Details for: TRAF2

Gene ID: 7186

Symbol: TRAF2

Ensembl ID: ENSG00000127191

Description: TNF receptor associated factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 79.7196
    Cell Significance Index: -12.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 50.4646
    Cell Significance Index: -12.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 29.9564
    Cell Significance Index: -12.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.0506
    Cell Significance Index: -12.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.4522
    Cell Significance Index: -14.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.4310
    Cell Significance Index: -11.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.6239
    Cell Significance Index: -14.3000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.2102
    Cell Significance Index: -9.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7459
    Cell Significance Index: 673.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6356
    Cell Significance Index: 69.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6107
    Cell Significance Index: 36.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5971
    Cell Significance Index: 97.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5537
    Cell Significance Index: 109.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4610
    Cell Significance Index: 12.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4585
    Cell Significance Index: 12.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4277
    Cell Significance Index: 22.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3474
    Cell Significance Index: 66.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3461
    Cell Significance Index: 69.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3192
    Cell Significance Index: 14.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3031
    Cell Significance Index: 20.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3005
    Cell Significance Index: 23.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2540
    Cell Significance Index: 11.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2499
    Cell Significance Index: 7.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1900
    Cell Significance Index: 11.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1718
    Cell Significance Index: 75.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1544
    Cell Significance Index: 6.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1540
    Cell Significance Index: 5.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1527
    Cell Significance Index: 15.1100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1431
    Cell Significance Index: 2.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1424
    Cell Significance Index: 98.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1400
    Cell Significance Index: 16.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1325
    Cell Significance Index: 2.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1312
    Cell Significance Index: 71.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1022
    Cell Significance Index: 13.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1006
    Cell Significance Index: 5.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1004
    Cell Significance Index: 4.6800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0935
    Cell Significance Index: 1.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0916
    Cell Significance Index: 32.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0859
    Cell Significance Index: 10.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0827
    Cell Significance Index: 2.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0766
    Cell Significance Index: 13.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0757
    Cell Significance Index: 2.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0522
    Cell Significance Index: 3.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0486
    Cell Significance Index: 6.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0485
    Cell Significance Index: 1.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0476
    Cell Significance Index: 2.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0378
    Cell Significance Index: 1.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0261
    Cell Significance Index: 3.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0224
    Cell Significance Index: 34.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0221
    Cell Significance Index: 0.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0184
    Cell Significance Index: 0.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0138
    Cell Significance Index: 1.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0130
    Cell Significance Index: 0.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0105
    Cell Significance Index: 19.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0088
    Cell Significance Index: 0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0080
    Cell Significance Index: 15.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0058
    Cell Significance Index: 0.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0043
    Cell Significance Index: 0.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0020
    Cell Significance Index: -2.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0111
    Cell Significance Index: -8.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0113
    Cell Significance Index: -1.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0122
    Cell Significance Index: -7.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0168
    Cell Significance Index: -12.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0175
    Cell Significance Index: -12.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0201
    Cell Significance Index: -3.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0213
    Cell Significance Index: -2.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0219
    Cell Significance Index: -9.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0228
    Cell Significance Index: -12.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0245
    Cell Significance Index: -15.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0293
    Cell Significance Index: -2.9900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0353
    Cell Significance Index: -0.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0374
    Cell Significance Index: -10.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0451
    Cell Significance Index: -3.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0487
    Cell Significance Index: -1.4300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0489
    Cell Significance Index: -1.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0499
    Cell Significance Index: -5.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0573
    Cell Significance Index: -3.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0753
    Cell Significance Index: -1.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0759
    Cell Significance Index: -15.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1063
    Cell Significance Index: -2.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1200
    Cell Significance Index: -3.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1276
    Cell Significance Index: -2.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1282
    Cell Significance Index: -7.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1297
    Cell Significance Index: -13.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1430
    Cell Significance Index: -3.7600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1550
    Cell Significance Index: -2.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1662
    Cell Significance Index: -13.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1774
    Cell Significance Index: -2.4200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1863
    Cell Significance Index: -2.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2090
    Cell Significance Index: -8.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2338
    Cell Significance Index: -6.0100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2392
    Cell Significance Index: -1.4500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2508
    Cell Significance Index: -3.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2509
    Cell Significance Index: -7.1600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2527
    Cell Significance Index: -3.0100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2561
    Cell Significance Index: -5.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2590
    Cell Significance Index: -7.6300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2616
    Cell Significance Index: -3.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2626
    Cell Significance Index: -2.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2632
    Cell Significance Index: -7.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Adaptor function:** TRAF2 serves as a bridging protein between TLRs and TNFRs, facilitating the recruitment of downstream signaling molecules. 2. **Signal transduction:** TRAF2 mediates the activation of NF-κB, JNK, and IRF7, among other transcription factors, which in turn regulate gene expression and immune responses. 3. **Cytokine production:** TRAF2 influences the production of pro-inflammatory and anti-inflammatory cytokines, such as TNF-α, IL-1β, and IL-10. 4. **Apoptosis and necrosis:** TRAF2 regulates the activity of caspases and RIPK1, influencing the induction of apoptosis and necrosis in various cell types. 5. **Cell type specificity:** TRAF2 expression is tissue-specific, with significant expression in germ cells, cardiac endothelial cells, and immune cells, such as T cells and B cells. **Pathways and Functions:** 1. **TLR signaling:** TRAF2 mediates the activation of NF-κB and IRF7 in response to TLR ligands, such as LPS, poly(I:C), and RSV. 2. **TNFR signaling:** TRAF2 regulates the activation of NF-κB and JNK in response to TNFR ligands, such as TNF-α and LTA. 3. **Apoptosis and necrosis:** TRAF2 influences the activity of caspases and RIPK1, regulating the induction of apoptosis and necrosis in response to various stimuli. 4. **Cytokine production:** TRAF2 regulates the production of pro-inflammatory and anti-inflammatory cytokines, influencing immune responses and tissue homeostasis. 5. **Immune cell development:** TRAF2 plays a role in the development and function of immune cells, including T cells, B cells, and dendritic cells. **Clinical Significance:** 1. **Autoimmune diseases:** TRAF2 dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Cancer:** TRAF2 is overexpressed in various cancers, including breast, lung, and colon cancer, and its dysregulation contributes to tumor progression and metastasis. 3. **Inflammatory conditions:** TRAF2 is involved in the pathogenesis of inflammatory conditions, such as atherosclerosis, psoriasis, and inflammatory bowel disease. 4. **Neurological disorders:** TRAF2 is implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. In conclusion, TRAF2 is a multifaceted adaptor protein that plays a crucial role in immune regulation and disease. Its dysregulation has been implicated in various immune-related disorders, and understanding its mechanisms of action may provide new therapeutic strategies for the treatment of these conditions.

Genular Protein ID: 3624271600

Symbol: TRAF2_HUMAN

Name: TNF receptor-associated factor 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7639698

Title: Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor.

PubMed ID: 7639698

DOI: 10.1042/bj3090825

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8069916

Title: A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.

PubMed ID: 8069916

DOI: 10.1016/0092-8674(94)90532-0

PubMed ID: 8627180

Title: T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors.

PubMed ID: 8627180

DOI: 10.1084/jem.183.2.669

PubMed ID: 8710854

Title: I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.

PubMed ID: 8710854

DOI: 10.1073/pnas.93.16.8241

PubMed ID: 9153189

Title: ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5.

PubMed ID: 9153189

DOI: 10.1074/jbc.272.21.13471

PubMed ID: 9104814

Title: TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation.

PubMed ID: 9104814

DOI: 10.1084/jem.185.7.1275

PubMed ID: 9020361

Title: MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.

PubMed ID: 9020361

DOI: 10.1038/385540a0

PubMed ID: 9718306

Title: CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization.

PubMed ID: 9718306

DOI: 10.1021/bi981067q

PubMed ID: 9705938

Title: Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.

PubMed ID: 9705938

DOI: 10.1016/s0960-9822(07)00352-1

PubMed ID: 9692890

Title: The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2.

PubMed ID: 9692890

DOI: 10.1002/(sici)1521-4141(199807)28:07<2208::aid-immu2208>3.0.co;2-l

PubMed ID: 9488716

Title: Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation.

PubMed ID: 9488716

DOI: 10.1074/jbc.273.10.5808

PubMed ID: 9774460

Title: The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.

PubMed ID: 9774460

DOI: 10.1074/jbc.273.43.28355

PubMed ID: 9827693

Title: Binding of CDK9 to TRAF2.

PubMed ID: 9827693

DOI: 10.1002/(sici)1097-4644(19981215)71:4<467::aid-jcb2>3.3.co;2-7

PubMed ID: 9607925

Title: CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand.

PubMed ID: 9607925

DOI: 10.1084/jem.187.11.1849

PubMed ID: 9774977

Title: ASK1 is essential for JNK/SAPK activation by TRAF2.

PubMed ID: 9774977

DOI: 10.1016/s1097-2765(00)80283-x

PubMed ID: 9418902

Title: 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB.

PubMed ID: 9418902

DOI: 10.1128/mcb.18.1.558

PubMed ID: 10581243

Title: NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase.

PubMed ID: 10581243

DOI: 10.1093/emboj/18.23.6694

PubMed ID: 10463949

Title: Death deflected: IL-15 inhibits TNF-alpha-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Ralpha chain.

PubMed ID: 10463949

DOI: 10.1096/fasebj.13.12.1575

PubMed ID: 21357251

Title:

PubMed ID: 21357251

DOI: 10.1096/fj.11-0309ret

PubMed ID: 10346818

Title: Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.

PubMed ID: 10346818

DOI: 10.1101/gad.13.10.1297

PubMed ID: 10037686

Title: Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand.

PubMed ID: 10037686

DOI: 10.1074/jbc.274.10.6056

PubMed ID: 10514511

Title: TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.

PubMed ID: 10514511

DOI: 10.1074/jbc.274.42.30202

PubMed ID: 10521462

Title: TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton.

PubMed ID: 10521462

DOI: 10.1074/jbc.274.43.30729

PubMed ID: 10809768

Title: TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death.

PubMed ID: 10809768

DOI: 10.1074/jbc.275.20.15336

PubMed ID: 10764746

Title: TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.

PubMed ID: 10764746

DOI: 10.1074/jbc.m000531200

PubMed ID: 10880535

Title: TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation.

PubMed ID: 10880535

DOI: 10.1084/jem.192.1.137

PubMed ID: 11035039

Title: The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A.

PubMed ID: 11035039

DOI: 10.1074/jbc.m008356200

PubMed ID: 11278723

Title: Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress.

PubMed ID: 11278723

DOI: 10.1074/jbc.m010677200

PubMed ID: 12411493

Title: Stress-induced decrease in TRAF2 stability is mediated by Siah2.

PubMed ID: 12411493

DOI: 10.1093/emboj/cdf576

PubMed ID: 11784851

Title: Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.

PubMed ID: 11784851

DOI: 10.1128/mcb.22.3.737-749.2002

PubMed ID: 11907583

Title: TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2.

PubMed ID: 11907583

DOI: 10.1038/416345a

PubMed ID: 12917689

Title: CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members.

PubMed ID: 12917689

DOI: 10.1038/nature01803

PubMed ID: 12917691

Title: The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.

PubMed ID: 12917691

DOI: 10.1038/nature01802

PubMed ID: 15310755

Title: AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.

PubMed ID: 15310755

DOI: 10.1074/jbc.m407617200

PubMed ID: 15383523

Title: TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.

PubMed ID: 15383523

DOI: 10.1074/jbc.m407284200

PubMed ID: 15121867

Title: TRAF family proteins link PKR with NF-kappa B activation.

PubMed ID: 15121867

DOI: 10.1128/mcb.24.10.4502-4512.2004

PubMed ID: 16153868

Title: VISA is an adapter protein required for virus-triggered IFN-beta Signaling.

PubMed ID: 16153868

DOI: 10.1016/j.molcel.2005.08.014

PubMed ID: 15870263

Title: Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation.

PubMed ID: 15870263

DOI: 10.1128/mcb.25.10.3886-3895.2005

PubMed ID: 15696169

Title: Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase.

PubMed ID: 15696169

DOI: 10.1038/ni1169

PubMed ID: 16214042

Title: Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB.

PubMed ID: 16214042

DOI: 10.1016/j.cellsig.2005.03.017

PubMed ID: 17389591

Title: RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation.

PubMed ID: 17389591

DOI: 10.1074/jbc.m701148200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19506082

Title: Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2.

PubMed ID: 19506082

DOI: 10.1074/jbc.m109.029983

PubMed ID: 19150425

Title: PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination.

PubMed ID: 19150425

DOI: 10.1016/j.molcel.2008.11.023

PubMed ID: 18981220

Title: TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis.

PubMed ID: 18981220

DOI: 10.1128/mcb.00699-08

PubMed ID: 19969290

Title: RELT induces cellular death in HEK 293 epithelial cells.

PubMed ID: 19969290

DOI: 10.1016/j.cellimm.2009.10.013

PubMed ID: 19918265

Title: TRAF2-MLK3 interaction is essential for TNF-alpha-induced MLK3 activation.

PubMed ID: 19918265

DOI: 10.1038/cr.2009.125

PubMed ID: 20447407

Title: Asymmetric recruitment of cIAPs by TRAF2.

PubMed ID: 20447407

DOI: 10.1016/j.jmb.2010.04.055

PubMed ID: 20064526

Title: The RING domain of TRAF2 plays an essential role in the inhibition of TNFalpha-induced cell death but not in the activation of NF-kappaB.

PubMed ID: 20064526

DOI: 10.1016/j.jmb.2010.01.008

PubMed ID: 19937093

Title: Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation.

PubMed ID: 19937093

DOI: 10.1007/s11010-009-0315-y

PubMed ID: 20047764

Title: Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway.

PubMed ID: 20047764

DOI: 10.1016/j.molimm.2009.12.002

PubMed ID: 20577214

Title: Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.

PubMed ID: 20577214

DOI: 10.1038/nature09128

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21307340

Title: UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation.

PubMed ID: 21307340

DOI: 10.1091/mbc.e10-10-0827

PubMed ID: 21302310

Title: Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-kappaB activation and endoplasmic reticulum stress-induced cell death.

PubMed ID: 21302310

DOI: 10.1002/jcp.22667

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22212761

Title: Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling.

PubMed ID: 22212761

DOI: 10.1111/j.1582-4934.2012.01524.x

PubMed ID: 22095282

Title: Arginine methylation-dependent regulation of ASK1 signaling by PRMT1.

PubMed ID: 22095282

DOI: 10.1038/cdd.2011.168

PubMed ID: 23453969

Title: IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.

PubMed ID: 23453969

DOI: 10.1016/j.celrep.2013.01.031

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23332158

Title: NleB, a bacterial effector with glycosyltransferase activity, targets GAPDH function to inhibit NF-kappaB activation.

PubMed ID: 23332158

DOI: 10.1016/j.chom.2012.11.010

PubMed ID: 25026888

Title: LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria.

PubMed ID: 25026888

DOI: 10.1038/ncomms5434

PubMed ID: 25609706

Title: Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2.

PubMed ID: 25609706

DOI: 10.1242/jcs.149385

PubMed ID: 29883609

Title: PELI1 selectively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation.

PubMed ID: 29883609

DOI: 10.1016/j.molcel.2018.05.016

PubMed ID: 38354704

Title: Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks.

PubMed ID: 38354704

DOI: 10.1016/j.immuni.2024.01.011

PubMed ID: 10206649

Title: Structural basis for self-association and receptor recognition of human TRAF2.

PubMed ID: 10206649

DOI: 10.1038/19110

PubMed ID: 10411888

Title: Crystallographic analysis of CD40 recognition and signaling by human TRAF2.

PubMed ID: 10411888

DOI: 10.1073/pnas.96.15.8408

PubMed ID: 10892748

Title: A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction.

PubMed ID: 10892748

DOI: 10.1016/s0092-8674(00)80889-2

PubMed ID: 19810754

Title: Structural basis for the lack of E2 interaction in the RING domain of TRAF2.

PubMed ID: 19810754

DOI: 10.1021/bi901462e

PubMed ID: 20385093

Title: Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation.

PubMed ID: 20385093

DOI: 10.1016/j.molcel.2010.03.009

Sequence Information:

  • Length: 501
  • Mass: 55859
  • Checksum: C508BE185B783B20
  • Sequence:
  • MAAASVTPPG SLELLQPGFS KTLLGTKLEA KYLCSACRNV LRRPFQAQCG HRYCSFCLAS 
    ILSSGPQNCA ACVHEGIYEE GISILESSSA FPDNAARREV ESLPAVCPSD GCTWKGTLKE 
    YESCHEGRCP LMLTECPACK GLVRLGEKER HLEHECPERS LSCRHCRAPC CGADVKAHHE 
    VCPKFPLTCD GCGKKKIPRE KFQDHVKTCG KCRVPCRFHA IGCLETVEGE KQQEHEVQWL 
    REHLAMLLSS VLEAKPLLGD QSHAGSELLQ RCESLEKKTA TFENIVCVLN REVERVAMTA 
    EACSRQHRLD QDKIEALSSK VQQLERSIGL KDLAMADLEQ KVLEMEASTY DGVFIWKISD 
    FARKRQEAVA GRIPAIFSPA FYTSRYGYKM CLRIYLNGDG TGRGTHLSLF FVVMKGPNDA 
    LLRWPFNQKV TLMLLDQNNR EHVIDAFRPD VTSSSFQRPV NDMNIASGCP LFCPVSKMEA 
    KNSYVRDDAI FIKAIVDLTG L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.