Gene UBE2G2 - ENSG00000184787 | NCBI Gene ID: 7327

Details for: UBE2G2

Gene ID: 7327

Symbol: UBE2G2

Ensembl ID: ENSG00000184787

Description: ubiquitin conjugating enzyme E2 G2

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Immune system
(R-HSA-168256)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Protein ubiquitination
(R-HSA-8852135)
Synthesis of active ubiquitin: roles of e1 and e2 enzymes
(R-HSA-8866652)
Atp binding
(GO:0005524)
Cellular response to interferon-beta
(GO:0035458)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Erad pathway
(GO:0036503)
Identical protein binding
(GO:0042802)
Lipid droplet
(GO:0005811)
Negative regulation of retrograde protein transport, er to cytosol
(GO:1904153)
Protein binding
(GO:0005515)
Protein k48-linked ubiquitination
(GO:0070936)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin conjugating enzyme activity
(GO:0061631)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 4.45
Marker Score: 59142.5
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 3
Marker Score: 1455
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.2
Marker Score: 47046
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.96
Marker Score: 2094
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 1.96
Marker Score: 1188
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.78
Marker Score: 3901
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.73
Marker Score: 63868
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.7
Marker Score: 104681
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 1.67
Marker Score: 2086
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.67
Marker Score: 15842
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.65
Marker Score: 32849
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.65
Marker Score: 62557
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.64
Marker Score: 6340
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.62
Marker Score: 13884
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.58
Marker Score: 14817
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.55
Marker Score: 23115
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.54
Marker Score: 6395
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.54
Marker Score: 11782
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1.54
Marker Score: 1371
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.51
Marker Score: 1739
Cell Name: classical monocyte (CL0000860)
Fold Change: 1.48
Marker Score: 6155
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.47
Marker Score: 553
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.46
Marker Score: 14786
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.45
Marker Score: 984
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.45
Marker Score: 1600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.44
Marker Score: 1517
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.44
Marker Score: 2221
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.4
Marker Score: 1884
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.39
Marker Score: 413.5
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 1.38
Marker Score: 1171
Cell Name: blood cell (CL0000081)
Fold Change: 1.37
Marker Score: 15952
Cell Name: fat cell (CL0000136)
Fold Change: 1.35
Marker Score: 752
Cell Name: follicular B cell (CL0000843)
Fold Change: 1.33
Marker Score: 1441
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.32
Marker Score: 1937
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.31
Marker Score: 1880
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.3
Marker Score: 380
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.3
Marker Score: 28994
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.29
Marker Score: 750
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.28
Marker Score: 2919
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.28
Marker Score: 902
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.27
Marker Score: 14333
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.25
Marker Score: 834
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.24
Marker Score: 1289
Cell Name: plasmablast (CL0000980)
Fold Change: 1.23
Marker Score: 1642
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.23
Marker Score: 820
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 1.22
Marker Score: 423
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 1.22
Marker Score: 683
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.22
Marker Score: 727
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.22
Marker Score: 2569
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.21
Marker Score: 290
Cell Name: Schwann cell (CL0002573)
Fold Change: 1.21
Marker Score: 421
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.21
Marker Score: 605
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.2
Marker Score: 440
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.2
Marker Score: 820
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.19
Marker Score: 895
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.19
Marker Score: 4993
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.19
Marker Score: 1094.5
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.19
Marker Score: 294
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.19
Marker Score: 1437
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.18
Marker Score: 5802.5
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.18
Marker Score: 649
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.16
Marker Score: 661
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.16
Marker Score: 471
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 1.15
Marker Score: 303
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.14
Marker Score: 1290
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.14
Marker Score: 39336
Cell Name: podocyte (CL0000653)
Fold Change: 1.13
Marker Score: 419
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.13
Marker Score: 350
Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.13
Marker Score: 422
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.13
Marker Score: 356
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 1.12
Marker Score: 1047
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 1.12
Marker Score: 1996
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 1.11
Marker Score: 293
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.11
Marker Score: 37886
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 1.11
Marker Score: 744
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.11
Marker Score: 321
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.11
Marker Score: 1195
Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.11
Marker Score: 867.5
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.11
Marker Score: 753
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.1
Marker Score: 4757
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.1
Marker Score: 474
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.1
Marker Score: 4068
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 1.1
Marker Score: 322
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 1.1
Marker Score: 2150
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.09
Marker Score: 1751
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.09
Marker Score: 637
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.09
Marker Score: 3868
Cell Name: keratocyte (CL0002363)
Fold Change: 1.09
Marker Score: 250
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.09
Marker Score: 261
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.09
Marker Score: 786
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.08
Marker Score: 539
Cell Name: melanocyte (CL0000148)
Fold Change: 1.08
Marker Score: 439
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.08
Marker Score: 683
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.07
Marker Score: 6895
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.07
Marker Score: 448
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.07
Marker Score: 2859
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.06
Marker Score: 2676
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 1.06
Marker Score: 4538
Cell Name: ependymal cell (CL0000065)
Fold Change: 1.06
Marker Score: 369
Cell Name: Unknown (CL0000548)
Fold Change: 1.06
Marker Score: 769

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**Key Characteristics:** UBE2G2 is a small, highly conserved protein that belongs to the ubiquitin-conjugating enzyme family. It is characterized by its ability to catalyze the transfer of ubiquitin molecules to target proteins, forming a ubiquitin-protein conjugate. The enzyme is specifically involved in the K48-linked ubiquitination pathway, which is a key mechanism for protein degradation. UBE2G2 is highly expressed in various cell types, including immune cells, neurons, and muscle cells, highlighting its importance in maintaining cellular homeostasis and regulating immune responses. **Pathways and Functions:** UBE2G2 is involved in several key pathways, including: 1. **Adaptive Immune System:** UBE2G2 plays a crucial role in the regulation of immune responses by modulating the ubiquitination and degradation of immune-related proteins. 2. **Antigen Processing and Presentation:** UBE2G2 is involved in the processing and presentation of antigens to the immune system, facilitating the activation of immune cells. 3. **Protein Degradation:** UBE2G2 is a key component of the UPS, regulating protein turnover and maintaining protein homeostasis. 4. **Metabolism of Proteins:** UBE2G2 is involved in the regulation of protein metabolism, including the degradation of damaged or misfolded proteins. **Clinical Significance:** Dysregulation of UBE2G2 has been implicated in various diseases, including: 1. **Autoimmune Disorders:** UBE2G2 dysfunction has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** Aberrant UBE2G2 expression has been observed in various types of cancer, including breast and lung cancer. 3. **Neurodegenerative Diseases:** UBE2G2 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 4. **Muscular Dystrophy:** UBE2G2 dysfunction has been linked to muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. In conclusion, UBE2G2 is a critical regulator of protein degradation and immune response, with implications for various diseases. Further research is needed to fully elucidate the mechanisms by which UBE2G2 regulates protein turnover and immune responses, and to explore its potential as a therapeutic target for disease treatment.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ubiquitin-conjugating enzyme E2 G2

Genular Protein ID: 649253390

Symbol: UB2G2_HUMAN

Name: Ubiquitin-conjugating enzyme E2 G2

UniProtKB Accession Codes:

P60604 A6NMQ7 A8K3L4 D3DSL7 P56554

Database IDs:

Citations:

PubMed ID: 9693041

Title: Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae UBC7 gene.

PubMed ID: 9693041

DOI: 10.1006/geno.1998.5263

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21127063

Title: Ancient ubiquitous protein 1 (AUP1) localizes to lipid droplets and binds the E2 ubiquitin conjugase G2 (Ube2g2) via its G2 binding region.

PubMed ID: 21127063

DOI: 10.1074/jbc.m110.190785

PubMed ID: 21857022

Title: Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control.

PubMed ID: 21857022

DOI: 10.1074/jbc.m111.284794

PubMed ID: 22607976

Title: STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein.

PubMed ID: 22607976

DOI: 10.1016/j.molcel.2012.04.015

PubMed ID: 23223569

Title: Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes.

PubMed ID: 23223569

DOI: 10.1091/mbc.e12-07-0564

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16582478

Title: Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7).

PubMed ID: 16582478

DOI: 10.1107/s1744309106009006

Sequence Information:

Length: 165
Mass: 18566
Checksum: 74DEC732A79575E3
Sequence:

MAGTALKRLM AEYKQLTLNP PEGIVAGPMN EENFFEWEAL IMGPEDTCFE FGVFPAILSF 
PLDYPLSPPK MRFTCEMFHP NIYPDGRVCI SILHAPGDDP MGYESSAERW SPVQSVEKIL 
LSVVSMLAEP NDESGANVDA SKMWRDDREQ FYKIAKQIVQ KSLGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: UBE2G2

Associated with

Cells (max top 100)

Other Information

Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae UBC7 gene. PubMed ID: 9693041

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 21. PubMed ID: 10830953

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. PubMed ID: 20061386

Initial characterization of the human central proteome. PubMed ID: 21269460

Ancient ubiquitous protein 1 (AUP1) localizes to lipid droplets and binds the E2 ubiquitin conjugase G2 (Ube2g2) via its G2 binding region. PubMed ID: 21127063

Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control. PubMed ID: 21857022

STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein. PubMed ID: 22607976

Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes. PubMed ID: 23223569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7). PubMed ID: 16582478