Details for: TRAF5

Gene ID: 7188

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: TRAF5

Ensembl ID: ENSG00000082512

Description: TNF receptor associated factor 5

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • plasmablast CL0000980
    CSI 13.49
    rCSI 10.61%
    PRS 86.25
  • choroid plexus epithelial cell CL0000706
    CSI 12.31
    rCSI 20.16%
    PRS 71.6
  • melanocyte CL0000148
    CSI 11.35
    rCSI 8.41%
    PRS 75.55
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI 7.63
    rCSI 7.05%
    PRS 94.22
  • group 3 innate lymphoid cell CL0001071
    CSI 7.53
    rCSI 5.66%
    PRS 87.13
  • helper T cell CL0000912
    CSI 7.18
    rCSI 10.16%
    PRS 80.28
  • hematopoietic precursor cell CL0008001
    CSI 6.77
    rCSI 6.96%
    PRS 91.75
  • myoepithelial cell CL0000185
    CSI 5.37
    rCSI 13.58%
    PRS 86.33
  • unswitched memory B cell CL0000970
    CSI 4.95
    rCSI 4.16%
    PRS 92.97
  • class switched memory B cell CL0000972
    CSI 4.78
    rCSI 3.57%
    PRS 92.23
  • early lymphoid progenitor CL0000936
    CSI 4.37
    rCSI 3.84%
    PRS 86.44
  • naive T cell CL0000898
    CSI 4.26
    rCSI 2.97%
    PRS 93.72
  • intestinal tuft cell CL0019032
    CSI 4.08
    rCSI 6.23%
    PRS 85.1
  • naive B cell CL0000788
    CSI 3.69
    rCSI 3.16%
    PRS 87.45
  • precursor B cell CL0000817
    CSI 3.68
    rCSI 3.23%
    PRS 88.33
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 3.47
    rCSI 2.49%
    PRS 92.96
  • basal cell CL0000646
    CSI 3.44
    rCSI 4.6%
    PRS 80.12
  • double negative thymocyte CL0002489
    CSI 3.38
    rCSI 2.35%
    PRS 92.06
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 3.36
    rCSI 1.98%
    PRS 94.8
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 3.12
    rCSI 2.1%
    PRS 92.96
  • mucosal invariant T cell CL0000940
    CSI 3.12
    rCSI 2.52%
    PRS 89.87
  • mature T cell CL0002419
    CSI 3.11
    rCSI 2.42%
    PRS 93.59
  • sncg GABAergic cortical interneuron CL4023015
    CSI 3.07
    rCSI 4.94%
    PRS 65.83
  • immature B cell CL0000816
    CSI 3.06
    rCSI 2.28%
    PRS 91.15
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 2.94
    rCSI 7.08%
    PRS 92.87
  • alpha-beta T cell CL0000789
    CSI 2.9
    rCSI 3.4%
    PRS 93.39
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 2.78
    rCSI 2.84%
    PRS 90.49
  • transitional stage B cell CL0000818
    CSI 2.77
    rCSI 9.06%
    PRS 94.79
  • T follicular helper cell CL0002038
    CSI 2.71
    rCSI 2.02%
    PRS 92.96
  • plasmacytoid dendritic cell, human CL0001058
    CSI 2.63
    rCSI 1.83%
    PRS 85.13
  • Kupffer cell CL0000091
    CSI 2.58
    rCSI 5.89%
    PRS 82.5
  • lung secretory cell CL1000272
    CSI 2.5
    rCSI 6.19%
    PRS 81.8
  • intestine goblet cell CL0019031
    CSI 2.44
    rCSI 2.17%
    PRS 79.55
  • vascular leptomeningeal cell CL4023051
    CSI 2.42
    rCSI 4.24%
    PRS 76.07
  • CD4-positive helper T cell CL0000492
    CSI 2.33
    rCSI 1.77%
    PRS 92.57
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 2.33
    rCSI 6.06%
    PRS 82.85
  • hematopoietic stem cell CL0000037
    CSI 2.3
    rCSI 1.53%
    PRS 84.22
  • hepatic stellate cell CL0000632
    CSI 2.27
    rCSI 8.5%
    PRS 74.53
  • blood vessel smooth muscle cell CL0019018
    CSI 2.25
    rCSI 18.27%
    PRS 76.3
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 2.24
    rCSI 2.04%
    PRS 92.07
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 2.21
    rCSI 5.72%
    PRS 77.34
  • direct pathway medium spiny neuron CL4023026
    CSI 2.21
    rCSI 52.89%
    PRS 62.38
  • lung pericyte CL0009089
    CSI 2.19
    rCSI 5.78%
    PRS 87.9
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 2.16
    rCSI 2.12%
    PRS 93.27
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 2.15
    rCSI 1.94%
    PRS 79.87
  • cerebral cortex endothelial cell CL1001602
    CSI 2.12
    rCSI 3.67%
    PRS 73.7
  • neural progenitor cell CL0011020
    CSI 2.12
    rCSI 9.34%
    PRS 70.35
  • enteric smooth muscle cell CL0002504
    CSI 2.09
    rCSI 2.98%
    PRS 82.5
  • common lymphoid progenitor CL0000051
    CSI 2.03
    rCSI 2.72%
    PRS 94.39
  • VIP GABAergic cortical interneuron CL4023016
    CSI 2.01
    rCSI 2.4%
    PRS 64.43
  • brush cell CL0002204
    CSI 1.91
    rCSI 3.78%
    PRS 89.18
  • tracheobronchial smooth muscle cell CL0019019
    CSI 1.88
    rCSI 3.31%
    PRS 86.45
  • mature B cell CL0000785
    CSI 1.87
    rCSI 1.62%
    PRS 90.13
  • indirect pathway medium spiny neuron CL4023029
    CSI 1.75
    rCSI 42.28%
    PRS 62.96
  • BEST4+ enteroycte CL4030026
    CSI 1.72
    rCSI 2.13%
    PRS 82.46
  • contractile cell CL0000183
    CSI 1.71
    rCSI 5.06%
    PRS 80.85
  • mononuclear phagocyte CL0000113
    CSI 1.71
    rCSI 3.76%
    PRS 85.21
  • memory T cell CL0000813
    CSI 1.67
    rCSI 3.21%
    PRS 95.89
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 1.61
    rCSI 4.6%
    PRS 95.62
  • myeloid dendritic cell CL0000782
    CSI 1.58
    rCSI 2.29%
    PRS 92.85
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 1.56
    rCSI 6.09%
    PRS 94.54
  • retinal pigment epithelial cell CL0002586
    CSI 1.49
    rCSI 2.96%
    PRS 77.56
  • basophil CL0000767
    CSI 1.45
    rCSI 3.07%
    PRS 91.35
  • Hofbauer cell CL3000001
    CSI 1.42
    rCSI 2.68%
    PRS 88.92
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.37
    rCSI 2.42%
    PRS 63.78
  • mesothelial cell CL0000077
    CSI 1.34
    rCSI 5.24%
    PRS 60.48
  • lung resident memory CD8-positive, alpha-beta T cell CL4033039
    CSI 1.32
    rCSI 3.42%
    PRS 95.08
  • innate lymphoid cell CL0001065
    CSI 1.21
    rCSI 2.5%
    PRS 78.38
  • retinal ganglion cell CL0000740
    CSI 1.11
    rCSI 2.45%
    PRS 67.94
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 1.05
    rCSI 5.28%
    PRS 92.09
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 0.99
    rCSI 1.67%
    PRS 64.34
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 0.96
    rCSI 3.01%
    PRS 68.29
  • follicular B cell CL0000843
    CSI 0.93
    rCSI 3.38%
    PRS 94.04
  • microcirculation associated smooth muscle cell CL0008035
    CSI 0.91
    rCSI 2.65%
    PRS 81.15
  • germinal center B cell CL0000844
    CSI 0.91
    rCSI 2.71%
    PRS 90.29
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 0.88
    rCSI 2.15%
    PRS 62.29
  • kidney connecting tubule epithelial cell CL1000768
    CSI 0.73
    rCSI 1.86%
    PRS 72.46
  • ON parasol ganglion cell CL4033052
    CSI 0.48
    rCSI 6.84%
    PRS 73.08
  • cytotoxic T cell CL0000910
    CSI 0.24
    rCSI 1.35%
    PRS 84.54
  • medium spiny neuron CL1001474
    CSI 0.18
    rCSI 1.53%
    PRS 70.06

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [TRAF5](/details-gene/7188) (TNF receptor associated factor 5) is a protein-coding gene located on chromosome 1q32.3 that functions as a crucial signaling adaptor molecule. As a member of the TRAF protein family, it plays a key role in transducing signals from members of the tumor necrosis factor receptor (TNFR) superfamily, including CD40 and OX40 [Link](https://doi.org/10.1021/bi981067q), [Link](https://doi.org/10.1074/jbc.273.10.5808). Its primary function involves the positive regulation of the canonical NF-kappaB signaling pathway ([GO:0043123](https://www.ebi.ac.uk/QuickGO/term/GO:0043123)), which is central to inflammation, immunity, cell proliferation, and apoptosis ([GO:0006915](https://www.ebi.ac.uk/QuickGO/term/GO:0006915)). Expression data indicates that [TRAF5](/details-gene/7188) is a significant gene in various immune cell types, particularly in [plasmablasts](/details-cell/CL0000980) and activated T cells, as well as in non-immune cells such as [choroid plexus epithelial cells](/details-cell/CL0000706) and [melanocytes](/details-cell/CL0000148). Its clinical relevance is noted under OMIM entry [602356](https://omim.org/entry/602356). ## Cellular Roles and Expression Landscape The expression profile of [TRAF5](/details-gene/7188) highlights its prominent role in the adaptive immune system. **Overall**, the gene shows the highest significance in [plasmablasts](/details-cell/CL0000980) (CSI: 13.49), a key cell type responsible for antibody production. High significance is also observed across the lymphocyte lineage, including in [activated CD4-positive, alpha-beta T cells](/details-cell/CL0000896), [group 3 innate lymphoid cells](/details-cell/CL0001071), [helper T cells](/details-cell/CL0000912), and various B cell subsets such as [unswitched memory B cells](/details-cell/CL0000970) and [class switched memory B cells](/details-cell/CL0000972). This pattern suggests a critical function for [TRAF5](/details-gene/7188) in the activation, differentiation, and effector functions of both B and T lymphocytes. Interestingly, [TRAF5](/details-gene/7188) also demonstrates high significance in several non-hematopoietic cell types. It is a major marker for [choroid plexus epithelial cells](/details-cell/CL0000706) (CSI: 12.31) and [melanocytes](/details-cell/CL0000148) (CSI: 11.35). Its presence in the choroid plexus suggests a potential role in regulating the blood-cerebrospinal fluid barrier or neuro-inflammatory processes. The high expression in melanocytes may indicate its involvement in cellular stress responses or signaling pathways relevant to pigmentation and skin immunity. This diverse expression landscape points to both canonical roles in immunity and potentially non-canonical functions in specialized epithelial and neural crest-derived cells. ## Pathways and Molecular Function Functionally, [TRAF5](/details-gene/7188) acts as a signaling adaptor protein ([GO:0035591](https://www.ebi.ac.uk/QuickGO/term/GO:0035591)) and possesses ubiquitin protein ligase activity ([GO:0061630](https://www.ebi.ac.uk/QuickGO/term/GO:0061630)), positioning it as a central hub in intracellular signaling cascades. It is a well-established component of the `Tumor necrosis factor-mediated signaling pathway` ([GO:0033209](https://www.ebi.ac.uk/QuickGO/term/GO:0033209)) and the `Cd40 signaling pathway` ([GO:0023035](https://www.ebi.ac.uk/QuickGO/term/GO:0023035)), which are critical for immune cell activation and survival. Research has shown that [TRAF5](/details-gene/7188) is directly involved in CD30-mediated NF-kappaB activation [Link](https://doi.org/10.1074/jbc.272.4.2042). Its engagement downstream of these receptors leads to the `Positive regulation of nf-kappab transcription factor activity` ([GO:0051092](https://www.ebi.ac.uk/QuickGO/term/GO:0051092)) and `Positive regulation of cell population proliferation` ([GO:0008284](https://www.ebi.ac.uk/QuickGO/term/GO:0008284)). Furthermore, its annotation in the `Interleukin-17-mediated signaling pathway` ([GO:0097400](https://www.ebi.ac.uk/QuickGO/term/GO:0097400)) is consistent with its high expression in Th17-related cell types like [group 3 innate lymphoid cells](/details-cell/CL0001071), implicating it in mucosal immunity and autoimmune inflammation. The molecule's ability to bind identical proteins ([GO:0042802](https://www.ebi.ac.uk/QuickGO/term/GO:0042802)) allows it to form homo- and hetero-oligomers with other TRAF proteins, such as TRAF2, thereby modulating the specificity and intensity of downstream signals [Link](https://doi.org/10.1021/bi981067q). ## Research Directions The expression and functional data for [TRAF5](/details-gene/7188) suggest several avenues for future investigation, particularly regarding its diverse cellular roles. The juxtaposition of its canonical immune function with high significance in unexpected cell types like choroid plexus epithelium provides fertile ground for new hypotheses. **Proposed Hypotheses:** 1. The exceptionally high significance of [TRAF5](/details-gene/7188) in [plasmablasts](/details-cell/CL0000980) suggests it is a critical mediator of terminal B cell differentiation and survival. It may function by sustaining NF-kappaB activity downstream of CD40 and BAFF receptor engagement, which is essential for preventing apoptosis and supporting high-level antibody production in this short-lived cell type. 2. In [choroid plexus epithelial cells](/details-cell/CL0000706), [TRAF5](/details-gene/7188) may play a non-canonical role in mediating inflammatory signaling at the blood-cerebrospinal fluid barrier. It could be essential for translating systemic inflammatory cues (e.g., circulating TNF-alpha) into local responses within the central nervous system, thereby regulating barrier integrity and immune cell trafficking. **Experimental Approach:** To test the second hypothesis regarding the role of [TRAF5](/details-gene/7188) in the choroid plexus, a conditional knockout mouse model could be employed, using a Cre-Lox system to specifically delete [TRAF5](/details-gene/7188) in choroid plexus epithelial cells. These mice and their wild-type littermates could be challenged with a systemic inflammatory agent like lipopolysaccharide (LPS). The integrity of the blood-CSF barrier could then be assessed by measuring the leakage of fluorescently-labeled tracers into the cerebrospinal fluid. Furthermore, isolated choroid plexus tissue from these animals could be analyzed by RNA-seq to determine how the loss of [TRAF5](/details-gene/7188) alters the transcriptional response to inflammation, particularly concerning genes for tight junction proteins, cytokines, and chemokines. **Therapeutic Potential:** As a key signaling adaptor protein that promotes NF-kappaB activation and cell survival, [TRAF5](/details-gene/7188) represents a potential therapeutic target for **inhibition**. In autoimmune diseases characterized by excessive B and T cell activation, or in B-cell malignancies like multiple myeloma where NF-kappaB is constitutively active, inhibiting [TRAF5](/details-gene/7188) function could dampen inflammatory responses and promote apoptosis of malignant cells. However, its broad role in the immune system suggests that systemic inhibition could lead to generalized immunosuppression. Therefore, developing strategies for targeted delivery (e.g., antibody-drug conjugates targeting B-cell markers) or designing small molecules that disrupt specific protein-protein interactions involving [TRAF5](/details-gene/7188) would be critical for therapeutic development.

Genular Protein ID: 194277036

Symbol: TRAF5_HUMAN

Name: TNF receptor-associated factor 5

UniProtKB Accession Codes:

O00463 B4DIS9 B4E0A2 Q6FHY1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 7 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9511754

Title: Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).

PubMed ID: 9511754

DOI: 10.1016/s0378-1119(97)00616-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9177772

Title: Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32.

PubMed ID: 9177772

DOI: 10.1006/geno.1997.4697

PubMed ID: 11384837

Title: The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.

PubMed ID: 11384837

DOI: 10.1016/s0898-6568(01)00160-7

PubMed ID: 11607847

Title: Tumor necrosis factor receptor-associated factors (TRAFs).

PubMed ID: 11607847

DOI: 10.1038/sj.onc.1204788

PubMed ID: 9162022

Title: Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1.

PubMed ID: 9162022

DOI: 10.1074/jbc.272.22.14029

PubMed ID: 9153189

Title: ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5.

PubMed ID: 9153189

DOI: 10.1074/jbc.272.21.13471

PubMed ID: 9275204

Title: Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2.

PubMed ID: 9275204

DOI: 10.1073/pnas.94.18.9792

PubMed ID: 8999898

Title: Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation.

PubMed ID: 8999898

DOI: 10.1074/jbc.272.4.2042

PubMed ID: 9774977

Title: ASK1 is essential for JNK/SAPK activation by TRAF2.

PubMed ID: 9774977

DOI: 10.1016/s1097-2765(00)80283-x

PubMed ID: 9718306

Title: CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization.

PubMed ID: 9718306

DOI: 10.1021/bi981067q

PubMed ID: 9488716

Title: Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation.

PubMed ID: 9488716

DOI: 10.1074/jbc.273.10.5808

PubMed ID: 9642260

Title: RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.

PubMed ID: 9642260

DOI: 10.1074/jbc.273.27.16968

PubMed ID: 10809768

Title: TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death.

PubMed ID: 10809768

DOI: 10.1074/jbc.275.20.15336

PubMed ID: 9774460

Title: The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.

PubMed ID: 9774460

DOI: 10.1074/jbc.273.43.28355

PubMed ID: 10764746

Title: TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.

PubMed ID: 10764746

DOI: 10.1074/jbc.m000531200

PubMed ID: 10880535

Title: TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation.

PubMed ID: 10880535

DOI: 10.1084/jem.192.1.137

PubMed ID: 10908663

Title: B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1.

PubMed ID: 10908663

DOI: 10.1073/pnas.160213497

PubMed ID: 15121867

Title: TRAF family proteins link PKR with NF-kappa B activation.

PubMed ID: 15121867

DOI: 10.1128/mcb.24.10.4502-4512.2004

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

Sequence Information:

  • Length: 557
  • Mass: 64406
  • Checksum: 86EB3724CE111176
  • Sequence:
    • MAYSEEHKGM PCGFIRQNSG NSISLDFEPS IEYQFVERLE ERYKCAFCHS VLHNPHQTGC 
GHRFCQHCIL SLRELNTVPI CPVDKEVIKS QEVFKDNCCK REVLNLYVYC SNAPGCNAKV 
ILGRYQDHLQ QCLFQPVQCS NEKCREPVLR KDLKEHLSAS CQFRKEKCLY CKKDVVVINL 
QNHEENLCPE YPVFCPNNCA KIILKTEVDE HLAVCPEAEQ DCPFKHYGCA VTDKRRNLQQ 
HEHSALREHM RLVLEKNVQL EEQISDLHKS LEQKESKIQQ LAETIKKLEK EFKQFAQLFG 
KNGSFLPNIQ VFASHIDKSA WLEAQVHQLL QMVNQQQNKF DLRPLMEAVD TVKQKITLLE 
NNDQRLAVLE EETNKHDTHI NIHKAQLSKN EERFKLLEGT CYNGKLIWKV TDYKMKKREA 
VDGHTVSIFS QSFYTSRCGY RLCARAYLNG DGSGRGSHLS LYFVVMRGEF DSLLQWPFRQ 
RVTLMLLDQS GKKNIMETFK PDPNSSSFKR PDGEMNIASG CPRFVAHSVL ENAKNAYIKD 
DTLFLKVAVD LTDLEDL