Details for: TNFRSF1B

Gene ID: 7133

Symbol: TNFRSF1B

Ensembl ID: ENSG00000028137

Description: TNF receptor superfamily member 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 130.3158
    Cell Significance Index: -20.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 87.1696
    Cell Significance Index: -22.1100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.2974
    Cell Significance Index: -25.7200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 54.9857
    Cell Significance Index: -25.9600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 53.9868
    Cell Significance Index: -27.7700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.6776
    Cell Significance Index: -26.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.1109
    Cell Significance Index: -22.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.4733
    Cell Significance Index: -20.0200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.3385
    Cell Significance Index: -22.5400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.2513
    Cell Significance Index: -15.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7830
    Cell Significance Index: -22.8200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 5.4494
    Cell Significance Index: 100.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.1265
    Cell Significance Index: 150.5600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.4184
    Cell Significance Index: 68.3600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.2399
    Cell Significance Index: 33.5600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.8009
    Cell Significance Index: 13.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6050
    Cell Significance Index: 36.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5402
    Cell Significance Index: 14.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5270
    Cell Significance Index: 475.8500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5229
    Cell Significance Index: 7.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4759
    Cell Significance Index: 47.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4117
    Cell Significance Index: 44.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3370
    Cell Significance Index: 64.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2956
    Cell Significance Index: 48.0800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2355
    Cell Significance Index: 12.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1689
    Cell Significance Index: 7.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1449
    Cell Significance Index: 92.0400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1191
    Cell Significance Index: 2.1100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0518
    Cell Significance Index: 0.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0298
    Cell Significance Index: 0.8600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0280
    Cell Significance Index: 0.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0106
    Cell Significance Index: 0.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0095
    Cell Significance Index: 1.3100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0025
    Cell Significance Index: 0.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0006
    Cell Significance Index: -0.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0068
    Cell Significance Index: -0.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0068
    Cell Significance Index: -3.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0088
    Cell Significance Index: -4.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0103
    Cell Significance Index: -19.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0126
    Cell Significance Index: -0.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0141
    Cell Significance Index: -2.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0149
    Cell Significance Index: -27.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0157
    Cell Significance Index: -24.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0159
    Cell Significance Index: -9.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0160
    Cell Significance Index: -11.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0199
    Cell Significance Index: -11.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0206
    Cell Significance Index: -27.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0256
    Cell Significance Index: -19.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0322
    Cell Significance Index: -6.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0338
    Cell Significance Index: -4.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0358
    Cell Significance Index: -4.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0374
    Cell Significance Index: -27.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0442
    Cell Significance Index: -1.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0526
    Cell Significance Index: -18.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0527
    Cell Significance Index: -23.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0572
    Cell Significance Index: -1.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0580
    Cell Significance Index: -2.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0629
    Cell Significance Index: -11.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0775
    Cell Significance Index: -22.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0807
    Cell Significance Index: -10.3400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0825
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0861
    Cell Significance Index: -14.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0903
    Cell Significance Index: -18.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0942
    Cell Significance Index: -9.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0957
    Cell Significance Index: -11.7700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1388
    Cell Significance Index: -7.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1518
    Cell Significance Index: -22.0600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1556
    Cell Significance Index: -0.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1710
    Cell Significance Index: -20.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1822
    Cell Significance Index: -20.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2161
    Cell Significance Index: -22.5000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2318
    Cell Significance Index: -3.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2345
    Cell Significance Index: -26.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2437
    Cell Significance Index: -14.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2444
    Cell Significance Index: -18.7600
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.2543
    Cell Significance Index: -2.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2795
    Cell Significance Index: -19.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2860
    Cell Significance Index: -6.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2892
    Cell Significance Index: -6.0000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3021
    Cell Significance Index: -4.2400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3125
    Cell Significance Index: -13.5900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3208
    Cell Significance Index: -3.6500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3266
    Cell Significance Index: -4.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3331
    Cell Significance Index: -8.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3346
    Cell Significance Index: -24.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3388
    Cell Significance Index: -19.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3621
    Cell Significance Index: -24.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3663
    Cell Significance Index: -23.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3944
    Cell Significance Index: -20.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4167
    Cell Significance Index: -25.6100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4373
    Cell Significance Index: -8.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4375
    Cell Significance Index: -12.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4853
    Cell Significance Index: -25.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4905
    Cell Significance Index: -22.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5042
    Cell Significance Index: -22.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5165
    Cell Significance Index: -10.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5236
    Cell Significance Index: -16.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5621
    Cell Significance Index: -15.7100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5643
    Cell Significance Index: -13.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5922
    Cell Significance Index: -22.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TNFRSF1B is characterized by its ability to bind to TNF and other ligands, triggering a cascade of intracellular signaling events. The protein exhibits significant homology to other TNF receptors, including TNFR1, which is widely known for its role in mediating inflammatory responses. Unlike TNFR1, TNFRSF1B exhibits distinct ligand specificity and signaling characteristics, which are crucial for its regulation of immune responses. **Pathways and Functions** TNFRSF1B is involved in several signaling pathways, including: 1. **Cytokine Signaling**: TNFRSF1B interacts with TNF and other cytokines, triggering a cascade of signaling events that regulate immune responses, inflammation, and cell growth. 2. **Apoptosis**: TNFRSF1B modulates apoptosis, either promoting or inhibiting cell death, depending on the context and ligand involved. 3. **Immune Response**: TNFRSF1B plays a critical role in regulating immune responses, including the activation of T cells, B cells, and natural killer cells. 4. **Neuroinflammatory Response**: TNFRSF1B is involved in the regulation of neuroinflammatory responses, which are critical for the development and maintenance of the central nervous system. 5. **Cardiac Muscle Hypertrophy**: TNFRSF1B negatively regulates cardiac muscle hypertrophy, which is a critical mechanism for preventing cardiac dysfunction. **Clinical Significance** TNFRSF1B has significant clinical implications in various diseases, including: 1. **Rheumatoid Arthritis**: TNFRSF1B has been implicated in the pathogenesis of rheumatoid arthritis, and its blockade has shown promise in reducing inflammation and disease activity. 2. **Cancer**: TNFRSF1B is involved in the regulation of apoptosis and immune responses, making it a potential target for cancer therapy. 3. **Neurological Disorders**: TNFRSF1B has been implicated in the regulation of neuroinflammatory responses, which are critical for the development and maintenance of neurological disorders, such as multiple sclerosis and Alzheimer's disease. 4. **Cardiovascular Disease**: TNFRSF1B negatively regulates cardiac muscle hypertrophy, which is a critical mechanism for preventing cardiac dysfunction and cardiovascular disease. In conclusion, TNFRSF1B is a critical component of the TNF receptor superfamily, playing a pivotal role in regulating various cellular processes, including inflammation, immune response, cell growth, and apoptosis. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic intervention.

Genular Protein ID: 2885709722

Symbol: TNR1B_HUMAN

Name: Tumor necrosis factor receptor superfamily member 1B

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2172983

Title: A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor.

PubMed ID: 2172983

DOI: 10.1073/pnas.87.21.8331

PubMed ID: 2160731

Title: A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins.

PubMed ID: 2160731

DOI: 10.1126/science.2160731

PubMed ID: 8661109

Title: Physical mapping and genomic structure of the human TNFR2 gene.

PubMed ID: 8661109

DOI: 10.1006/geno.1996.0327

PubMed ID: 14688072

Title: Identification and characterization of a novel spliced variant that encodes human soluble tumor necrosis factor receptor 2.

PubMed ID: 14688072

DOI: 10.1093/intimm/dxh014

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2173696

Title: Purification and partial amino acid sequence analysis of two distinct tumor necrosis factor receptors from HL60 cells.

PubMed ID: 2173696

DOI: 10.1016/s0021-9258(17)30479-9

PubMed ID: 8015639

Title: Purification of two types of TNF inhibitors in the urine of the patient with chronic glomerulonephritis.

PubMed ID: 8015639

DOI: 10.1159/000187851

PubMed ID: 2153136

Title: Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors.

PubMed ID: 2153136

DOI: 10.1016/s0021-9258(19)40049-5

PubMed ID: 1966549

Title: Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences.

PubMed ID: 1966549

DOI: 10.1016/1043-4666(90)90022-l

PubMed ID: 2166946

Title: Complementary DNA cloning of a receptor for tumor necrosis factor and demonstration of a shed form of the receptor.

PubMed ID: 2166946

DOI: 10.1073/pnas.87.16.6151

PubMed ID: 11197692

Title: New single nucleotide polymorphisms in the coding region of human TNFR2: association with systemic lupus erythematosus.

PubMed ID: 11197692

DOI: 10.1038/sj.gene.6363700

PubMed ID: 1328224

Title: Biochemical properties of the 75-kDa tumor necrosis factor receptor. Characterization of ligand binding, internalization, and receptor phosphorylation.

PubMed ID: 1328224

DOI: 10.1016/s0021-9258(19)36813-9

PubMed ID: 8069916

Title: A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.

PubMed ID: 8069916

DOI: 10.1016/0092-8674(94)90532-0

PubMed ID: 12370298

Title: Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis.

PubMed ID: 12370298

DOI: 10.1128/mcb.22.21.7512-7523.2002

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25456591

Title: Identification of protein O-glycosylation site and corresponding glycans using liquid chromatography-tandem mass spectrometry via mapping accurate mass and retention time shift.

PubMed ID: 25456591

DOI: 10.1016/j.chroma.2014.10.046

PubMed ID: 25609706

Title: Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2.

PubMed ID: 25609706

DOI: 10.1242/jcs.149385

PubMed ID: 10206649

Title: Structural basis for self-association and receptor recognition of human TRAF2.

PubMed ID: 10206649

DOI: 10.1038/19110

PubMed ID: 11762942

Title: Association of tumor necrosis factor receptor type II polymorphism 196R with systemic lupus erythematosus in the Japanese: molecular and functional analysis.

PubMed ID: 11762942

DOI: 10.1002/1529-0131(200112)44:12<2819::aid-art469>3.0.co;2-2

PubMed ID: 12161545

Title: Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism.

PubMed ID: 12161545

DOI: 10.1210/jcem.87.8.8715

Sequence Information:

  • Length: 461
  • Mass: 48291
  • Checksum: 603D0AE1CD69ACBF
  • Sequence:
  • MAPVAVWAAL AVGLELWAAA HALPAQVAFT PYAPEPGSTC RLREYYDQTA QMCCSKCSPG 
    QHAKVFCTKT SDTVCDSCED STYTQLWNWV PECLSCGSRC SSDQVETQAC TREQNRICTC 
    RPGWYCALSK QEGCRLCAPL RKCRPGFGVA RPGTETSDVV CKPCAPGTFS NTTSSTDICR 
    PHQICNVVAI PGNASMDAVC TSTSPTRSMA PGAVHLPQPV STRSQHTQPT PEPSTAPSTS 
    FLLPMGPSPP AEGSTGDFAL PVGLIVGVTA LGLLIIGVVN CVIMTQVKKK PLCLQREAKV 
    PHLPADKARG TQGPEQQHLL ITAPSSSSSS LESSASALDR RAPTRNQPQA PGVEASGAGE 
    ARASTGSSDS SPGGHGTQVN VTCIVNVCSS SDHSSQCSSQ ASSTMGDTDS SPSESPKDEQ 
    VPFSKEECAF RSQLETPETL LGSTEEKPLP LGVPDAGMKP S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.