Details for: UBE2G2

Gene ID: 7327

Symbol: UBE2G2

Ensembl ID: ENSG00000184787

Description: ubiquitin conjugating enzyme E2 G2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 308.0776
    Cell Significance Index: -47.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 183.8014
    Cell Significance Index: -46.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 122.6588
    Cell Significance Index: -57.9100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 115.8749
    Cell Significance Index: -47.0800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 104.8825
    Cell Significance Index: -53.9500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 49.4636
    Cell Significance Index: -47.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 42.8239
    Cell Significance Index: -52.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.0869
    Cell Significance Index: -53.8100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.4524
    Cell Significance Index: -44.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.6491
    Cell Significance Index: -53.8600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.2349
    Cell Significance Index: -22.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0493
    Cell Significance Index: 411.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.4660
    Cell Significance Index: 112.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4510
    Cell Significance Index: 143.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2509
    Cell Significance Index: 248.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1811
    Cell Significance Index: 423.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1109
    Cell Significance Index: 1003.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0262
    Cell Significance Index: 66.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9821
    Cell Significance Index: 106.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9514
    Cell Significance Index: 130.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9413
    Cell Significance Index: 56.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9359
    Cell Significance Index: 115.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9244
    Cell Significance Index: 150.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9053
    Cell Significance Index: 163.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8731
    Cell Significance Index: 24.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7905
    Cell Significance Index: 22.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7689
    Cell Significance Index: 48.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7199
    Cell Significance Index: 19.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6712
    Cell Significance Index: 25.4200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.6667
    Cell Significance Index: 11.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6644
    Cell Significance Index: 362.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6535
    Cell Significance Index: 28.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5908
    Cell Significance Index: 261.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5225
    Cell Significance Index: 24.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4035
    Cell Significance Index: 27.9100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4018
    Cell Significance Index: 4.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3951
    Cell Significance Index: 18.4200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3292
    Cell Significance Index: 227.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3228
    Cell Significance Index: 55.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3168
    Cell Significance Index: 22.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2437
    Cell Significance Index: 46.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2229
    Cell Significance Index: 11.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2228
    Cell Significance Index: 12.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1742
    Cell Significance Index: 10.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1170
    Cell Significance Index: 7.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0841
    Cell Significance Index: 38.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0809
    Cell Significance Index: 51.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0772
    Cell Significance Index: 145.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0748
    Cell Significance Index: 1.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0728
    Cell Significance Index: 9.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0727
    Cell Significance Index: 134.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0720
    Cell Significance Index: 1.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0621
    Cell Significance Index: 7.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0594
    Cell Significance Index: 91.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0524
    Cell Significance Index: 6.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0097
    Cell Significance Index: 13.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0082
    Cell Significance Index: 0.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0034
    Cell Significance Index: 0.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0127
    Cell Significance Index: -9.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0149
    Cell Significance Index: -9.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0159
    Cell Significance Index: -12.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0173
    Cell Significance Index: -12.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0298
    Cell Significance Index: -0.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0556
    Cell Significance Index: -31.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0706
    Cell Significance Index: -7.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0845
    Cell Significance Index: -9.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1145
    Cell Significance Index: -6.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1390
    Cell Significance Index: -29.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1401
    Cell Significance Index: -20.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1503
    Cell Significance Index: -11.2000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1599
    Cell Significance Index: -2.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1936
    Cell Significance Index: -55.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1995
    Cell Significance Index: -10.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2183
    Cell Significance Index: -4.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2328
    Cell Significance Index: -8.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2352
    Cell Significance Index: -27.4100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3043
    Cell Significance Index: -34.7400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3440
    Cell Significance Index: -9.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3854
    Cell Significance Index: -6.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4072
    Cell Significance Index: -42.4000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4451
    Cell Significance Index: -6.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4645
    Cell Significance Index: -21.0600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4878
    Cell Significance Index: -13.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5263
    Cell Significance Index: -12.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5319
    Cell Significance Index: -15.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5871
    Cell Significance Index: -46.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6164
    Cell Significance Index: -8.4100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6701
    Cell Significance Index: -16.0700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6793
    Cell Significance Index: -8.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7014
    Cell Significance Index: -12.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7692
    Cell Significance Index: -19.6500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7747
    Cell Significance Index: -20.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7852
    Cell Significance Index: -48.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7866
    Cell Significance Index: -25.2000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.9134
    Cell Significance Index: -7.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9550
    Cell Significance Index: -30.4200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9621
    Cell Significance Index: -20.4200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9633
    Cell Significance Index: -5.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.0036
    Cell Significance Index: -50.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0428
    Cell Significance Index: -34.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UBE2G2 is a small, highly conserved protein that belongs to the ubiquitin-conjugating enzyme family. It is characterized by its ability to catalyze the transfer of ubiquitin molecules to target proteins, forming a ubiquitin-protein conjugate. The enzyme is specifically involved in the K48-linked ubiquitination pathway, which is a key mechanism for protein degradation. UBE2G2 is highly expressed in various cell types, including immune cells, neurons, and muscle cells, highlighting its importance in maintaining cellular homeostasis and regulating immune responses. **Pathways and Functions:** UBE2G2 is involved in several key pathways, including: 1. **Adaptive Immune System:** UBE2G2 plays a crucial role in the regulation of immune responses by modulating the ubiquitination and degradation of immune-related proteins. 2. **Antigen Processing and Presentation:** UBE2G2 is involved in the processing and presentation of antigens to the immune system, facilitating the activation of immune cells. 3. **Protein Degradation:** UBE2G2 is a key component of the UPS, regulating protein turnover and maintaining protein homeostasis. 4. **Metabolism of Proteins:** UBE2G2 is involved in the regulation of protein metabolism, including the degradation of damaged or misfolded proteins. **Clinical Significance:** Dysregulation of UBE2G2 has been implicated in various diseases, including: 1. **Autoimmune Disorders:** UBE2G2 dysfunction has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** Aberrant UBE2G2 expression has been observed in various types of cancer, including breast and lung cancer. 3. **Neurodegenerative Diseases:** UBE2G2 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 4. **Muscular Dystrophy:** UBE2G2 dysfunction has been linked to muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. In conclusion, UBE2G2 is a critical regulator of protein degradation and immune response, with implications for various diseases. Further research is needed to fully elucidate the mechanisms by which UBE2G2 regulates protein turnover and immune responses, and to explore its potential as a therapeutic target for disease treatment.

Genular Protein ID: 649253390

Symbol: UB2G2_HUMAN

Name: Ubiquitin-conjugating enzyme E2 G2

UniProtKB Accession Codes:

P60604 A6NMQ7 A8K3L4 D3DSL7 P56554

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EC 1 EMBL 11 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9693041

Title: Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae UBC7 gene.

PubMed ID: 9693041

DOI: 10.1006/geno.1998.5263

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21127063

Title: Ancient ubiquitous protein 1 (AUP1) localizes to lipid droplets and binds the E2 ubiquitin conjugase G2 (Ube2g2) via its G2 binding region.

PubMed ID: 21127063

DOI: 10.1074/jbc.m110.190785

PubMed ID: 21857022

Title: Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control.

PubMed ID: 21857022

DOI: 10.1074/jbc.m111.284794

PubMed ID: 22607976

Title: STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein.

PubMed ID: 22607976

DOI: 10.1016/j.molcel.2012.04.015

PubMed ID: 23223569

Title: Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes.

PubMed ID: 23223569

DOI: 10.1091/mbc.e12-07-0564

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16582478

Title: Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7).

PubMed ID: 16582478

DOI: 10.1107/s1744309106009006

Sequence Information:

  • Length: 165
  • Mass: 18566
  • Checksum: 74DEC732A79575E3
  • Sequence:
    • MAGTALKRLM AEYKQLTLNP PEGIVAGPMN EENFFEWEAL IMGPEDTCFE FGVFPAILSF 
PLDYPLSPPK MRFTCEMFHP NIYPDGRVCI SILHAPGDDP MGYESSAERW SPVQSVEKIL 
LSVVSMLAEP NDESGANVDA SKMWRDDREQ FYKIAKQIVQ KSLGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.