of tumor necrosis factor receptor type II polymorphism 196R with systemic lupus erythematosus in the Japanese: molecular and functional analysis.
PubMed ID: 11762942
DOI: 10.1002/1529-0131(200112)44:12<2819::aid-art469>3.0.co;2-2
PubMed ID: 12161545
Title: Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism.
PubMed ID: 12161545
Sequence Information:
- Length: 461
- Mass: 48291
- Checksum: 603D0AE1CD69ACBF
- Sequence:
MAPVAVWAAL AVGLELWAAA HALPAQVAFT PYAPEPGSTC RLREYYDQTA QMCCSKCSPG QHAKVFCTKT SDTVCDSCED STYTQLWNWV PECLSCGSRC SSDQVETQAC TREQNRICTC RPGWYCALSK QEGCRLCAPL RKCRPGFGVA RPGTETSDVV CKPCAPGTFS NTTSSTDICR PHQICNVVAI PGNASMDAVC TSTSPTRSMA PGAVHLPQPV STRSQHTQPT PEPSTAPSTS FLLPMGPSPP AEGSTGDFAL PVGLIVGVTA LGLLIIGVVN CVIMTQVKKK PLCLQREAKV PHLPADKARG TQGPEQQHLL ITAPSSSSSS LESSASALDR RAPTRNQPQA PGVEASGAGE ARASTGSSDS SPGGHGTQVN VTCIVNVCSS SDHSSQCSSQ ASSTMGDTDS SPSESPKDEQ VPFSKEECAF RSQLETPETL LGSTEEKPLP LGVPDAGMKP S
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.