Details for: TRAF1

Gene ID: 7185

Symbol: TRAF1

Ensembl ID: ENSG00000056558

Description: TNF receptor associated factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 61.3326
    Cell Significance Index: -9.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 37.5330
    Cell Significance Index: -9.5200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 22.5719
    Cell Significance Index: -9.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.9189
    Cell Significance Index: -9.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.7294
    Cell Significance Index: -9.5300
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 2.5530
    Cell Significance Index: 43.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.4303
    Cell Significance Index: -9.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.4077
    Cell Significance Index: -6.4500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.1781
    Cell Significance Index: -6.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.7591
    Cell Significance Index: -3.8500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1980
    Cell Significance Index: 35.1900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.0173
    Cell Significance Index: 10.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7977
    Cell Significance Index: 21.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4173
    Cell Significance Index: 79.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3168
    Cell Significance Index: 14.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2921
    Cell Significance Index: 28.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2897
    Cell Significance Index: 34.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2473
    Cell Significance Index: 223.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1914
    Cell Significance Index: 3.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1467
    Cell Significance Index: 23.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1083
    Cell Significance Index: 13.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0894
    Cell Significance Index: 9.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0851
    Cell Significance Index: 2.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0755
    Cell Significance Index: 14.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0719
    Cell Significance Index: 14.4200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0696
    Cell Significance Index: 7.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0691
    Cell Significance Index: 1.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0427
    Cell Significance Index: 2.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0297
    Cell Significance Index: 3.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0269
    Cell Significance Index: 0.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0188
    Cell Significance Index: 6.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0175
    Cell Significance Index: 1.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0107
    Cell Significance Index: 20.0800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0095
    Cell Significance Index: 0.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0057
    Cell Significance Index: 0.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0056
    Cell Significance Index: 10.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0022
    Cell Significance Index: 3.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0011
    Cell Significance Index: 0.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0010
    Cell Significance Index: -0.4300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0036
    Cell Significance Index: -0.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0037
    Cell Significance Index: -2.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0044
    Cell Significance Index: -2.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0054
    Cell Significance Index: -7.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0059
    Cell Significance Index: -4.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0085
    Cell Significance Index: -0.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0090
    Cell Significance Index: -4.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0092
    Cell Significance Index: -0.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0101
    Cell Significance Index: -7.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0120
    Cell Significance Index: -8.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0121
    Cell Significance Index: -6.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0167
    Cell Significance Index: -3.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0185
    Cell Significance Index: -1.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0204
    Cell Significance Index: -2.9600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0209
    Cell Significance Index: -0.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0216
    Cell Significance Index: -6.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0223
    Cell Significance Index: -3.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0246
    Cell Significance Index: -3.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0254
    Cell Significance Index: -5.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0283
    Cell Significance Index: -0.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0298
    Cell Significance Index: -0.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0341
    Cell Significance Index: -1.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0342
    Cell Significance Index: -0.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0356
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0373
    Cell Significance Index: -4.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0382
    Cell Significance Index: -3.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0460
    Cell Significance Index: -5.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0696
    Cell Significance Index: -8.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0737
    Cell Significance Index: -4.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0752
    Cell Significance Index: -2.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0807
    Cell Significance Index: -1.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0810
    Cell Significance Index: -8.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0830
    Cell Significance Index: -5.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0961
    Cell Significance Index: -7.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1006
    Cell Significance Index: -4.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1163
    Cell Significance Index: -7.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1174
    Cell Significance Index: -6.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1214
    Cell Significance Index: -6.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1268
    Cell Significance Index: -10.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1311
    Cell Significance Index: -8.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1320
    Cell Significance Index: -2.8900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1325
    Cell Significance Index: -1.5800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1400
    Cell Significance Index: -2.1100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1633
    Cell Significance Index: -2.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1648
    Cell Significance Index: -7.2900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1726
    Cell Significance Index: -3.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1806
    Cell Significance Index: -9.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1809
    Cell Significance Index: -4.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1904
    Cell Significance Index: -7.2100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2182
    Cell Significance Index: -1.1900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2232
    Cell Significance Index: -3.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2289
    Cell Significance Index: -8.0200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2310
    Cell Significance Index: -8.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2334
    Cell Significance Index: -6.0000
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.2349
    Cell Significance Index: -1.6900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2353
    Cell Significance Index: -2.4400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2400
    Cell Significance Index: -1.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2406
    Cell Significance Index: -9.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2477
    Cell Significance Index: -8.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2490
    Cell Significance Index: -7.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAF1 is a member of the TRAF family of proteins, which are characterized by their ability to interact with TNF receptors and other signaling molecules. TRAF1 is a 63-kDa protein that contains multiple domains, including a TRAF homology domain, a RING finger domain, and a proline-rich domain. These domains enable TRAF1 to interact with various proteins, including TNF receptors, NF-κB, and ubiquitin ligases, thereby regulating signaling pathways. TRAF1 is highly expressed in various cell types, including immune cells, epithelial cells, and neural cells. Its expression is often upregulated in response to inflammatory stimuli, such as TNF-α, and is also involved in the regulation of cell proliferation, differentiation, and survival. **Pathways and Functions:** TRAF1 is a central component of the TNF receptor signaling complex, which is involved in the regulation of apoptosis, inflammation, and immune responses. The key pathways and functions of TRAF1 include: 1. **Apoptotic signaling pathway:** TRAF1 interacts with TNF receptors and other signaling molecules to regulate apoptosis, a process of programmed cell death. 2. **NF-κB signaling pathway:** TRAF1 interacts with NF-κB, a transcription factor that regulates the expression of genes involved in inflammation and immune responses. 3. **Inflammatory signaling pathway:** TRAF1 is involved in the regulation of inflammatory responses, including the production of pro-inflammatory cytokines and chemokines. 4. **Immune cell development and function:** TRAF1 is essential for the development and function of immune cells, including T cells, B cells, and dendritic cells. 5. **Cell proliferation and differentiation:** TRAF1 regulates cell proliferation and differentiation in response to inflammatory stimuli. **Clinical Significance:** Dysregulation of TRAF1 has been implicated in several diseases, including: 1. **Cancer:** TRAF1 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Autoimmune disorders:** TRAF1 is involved in the regulation of autoimmune responses, and its dysregulation is implicated in diseases such as rheumatoid arthritis and lupus. 3. **Inflammatory conditions:** TRAF1 is involved in the regulation of inflammatory responses, and its dysregulation is implicated in diseases such as atherosclerosis and inflammatory bowel disease. 4. **Neurological disorders:** TRAF1 is involved in the regulation of neural cell function and survival, and its dysregulation is implicated in diseases such as Alzheimer's disease and Parkinson's disease. In conclusion, TRAF1 is a multifunctional adaptor protein that plays a crucial role in the regulation of various signaling pathways, including those involved in apoptosis, inflammation, and immune responses. Its dysregulation has been implicated in several diseases, and further research is needed to fully understand its role in human disease.

Genular Protein ID: 2315030296

Symbol: TRAF1_HUMAN

Name: TNF receptor-associated factor 1

UniProtKB Accession Codes:

Q13077 B4DJ77 Q658U1 Q8NF13

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 EvolutionaryTrace 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7859281

Title: The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family.

PubMed ID: 7859281

DOI: 10.1016/0092-8674(95)90489-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8069916

Title: A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.

PubMed ID: 8069916

DOI: 10.1016/0092-8674(94)90532-0

PubMed ID: 8710854

Title: I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.

PubMed ID: 8710854

DOI: 10.1073/pnas.93.16.8241

PubMed ID: 8627180

Title: T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors.

PubMed ID: 8627180

DOI: 10.1084/jem.183.2.669

PubMed ID: 9718306

Title: CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization.

PubMed ID: 9718306

DOI: 10.1021/bi981067q

PubMed ID: 9705938

Title: Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.

PubMed ID: 9705938

DOI: 10.1016/s0960-9822(07)00352-1

PubMed ID: 9642260

Title: RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.

PubMed ID: 9642260

DOI: 10.1074/jbc.273.27.16968

PubMed ID: 9774460

Title: The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.

PubMed ID: 9774460

DOI: 10.1074/jbc.273.43.28355

PubMed ID: 9607925

Title: CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand.

PubMed ID: 9607925

DOI: 10.1084/jem.187.11.1849

PubMed ID: 9418902

Title: 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB.

PubMed ID: 9418902

DOI: 10.1128/mcb.18.1.558

PubMed ID: 10037686

Title: Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand.

PubMed ID: 10037686

DOI: 10.1074/jbc.274.10.6056

PubMed ID: 10692572

Title: Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis.

PubMed ID: 10692572

DOI: 10.1016/s0014-5793(00)01206-0

PubMed ID: 10809768

Title: TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death.

PubMed ID: 10809768

DOI: 10.1074/jbc.275.20.15336

PubMed ID: 10903733

Title: TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase.

PubMed ID: 10903733

DOI: 10.4049/jimmunol.165.3.1322

PubMed ID: 11313261

Title: RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB.

PubMed ID: 11313261

DOI: 10.1182/blood.v97.9.2702

PubMed ID: 11035039

Title: The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A.

PubMed ID: 11035039

DOI: 10.1074/jbc.m008356200

PubMed ID: 11907583

Title: TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2.

PubMed ID: 11907583

DOI: 10.1038/416345a

PubMed ID: 15383523

Title: TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.

PubMed ID: 15383523

DOI: 10.1074/jbc.m407284200

PubMed ID: 15468071

Title: Mass spectrometric analysis of tumor necrosis factor receptor-associated factor 1 ubiquitination mediated by cellular inhibitor of apoptosis 2.

PubMed ID: 15468071

DOI: 10.1002/pmic.200401000

PubMed ID: 16323247

Title: TNF receptor-associated factor-1 (TRAF1) negatively regulates Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling.

PubMed ID: 16323247

DOI: 10.1002/eji.200535415

PubMed ID: 18429822

Title: Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1.

PubMed ID: 18429822

DOI: 10.1111/j.1365-2443.2008.01182.x

PubMed ID: 19698991

Title: TNF receptor-associated factor 1 is a positive regulator of the NF-kappaB alternative pathway.

PubMed ID: 19698991

DOI: 10.1016/j.molimm.2009.07.029

PubMed ID: 19287455

Title: Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation.

PubMed ID: 19287455

DOI: 10.1038/onc.2009.29

PubMed ID: 20447407

Title: Asymmetric recruitment of cIAPs by TRAF2.

PubMed ID: 20447407

DOI: 10.1016/j.jmb.2010.04.055

PubMed ID: 19937093

Title: Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation.

PubMed ID: 19937093

DOI: 10.1007/s11010-009-0315-y

PubMed ID: 20385093

Title: Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation.

PubMed ID: 20385093

DOI: 10.1016/j.molcel.2010.03.009

PubMed ID: 18987736

Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

PubMed ID: 18987736

DOI: 10.1038/nature07485

Sequence Information:

  • Length: 416
  • Mass: 46164
  • Checksum: A956A123A40D284A
  • Sequence:
    • MASSSGSSPR PAPDENEFPF GCPPTVCQDP KEPRALCCAG CLSENPRNGE DQICPKCRGE 
DLQSISPGSR LRTQEKAHPE VAEAGIGCPF AGVGCSFKGS PQSVQEHEVT SQTSHLNLLL 
GFMKQWKARL GCGLESGPMA LEQNLSDLQL QAAVEVAGDL EVDCYRAPCS ESQEELALQH 
FMKEKLLAEL EGKLRVFENI VAVLNKEVEA SHLALATSIH QSQLDRERIL SLEQRVVELQ 
QTLAQKDQAL GKLEQSLRLM EEASFDGTFL WKITNVTRRC HESACGRTVS LFSPAFYTAK 
YGYKLCLRLY LNGDGTGKRT HLSLFIVIMR GEYDALLPWP FRNKVTFMLL DQNNREHAID 
AFRPDLSSAS FQRPQSETNV ASGCPLFFPL SKLQSPKHAY VKDDTMFLKC IVETST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.