Details for: TRAF5
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 115.5612
Cell Significance Index: -17.9800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 47.0345
Cell Significance Index: -11.9300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 40.1470
Cell Significance Index: -16.3100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 39.5872
Cell Significance Index: -18.6900 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 14.5463
Cell Significance Index: -17.9400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.7748
Cell Significance Index: -15.4700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.6122
Cell Significance Index: -18.2000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 4.4279
Cell Significance Index: -13.6000 - Cell Name: centroblast (CL0009112)
Fold Change: 1.3030
Cell Significance Index: 3.0400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1307
Cell Significance Index: 183.9100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.0627
Cell Significance Index: 40.2400 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.0531
Cell Significance Index: 23.0600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.9108
Cell Significance Index: 54.6800 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.7565
Cell Significance Index: 89.2200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.7513
Cell Significance Index: 33.2300 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.7096
Cell Significance Index: 13.8500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.6120
Cell Significance Index: 42.3300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5410
Cell Significance Index: 108.5200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4747
Cell Significance Index: 170.2500 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.3110
Cell Significance Index: 15.7200 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.2910
Cell Significance Index: 8.5500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2676
Cell Significance Index: 7.7100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2553
Cell Significance Index: 50.6600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2425
Cell Significance Index: 15.6500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2384
Cell Significance Index: 5.9600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2365
Cell Significance Index: 163.5400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2128
Cell Significance Index: 29.2200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2042
Cell Significance Index: 9.5200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1912
Cell Significance Index: 9.9300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1713
Cell Significance Index: 29.2500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1652
Cell Significance Index: 104.9500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1586
Cell Significance Index: 30.1900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1516
Cell Significance Index: 6.8700 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.1463
Cell Significance Index: 0.7700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1279
Cell Significance Index: 58.0500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1276
Cell Significance Index: 240.2600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.1245
Cell Significance Index: 3.3400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1049
Cell Significance Index: 18.9100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0861
Cell Significance Index: 2.3000 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.0730
Cell Significance Index: 1.5600 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 0.0694
Cell Significance Index: 0.7000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0641
Cell Significance Index: 35.0300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0573
Cell Significance Index: 7.0500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.0457
Cell Significance Index: 4.7600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0453
Cell Significance Index: 4.4800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0391
Cell Significance Index: 1.3800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.0368
Cell Significance Index: 1.0500 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0115
Cell Significance Index: 1.4800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0055
Cell Significance Index: 0.1200 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.0048
Cell Significance Index: 0.0400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0007
Cell Significance Index: -0.0200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0013
Cell Significance Index: -1.9900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0036
Cell Significance Index: -1.5700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0043
Cell Significance Index: -5.8700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0056
Cell Significance Index: -10.4000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0150
Cell Significance Index: -11.0300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0234
Cell Significance Index: -17.3600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0244
Cell Significance Index: -18.5000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0309
Cell Significance Index: -17.4200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0318
Cell Significance Index: -19.8700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0328
Cell Significance Index: -1.7100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0374
Cell Significance Index: -1.7600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0401
Cell Significance Index: -2.9900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0524
Cell Significance Index: -15.0700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0528
Cell Significance Index: -7.6700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0588
Cell Significance Index: -3.3000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0644
Cell Significance Index: -7.5000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0717
Cell Significance Index: -7.3200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0737
Cell Significance Index: -4.5300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0763
Cell Significance Index: -1.6300 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0849
Cell Significance Index: -2.1700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0862
Cell Significance Index: -2.4100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0930
Cell Significance Index: -19.5900 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0981
Cell Significance Index: -0.8000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0995
Cell Significance Index: -12.8500 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: -0.1029
Cell Significance Index: -0.4600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1032
Cell Significance Index: -2.1400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1274
Cell Significance Index: -9.0100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1398
Cell Significance Index: -2.3400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1441
Cell Significance Index: -16.5100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1750
Cell Significance Index: -13.4300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1825
Cell Significance Index: -12.2700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1874
Cell Significance Index: -9.8400 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1997
Cell Significance Index: -4.0100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2233
Cell Significance Index: -17.6900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2273
Cell Significance Index: -7.2800 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2358
Cell Significance Index: -6.2000 - Cell Name: peg cell (CL4033014)
Fold Change: -0.2411
Cell Significance Index: -5.5700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2796
Cell Significance Index: -17.1400 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2804
Cell Significance Index: -5.8700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2944
Cell Significance Index: -8.4400 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2966
Cell Significance Index: -4.4700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2977
Cell Significance Index: -18.7600 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.3087
Cell Significance Index: -3.8500 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.3131
Cell Significance Index: -7.5100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3518
Cell Significance Index: -12.2300 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.3589
Cell Significance Index: -4.5300 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.3607
Cell Significance Index: -5.1800 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.3661
Cell Significance Index: -5.5700 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.3881
Cell Significance Index: -6.6900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 194277036
Symbol: TRAF5_HUMAN
Name: TNF receptor-associated factor 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9511754
Title: Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).
PubMed ID: 9511754
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9177772
Title: Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32.
PubMed ID: 9177772
PubMed ID: 11384837
Title: The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.
PubMed ID: 11384837
PubMed ID: 11607847
Title: Tumor necrosis factor receptor-associated factors (TRAFs).
PubMed ID: 11607847
PubMed ID: 9162022
Title: Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1.
PubMed ID: 9162022
PubMed ID: 9153189
Title: ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5.
PubMed ID: 9153189
PubMed ID: 9275204
Title: Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2.
PubMed ID: 9275204
PubMed ID: 8999898
Title: Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation.
PubMed ID: 8999898
PubMed ID: 9774977
Title: ASK1 is essential for JNK/SAPK activation by TRAF2.
PubMed ID: 9774977
PubMed ID: 9718306
Title: CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization.
PubMed ID: 9718306
DOI: 10.1021/bi981067q
PubMed ID: 9488716
Title: Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation.
PubMed ID: 9488716
PubMed ID: 9642260
Title: RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.
PubMed ID: 9642260
PubMed ID: 10809768
Title: TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death.
PubMed ID: 10809768
PubMed ID: 9774460
Title: The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.
PubMed ID: 9774460
PubMed ID: 10764746
Title: TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.
PubMed ID: 10764746
PubMed ID: 10880535
Title: TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation.
PubMed ID: 10880535
PubMed ID: 10908663
Title: B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1.
PubMed ID: 10908663
PubMed ID: 15121867
Title: TRAF family proteins link PKR with NF-kappa B activation.
PubMed ID: 15121867
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
Sequence Information:
- Length: 557
- Mass: 64406
- Checksum: 86EB3724CE111176
- Sequence:
MAYSEEHKGM PCGFIRQNSG NSISLDFEPS IEYQFVERLE ERYKCAFCHS VLHNPHQTGC GHRFCQHCIL SLRELNTVPI CPVDKEVIKS QEVFKDNCCK REVLNLYVYC SNAPGCNAKV ILGRYQDHLQ QCLFQPVQCS NEKCREPVLR KDLKEHLSAS CQFRKEKCLY CKKDVVVINL QNHEENLCPE YPVFCPNNCA KIILKTEVDE HLAVCPEAEQ DCPFKHYGCA VTDKRRNLQQ HEHSALREHM RLVLEKNVQL EEQISDLHKS LEQKESKIQQ LAETIKKLEK EFKQFAQLFG KNGSFLPNIQ VFASHIDKSA WLEAQVHQLL QMVNQQQNKF DLRPLMEAVD TVKQKITLLE NNDQRLAVLE EETNKHDTHI NIHKAQLSKN EERFKLLEGT CYNGKLIWKV TDYKMKKREA VDGHTVSIFS QSFYTSRCGY RLCARAYLNG DGSGRGSHLS LYFVVMRGEF DSLLQWPFRQ RVTLMLLDQS GKKNIMETFK PDPNSSSFKR PDGEMNIASG CPRFVAHSVL ENAKNAYIKD DTLFLKVAVD LTDLEDL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.