Details for: TP73

Gene ID: 7161

Symbol: TP73

Ensembl ID: ENSG00000078900

Description: tumor protein p73

Associated with

  • Activation of bh3-only proteins
    (R-HSA-114452)
  • Activation of puma and translocation to mitochondria
    (R-HSA-139915)
  • Apoptosis
    (R-HSA-109581)
  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Intrinsic pathway for apoptosis
    (R-HSA-109606)
  • Programmed cell death
    (R-HSA-5357801)
  • Regulation of tp53 activity
    (R-HSA-5633007)
  • Regulation of tp53 activity through association with co-factors
    (R-HSA-6804759)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Runx1 regulates transcription of genes involved in differentiation of hscs
    (R-HSA-8939236)
  • Tp53 regulates transcription of caspase activators and caspases
    (R-HSA-6803207)
  • Tp53 regulates transcription of cell death genes
    (R-HSA-5633008)
  • Tp53 regulates transcription of death receptors and ligands
    (R-HSA-6803211)
  • Tp53 regulates transcription of genes involved in cytochrome c release
    (R-HSA-6803204)
  • Tp53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
    (R-HSA-6803205)
  • Transcriptional regulation by runx1
    (R-HSA-8878171)
  • Transcriptional regulation by tp53
    (R-HSA-3700989)
  • Cell junction
    (GO:0030054)
  • Chromatin
    (GO:0000785)
  • Cytosol
    (GO:0005829)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna damage response
    (GO:0006974)
  • Golgi apparatus
    (GO:0005794)
  • Identical protein binding
    (GO:0042802)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Intrinsic apoptotic signaling pathway in response to dna damage
    (GO:0008630)
  • Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
    (GO:0042771)
  • Kidney development
    (GO:0001822)
  • Mdm2/mdm4 family protein binding
    (GO:0097371)
  • Metal ion binding
    (GO:0046872)
  • Mismatch repair
    (GO:0006298)
  • Negative regulation of cardiac muscle cell proliferation
    (GO:0060044)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of neuron differentiation
    (GO:0045665)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • P53 binding
    (GO:0002039)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of lung ciliated cell differentiation
    (GO:1901248)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of oligodendrocyte differentiation
    (GO:0048714)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein kinase binding
    (GO:0019901)
  • Protein tetramerization
    (GO:0051262)
  • Regulation of cell cycle
    (GO:0051726)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of mitotic cell cycle
    (GO:0007346)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to xenobiotic stimulus
    (GO:0009410)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription corepressor binding
    (GO:0001222)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 19.2870
    Cell Significance Index: -3.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.4616
    Cell Significance Index: -3.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 2.1891
    Cell Significance Index: -2.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8250
    Cell Significance Index: 39.5400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.5089
    Cell Significance Index: 36.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6122
    Cell Significance Index: 17.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5510
    Cell Significance Index: 11.7400
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.5006
    Cell Significance Index: 4.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4596
    Cell Significance Index: 203.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4450
    Cell Significance Index: 31.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3373
    Cell Significance Index: 33.3700
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.3019
    Cell Significance Index: 2.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2928
    Cell Significance Index: 17.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.2398
    Cell Significance Index: 14.7100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.2372
    Cell Significance Index: 3.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2237
    Cell Significance Index: 24.3300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2104
    Cell Significance Index: 3.0000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.1860
    Cell Significance Index: 1.8200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.1676
    Cell Significance Index: 1.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1638
    Cell Significance Index: 26.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1371
    Cell Significance Index: 1.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1190
    Cell Significance Index: 22.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1041
    Cell Significance Index: 56.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0758
    Cell Significance Index: 2.0300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0754
    Cell Significance Index: 0.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0704
    Cell Significance Index: 4.8700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0701
    Cell Significance Index: 1.6200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0692
    Cell Significance Index: 0.9600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0674
    Cell Significance Index: 0.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0544
    Cell Significance Index: 49.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0484
    Cell Significance Index: 5.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0428
    Cell Significance Index: 2.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0400
    Cell Significance Index: 7.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0371
    Cell Significance Index: 1.9300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.0360
    Cell Significance Index: 0.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0299
    Cell Significance Index: 1.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0283
    Cell Significance Index: 1.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0230
    Cell Significance Index: 0.4000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0203
    Cell Significance Index: 0.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0179
    Cell Significance Index: 0.8100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0166
    Cell Significance Index: 0.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0135
    Cell Significance Index: 2.4300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.0131
    Cell Significance Index: 0.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0088
    Cell Significance Index: 0.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0047
    Cell Significance Index: 0.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0011
    Cell Significance Index: 0.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0011
    Cell Significance Index: 0.1900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0008
    Cell Significance Index: 0.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0007
    Cell Significance Index: -1.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0009
    Cell Significance Index: -1.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0013
    Cell Significance Index: -0.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0023
    Cell Significance Index: -1.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0028
    Cell Significance Index: -2.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0038
    Cell Significance Index: -2.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0046
    Cell Significance Index: -2.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0047
    Cell Significance Index: -0.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0047
    Cell Significance Index: -1.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0068
    Cell Significance Index: -0.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0078
    Cell Significance Index: -2.2300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0087
    Cell Significance Index: -0.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0098
    Cell Significance Index: -1.3400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0100
    Cell Significance Index: -0.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0101
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0113
    Cell Significance Index: -2.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0118
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0168
    Cell Significance Index: -1.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0172
    Cell Significance Index: -1.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0187
    Cell Significance Index: -2.4100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0204
    Cell Significance Index: -0.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0221
    Cell Significance Index: -2.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0222
    Cell Significance Index: -2.8500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0254
    Cell Significance Index: -0.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0269
    Cell Significance Index: -0.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0297
    Cell Significance Index: -2.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0324
    Cell Significance Index: -2.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0331
    Cell Significance Index: -2.4700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0332
    Cell Significance Index: -1.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0350
    Cell Significance Index: -2.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0352
    Cell Significance Index: -0.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0354
    Cell Significance Index: -1.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0394
    Cell Significance Index: -1.8500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0398
    Cell Significance Index: -1.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0407
    Cell Significance Index: -2.1200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0460
    Cell Significance Index: -0.6700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0502
    Cell Significance Index: -0.5400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0518
    Cell Significance Index: -0.4400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0520
    Cell Significance Index: -0.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0520
    Cell Significance Index: -2.7300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0529
    Cell Significance Index: -0.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0531
    Cell Significance Index: -1.8600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0550
    Cell Significance Index: -0.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0558
    Cell Significance Index: -2.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0568
    Cell Significance Index: -0.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0587
    Cell Significance Index: -1.8700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0594
    Cell Significance Index: -1.8800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0606
    Cell Significance Index: -1.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TP73 is a member of the p53 family of proteins, which are crucial regulators of cell growth, differentiation, and survival. TP73 shares similarities with TP53, but its expression and function are distinct. TP73 is a transcriptional activator that binds to specific DNA sequences, influencing the expression of various genes involved in apoptosis, cell cycle regulation, and immune response. Its expression is tissue-specific, with significant levels found in neuroendocrine cells, colon goblet cells, and other epithelial tissues. **Pathways and Functions:** TP73 is involved in several key pathways, including: 1. **Apoptosis**: TP73 regulates the expression of pro-apoptotic and anti-apoptotic genes, influencing the intrinsic apoptotic signaling pathway in response to DNA damage. 2. **Cell Cycle Regulation**: TP73 modulates the expression of cell cycle regulators, including p21 and p27, to control cell proliferation and prevent tumor formation. 3. **Transcriptional Control**: TP73 binds to specific DNA sequences, influencing the expression of genes involved in immune response, cell differentiation, and development. 4. **DNA Damage Response**: TP73 interacts with other proteins, such as MDM2 and p53, to regulate the response to DNA damage and prevent genomic instability. 5. **Immune Regulation**: TP73 is expressed in immune cells, including T cells and dendritic cells, and regulates the expression of genes involved in immune response, including cytokines and chemokines. **Clinical Significance:** TP73's role in immune regulation and cancer makes it a potential therapeutic target. Abnormal expression of TP73 has been linked to various cancers, including leukemia, lymphoma, and breast cancer. TP73's ability to regulate apoptosis and cell cycle makes it a potential target for cancer therapy. Additionally, TP73's expression in immune cells suggests its potential role in modulating the immune response in autoimmune diseases and cancer. **Implications for Immune Regulation:** TP73's involvement in immune regulation highlights its potential role in maintaining immune homeostasis. Dysregulation of TP73 expression may contribute to autoimmune diseases and cancer. Understanding TP73's function in immune regulation may provide insights into the development of novel immunotherapies and cancer treatments. **Conclusion:** In conclusion, TP73 is a multifunctional protein involved in various cellular processes, including apoptosis, cell cycle regulation, and transcriptional control. Its expression and function are distinct from TP53, and its involvement in immune regulation and cancer makes it a potential therapeutic target. Further research is needed to fully understand TP73's role in immune regulation and cancer, but its multifaceted function highlights its importance in maintaining immune homeostasis and preventing disease.

Genular Protein ID: 948976148

Symbol: P73_HUMAN

Name: Tumor protein p73

UniProtKB Accession Codes:

O15350 B7Z7J4 B7Z8Z1 B7Z9C1 C9J521 O15351 Q17RN8 Q5TBV5 Q5TBV6 Q8NHW9 Q8TDY5 Q8TDY6 Q9NTK8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 8 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 4 ELM 1 EMBL 39 EMDB 1 Ensembl 10 EvolutionaryTrace 1 ExpressionAtlas 1 GO 41 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 26 PDBsum 26 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 11 Pumba 1 RNAct 1 Reactome 7 RefSeq 13 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9288759

Title: Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers.

PubMed ID: 9288759

DOI: 10.1016/s0092-8674(00)80540-1

PubMed ID: 9721206

Title: Genomic organization and mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-arm deletions.

PubMed ID: 9721206

DOI: 10.1006/geno.1998.5387

PubMed ID: 9802988

Title: Two new p73 splice variants, gamma and delta, with different transcriptional activity.

PubMed ID: 9802988

DOI: 10.1084/jem.188.9.1763

PubMed ID: 10381648

Title: Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants epsilon and zeta.

PubMed ID: 10381648

DOI: 10.1038/sj.cdd.4400521

PubMed ID: 10362363

Title: Mutational analysis of p73 and p53 in human cancer cell lines.

PubMed ID: 10362363

DOI: 10.1038/sj.onc.1202677

PubMed ID: 11753569

Title: Human DeltaNp73 regulates a dominant negative feedback loop for TAp73 and p53.

PubMed ID: 11753569

DOI: 10.1038/sj.cdd.4400962

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10391251

Title: p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage.

PubMed ID: 10391251

DOI: 10.1038/21704

PubMed ID: 10203277

Title: The emerging p53 gene family.

PubMed ID: 10203277

DOI: 10.1093/jnci/91.7.594

PubMed ID: 10961991

Title: Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif.

PubMed ID: 10961991

DOI: 10.1074/jbc.m004293200

PubMed ID: 11706030

Title: Differential effect of ik3-1/cables on p53- and p73-induced cell death.

PubMed ID: 11706030

DOI: 10.1074/jbc.m108535200

PubMed ID: 11925430

Title: Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo.

PubMed ID: 11925430

DOI: 10.1074/jbc.m200153200

PubMed ID: 12890487

Title: A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity.

PubMed ID: 12890487

DOI: 10.1016/s0006-291x(03)01347-0

PubMed ID: 15070730

Title: Functional association between Wwox tumor suppressor protein and p73, a p53 homolog.

PubMed ID: 15070730

DOI: 10.1073/pnas.0400805101

PubMed ID: 15558019

Title: Protein stability and function of p73 are modulated by a physical interaction with RanBPM in mammalian cultured cells.

PubMed ID: 15558019

DOI: 10.1038/sj.onc.1208257

PubMed ID: 16461361

Title: Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73.

PubMed ID: 16461361

DOI: 10.1083/jcb.200509132

PubMed ID: 18418051

Title: p73-mediated transcriptional activity is negatively regulated by polo-like kinase 1.

PubMed ID: 18418051

DOI: 10.4161/cc.7.9.5777

PubMed ID: 18174154

Title: Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation.

PubMed ID: 18174154

DOI: 10.1074/jbc.m710608200

PubMed ID: 17535448

Title: Regulation of p73 by Hck through kinase-dependent and independent mechanisms.

PubMed ID: 17535448

DOI: 10.1186/1471-2199-8-45

PubMed ID: 18280240

Title: Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage.

PubMed ID: 18280240

DOI: 10.1016/j.molcel.2007.12.022

PubMed ID: 19490146

Title: Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation.

PubMed ID: 19490146

DOI: 10.1111/j.1365-2443.2009.01309.x

PubMed ID: 19581926

Title: The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73.

PubMed ID: 19581926

DOI: 10.1038/onc.2009.177

PubMed ID: 21994467

Title: Pirh2, a ubiquitin E3 ligase, inhibits p73 transcriptional activity by promoting its ubiquitination.

PubMed ID: 21994467

DOI: 10.1158/1541-7786.mcr-11-0157

PubMed ID: 24314664

Title: Epstein-Barr virus nuclear antigen 3C interact with p73: Interplay between a viral oncoprotein and cellular tumor suppressor.

PubMed ID: 24314664

DOI: 10.1016/j.virol.2013.10.023

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28291250

Title: Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism.

PubMed ID: 28291250

DOI: 10.1038/srep44532

PubMed ID: 10449409

Title: Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain.

PubMed ID: 10449409

DOI: 10.1093/emboj/18.16.4438

PubMed ID: 34077761

Title: Mutations in TP73 cause impaired mucociliary clearance and lissencephaly.

PubMed ID: 34077761

DOI: 10.1016/j.ajhg.2021.05.002

Sequence Information:

  • Length: 636
  • Mass: 69623
  • Checksum: A467493C5D93EEE0
  • Sequence:
    • MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS 
VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD 
YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV 
YKKAEHVTDV VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY 
EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR 
DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG DEDTYYLQVR 
GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS HLQPPSYGPV LSPMNKVHGG 
MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP GMLNNHGHAV PANGEMSSSH SAQSMVSGSH 
CTPPPPYHAD PSLVSFLTGL GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT 
IWRGLQDLKQ GHDYSTAQQL LRSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG 
GPGGGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH

Genular Protein ID: 988653164

Symbol: A0A0C4DFW9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DFW9

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 8 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PIRSR 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 426
  • Mass: 47696
  • Checksum: 18BB215365AED592
  • Sequence:
    • MLYVGDPARH LATAQFNLLS STMDQMSSRA ASASPYTPEH AASVPTHSPY AQPSSTFDTM 
SPAPVIPSNT DYPGPHHFEV TFQQSSTAKS ATWTYSPLLK KLYCQIAKTC PIQIKVSTPP 
PPGTAIRAMP VYKKAEHVTD VVKRCPNHEL GRDFNEGQSA PASHLIRVEG NNLSQYVDDP 
VTGRQSVVVP YEPPQVGTEF TTILYNFMCN SSCVGGMNRR PILIIITLEM RDGQVLGRRS 
FEGRICACPG RDRKADEDHY REQQALNESS AKNGAASKRA FKQSPPAVPA LGAGVKKRRH 
GDEDTYYLQV RGRENFEILM KLKESLELME LVPQPLVDSY RQQQQLLQRP PRDAQQPWPR 
SASQRRDEQQ PQRPVHGLGV PLHSATPLPR RPQPRQFFNR IGVSKLHRVF HLPRVTEHLP 
PAEPDH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.