Details for: TSNAX

Gene ID: 7257

Symbol: TSNAX

Ensembl ID: ENSG00000116918

Description: translin associated factor X

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 220.2575
    Cell Significance Index: -34.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 135.1307
    Cell Significance Index: -34.2800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 86.7571
    Cell Significance Index: -40.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 76.2817
    Cell Significance Index: -30.9900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 70.5697
    Cell Significance Index: -36.3000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 61.1753
    Cell Significance Index: -41.0500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.5952
    Cell Significance Index: -31.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.1447
    Cell Significance Index: -38.4000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.5385
    Cell Significance Index: -30.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.2520
    Cell Significance Index: -40.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.3050
    Cell Significance Index: -28.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.0472
    Cell Significance Index: 238.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.0098
    Cell Significance Index: 198.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3577
    Cell Significance Index: 147.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2375
    Cell Significance Index: 79.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9824
    Cell Significance Index: 26.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9446
    Cell Significance Index: 153.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9111
    Cell Significance Index: 182.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8799
    Cell Significance Index: 108.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8771
    Cell Significance Index: 158.1200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.7949
    Cell Significance Index: 9.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7942
    Cell Significance Index: 41.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7005
    Cell Significance Index: 48.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6684
    Cell Significance Index: 51.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6498
    Cell Significance Index: 354.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5840
    Cell Significance Index: 258.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5750
    Cell Significance Index: 78.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4893
    Cell Significance Index: 175.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4298
    Cell Significance Index: 55.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4296
    Cell Significance Index: 30.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3478
    Cell Significance Index: 21.9200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3202
    Cell Significance Index: 2.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3185
    Cell Significance Index: 220.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2583
    Cell Significance Index: 8.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2537
    Cell Significance Index: 48.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2172
    Cell Significance Index: 13.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1643
    Cell Significance Index: 3.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1359
    Cell Significance Index: 23.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0779
    Cell Significance Index: 3.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0727
    Cell Significance Index: 3.4200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0706
    Cell Significance Index: 0.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0562
    Cell Significance Index: 1.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0501
    Cell Significance Index: 2.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0094
    Cell Significance Index: 0.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0048
    Cell Significance Index: 3.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0056
    Cell Significance Index: -0.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0068
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0091
    Cell Significance Index: -5.6600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0203
    Cell Significance Index: -0.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0213
    Cell Significance Index: -40.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0236
    Cell Significance Index: -17.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0263
    Cell Significance Index: -48.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0298
    Cell Significance Index: -1.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0312
    Cell Significance Index: -48.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0321
    Cell Significance Index: -1.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0354
    Cell Significance Index: -48.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0356
    Cell Significance Index: -1.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0368
    Cell Significance Index: -20.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0526
    Cell Significance Index: -33.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0566
    Cell Significance Index: -2.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0666
    Cell Significance Index: -6.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0721
    Cell Significance Index: -15.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0781
    Cell Significance Index: -10.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0858
    Cell Significance Index: -38.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1071
    Cell Significance Index: -12.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1121
    Cell Significance Index: -32.2600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1192
    Cell Significance Index: -3.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1284
    Cell Significance Index: -15.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1323
    Cell Significance Index: -3.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1711
    Cell Significance Index: -4.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1742
    Cell Significance Index: -2.9200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1974
    Cell Significance Index: -1.6100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2290
    Cell Significance Index: -26.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2684
    Cell Significance Index: -39.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2809
    Cell Significance Index: -12.4300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3150
    Cell Significance Index: -4.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3160
    Cell Significance Index: -6.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3164
    Cell Significance Index: -25.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3299
    Cell Significance Index: -8.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3602
    Cell Significance Index: -13.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3938
    Cell Significance Index: -41.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4147
    Cell Significance Index: -9.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4283
    Cell Significance Index: -26.2600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4668
    Cell Significance Index: -5.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4947
    Cell Significance Index: -6.7500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5081
    Cell Significance Index: -10.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5498
    Cell Significance Index: -15.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6337
    Cell Significance Index: -15.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6368
    Cell Significance Index: -13.3300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.6751
    Cell Significance Index: -5.3900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6821
    Cell Significance Index: -14.5800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7168
    Cell Significance Index: -17.1900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7211
    Cell Significance Index: -29.5500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7458
    Cell Significance Index: -13.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7531
    Cell Significance Index: -24.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7583
    Cell Significance Index: -19.9400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8105
    Cell Significance Index: -14.9800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.8512
    Cell Significance Index: -7.2400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8812
    Cell Significance Index: -32.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TSNAX is a member of the Translin-associated protein (TAP) family, which is characterized by its ability to interact with translin, a protein involved in chromatin remodeling and gene expression. TSNAX is specifically bound to the cytoplasmic domain of translin and has been implicated in various cellular processes, including cell differentiation, gene silencing, and RNA processing. Its expression is widespread, with significant levels detected in GABAergic neurons, B-2 B cells, early pro-B cells, and myeloid dendritic cells. **Pathways and Functions:** TSNAX is involved in multiple signaling pathways, including: 1. **A2a adenosine receptor binding**: TSNAX interacts with the A2a adenosine receptor, modulating its activity and influencing cellular responses. 2. **Gene expression (transcription)**: TSNAX regulates gene expression by interacting with chromatin remodeling complexes, influencing the recruitment of transcription factors and modifying chromatin structure. 3. **Gene silencing by RNA**: TSNAX is involved in RNA-mediated post-transcriptional gene silencing, regulating the expression of specific genes through RNA interference. 4. **Sirna processing**: TSNAX is required for the processing of small interfering RNA (siRNA), a crucial step in the RNA interference pathway. 5. **Spermatogenesis**: TSNAX is expressed in spermatogenic cells, where it plays a role in regulating the expression of specific genes involved in spermatogenesis. **Clinical Significance:** TSNAX has been implicated in various diseases, including: 1. **Immune disorders**: TSNAX has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where it is thought to contribute to the dysregulation of immune responses. 2. **Cancer**: TSNAX has been found to be overexpressed in certain types of cancer, including leukemia and lymphoma, where it is thought to contribute to tumorigenesis. 3. **Neurological disorders**: TSNAX has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it is thought to contribute to the dysregulation of gene expression and cellular differentiation. In conclusion, TSNAX is a multifunctional protein that plays a critical role in various cellular processes, including gene expression, transcription, and post-transcriptional regulation. Its involvement in immune regulation and cellular differentiation has significant implications for our understanding of disease mechanisms and the development of novel therapeutic strategies. Further research is needed to fully elucidate the role of TSNAX in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 519322521

Symbol: TSNAX_HUMAN

Name: Translin-associated protein X

UniProtKB Accession Codes:

Q99598 B1APC6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 ChEMBL 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9013868

Title: Isolation and characterization of a cDNA encoding a translin-like protein, TRAX.

PubMed ID: 9013868

DOI: 10.1016/s0014-5793(96)01444-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12036294

Title: Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X.

PubMed ID: 12036294

DOI: 10.1006/geno.2002.6779

PubMed ID: 11801738

Title: DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX).

PubMed ID: 11801738

DOI: 10.1242/jcs.115.1.207

PubMed ID: 15919079

Title: Co-expressed recombinant human Translin-Trax complex binds DNA.

PubMed ID: 15919079

DOI: 10.1016/j.febslet.2005.05.007

PubMed ID: 15561718

Title: Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.

PubMed ID: 15561718

DOI: 10.1074/jbc.m411718200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 21552258

Title: Structure of C3PO and mechanism of human RISC activation.

PubMed ID: 21552258

DOI: 10.1038/nsmb.2032

Sequence Information:

  • Length: 290
  • Mass: 33112
  • Checksum: D38B0DD96B50C0B9
  • Sequence:
    • MSNKEGSGGF RKRKHDNFPH NQRREGKDVN SSSPVMLAFK SFQQELDARH DKYERLVKLS 
RDITVESKRT IFLLHRITSA PDMEDILTES EIKLDGVRQK IFQVAQELSG EDMHQFHRAI 
TTGLQEYVEA VSFQHFIKTR SLISMDEINK QLIFTTEDNG KENKTPSSDA QDKQFGTWRL 
RVTPVDYLLG VADLTGELMR MCINSVGNGD IDTPFEVSQF LRQVYDGFSF IGNTGPYEVS 
KKLYTLKQSL AKVENACYAL KVRGSEIPKH MLADVFSVKT EMIDQEEGIS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.