TUBA4A | ENSG00000127824 | NCBI 7277

Details for: TUBA4A

Gene ID: 7277

Symbol: TUBA4A

Ensembl ID: ENSG00000127824

Description: tubulin alpha 4a

Associated with

Activation of ampk downstream of nmdars
(R-HSA-9619483)
Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adaptive immune system
(R-HSA-1280218)
Aggrephagy
(R-HSA-9646399)
Anchoring of the basal body to the plasma membrane
(R-HSA-5620912)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Asparagine n-linked glycosylation
(R-HSA-446203)
Assembly and cell surface presentation of nmda receptors
(R-HSA-9609736)
Aurka activation by tpx2
(R-HSA-8854518)
Autophagy
(R-HSA-9612973)
Axon guidance
(R-HSA-422475)
Carboxyterminal post-translational modifications of tubulin
(R-HSA-8955332)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Centrosome maturation
(R-HSA-380287)
Chaperonin-mediated protein folding
(R-HSA-390466)
Cilium assembly
(R-HSA-5617833)
Cooperation of prefoldin and tric/cct in actin and tubulin folding
(R-HSA-389958)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Copi-independent golgi-to-er retrograde traffic
(R-HSA-6811436)
Copi-mediated anterograde transport
(R-HSA-6807878)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Er to golgi anterograde transport
(R-HSA-199977)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of tubulin folding intermediates by cct/tric
(R-HSA-389960)
G2/m transition
(R-HSA-69275)
Gap junction assembly
(R-HSA-190861)
Gap junction trafficking
(R-HSA-190828)
Gap junction trafficking and regulation
(R-HSA-157858)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hedgehog 'off' state
(R-HSA-5610787)
Hemostasis
(R-HSA-109582)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-HSA-3371497)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interferon signaling
(R-HSA-913531)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Intraflagellar transport
(R-HSA-5620924)
Kinesins
(R-HSA-983189)
L1cam interactions
(R-HSA-373760)
Loss of nlp from mitotic centrosomes
(R-HSA-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-HSA-380284)
Macroautophagy
(R-HSA-1632852)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Mhc class ii antigen presentation
(R-HSA-2132295)
Microtubule-dependent trafficking of connexons from golgi to the plasma membrane
(R-HSA-190840)
Mitotic anaphase
(R-HSA-68882)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Nuclear envelope (ne) reassembly
(R-HSA-2995410)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Pkr-mediated signaling
(R-HSA-9833482)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Post-chaperonin tubulin folding pathway
(R-HSA-389977)
Post-translational protein modification
(R-HSA-597592)
Post nmda receptor activation events
(R-HSA-438064)
Prefoldin mediated transfer of substrate to cct/tric
(R-HSA-389957)
Protein folding
(R-HSA-391251)
Recruitment of mitotic centrosome proteins and complexes
(R-HSA-380270)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
Recycling pathway of l1
(R-HSA-437239)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Rho gtpases activate iqgaps
(R-HSA-5626467)
Sealing of the nuclear envelope (ne) by escrt-iii
(R-HSA-9668328)
Selective autophagy
(R-HSA-9663891)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-HSA-8852276)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Transmission across chemical synapses
(R-HSA-112315)
Transport of connexons to the plasma membrane
(R-HSA-190872)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Gtp binding
(GO:0005525)
Hydrolase activity
(GO:0016787)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Structural constituent of cytoskeleton
(GO:0005200)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 150.6314
Cell Significance Index: -23.4300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 130.8136
Cell Significance Index: -33.1800
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 83.5924
Cell Significance Index: -33.9600
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 74.1468
Cell Significance Index: -38.1400
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 71.6657
Cell Significance Index: -33.8400
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 50.2740
Cell Significance Index: -33.7400
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 36.7010
Cell Significance Index: -35.0400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 25.4226
Cell Significance Index: -31.3500
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 9.5846
Cell Significance Index: 82.3600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 9.1650
Cell Significance Index: -28.1500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.5845
Cell Significance Index: -33.8800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.8271
Cell Significance Index: -15.6100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 3.6052
Cell Significance Index: 420.1500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.9149
Cell Significance Index: 79.3400
Cell Name: type II muscle cell (CL0002212)
Fold Change: 2.8999
Cell Significance Index: 46.7900
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.8905
Cell Significance Index: 84.8900
Cell Name: type I muscle cell (CL0002211)
Fold Change: 2.4283
Cell Significance Index: 59.2500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.1930
Cell Significance Index: 29.9200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.1330
Cell Significance Index: 111.9900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.6558
Cell Significance Index: 195.2700
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 1.6554
Cell Significance Index: 12.7600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.6537
Cell Significance Index: 77.7200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.5150
Cell Significance Index: 90.9500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.2620
Cell Significance Index: 58.8400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.1036
Cell Significance Index: 487.9200
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.0677
Cell Significance Index: 68.8900
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 0.9684
Cell Significance Index: 2.8800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.8626
Cell Significance Index: 59.6600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.7963
Cell Significance Index: 159.7300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.7270
Cell Significance Index: 131.0500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7095
Cell Significance Index: 32.1600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6912
Cell Significance Index: 85.0000
Cell Name: lactocyte (CL0002325)
Fold Change: 0.5390
Cell Significance Index: 69.6300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5225
Cell Significance Index: 51.6900
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.5153
Cell Significance Index: 14.7100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5031
Cell Significance Index: 14.5000
Cell Name: centroblast (CL0009112)
Fold Change: 0.4801
Cell Significance Index: 1.1200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.4681
Cell Significance Index: 60.0100
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4550
Cell Significance Index: 248.5100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.3772
Cell Significance Index: 26.6800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3753
Cell Significance Index: 8.1300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3253
Cell Significance Index: 16.9000
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.3229
Cell Significance Index: 0.8700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2528
Cell Significance Index: 48.1200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1993
Cell Significance Index: 71.4800
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.1929
Cell Significance Index: 5.1700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1923
Cell Significance Index: 12.1200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1825
Cell Significance Index: 5.1000
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.1812
Cell Significance Index: 2.1600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0941
Cell Significance Index: 6.3300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0865
Cell Significance Index: 14.0700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0343
Cell Significance Index: 5.8600
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0336
Cell Significance Index: 0.5200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0196
Cell Significance Index: 36.9800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0025
Cell Significance Index: 1.8800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0008
Cell Significance Index: -0.6100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0066
Cell Significance Index: -4.1100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0069
Cell Significance Index: -0.7900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0085
Cell Significance Index: -6.3100
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0174
Cell Significance Index: -32.0100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0186
Cell Significance Index: -28.6300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0203
Cell Significance Index: -12.8900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0233
Cell Significance Index: -31.7200
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0297
Cell Significance Index: -5.8900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0385
Cell Significance Index: -21.7100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0388
Cell Significance Index: -26.8700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0464
Cell Significance Index: -21.0500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0522
Cell Significance Index: -11.0000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0610
Cell Significance Index: -1.3000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0998
Cell Significance Index: -28.7300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1058
Cell Significance Index: -10.8100
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.1462
Cell Significance Index: -2.5200
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1543
Cell Significance Index: -17.6100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1590
Cell Significance Index: -11.8500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1851
Cell Significance Index: -5.9300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1897
Cell Significance Index: -26.0500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1941
Cell Significance Index: -28.2200
Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.1980
Cell Significance Index: -2.1700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2515
Cell Significance Index: -13.1000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3202
Cell Significance Index: -33.3400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3393
Cell Significance Index: -26.0400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3665
Cell Significance Index: -29.0300
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.3811
Cell Significance Index: -5.7100
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3962
Cell Significance Index: -12.6200
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.4255
Cell Significance Index: -17.4300
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.4569
Cell Significance Index: -6.0900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4642
Cell Significance Index: -28.5300
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.4777
Cell Significance Index: -6.8000
Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
Fold Change: -0.4993
Cell Significance Index: -5.3900
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.5286
Cell Significance Index: -11.2200
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.5298
Cell Significance Index: -9.0800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.5459
Cell Significance Index: -10.0900
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.5555
Cell Significance Index: -5.5700
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.5623
Cell Significance Index: -18.4100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5776
Cell Significance Index: -35.4100
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.5862
Cell Significance Index: -6.6600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.6120
Cell Significance Index: -27.0700
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6280
Cell Significance Index: -22.0000
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.6344
Cell Significance Index: -6.7400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.6398
Cell Significance Index: -35.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** TUBA4A is a gene that encodes a 58-kDa protein, which is a subunit of microtubules. The protein is characterized by its ability to bind to tubulin and form microtubules, which are essential for various cellular processes. TUBA4A is highly expressed in immune cells, particularly in T cells and natural killer T cells, where it plays a crucial role in the regulation of immune responses. The gene is also expressed in other cell types, including epithelial cells and neurons, where it contributes to the formation and maintenance of microtubules. **Pathways and Functions** TUBA4A is involved in various cellular pathways, including: 1. **Activation of AMPK downstream of NMDARs**: TUBA4A is involved in the regulation of AMP-activated protein kinase (AMPK) signaling, which is a key pathway for glucose metabolism and energy homeostasis. 2. **Activation of NMDA receptors and postsynaptic events**: TUBA4A is involved in the regulation of NMDA receptors, which are essential for synaptic plasticity and learning. 3. **Adaptive immune system**: TUBA4A is involved in the regulation of immune responses, particularly in T cells and natural killer T cells. 4. **Autophagy**: TUBA4A is involved in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional components. 5. **Mitotic spindle formation**: TUBA4A is involved in the regulation of mitotic spindle formation, which is essential for cell division. **Clinical Significance** TUBA4A has been implicated in various diseases, including: 1. **Autoimmune disorders**: TUBA4A has been implicated in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: TUBA4A has been implicated in cancer, particularly in T-cell acute lymphoblastic leukemia (T-ALL). 3. **Neurological disorders**: TUBA4A has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Viral infections**: TUBA4A has been implicated in viral infections, such as HIV and herpes simplex virus. In conclusion, TUBA4A is a gene that encodes a subunit of microtubules, which plays a crucial role in various cellular processes, including immune responses, cell division, and signaling. The gene is significantly expressed in immune cells and is involved in the regulation of immune responses. TUBA4A has been implicated in various diseases, including autoimmune disorders, cancer, neurological disorders, and viral infections. Further research is needed to fully understand the role of TUBA4A in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Tubulin alpha-4A chain

Genular Protein ID: 2285122662

Symbol: TBA4A_HUMAN

Name: Tubulin alpha-4A chain

UniProtKB Accession Codes:

P68366 A8MUB1 B3KNQ6 P05215

Database IDs:

Citations:

PubMed ID: 3029670

Title: Alternative 5' exons either provide or deny an initiator methionine codon to the same alpha-tubulin coding region.

PubMed ID: 3029670

DOI: 10.1093/nar/15.1.199

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19524510

Title: Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.

PubMed ID: 19524510

DOI: 10.1016/j.cell.2009.05.020

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24906155

Title: Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase.

PubMed ID: 24906155

DOI: 10.1016/j.cell.2014.03.061

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25374358

Title: Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS.

PubMed ID: 25374358

DOI: 10.1016/j.neuron.2014.09.027

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26875866

Title: Graded control of microtubule severing by tubulin glutamylation.

PubMed ID: 26875866

DOI: 10.1016/j.cell.2016.01.019

PubMed ID: 35482892

Title: Posttranslational modification of microtubules by the MATCAP detyrosinase.

PubMed ID: 35482892

DOI: 10.1126/science.abn6020

Sequence Information:

Length: 448
Mass: 49924
Checksum: C00ED90A183FE8F2
Sequence:

MRECISVHVG QAGVQMGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFT TFFCETGAGK 
HVPRAVFVDL EPTVIDEIRN GPYRQLFHPE QLITGKEDAA NNYARGHYTI GKEIIDPVLD 
RIRKLSDQCT GLQGFLVFHS FGGGTGSGFT SLLMERLSVD YGKKSKLEFS IYPAPQVSTA 
VVEPYNSILT THTTLEHSDC AFMVDNEAIY DICRRNLDIE RPTYTNLNRL ISQIVSSITA 
SLRFDGALNV DLTEFQTNLV PYPRIHFPLA TYAPVISAEK AYHEQLSVAE ITNACFEPAN 
QMVKCDPRHG KYMACCLLYR GDVVPKDVNA AIAAIKTKRS IQFVDWCPTG FKVGINYQPP 
TVVPGGDLAK VQRAVCMLSN TTAIAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE 
AREDMAALEK DYEEVGIDSY EDEDEGEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TUBA4A

Associated with

Cells (max top 100)

Other Information

Alternative 5' exons either provide or deny an initiator methionine codon to the same alpha-tubulin coding region. PubMed ID: 3029670

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Phosphoproteome of resting human platelets. PubMed ID: 18088087

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. PubMed ID: 19524510

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase. PubMed ID: 24906155

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS. PubMed ID: 25374358

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Graded control of microtubule severing by tubulin glutamylation. PubMed ID: 26875866

Posttranslational modification of microtubules by the MATCAP detyrosinase. PubMed ID: 35482892