Details for: TRIP6

Gene ID: 7205

Symbol: TRIP6

Ensembl ID: ENSG00000087077

Description: thyroid hormone receptor interactor 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 178.0190
    Cell Significance Index: -27.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 89.3380
    Cell Significance Index: -22.6600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 79.2091
    Cell Significance Index: -32.6300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 61.4035
    Cell Significance Index: -28.9900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 55.2606
    Cell Significance Index: -22.4500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.5508
    Cell Significance Index: -22.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.3504
    Cell Significance Index: -28.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.7583
    Cell Significance Index: -28.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.4074
    Cell Significance Index: -29.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.6969
    Cell Significance Index: 127.8500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0346
    Cell Significance Index: -8.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.5393
    Cell Significance Index: 131.9100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.0077
    Cell Significance Index: 16.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3458
    Cell Significance Index: 28.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1765
    Cell Significance Index: 83.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1475
    Cell Significance Index: 148.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1015
    Cell Significance Index: 151.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0702
    Cell Significance Index: 137.1900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.9891
    Cell Significance Index: 8.1800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.9778
    Cell Significance Index: 10.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9622
    Cell Significance Index: 868.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9556
    Cell Significance Index: 26.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9374
    Cell Significance Index: 115.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9137
    Cell Significance Index: 403.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8609
    Cell Significance Index: 64.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8017
    Cell Significance Index: 21.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7785
    Cell Significance Index: 84.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7735
    Cell Significance Index: 36.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7586
    Cell Significance Index: 136.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7537
    Cell Significance Index: 35.1400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7445
    Cell Significance Index: 17.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7296
    Cell Significance Index: 118.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6433
    Cell Significance Index: 74.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5105
    Cell Significance Index: 50.5000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5001
    Cell Significance Index: 4.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4414
    Cell Significance Index: 241.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4011
    Cell Significance Index: 10.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3774
    Cell Significance Index: 26.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3366
    Cell Significance Index: 9.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2296
    Cell Significance Index: 7.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2025
    Cell Significance Index: 9.1800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1679
    Cell Significance Index: 2.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1367
    Cell Significance Index: 3.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0779
    Cell Significance Index: 15.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0708
    Cell Significance Index: 13.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0299
    Cell Significance Index: 0.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0197
    Cell Significance Index: 37.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0174
    Cell Significance Index: 13.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0144
    Cell Significance Index: 0.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0123
    Cell Significance Index: 8.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0096
    Cell Significance Index: 7.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0094
    Cell Significance Index: 0.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0030
    Cell Significance Index: 5.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0011
    Cell Significance Index: -1.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0014
    Cell Significance Index: -2.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0019
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0030
    Cell Significance Index: -0.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0143
    Cell Significance Index: -1.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0171
    Cell Significance Index: -7.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0446
    Cell Significance Index: -33.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0528
    Cell Significance Index: -33.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0554
    Cell Significance Index: -31.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0582
    Cell Significance Index: -1.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0608
    Cell Significance Index: -0.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0633
    Cell Significance Index: -18.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0755
    Cell Significance Index: -27.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0792
    Cell Significance Index: -9.0800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1075
    Cell Significance Index: -1.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1097
    Cell Significance Index: -15.9500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1136
    Cell Significance Index: -1.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1143
    Cell Significance Index: -13.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1274
    Cell Significance Index: -25.5500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1318
    Cell Significance Index: -6.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1588
    Cell Significance Index: -3.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1616
    Cell Significance Index: -34.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1872
    Cell Significance Index: -12.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1960
    Cell Significance Index: -15.5200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1973
    Cell Significance Index: -3.1300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2155
    Cell Significance Index: -1.8100
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.2494
    Cell Significance Index: -1.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2573
    Cell Significance Index: -26.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2634
    Cell Significance Index: -7.7600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2965
    Cell Significance Index: -12.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2993
    Cell Significance Index: -18.3500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3006
    Cell Significance Index: -1.8500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3169
    Cell Significance Index: -8.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3227
    Cell Significance Index: -16.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3333
    Cell Significance Index: -25.5800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.3625
    Cell Significance Index: -2.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4031
    Cell Significance Index: -12.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4129
    Cell Significance Index: -23.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4285
    Cell Significance Index: -27.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4352
    Cell Significance Index: -26.7500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4364
    Cell Significance Index: -10.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4598
    Cell Significance Index: -30.9200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.4736
    Cell Significance Index: -4.0700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4922
    Cell Significance Index: -5.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5571
    Cell Significance Index: -29.2500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5756
    Cell Significance Index: -21.1300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.5849
    Cell Significance Index: -3.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRIP6 is a cytoplasmic protein that belongs to the TRIP family of proteins, which are known to interact with various signaling molecules, including thyroid hormone receptors. TRIP6 exhibits a unique structure, consisting of three tandem N-terminal domains and a C-terminal domain that interacts with thyroid hormone receptors. The protein is highly expressed in various cell types, including epithelial cells, stromal cells, and immune cells. **Pathways and Functions:** TRIP6 is involved in multiple signaling pathways, including: 1. **Thyroid Hormone Signaling:** TRIP6 acts as a cofactor for thyroid hormone receptors, modulating their activity and regulating gene expression. 2. **Cell Migration:** TRIP6 is required for the regulation of cell migration, particularly in the context of tissue development and repair. 3. **Non-canonical NF-κB Signaling:** TRIP6 interacts with components of the NF-κB signaling pathway, influencing the regulation of gene expression and immune responses. 4. **Focal Adhesion Assembly:** TRIP6 is involved in the assembly of focal adhesions, which are critical for cell adhesion, migration, and signaling. 5. **Stress Fiber Formation:** TRIP6 is required for the formation of stress fibers, which are essential for cell migration and cytoskeletal organization. **Clinical Significance:** Dysregulation of TRIP6 has been implicated in various diseases, including: 1. **Thyroid Disorders:** Alterations in TRIP6 expression have been linked to thyroid dysfunction, including hypothyroidism and hyperthyroidism. 2. **Cancer:** TRIP6 is overexpressed in various cancers, including breast, lung, and colon cancer, and has been associated with poor prognosis. 3. **Autoimmune Diseases:** TRIP6 has been implicated in autoimmune diseases, including rheumatoid arthritis and lupus, where it regulates immune cell function and signaling. 4. **Neurological Disorders:** TRIP6 has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease, where it regulates neuronal function and survival. In conclusion, TRIP6 is a multifunctional protein that plays a crucial role in regulating various cellular processes, including development, migration, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying TRIP6 function and its clinical significance.

Genular Protein ID: 287477190

Symbol: TRIP6_HUMAN

Name: Thyroid receptor-interacting protein 6

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9598321

Title: The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis.

PubMed ID: 9598321

DOI: 10.1006/geno.1998.5248

PubMed ID: 10400701

Title: ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E.

PubMed ID: 10400701

DOI: 10.1074/jbc.274.29.20679

PubMed ID: 11239002

Title: Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.

PubMed ID: 11239002

DOI: 10.1093/nar/29.6.1352

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7776974

Title: Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.

PubMed ID: 7776974

DOI: 10.1210/mend.9.2.7776974

PubMed ID: 10826496

Title: The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL.

PubMed ID: 10826496

DOI: 10.1078/s0171-9335(04)70031-x

PubMed ID: 15489293

Title: A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB-regulated promoters.

PubMed ID: 15489293

DOI: 10.1101/gad.322404

PubMed ID: 14688263

Title: TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor.

PubMed ID: 14688263

DOI: 10.1074/jbc.m311891200

PubMed ID: 16137684

Title: The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins.

PubMed ID: 16137684

DOI: 10.1016/j.febslet.2005.08.012

PubMed ID: 15988003

Title: c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration.

PubMed ID: 15988003

DOI: 10.1128/mcb.25.14.5859-5868.2005

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16624523

Title: TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase.

PubMed ID: 16624523

DOI: 10.1016/j.cellsig.2006.01.021

PubMed ID: 16880273

Title: Supervillin modulation of focal adhesions involving TRIP6/ZRP-1.

PubMed ID: 16880273

DOI: 10.1083/jcb.200512051

PubMed ID: 17095609

Title: Salmonella typhimurium disseminates within its host by manipulating the motility of infected cells.

PubMed ID: 17095609

DOI: 10.1073/pnas.0604054103

PubMed ID: 17591779

Title: PTPL1/FAP-1 negatively regulates TRIP6 function in lysophosphatidic acid-induced cell migration.

PubMed ID: 17591779

DOI: 10.1074/jbc.m701499200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19017743

Title: TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness.

PubMed ID: 19017743

DOI: 10.1096/fj.08-106344

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 476
  • Mass: 50288
  • Checksum: 2BA7C747DF30A8FD
  • Sequence:
  • MSGPTWLPPK QPEPARAPQG RAIPRGTPGP PPAHGAALQP HPRVNFCPLP SEQCYQAPGG 
    PEDRGPAWVG SHGVLQHTQG LPADRGGLRP GSLDAEIDLL SSTLAELNGG RGHASRRPDR 
    QAYEPPPPPA YRTGSLKPNP ASPLPASPYG GPTPASYTTA STPAGPAFPV QVKVAQPVRG 
    CGPPRRGASQ ASGPLPGPHF PLPGRGEVWG PGYRSQREPG PGAKEEAAGV SGPAGRGRGG 
    EHGPQVPLSQ PPEDELDRLT KKLVHDMNHP PSGEYFGQCG GCGEDVVGDG AGVVALDRVF 
    HVGCFVCSTC RAQLRGQHFY AVERRAYCEG CYVATLEKCA TCSQPILDRI LRAMGKAYHP 
    GCFTCVVCHR GLDGIPFTVD ATSQIHCIED FHRKFAPRCS VCGGAIMPEP GQEETVRIVA 
    LDRSFHIGCY KCEECGLLLS SEGECQGCYP LDGHILCKAC SAWRIQELSA TVTTDC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.