Details for: UBA1
Gene ID: 7317
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: UBA1
Ensembl ID: ENSG00000130985
Description: ubiquitin like modifier activating enzyme 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 30.05rCSI 28.93%PRS 27.55
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CSI 11.79rCSI 20.83%PRS 15.93
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CSI 10.57rCSI 14.99%PRS 24.77
-
CSI 9.72rCSI 9.55%PRS 40.23
-
CSI 8.58rCSI 8.96%PRS 27.44
-
CSI 8.1rCSI 7.32%PRS 24.31
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CSI 7.76rCSI 20.48%PRS 31.8
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CSI 7.18rCSI 14.26%PRS 27.62
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CSI 6.85rCSI 7.5%PRS 29.79
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CSI 6.66rCSI 16.92%PRS 26.03
-
CSI 5.88rCSI 8.6%PRS 28.38
-
CSI 5.75rCSI 4.98%PRS 29.83
-
CSI 5.62rCSI 4.94%PRS 19.57
-
CSI 5.57rCSI 8%PRS 20.97
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CSI 5.19rCSI 5.18%PRS 22.84
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CSI 4.56rCSI 4.22%PRS 45.71
-
CSI 4.51rCSI 5.45%PRS 32.07
-
CSI 4.2rCSI 26.21%PRS 21.36
-
CSI 3.98rCSI 4.95%PRS 15.32
-
CSI 3.8rCSI 3.28%PRS 38.19
-
CSI 3.77rCSI 18.92%PRS 35.01
-
CSI 3.7rCSI 5.44%PRS 24.6
-
CSI 3.7rCSI 39.18%PRS 31.97
-
CSI 3.58rCSI 5.32%PRS 30.29
-
CSI 3.14rCSI 2.52%PRS 45.45
-
CSI 3.05rCSI 6.48%PRS 40.74
-
CSI 2.84rCSI 2.16%PRS 35.14
-
CSI 2.8rCSI 2.92%PRS 27.39
-
CSI 2.74rCSI 2.03%PRS 38.18
-
CSI 2.69rCSI 29.47%PRS 44.6
-
CSI 2.66rCSI 1.97%PRS 22.87
-
CSI 2.66rCSI 1.85%PRS 36.93
-
CSI 2.64rCSI 3.61%PRS 29.42
-
CSI 2.62rCSI 1.82%PRS 32.18
-
CSI 2.62rCSI 2.13%PRS 27.76
-
CSI 2.61rCSI 1.76%PRS 33.13
-
CSI 2.61rCSI 5.98%PRS 26.09
-
CSI 2.59rCSI 3.45%PRS 29.37
-
CSI 2.59rCSI 8.31%PRS 35.65
-
CSI 2.57rCSI 13.29%PRS 49.03
-
CSI 2.51rCSI 2.2%PRS 34.8
-
CSI 2.5rCSI 2.22%PRS 26.84
-
CSI 2.49rCSI 2.99%PRS 25.82
-
CSI 2.46rCSI 1.91%PRS 26.01
-
CSI 2.4rCSI 2.11%PRS 30.46
-
CSI 2.36rCSI 3.46%PRS 34.77
-
CSI 2.36rCSI 3.03%PRS 30.67
-
CSI 2.36rCSI 3.26%PRS 34.87
-
CSI 2.35rCSI 2.99%PRS 30.62
-
CSI 2.34rCSI 3.18%PRS 23.18
-
CSI 2.33rCSI 3.44%PRS 40.73
-
CSI 2.33rCSI 10.39%PRS 18.45
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CSI 2.3rCSI 3.15%PRS 30.1
-
CSI 2.28rCSI 3.3%PRS 39.76
-
CSI 2.26rCSI 5.95%PRS 48.72
-
CSI 2.26rCSI 5.04%PRS 31.23
-
CSI 2.23rCSI 5.53%PRS 24.88
-
CSI 2.2rCSI 1.47%PRS 31.13
-
CSI 2.16rCSI 3.69%PRS 50.98
-
CSI 2.15rCSI 9.87%PRS 52.42
-
CSI 2.15rCSI 4.31%PRS 19.86
-
CSI 2.14rCSI 1.99%PRS 26.66
-
CSI 2.14rCSI 5.02%PRS 36.78
-
CSI 2.13rCSI 3.27%PRS 33.66
-
CSI 2.11rCSI 1.74%PRS 27.09
-
CSI 2.08rCSI 1.23%PRS 37.29
-
CSI 2.07rCSI 2.43%PRS 37.39
-
CSI 2.05rCSI 1.63%PRS 45.68
-
CSI 2.05rCSI 1.61%PRS 31.99
-
CSI 1.97rCSI 1.86%PRS 27.92
-
CSI 1.95rCSI 2.81%PRS 40.34
-
CSI 1.92rCSI 2.94%PRS 26.86
-
CSI 1.9rCSI 2.24%PRS 30.37
-
CSI 1.9rCSI 2.54%PRS 33.72
-
CSI 1.9rCSI 1.86%PRS 28.59
-
CSI 1.89rCSI 2.47%PRS 37.37
-
CSI 1.87rCSI 5.51%PRS 30.94
-
CSI 1.83rCSI 4.64%PRS 20.48
-
CSI 1.82rCSI 1.44%PRS 18.44
-
CSI 1.78rCSI 5.11%PRS 39.55
-
CSI 1.77rCSI 3.19%PRS 22.2
-
CSI 1.77rCSI 3.11%PRS 20.87
-
CSI 1.77rCSI 4.61%PRS 25.34
-
CSI 1.74rCSI 2.77%PRS 29.23
-
CSI 1.72rCSI 5.11%PRS 36.15
-
CSI 1.72rCSI 1.23%PRS 36.35
-
CSI 1.72rCSI 3.22%PRS 19.63
-
CSI 1.72rCSI 1.29%PRS 28.61
-
CSI 1.72rCSI 2.77%PRS 38.19
-
CSI 1.71rCSI 3.55%PRS 26.36
-
CSI 1.7rCSI 1.92%PRS 41.28
-
CSI 1.7rCSI 4.86%PRS 44.16
-
CSI 1.7rCSI 4.07%PRS 44.16
-
CSI 1.69rCSI 1.42%PRS 31.26
-
CSI 1.68rCSI 1.78%PRS 42.79
-
CSI 1.68rCSI 2.04%PRS 32.96
-
CSI 1.67rCSI 4.23%PRS 32.7
-
CSI 1.66rCSI 3.62%PRS 47.76
-
CSI 1.64rCSI 2.43%PRS 30.32
-
CSI 1.63rCSI 1.22%PRS 40.45
-
CSI 0.1rCSI 2.1%PRS 65.0%
-
CSI 0.2rCSI 0.4%PRS 42.1%
-
CSI 0.2rCSI 5.2%PRS 47.7%
-
CSI 0.3rCSI 6.5%PRS 82.2%
-
CSI 0.4rCSI 2.1%PRS 42.1%
-
CSI 0.4rCSI 2.8%PRS 59.6%
-
CSI 0.4rCSI 2.8%PRS 59.7%
-
CSI 0.5rCSI 2.4%PRS 71.1%
-
CSI 0.5rCSI 0.8%PRS 22.9%
-
CSI 0.5rCSI 2.7%PRS 38.0%
-
CSI 0.5rCSI 2.9%PRS 53.4%
-
CSI 0.5rCSI 1.7%PRS 41.2%
-
CSI 0.5rCSI 1.8%PRS 17.0%
-
CSI 0.5rCSI 0.7%PRS 26.0%
-
CSI 0.5rCSI 2.0%PRS 42.9%
-
CSI 0.6rCSI 2.9%PRS 42.8%
-
CSI 0.6rCSI 1.2%PRS 35.1%
-
CSI 0.6rCSI 1.0%PRS 16.3%
-
CSI 0.6rCSI 1.1%PRS 51.4%
-
CSI 0.6rCSI 0.7%PRS 49.6%
-
CSI 0.7rCSI 2.6%PRS 42.9%
-
CSI 0.7rCSI 2.8%PRS 45.0%
-
CSI 0.7rCSI 1.5%PRS 26.9%
-
CSI 0.7rCSI 1.9%PRS 41.9%
-
CSI 0.7rCSI 1.0%PRS 41.7%
-
CSI 0.7rCSI 3.9%PRS 16.5%
-
CSI 0.7rCSI 2.2%PRS 17.1%
-
CSI 0.7rCSI 5.5%PRS 46.9%
-
CSI 0.7rCSI 1.7%PRS 15.9%
-
CSI 0.7rCSI 0.7%PRS 31.8%
-
CSI 0.7rCSI 1.3%PRS 24.9%
-
CSI 0.7rCSI 2.3%PRS 22.9%
-
CSI 0.7rCSI 2.6%PRS 15.5%
-
CSI 0.7rCSI 2.6%PRS 43.4%
-
CSI 0.8rCSI 2.0%PRS 22.3%
-
CSI 0.8rCSI 2.0%PRS 60.9%
-
CSI 0.8rCSI 0.8%PRS 31.4%
-
CSI 0.8rCSI 2.2%PRS 40.4%
-
CSI 0.8rCSI 4.1%PRS 35.6%
-
CSI 0.8rCSI 1.3%PRS 20.5%
-
CSI 0.8rCSI 1.3%PRS 24.6%
-
CSI 0.8rCSI 2.6%PRS 18.6%
-
CSI 0.9rCSI 2.6%PRS 38.3%
-
CSI 0.9rCSI 1.8%PRS 42.9%
-
CSI 0.9rCSI 3.1%PRS 39.5%
-
CSI 0.9rCSI 3.7%PRS 50.6%
-
CSI 0.9rCSI 27.5%PRS 52.0%
-
CSI 0.9rCSI 2.4%PRS 24.6%
-
CSI 0.9rCSI 2.1%PRS 19.2%
-
CSI 0.9rCSI 1.1%PRS 19.9%
-
CSI 0.9rCSI 1.1%PRS 44.2%
-
CSI 1.0rCSI 0.9%PRS 50.0%
-
CSI 1.0rCSI 6.2%PRS 66.6%
-
CSI 1.0rCSI 1.3%PRS 28.6%
-
CSI 1.0rCSI 0.8%PRS 26.8%
-
CSI 1.0rCSI 5.9%PRS 37.6%
-
CSI 1.0rCSI 1.7%PRS 17.7%
-
CSI 1.1rCSI 2.3%PRS 39.3%
-
CSI 1.1rCSI 2.5%PRS 38.4%
-
CSI 1.1rCSI 1.6%PRS 29.5%
-
CSI 1.1rCSI 2.6%PRS 32.2%
-
CSI 1.1rCSI 1.6%PRS 36.1%
-
CSI 1.1rCSI 1.2%PRS 24.7%
-
CSI 1.1rCSI 2.0%PRS 35.3%
-
CSI 1.2rCSI 1.8%PRS 25.1%
-
CSI 1.2rCSI 1.8%PRS 22.5%
-
CSI 1.2rCSI 1.5%PRS 23.5%
-
CSI 1.2rCSI 2.8%PRS 55.3%
-
CSI 1.2rCSI 2.2%PRS 40.1%
-
CSI 1.2rCSI 2.3%PRS 27.5%
-
CSI 1.2rCSI 5.5%PRS 52.3%
-
CSI 1.2rCSI 1.6%PRS 47.5%
-
CSI 1.2rCSI 1.5%PRS 34.2%
-
CSI 1.2rCSI 4.8%PRS 35.6%
-
CSI 1.3rCSI 2.0%PRS 22.8%
-
CSI 1.3rCSI 2.0%PRS 20.7%
-
CSI 1.3rCSI 1.8%PRS 29.5%
-
CSI 1.3rCSI 3.8%PRS 53.0%
-
CSI 1.3rCSI 1.1%PRS 25.4%
-
CSI 1.3rCSI 2.4%PRS 33.8%
-
CSI 1.3rCSI 2.2%PRS 20.5%
-
CSI 1.3rCSI 1.7%PRS 28.8%
-
CSI 1.3rCSI 2.3%PRS 41.9%
-
CSI 1.3rCSI 1.8%PRS 26.9%
-
CSI 1.3rCSI 2.0%PRS 34.1%
-
CSI 1.3rCSI 7.2%PRS 43.4%
-
CSI 1.3rCSI 1.7%PRS 25.5%
-
CSI 1.4rCSI 7.0%PRS 69.1%
-
CSI 1.4rCSI 3.0%PRS 30.3%
-
CSI 1.4rCSI 1.6%PRS 16.1%
-
CSI 1.4rCSI 2.1%PRS 31.9%
-
CSI 1.4rCSI 1.6%PRS 37.4%
-
CSI 1.4rCSI 2.0%PRS 34.9%
-
CSI 1.4rCSI 2.2%PRS 26.9%
-
CSI 1.4rCSI 1.6%PRS 23.1%
-
CSI 1.4rCSI 1.5%PRS 24.9%
-
CSI 1.4rCSI 3.1%PRS 24.6%
-
CSI 1.4rCSI 2.3%PRS 31.1%
-
CSI 1.4rCSI 1.4%PRS 19.9%
-
CSI 1.4rCSI 2.7%PRS 41.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3230077572
Symbol: UBA1_HUMAN
Name: Ubiquitin-like modifier-activating enzyme 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1606621
Title: Complementation by a cloned human ubiquitin-activating enzyme E1 of the S-phase-arrested mouse FM3A cell mutant with thermolabile E1.
PubMed ID: 1606621
DOI: 10.1247/csf.17.113
PubMed ID: 1986373
Title: Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1.
PubMed ID: 1986373
PubMed ID: 1871145
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2390975
Title: Molecular cloning, primary structure and expression of the human X linked A1S9 gene cDNA which complements the ts A1S9 mouse L cell defect in DNA replication.
PubMed ID: 2390975
PubMed ID: 1447181
Title: Isoforms of mammalian ubiquitin-activating enzyme.
PubMed ID: 1447181
PubMed ID: 1376922
Title: Immunoelectron microscopic localization of the ubiquitin-activating enzyme E1 in HepG2 cells.
PubMed ID: 1376922
PubMed ID: 7528747
Title: Human ubiquitin-activating enzyme, E1. Indication of potential nuclear and cytoplasmic subpopulations using epitope-tagged cDNA constructs.
PubMed ID: 7528747
PubMed ID: 9099746
Title: Identification of a region within the ubiquitin-activating enzyme required for nuclear targeting and phosphorylation.
PubMed ID: 9099746
PubMed ID: 16139798
Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.
PubMed ID: 16139798
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 16227972
Title: Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival.
PubMed ID: 16227972
DOI: 10.1038/nature04256
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22456334
Title: Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage.
PubMed ID: 22456334
DOI: 10.4161/cc.19978
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 33108101
Title: Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.
PubMed ID: 33108101
PubMed ID: 25209502
Title: Expression, purification, and crystal structure of N-terminal domains of human ubiquitin-activating enzyme (E1).
PubMed ID: 25209502
PubMed ID: 18179898
Title: Rare missense and synonymous variants in UBE1 are associated with X-linked infantile spinal muscular atrophy.
PubMed ID: 18179898
PubMed ID: 23518311
Title: Clinical and neuropathological features of X-linked spinal muscular atrophy (SMAX2) associated with a novel mutation in the UBA1 gene.
PubMed ID: 23518311
Sequence Information:
- Length: 1058
- Mass: 117849
- Checksum: 4B413AAA75FAA562
- Sequence:
MSSSPLSKKR RVSGPDPKPG SNCSPAQSVL SEVPSVPTNG MAKNGSEADI DEGLYSRQLY VLGHEAMKRL QTSSVLVSGL RGLGVEIAKN IILGGVKAVT LHDQGTAQWA DLSSQFYLRE EDIGKNRAEV SQPRLAELNS YVPVTAYTGP LVEDFLSGFQ VVVLTNTPLE DQLRVGEFCH NRGIKLVVAD TRGLFGQLFC DFGEEMILTD SNGEQPLSAM VSMVTKDNPG VVTCLDEARH GFESGDFVSF SEVQGMVELN GNQPMEIKVL GPYTFSICDT SNFSDYIRGG IVSQVKVPKK ISFKSLVASL AEPDFVVTDF AKFSRPAQLH IGFQALHQFC AQHGRPPRPR NEEDAAELVA LAQAVNARAL PAVQQNNLDE DLIRKLAYVA AGDLAPINAF IGGLAAQEVM KACSGKFMPI MQWLYFDALE CLPEDKEVLT EDKCLQRQNR YDGQVAVFGS DLQEKLGKQK YFLVGAGAIG CELLKNFAMI GLGCGEGGEI IVTDMDTIEK SNLNRQFLFR PWDVTKLKSD TAAAAVRQMN PHIRVTSHQN RVGPDTERIY DDDFFQNLDG VANALDNVDA RMYMDRRCVY YRKPLLESGT LGTKGNVQVV IPFLTESYSS SQDPPEKSIP ICTLKNFPNA IEHTLQWARD EFEGLFKQPA ENVNQYLTDP KFVERTLRLA GTQPLEVLEA VQRSLVLQRP QTWADCVTWA CHHWHTQYSN NIRQLLHNFP PDQLTSSGAP FWSGPKRCPH PLTFDVNNPL HLDYVMAAAN LFAQTYGLTG SQDRAAVATF LQSVQVPEFT PKSGVKIHVS DQELQSANAS VDDSRLEELK ATLPSPDKLP GFKMYPIDFE KDDDSNFHMD FIVAASNLRA ENYDIPSADR HKSKLIAGKI IPAIATTTAA VVGLVCLELY KVVQGHRQLD SYKNGFLNLA LPFFGFSEPL AAPRHQYYNQ EWTLWDRFEV QGLQPNGEEM TLKQFLDYFK TEHKLEITML SQGVSMLYSF FMPAAKLKER LDQPMTEIVS RVSKRKLGRH VRALVLELCC NDESGEDVEV PYVRYTIR