Details for: TRIP6
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 178.0190
Cell Significance Index: -27.6900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 89.3380
Cell Significance Index: -22.6600 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 79.2091
Cell Significance Index: -32.6300 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 61.4035
Cell Significance Index: -28.9900 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 55.2606
Cell Significance Index: -22.4500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 23.5508
Cell Significance Index: -22.4900 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 23.3504
Cell Significance Index: -28.7900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.7583
Cell Significance Index: -28.8200 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.4074
Cell Significance Index: -29.2300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.6969
Cell Significance Index: 127.8500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.0346
Cell Significance Index: -8.8300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.5393
Cell Significance Index: 131.9100 - Cell Name: kidney cell (CL1000497)
Fold Change: 2.0077
Cell Significance Index: 16.0300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.3458
Cell Significance Index: 28.1700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.1765
Cell Significance Index: 83.2100 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.1475
Cell Significance Index: 148.2500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.1015
Cell Significance Index: 151.2700 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.0702
Cell Significance Index: 137.1900 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.9891
Cell Significance Index: 8.1800 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.9778
Cell Significance Index: 10.6300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9622
Cell Significance Index: 868.8100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.9556
Cell Significance Index: 26.7100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.9374
Cell Significance Index: 115.2700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.9137
Cell Significance Index: 403.9700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.8609
Cell Significance Index: 64.1600 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.8017
Cell Significance Index: 21.0800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7785
Cell Significance Index: 84.6800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.7735
Cell Significance Index: 36.3600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.7586
Cell Significance Index: 136.7600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.7537
Cell Significance Index: 35.1400 - Cell Name: peg cell (CL4033014)
Fold Change: 0.7445
Cell Significance Index: 17.2000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7296
Cell Significance Index: 118.6600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.6433
Cell Significance Index: 74.9700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5105
Cell Significance Index: 50.5000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.5001
Cell Significance Index: 4.6100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4414
Cell Significance Index: 241.0400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4011
Cell Significance Index: 10.7100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3774
Cell Significance Index: 26.1000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.3366
Cell Significance Index: 9.6500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.2296
Cell Significance Index: 7.9800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2025
Cell Significance Index: 9.1800 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.1679
Cell Significance Index: 2.1500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1367
Cell Significance Index: 3.9400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0779
Cell Significance Index: 15.4600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0708
Cell Significance Index: 13.4800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0299
Cell Significance Index: 0.5000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0197
Cell Significance Index: 37.1800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0174
Cell Significance Index: 13.1800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0144
Cell Significance Index: 0.3600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0123
Cell Significance Index: 8.4800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0096
Cell Significance Index: 7.0200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0094
Cell Significance Index: 0.3300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0030
Cell Significance Index: 5.5100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0011
Cell Significance Index: -1.5500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0014
Cell Significance Index: -2.1100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0019
Cell Significance Index: -1.1800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0030
Cell Significance Index: -0.5100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0143
Cell Significance Index: -1.4700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0171
Cell Significance Index: -7.7500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0446
Cell Significance Index: -33.0700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0528
Cell Significance Index: -33.0000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0554
Cell Significance Index: -31.2400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0582
Cell Significance Index: -1.2400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0608
Cell Significance Index: -0.8300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0633
Cell Significance Index: -18.2200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0755
Cell Significance Index: -27.0900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0792
Cell Significance Index: -9.0800 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.1075
Cell Significance Index: -1.5300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1097
Cell Significance Index: -15.9500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1136
Cell Significance Index: -1.2900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1143
Cell Significance Index: -13.4800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1274
Cell Significance Index: -25.5500 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1318
Cell Significance Index: -6.6600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1588
Cell Significance Index: -3.4400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1616
Cell Significance Index: -34.0300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1872
Cell Significance Index: -12.0800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1960
Cell Significance Index: -15.5200 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.1973
Cell Significance Index: -3.1300 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.2155
Cell Significance Index: -1.8100 - Cell Name: theca cell (CL0000503)
Fold Change: -0.2494
Cell Significance Index: -1.4700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2573
Cell Significance Index: -26.7900 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2634
Cell Significance Index: -7.7600 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2965
Cell Significance Index: -12.1500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2993
Cell Significance Index: -18.3500 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.3006
Cell Significance Index: -1.8500 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3169
Cell Significance Index: -8.1000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3227
Cell Significance Index: -16.8100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3333
Cell Significance Index: -25.5800 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: -0.3625
Cell Significance Index: -2.2400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4031
Cell Significance Index: -12.9100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4129
Cell Significance Index: -23.1700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4285
Cell Significance Index: -27.0100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4352
Cell Significance Index: -26.7500 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.4364
Cell Significance Index: -10.9000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.4598
Cell Significance Index: -30.9200 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.4736
Cell Significance Index: -4.0700 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.4922
Cell Significance Index: -5.1000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.5571
Cell Significance Index: -29.2500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.5756
Cell Significance Index: -21.1300 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -0.5849
Cell Significance Index: -3.6200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 287477190
Symbol: TRIP6_HUMAN
Name: Thyroid receptor-interacting protein 6
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9598321
Title: The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis.
PubMed ID: 9598321
PubMed ID: 10400701
Title: ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E.
PubMed ID: 10400701
PubMed ID: 11239002
Title: Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.
PubMed ID: 11239002
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12853948
PubMed ID: 12690205
Title: Human chromosome 7: DNA sequence and biology.
PubMed ID: 12690205
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7776974
Title: Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.
PubMed ID: 7776974
PubMed ID: 10826496
Title: The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL.
PubMed ID: 10826496
PubMed ID: 15489293
Title: A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB-regulated promoters.
PubMed ID: 15489293
DOI: 10.1101/gad.322404
PubMed ID: 14688263
Title: TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor.
PubMed ID: 14688263
PubMed ID: 16137684
Title: The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins.
PubMed ID: 16137684
PubMed ID: 15988003
Title: c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration.
PubMed ID: 15988003
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16624523
Title: TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase.
PubMed ID: 16624523
PubMed ID: 16880273
Title: Supervillin modulation of focal adhesions involving TRIP6/ZRP-1.
PubMed ID: 16880273
PubMed ID: 17095609
Title: Salmonella typhimurium disseminates within its host by manipulating the motility of infected cells.
PubMed ID: 17095609
PubMed ID: 17591779
Title: PTPL1/FAP-1 negatively regulates TRIP6 function in lysophosphatidic acid-induced cell migration.
PubMed ID: 17591779
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19017743
Title: TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness.
PubMed ID: 19017743
DOI: 10.1096/fj.08-106344
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
Sequence Information:
- Length: 476
- Mass: 50288
- Checksum: 2BA7C747DF30A8FD
- Sequence:
MSGPTWLPPK QPEPARAPQG RAIPRGTPGP PPAHGAALQP HPRVNFCPLP SEQCYQAPGG PEDRGPAWVG SHGVLQHTQG LPADRGGLRP GSLDAEIDLL SSTLAELNGG RGHASRRPDR QAYEPPPPPA YRTGSLKPNP ASPLPASPYG GPTPASYTTA STPAGPAFPV QVKVAQPVRG CGPPRRGASQ ASGPLPGPHF PLPGRGEVWG PGYRSQREPG PGAKEEAAGV SGPAGRGRGG EHGPQVPLSQ PPEDELDRLT KKLVHDMNHP PSGEYFGQCG GCGEDVVGDG AGVVALDRVF HVGCFVCSTC RAQLRGQHFY AVERRAYCEG CYVATLEKCA TCSQPILDRI LRAMGKAYHP GCFTCVVCHR GLDGIPFTVD ATSQIHCIED FHRKFAPRCS VCGGAIMPEP GQEETVRIVA LDRSFHIGCY KCEECGLLLS SEGECQGCYP LDGHILCKAC SAWRIQELSA TVTTDC
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.