Details for: TRAF5

Gene ID: 7188

Symbol: TRAF5

Ensembl ID: ENSG00000082512

Description: TNF receptor associated factor 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 115.5612
    Cell Significance Index: -17.9800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 47.0345
    Cell Significance Index: -11.9300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 40.1470
    Cell Significance Index: -16.3100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.5872
    Cell Significance Index: -18.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.5463
    Cell Significance Index: -17.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.7748
    Cell Significance Index: -15.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6122
    Cell Significance Index: -18.2000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.4279
    Cell Significance Index: -13.6000
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.3030
    Cell Significance Index: 3.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1307
    Cell Significance Index: 183.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0627
    Cell Significance Index: 40.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.0531
    Cell Significance Index: 23.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9108
    Cell Significance Index: 54.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7565
    Cell Significance Index: 89.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7513
    Cell Significance Index: 33.2300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7096
    Cell Significance Index: 13.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6120
    Cell Significance Index: 42.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5410
    Cell Significance Index: 108.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4747
    Cell Significance Index: 170.2500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3110
    Cell Significance Index: 15.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2910
    Cell Significance Index: 8.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2676
    Cell Significance Index: 7.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2553
    Cell Significance Index: 50.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2425
    Cell Significance Index: 15.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2384
    Cell Significance Index: 5.9600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2365
    Cell Significance Index: 163.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2128
    Cell Significance Index: 29.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2042
    Cell Significance Index: 9.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1912
    Cell Significance Index: 9.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1713
    Cell Significance Index: 29.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1652
    Cell Significance Index: 104.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1586
    Cell Significance Index: 30.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1516
    Cell Significance Index: 6.8700
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.1463
    Cell Significance Index: 0.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1279
    Cell Significance Index: 58.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1276
    Cell Significance Index: 240.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1245
    Cell Significance Index: 3.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1049
    Cell Significance Index: 18.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0861
    Cell Significance Index: 2.3000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0730
    Cell Significance Index: 1.5600
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.0694
    Cell Significance Index: 0.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0641
    Cell Significance Index: 35.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0573
    Cell Significance Index: 7.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0457
    Cell Significance Index: 4.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0453
    Cell Significance Index: 4.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0391
    Cell Significance Index: 1.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0368
    Cell Significance Index: 1.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0115
    Cell Significance Index: 1.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0055
    Cell Significance Index: 0.1200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0048
    Cell Significance Index: 0.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0013
    Cell Significance Index: -1.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0036
    Cell Significance Index: -1.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0043
    Cell Significance Index: -5.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0056
    Cell Significance Index: -10.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0150
    Cell Significance Index: -11.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0234
    Cell Significance Index: -17.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0244
    Cell Significance Index: -18.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0309
    Cell Significance Index: -17.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0318
    Cell Significance Index: -19.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0328
    Cell Significance Index: -1.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0374
    Cell Significance Index: -1.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0401
    Cell Significance Index: -2.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0524
    Cell Significance Index: -15.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0528
    Cell Significance Index: -7.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0588
    Cell Significance Index: -3.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0644
    Cell Significance Index: -7.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0717
    Cell Significance Index: -7.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0737
    Cell Significance Index: -4.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0763
    Cell Significance Index: -1.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0849
    Cell Significance Index: -2.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0862
    Cell Significance Index: -2.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0930
    Cell Significance Index: -19.5900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0981
    Cell Significance Index: -0.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0995
    Cell Significance Index: -12.8500
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: -0.1029
    Cell Significance Index: -0.4600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1032
    Cell Significance Index: -2.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1274
    Cell Significance Index: -9.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1398
    Cell Significance Index: -2.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1441
    Cell Significance Index: -16.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1750
    Cell Significance Index: -13.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1825
    Cell Significance Index: -12.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1874
    Cell Significance Index: -9.8400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1997
    Cell Significance Index: -4.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2233
    Cell Significance Index: -17.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2273
    Cell Significance Index: -7.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2358
    Cell Significance Index: -6.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2411
    Cell Significance Index: -5.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2796
    Cell Significance Index: -17.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2804
    Cell Significance Index: -5.8700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2944
    Cell Significance Index: -8.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2966
    Cell Significance Index: -4.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2977
    Cell Significance Index: -18.7600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3087
    Cell Significance Index: -3.8500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3131
    Cell Significance Index: -7.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3518
    Cell Significance Index: -12.2300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3589
    Cell Significance Index: -4.5300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3607
    Cell Significance Index: -5.1800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3661
    Cell Significance Index: -5.5700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3881
    Cell Significance Index: -6.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAF5 is a member of the TRAF family, which consists of five proteins known to interact with TNF receptors and other ligands. TRAF5 possesses a unique structure, featuring a RING finger domain, a ubiquitin-like domain, and a coiled-coil motif. This protein exhibits high homology with TRAF3, TRAF6, and TRAF7, suggesting its conserved role in mediating immune responses. TRAF5 is also characterized by its ability to bind to various proteins, including NF-κB, TRAF3, and TRAF6, facilitating the activation of downstream signaling pathways. **Pathways and Functions:** TRAF5 is integral to several signaling pathways that regulate immune responses, including: 1. **TNF-mediated signaling pathway**: TRAF5 mediates the signaling of TNF receptors, leading to the activation of NF-κB transcription factor activity, which regulates the expression of genes involved in inflammation and immune response. 2. **NF-κB signaling pathway**: TRAF5 interacts with NF-κB, facilitating its activation and nuclear translocation, which in turn regulates the expression of genes involved in immune responses, cell proliferation, and survival. 3. **Apoptotic process**: TRAF5 has been implicated in the regulation of apoptosis, particularly in the context of TNF-mediated signaling. Its interaction with TRAF3 and TRAF6 leads to the activation of caspase-8, which promotes apoptosis. 4. **Cell population proliferation**: TRAF5 regulates cell population proliferation by modulating the activity of NF-κB and other transcription factors, influencing the expression of genes involved in cell cycle progression. **Clinical Significance:** TRAF5 has been implicated in various immune-related disorders, including: 1. **Atherosclerosis**: TRAF5 has been shown to play a role in the development of atherosclerosis by regulating the expression of genes involved in inflammation and immune response. 2. **Autoimmune diseases**: TRAF5 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, where dysregulation of NF-κB signaling contributes to disease progression. 3. **Cancer**: TRAF5 has been shown to be overexpressed in certain types of cancer, including breast and lung cancer, where its interaction with NF-κB and other transcription factors promotes tumor growth and survival. 4. **Neurological disorders**: TRAF5 has been implicated in the pathogenesis of neurological disorders, such as multiple sclerosis and Alzheimer's disease, where its dysregulation of NF-κB signaling contributes to disease progression. In conclusion, TRAF5 is a multifaceted protein that plays a crucial role in regulating immune responses, cell proliferation, and apoptosis. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of TRAF5 in the development of novel therapeutic strategies for these conditions.

Genular Protein ID: 194277036

Symbol: TRAF5_HUMAN

Name: TNF receptor-associated factor 5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9511754

Title: Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).

PubMed ID: 9511754

DOI: 10.1016/s0378-1119(97)00616-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9177772

Title: Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32.

PubMed ID: 9177772

DOI: 10.1006/geno.1997.4697

PubMed ID: 11384837

Title: The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.

PubMed ID: 11384837

DOI: 10.1016/s0898-6568(01)00160-7

PubMed ID: 11607847

Title: Tumor necrosis factor receptor-associated factors (TRAFs).

PubMed ID: 11607847

DOI: 10.1038/sj.onc.1204788

PubMed ID: 9162022

Title: Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1.

PubMed ID: 9162022

DOI: 10.1074/jbc.272.22.14029

PubMed ID: 9153189

Title: ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5.

PubMed ID: 9153189

DOI: 10.1074/jbc.272.21.13471

PubMed ID: 9275204

Title: Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2.

PubMed ID: 9275204

DOI: 10.1073/pnas.94.18.9792

PubMed ID: 8999898

Title: Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation.

PubMed ID: 8999898

DOI: 10.1074/jbc.272.4.2042

PubMed ID: 9774977

Title: ASK1 is essential for JNK/SAPK activation by TRAF2.

PubMed ID: 9774977

DOI: 10.1016/s1097-2765(00)80283-x

PubMed ID: 9718306

Title: CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization.

PubMed ID: 9718306

DOI: 10.1021/bi981067q

PubMed ID: 9488716

Title: Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation.

PubMed ID: 9488716

DOI: 10.1074/jbc.273.10.5808

PubMed ID: 9642260

Title: RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.

PubMed ID: 9642260

DOI: 10.1074/jbc.273.27.16968

PubMed ID: 10809768

Title: TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death.

PubMed ID: 10809768

DOI: 10.1074/jbc.275.20.15336

PubMed ID: 9774460

Title: The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.

PubMed ID: 9774460

DOI: 10.1074/jbc.273.43.28355

PubMed ID: 10764746

Title: TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.

PubMed ID: 10764746

DOI: 10.1074/jbc.m000531200

PubMed ID: 10880535

Title: TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation.

PubMed ID: 10880535

DOI: 10.1084/jem.192.1.137

PubMed ID: 10908663

Title: B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1.

PubMed ID: 10908663

DOI: 10.1073/pnas.160213497

PubMed ID: 15121867

Title: TRAF family proteins link PKR with NF-kappa B activation.

PubMed ID: 15121867

DOI: 10.1128/mcb.24.10.4502-4512.2004

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

Sequence Information:

  • Length: 557
  • Mass: 64406
  • Checksum: 86EB3724CE111176
  • Sequence:
  • MAYSEEHKGM PCGFIRQNSG NSISLDFEPS IEYQFVERLE ERYKCAFCHS VLHNPHQTGC 
    GHRFCQHCIL SLRELNTVPI CPVDKEVIKS QEVFKDNCCK REVLNLYVYC SNAPGCNAKV 
    ILGRYQDHLQ QCLFQPVQCS NEKCREPVLR KDLKEHLSAS CQFRKEKCLY CKKDVVVINL 
    QNHEENLCPE YPVFCPNNCA KIILKTEVDE HLAVCPEAEQ DCPFKHYGCA VTDKRRNLQQ 
    HEHSALREHM RLVLEKNVQL EEQISDLHKS LEQKESKIQQ LAETIKKLEK EFKQFAQLFG 
    KNGSFLPNIQ VFASHIDKSA WLEAQVHQLL QMVNQQQNKF DLRPLMEAVD TVKQKITLLE 
    NNDQRLAVLE EETNKHDTHI NIHKAQLSKN EERFKLLEGT CYNGKLIWKV TDYKMKKREA 
    VDGHTVSIFS QSFYTSRCGY RLCARAYLNG DGSGRGSHLS LYFVVMRGEF DSLLQWPFRQ 
    RVTLMLLDQS GKKNIMETFK PDPNSSSFKR PDGEMNIASG CPRFVAHSVL ENAKNAYIKD 
    DTLFLKVAVD LTDLEDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.