Details for: TRAF2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 79.7196
Cell Significance Index: -12.4000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 50.4646
Cell Significance Index: -12.8000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 29.9564
Cell Significance Index: -12.1700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 13.0506
Cell Significance Index: -12.4600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 11.4522
Cell Significance Index: -14.1200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 4.4310
Cell Significance Index: -11.8700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.6239
Cell Significance Index: -14.3000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 3.2102
Cell Significance Index: -9.8600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7459
Cell Significance Index: 673.4800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6356
Cell Significance Index: 69.1400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6107
Cell Significance Index: 36.6700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5971
Cell Significance Index: 97.1200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5537
Cell Significance Index: 109.8900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4610
Cell Significance Index: 12.3100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.4585
Cell Significance Index: 12.4800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.4277
Cell Significance Index: 22.2800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3474
Cell Significance Index: 66.1100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3461
Cell Significance Index: 69.4200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3192
Cell Significance Index: 14.4700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3031
Cell Significance Index: 20.9600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3005
Cell Significance Index: 23.0600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2540
Cell Significance Index: 11.9400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2499
Cell Significance Index: 7.2000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1900
Cell Significance Index: 11.9800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1718
Cell Significance Index: 75.9600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.1544
Cell Significance Index: 6.8300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.1540
Cell Significance Index: 5.8300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1527
Cell Significance Index: 15.1100 - Cell Name: proerythroblast (CL0000547)
Fold Change: 0.1431
Cell Significance Index: 2.0500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1424
Cell Significance Index: 98.5000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1400
Cell Significance Index: 16.5100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1325
Cell Significance Index: 2.8700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1312
Cell Significance Index: 71.6800 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.1022
Cell Significance Index: 13.2100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1006
Cell Significance Index: 5.2800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1004
Cell Significance Index: 4.6800 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.0935
Cell Significance Index: 1.5000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0916
Cell Significance Index: 32.8400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0859
Cell Significance Index: 10.5600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0827
Cell Significance Index: 2.2200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0766
Cell Significance Index: 13.8200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0757
Cell Significance Index: 2.6600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0522
Cell Significance Index: 3.6900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0486
Cell Significance Index: 6.6800 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.0485
Cell Significance Index: 1.6900 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0476
Cell Significance Index: 2.4100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0378
Cell Significance Index: 1.2100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0261
Cell Significance Index: 3.8000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0224
Cell Significance Index: 34.4800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0221
Cell Significance Index: 0.4700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0184
Cell Significance Index: 0.4600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0138
Cell Significance Index: 1.0300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0130
Cell Significance Index: 0.8400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0105
Cell Significance Index: 19.3700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0088
Cell Significance Index: 0.1500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0080
Cell Significance Index: 15.0000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0058
Cell Significance Index: 0.3000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0043
Cell Significance Index: 0.2400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0020
Cell Significance Index: -2.7200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0111
Cell Significance Index: -8.4100 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0113
Cell Significance Index: -1.4500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0122
Cell Significance Index: -7.7700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0168
Cell Significance Index: -12.2900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0175
Cell Significance Index: -12.9600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0201
Cell Significance Index: -3.4300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0213
Cell Significance Index: -2.4400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0219
Cell Significance Index: -9.9600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0228
Cell Significance Index: -12.8400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0245
Cell Significance Index: -15.3200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0293
Cell Significance Index: -2.9900 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0353
Cell Significance Index: -0.3700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0374
Cell Significance Index: -10.7600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0451
Cell Significance Index: -3.0300 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0487
Cell Significance Index: -1.4300 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0489
Cell Significance Index: -1.2500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0499
Cell Significance Index: -5.8100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0573
Cell Significance Index: -3.5200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0753
Cell Significance Index: -1.2600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0759
Cell Significance Index: -15.9900 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.1063
Cell Significance Index: -2.3300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1200
Cell Significance Index: -3.4400 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1276
Cell Significance Index: -2.6700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1282
Cell Significance Index: -7.8600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1297
Cell Significance Index: -13.5100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1430
Cell Significance Index: -3.7600 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1550
Cell Significance Index: -2.2200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1662
Cell Significance Index: -13.1600 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1774
Cell Significance Index: -2.4200 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1863
Cell Significance Index: -2.7500 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2090
Cell Significance Index: -8.5600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2338
Cell Significance Index: -6.0100 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2392
Cell Significance Index: -1.4500 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2508
Cell Significance Index: -3.7800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2509
Cell Significance Index: -7.1600 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.2527
Cell Significance Index: -3.0100 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2561
Cell Significance Index: -5.4800 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2590
Cell Significance Index: -7.6300 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.2616
Cell Significance Index: -3.6300 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.2626
Cell Significance Index: -2.8600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2632
Cell Significance Index: -7.0400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3624271600
Symbol: TRAF2_HUMAN
Name: TNF receptor-associated factor 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7639698
Title: Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor.
PubMed ID: 7639698
DOI: 10.1042/bj3090825
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8069916
Title: A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.
PubMed ID: 8069916
PubMed ID: 8627180
Title: T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors.
PubMed ID: 8627180
PubMed ID: 8710854
Title: I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.
PubMed ID: 8710854
PubMed ID: 9153189
Title: ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5.
PubMed ID: 9153189
PubMed ID: 9104814
Title: TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation.
PubMed ID: 9104814
PubMed ID: 9020361
Title: MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.
PubMed ID: 9020361
DOI: 10.1038/385540a0
PubMed ID: 9718306
Title: CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization.
PubMed ID: 9718306
DOI: 10.1021/bi981067q
PubMed ID: 9705938
Title: Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.
PubMed ID: 9705938
PubMed ID: 9692890
Title: The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2.
PubMed ID: 9692890
DOI: 10.1002/(sici)1521-4141(199807)28:07<2208::aid-immu2208>3.0.co;2-l
PubMed ID: 9488716
Title: Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation.
PubMed ID: 9488716
PubMed ID: 9774460
Title: The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.
PubMed ID: 9774460
PubMed ID: 9827693
Title: Binding of CDK9 to TRAF2.
PubMed ID: 9827693
DOI: 10.1002/(sici)1097-4644(19981215)71:4<467::aid-jcb2>3.3.co;2-7
PubMed ID: 9607925
Title: CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand.
PubMed ID: 9607925
PubMed ID: 9774977
Title: ASK1 is essential for JNK/SAPK activation by TRAF2.
PubMed ID: 9774977
PubMed ID: 9418902
Title: 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB.
PubMed ID: 9418902
DOI: 10.1128/mcb.18.1.558
PubMed ID: 10581243
Title: NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase.
PubMed ID: 10581243
PubMed ID: 10463949
Title: Death deflected: IL-15 inhibits TNF-alpha-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Ralpha chain.
PubMed ID: 10463949
PubMed ID: 21357251
PubMed ID: 10346818
Title: Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.
PubMed ID: 10346818
PubMed ID: 10037686
Title: Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand.
PubMed ID: 10037686
PubMed ID: 10514511
Title: TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.
PubMed ID: 10514511
PubMed ID: 10521462
Title: TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton.
PubMed ID: 10521462
PubMed ID: 10809768
Title: TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death.
PubMed ID: 10809768
PubMed ID: 10764746
Title: TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.
PubMed ID: 10764746
PubMed ID: 10880535
Title: TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation.
PubMed ID: 10880535
PubMed ID: 11035039
Title: The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A.
PubMed ID: 11035039
PubMed ID: 11278723
Title: Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress.
PubMed ID: 11278723
PubMed ID: 12411493
Title: Stress-induced decrease in TRAF2 stability is mediated by Siah2.
PubMed ID: 12411493
DOI: 10.1093/emboj/cdf576
PubMed ID: 11784851
Title: Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.
PubMed ID: 11784851
PubMed ID: 11907583
Title: TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2.
PubMed ID: 11907583
DOI: 10.1038/416345a
PubMed ID: 12917689
Title: CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members.
PubMed ID: 12917689
DOI: 10.1038/nature01803
PubMed ID: 12917691
Title: The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.
PubMed ID: 12917691
DOI: 10.1038/nature01802
PubMed ID: 15310755
Title: AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.
PubMed ID: 15310755
PubMed ID: 15383523
Title: TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.
PubMed ID: 15383523
PubMed ID: 15121867
Title: TRAF family proteins link PKR with NF-kappa B activation.
PubMed ID: 15121867
PubMed ID: 16153868
Title: VISA is an adapter protein required for virus-triggered IFN-beta Signaling.
PubMed ID: 16153868
PubMed ID: 15870263
Title: Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation.
PubMed ID: 15870263
PubMed ID: 15696169
Title: Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase.
PubMed ID: 15696169
DOI: 10.1038/ni1169
PubMed ID: 16214042
Title: Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB.
PubMed ID: 16214042
PubMed ID: 17389591
Title: RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation.
PubMed ID: 17389591
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19506082
Title: Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2.
PubMed ID: 19506082
PubMed ID: 19150425
Title: PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination.
PubMed ID: 19150425
PubMed ID: 18981220
Title: TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis.
PubMed ID: 18981220
DOI: 10.1128/mcb.00699-08
PubMed ID: 19969290
Title: RELT induces cellular death in HEK 293 epithelial cells.
PubMed ID: 19969290
PubMed ID: 19918265
Title: TRAF2-MLK3 interaction is essential for TNF-alpha-induced MLK3 activation.
PubMed ID: 19918265
DOI: 10.1038/cr.2009.125
PubMed ID: 20447407
PubMed ID: 20064526
Title: The RING domain of TRAF2 plays an essential role in the inhibition of TNFalpha-induced cell death but not in the activation of NF-kappaB.
PubMed ID: 20064526
PubMed ID: 19937093
Title: Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation.
PubMed ID: 19937093
PubMed ID: 20047764
Title: Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway.
PubMed ID: 20047764
PubMed ID: 20577214
Title: Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.
PubMed ID: 20577214
DOI: 10.1038/nature09128
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21307340
Title: UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation.
PubMed ID: 21307340
PubMed ID: 21302310
Title: Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-kappaB activation and endoplasmic reticulum stress-induced cell death.
PubMed ID: 21302310
DOI: 10.1002/jcp.22667
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22212761
Title: Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling.
PubMed ID: 22212761
PubMed ID: 22095282
Title: Arginine methylation-dependent regulation of ASK1 signaling by PRMT1.
PubMed ID: 22095282
DOI: 10.1038/cdd.2011.168
PubMed ID: 23453969
Title: IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.
PubMed ID: 23453969
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23332158
Title: NleB, a bacterial effector with glycosyltransferase activity, targets GAPDH function to inhibit NF-kappaB activation.
PubMed ID: 23332158
PubMed ID: 25026888
Title: LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria.
PubMed ID: 25026888
DOI: 10.1038/ncomms5434
PubMed ID: 25609706
Title: Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2.
PubMed ID: 25609706
DOI: 10.1242/jcs.149385
PubMed ID: 29883609
Title: PELI1 selectively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation.
PubMed ID: 29883609
PubMed ID: 38354704
Title: Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks.
PubMed ID: 38354704
PubMed ID: 10206649
Title: Structural basis for self-association and receptor recognition of human TRAF2.
PubMed ID: 10206649
DOI: 10.1038/19110
PubMed ID: 10411888
Title: Crystallographic analysis of CD40 recognition and signaling by human TRAF2.
PubMed ID: 10411888
PubMed ID: 10892748
Title: A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction.
PubMed ID: 10892748
PubMed ID: 19810754
Title: Structural basis for the lack of E2 interaction in the RING domain of TRAF2.
PubMed ID: 19810754
DOI: 10.1021/bi901462e
PubMed ID: 20385093
Title: Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation.
PubMed ID: 20385093
Sequence Information:
- Length: 501
- Mass: 55859
- Checksum: C508BE185B783B20
- Sequence:
MAAASVTPPG SLELLQPGFS KTLLGTKLEA KYLCSACRNV LRRPFQAQCG HRYCSFCLAS ILSSGPQNCA ACVHEGIYEE GISILESSSA FPDNAARREV ESLPAVCPSD GCTWKGTLKE YESCHEGRCP LMLTECPACK GLVRLGEKER HLEHECPERS LSCRHCRAPC CGADVKAHHE VCPKFPLTCD GCGKKKIPRE KFQDHVKTCG KCRVPCRFHA IGCLETVEGE KQQEHEVQWL REHLAMLLSS VLEAKPLLGD QSHAGSELLQ RCESLEKKTA TFENIVCVLN REVERVAMTA EACSRQHRLD QDKIEALSSK VQQLERSIGL KDLAMADLEQ KVLEMEASTY DGVFIWKISD FARKRQEAVA GRIPAIFSPA FYTSRYGYKM CLRIYLNGDG TGRGTHLSLF FVVMKGPNDA LLRWPFNQKV TLMLLDQNNR EHVIDAFRPD VTSSSFQRPV NDMNIASGCP LFCPVSKMEA KNSYVRDDAI FIKAIVDLTG L
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.