UBE2E1 | ENSG00000170142 | NCBI 7324

Details for: UBE2E1

Gene ID: 7324

Symbol: UBE2E1

Ensembl ID: ENSG00000170142

Description: ubiquitin conjugating enzyme E2 E1

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic exit in cancer due to rb1 defects
(R-HSA-9687136)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Apc-cdc20 mediated degradation of nek2a
(R-HSA-179409)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of cyclin b
(R-HSA-174048)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc/c:cdc20 mediated degradation of securin
(R-HSA-174154)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-HSA-174178)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Assembly of the pre-replicative complex
(R-HSA-68867)
Autodegradation of cdh1 by cdh1:apc/c
(R-HSA-174084)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Conversion from apc/c:cdc20 to apc/c:cdh1 in late anaphase
(R-HSA-176407)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
E3 ubiquitin ligases ubiquitinate target proteins
(R-HSA-8866654)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Inactivation of apc/c via direct inhibition of the apc/c complex
(R-HSA-141430)
Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components
(R-HSA-141405)
Interferon signaling
(R-HSA-913531)
Isg15 antiviral mechanism
(R-HSA-1169408)
Metabolism of proteins
(R-HSA-392499)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Phosphorylation of the apc/c
(R-HSA-176412)
Post-translational protein modification
(R-HSA-597592)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Regulation of mitotic cell cycle
(R-HSA-453276)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Separation of sister chromatids
(R-HSA-2467813)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of active ubiquitin: roles of e1 and e2 enzymes
(R-HSA-8866652)
Synthesis of dna
(R-HSA-69239)
Transcriptional regulation by ventx
(R-HSA-8853884)
Atp binding
(GO:0005524)
Cytosol
(GO:0005829)
Isg15 transferase activity
(GO:0042296)
Isg15-protein conjugation
(GO:0032020)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein k48-linked ubiquitination
(GO:0070936)
Protein polyubiquitination
(GO:0000209)
Protein ubiquitination
(GO:0016567)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin conjugating enzyme activity
(GO:0061631)
Ubiquitin ligase complex
(GO:0000151)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 397.2478
Cell Significance Index: -61.7900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 197.4426
Cell Significance Index: -50.0800
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 150.8687
Cell Significance Index: -62.1500
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 141.8434
Cell Significance Index: -66.9700
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 136.8591
Cell Significance Index: -55.6000
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 122.7096
Cell Significance Index: -63.1200
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 99.8998
Cell Significance Index: -67.0400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 52.3052
Cell Significance Index: -64.4900
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 19.8741
Cell Significance Index: -53.2400
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 18.3223
Cell Significance Index: -40.1000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 16.6445
Cell Significance Index: -65.6800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 3.5608
Cell Significance Index: 95.0800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.3567
Cell Significance Index: 162.9800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.0508
Cell Significance Index: 115.0800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.8808
Cell Significance Index: 305.8900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.7311
Cell Significance Index: 343.5400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.6553
Cell Significance Index: 46.2600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.5114
Cell Significance Index: 303.1800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.1300
Cell Significance Index: 67.8400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.0570
Cell Significance Index: 81.1100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.8741
Cell Significance Index: 53.7300
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.8331
Cell Significance Index: 16.2600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.8194
Cell Significance Index: 96.6300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.7990
Cell Significance Index: 144.0400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6521
Cell Significance Index: 124.1000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6384
Cell Significance Index: 78.5000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.6296
Cell Significance Index: 40.6200
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6178
Cell Significance Index: 337.3700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4764
Cell Significance Index: 65.4200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4760
Cell Significance Index: 170.7300
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4519
Cell Significance Index: 312.5500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4268
Cell Significance Index: 188.7200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3930
Cell Significance Index: 354.8200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3557
Cell Significance Index: 18.4800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3499
Cell Significance Index: 10.0800
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.3435
Cell Significance Index: 8.8300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3037
Cell Significance Index: 14.2800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.2994
Cell Significance Index: 135.8800
Cell Name: lactocyte (CL0002325)
Fold Change: 0.2990
Cell Significance Index: 38.6300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2760
Cell Significance Index: 14.4900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2586
Cell Significance Index: 486.9200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.2374
Cell Significance Index: 30.4300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1854
Cell Significance Index: 1.1200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1755
Cell Significance Index: 6.1000
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.1574
Cell Significance Index: 4.1400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1378
Cell Significance Index: 10.2700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1302
Cell Significance Index: 200.4700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1301
Cell Significance Index: 82.6500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1077
Cell Significance Index: 5.0200
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0939
Cell Significance Index: 173.2600
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0927
Cell Significance Index: 125.9900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0854
Cell Significance Index: 5.7400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0599
Cell Significance Index: 10.2200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0504
Cell Significance Index: 4.9900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0308
Cell Significance Index: 2.1800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0183
Cell Significance Index: -0.8300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0254
Cell Significance Index: -19.2000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0276
Cell Significance Index: -17.2300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0277
Cell Significance Index: -20.5500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0289
Cell Significance Index: -4.2100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0466
Cell Significance Index: -34.1800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0690
Cell Significance Index: -1.1600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0903
Cell Significance Index: -50.9300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0983
Cell Significance Index: -10.0400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1211
Cell Significance Index: -3.2400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1260
Cell Significance Index: -2.1600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1903
Cell Significance Index: -40.0900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1930
Cell Significance Index: -55.5400
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2106
Cell Significance Index: -5.3800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2475
Cell Significance Index: -25.7700
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.2750
Cell Significance Index: -3.9600
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.2756
Cell Significance Index: -6.6100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2842
Cell Significance Index: -7.7400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2881
Cell Significance Index: -18.1600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3746
Cell Significance Index: -43.6600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3787
Cell Significance Index: -43.3900
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.3992
Cell Significance Index: -9.7400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4114
Cell Significance Index: -13.1800
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.4176
Cell Significance Index: -12.2700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.4251
Cell Significance Index: -9.2100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4273
Cell Significance Index: -5.8300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4302
Cell Significance Index: -19.0300
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4603
Cell Significance Index: -52.5400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5818
Cell Significance Index: -22.0300
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.6060
Cell Significance Index: -5.0900
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.6651
Cell Significance Index: -6.8900
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.6657
Cell Significance Index: -9.5600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6792
Cell Significance Index: -53.7900
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.7847
Cell Significance Index: -11.5900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8328
Cell Significance Index: -51.0600
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.8584
Cell Significance Index: -7.9100
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.8716
Cell Significance Index: -10.3900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.8788
Cell Significance Index: -30.8800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.9097
Cell Significance Index: -19.3800
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.9147
Cell Significance Index: -11.3500
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.9672
Cell Significance Index: -27.6000
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -1.0169
Cell Significance Index: -52.9700
Cell Name: Purkinje cell (CL0000121)
Fold Change: -1.0513
Cell Significance Index: -23.0200
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -1.0937
Cell Significance Index: -55.2800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -1.1079
Cell Significance Index: -31.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** UBE2E1 is a small protein with a molecular weight of approximately 28 kDa. It belongs to the ubiquitin-conjugating enzyme family, which consists of proteins that catalyze the transfer of ubiquitin molecules to target proteins. UBE2E1 is characterized by its ability to recognize and bind to specific ubiquitin-activating enzymes (E1s) and ubiquitin-conjugating enzymes (E2s), facilitating the transfer of ubiquitin molecules to target proteins. UBE22E1 is also known to interact with various proteins, including E3 ubiquitin ligases, which are responsible for the recognition and targeting of specific substrates for degradation. **Pathways and Functions** UBE2E1 is involved in multiple cellular pathways, including: 1. **Cell Cycle Regulation**: UBE2E1 plays a crucial role in the regulation of the cell cycle, particularly during mitosis. It interacts with E3 ubiquitin ligases to target proteins involved in the cell cycle, such as cyclin B and securin, for degradation. 2. **Antigen Processing**: UBE2E1 is involved in the processing and presentation of antigens to the immune system. It recognizes and binds to ubiquitin-activating enzymes (E1s) and ubiquitin-conjugating enzymes (E2s) to facilitate the transfer of ubiquitin molecules to target proteins, which can then be degraded and presented by MHC class I molecules. 3. **Immune Response**: UBE2E1 is expressed in immune cells and plays a role in the regulation of immune responses. It interacts with E3 ubiquitin ligases to target proteins involved in the immune response, such as cytokines and chemokines, for degradation. 4. **Protein Degradation**: UBE2E1 is involved in the degradation of proteins through the ubiquitin-proteasome pathway. It recognizes and binds to ubiquitin-activating enzymes (E1s) and ubiquitin-conjugating enzymes (E2s) to facilitate the transfer of ubiquitin molecules to target proteins, which can then be degraded by the proteasome. **Clinical Significance** UBE2E1 has been implicated in various diseases, including: 1. **Cancer**: UBE2E1 is overexpressed in certain types of cancer, including breast and ovarian cancer. Its overexpression is associated with poor prognosis and reduced survival rates. 2. **Autoimmune Diseases**: UBE2E1 is involved in the regulation of immune responses and has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Neurodegenerative Diseases**: UBE2E1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it plays a role in the regulation of protein degradation and immune responses. In conclusion, UBE2E1 is a crucial protein involved in various cellular processes, including cell cycle regulation, antigen processing, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and mechanisms of UBE2E1.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ubiquitin-conjugating enzyme E2 E1
B7Z306_HUMAN

Genular Protein ID: 3801050159

Symbol: UB2E1_HUMAN

Name: Ubiquitin-conjugating enzyme E2 E1

UniProtKB Accession Codes:

P51965 B2RBX4 C9J8K2 K4DI90

Database IDs:

Citations:

PubMed ID: 8576257

Title: Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5.

PubMed ID: 8576257

DOI: 10.1074/jbc.271.5.2795

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16428300

Title: Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme.

PubMed ID: 16428300

DOI: 10.1093/jb/mvi172

PubMed ID: 17588522

Title: E3-independent monoubiquitination of ubiquitin-binding proteins.

PubMed ID: 17588522

DOI: 10.1016/j.molcel.2007.05.014

PubMed ID: 18845142

Title: The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide.

PubMed ID: 18845142

DOI: 10.1016/j.yexcr.2008.09.011

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22496338

Title: A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.

PubMed ID: 22496338

DOI: 10.1074/mcp.o111.013706

Sequence Information:

Length: 193
Mass: 21404
Checksum: 2FBC50BE2A6A0008
Sequence:

MSDDDSRAST SSSSSSSSNQ QTEKETNTPK KKESKVSMSK NSKLLSTSAK RIQKELADIT 
LDPPPNCSAG PKGDNIYEWR STILGPPGSV YEGGVFFLDI TFTPEYPFKP PKVTFRTRIY 
HCNINSQGVI CLDILKDNWS PALTISKVLL SICSLLTDCN PADPLVGSIA TQYMTNRAEH 
DRMARQWTKR YAT

Genular Protein ID: 1328919374

Symbol: B7Z306_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z306

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

Length: 167
Mass: 18769
Checksum: 6A931D4AA76F8077
Sequence:

MKEVGRPREV RGRPGKSRIQ KELADITLDP PPNCSAGPKG DNIYEWRSTI LGPPGSVYEG 
GVFFLDITFT PEYPFKPPKV TFRTRIYHCN INSQGVICLD ILKDNWSPAL TISKVLLSIC 
SLLTDCNPGK VHNSLPCFIL PYLKNTCFQK LSKDKTNFSA QVCEYKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: UBE2E1

Associated with

Cells (max top 100)

Other Information

Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5. PubMed ID: 8576257

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme. PubMed ID: 16428300

E3-independent monoubiquitination of ubiquitin-binding proteins. PubMed ID: 17588522

The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide. PubMed ID: 18845142

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. PubMed ID: 20061386

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. PubMed ID: 22496338

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

Initial characterization of the human central proteome. PubMed ID: 21269460

Database document:

PubMed ID: 8576257

PubMed ID: 14702039

PubMed ID: 16641997

PubMed ID: 15489334

PubMed ID: 16428300

PubMed ID: 17588522

PubMed ID: 18845142

PubMed ID: 19413330

PubMed ID: 20061386

PubMed ID: 21269460

PubMed ID: 21406692

PubMed ID: 22496338

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 16641997

PubMed ID: 21269460