Details for: UGCG

Gene ID: 7357

Symbol: UGCG

Ensembl ID: ENSG00000148154

Description: UDP-glucose ceramide glucosyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 278.0863
    Cell Significance Index: -43.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 188.9267
    Cell Significance Index: -47.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 103.3336
    Cell Significance Index: -41.9800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 74.5952
    Cell Significance Index: -50.0600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.0328
    Cell Significance Index: -42.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.3266
    Cell Significance Index: -47.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.0133
    Cell Significance Index: -48.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.0627
    Cell Significance Index: -47.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.8615
    Cell Significance Index: -25.9600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.6915
    Cell Significance Index: -35.9100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.2662
    Cell Significance Index: 26.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.0487
    Cell Significance Index: 108.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.4276
    Cell Significance Index: 98.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.9241
    Cell Significance Index: 151.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.6242
    Cell Significance Index: 3058.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.4519
    Cell Significance Index: 108.2100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.2998
    Cell Significance Index: 22.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2986
    Cell Significance Index: 260.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2435
    Cell Significance Index: 152.9100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.0262
    Cell Significance Index: 14.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9605
    Cell Significance Index: 524.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9334
    Cell Significance Index: 101.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9287
    Cell Significance Index: 167.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9113
    Cell Significance Index: 148.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7631
    Cell Significance Index: 45.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6479
    Cell Significance Index: 232.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5820
    Cell Significance Index: 79.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5777
    Cell Significance Index: 27.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5214
    Cell Significance Index: 103.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4983
    Cell Significance Index: 49.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4305
    Cell Significance Index: 12.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4113
    Cell Significance Index: 25.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3925
    Cell Significance Index: 11.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3782
    Cell Significance Index: 44.6100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.3691
    Cell Significance Index: 2.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3575
    Cell Significance Index: 247.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3452
    Cell Significance Index: 8.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3374
    Cell Significance Index: 7.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3069
    Cell Significance Index: 13.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2974
    Cell Significance Index: 131.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2864
    Cell Significance Index: 14.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1969
    Cell Significance Index: 37.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1951
    Cell Significance Index: 25.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1467
    Cell Significance Index: 93.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1312
    Cell Significance Index: 10.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1088
    Cell Significance Index: 200.6300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0959
    Cell Significance Index: 1.0900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0912
    Cell Significance Index: 0.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0495
    Cell Significance Index: 76.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0489
    Cell Significance Index: 1.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0348
    Cell Significance Index: 5.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0201
    Cell Significance Index: 9.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0058
    Cell Significance Index: -7.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0120
    Cell Significance Index: -0.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0143
    Cell Significance Index: -0.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0162
    Cell Significance Index: -1.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0237
    Cell Significance Index: -17.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0341
    Cell Significance Index: -24.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0400
    Cell Significance Index: -30.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0546
    Cell Significance Index: -34.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0615
    Cell Significance Index: -34.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0645
    Cell Significance Index: -4.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0672
    Cell Significance Index: -8.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0723
    Cell Significance Index: -1.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0768
    Cell Significance Index: -7.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0964
    Cell Significance Index: -11.0400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1018
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1325
    Cell Significance Index: -15.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1370
    Cell Significance Index: -39.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1408
    Cell Significance Index: -20.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1611
    Cell Significance Index: -33.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1777
    Cell Significance Index: -7.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2314
    Cell Significance Index: -26.9700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2385
    Cell Significance Index: -2.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2672
    Cell Significance Index: -5.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2850
    Cell Significance Index: -17.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2884
    Cell Significance Index: -10.9200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.2925
    Cell Significance Index: -1.8100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2995
    Cell Significance Index: -3.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3119
    Cell Significance Index: -10.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3342
    Cell Significance Index: -15.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3399
    Cell Significance Index: -35.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3596
    Cell Significance Index: -23.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4170
    Cell Significance Index: -5.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4353
    Cell Significance Index: -10.4400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4636
    Cell Significance Index: -3.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5050
    Cell Significance Index: -14.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5439
    Cell Significance Index: -17.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5460
    Cell Significance Index: -12.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5640
    Cell Significance Index: -44.6700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5700
    Cell Significance Index: -11.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6650
    Cell Significance Index: -17.4900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7043
    Cell Significance Index: -12.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7926
    Cell Significance Index: -13.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8058
    Cell Significance Index: -28.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8075
    Cell Significance Index: -49.5100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8356
    Cell Significance Index: -24.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8906
    Cell Significance Index: -45.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8948
    Cell Significance Index: -18.7300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.9013
    Cell Significance Index: -5.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cell-specific expression**: UGCG is significantly expressed in epithelial cells, endothelial cells, and keratinocytes, suggesting its role in epithelial cell differentiation and development. 2. **Enzymatic activity**: The encoded protein, CEGT_HUMAN (GLCT-1), possesses glucosyltransferase activity, catalyzing the transfer of glucose molecules from UDP-glucose to ceramide. 3. **Glycosphingolipid biosynthesis**: UGCG is involved in the biosynthesis of glycosphingolipids, which are essential components of cellular membranes and play a significant role in various physiological processes. 4. **Signal transduction regulation**: The UGCG gene is involved in the regulation of signal transduction pathways, including the leptin-mediated signaling pathway, which is crucial for energy balance and metabolism. **Pathways and Functions** 1. **Cell differentiation**: UGCG plays a crucial role in epithelial cell differentiation, particularly in the development of the epidermis and the establishment of the skin barrier. 2. **Glycosphingolipid biosynthesis**: The UGCG gene is involved in the biosynthesis of glycosphingolipids, which are essential components of cellular membranes and play a significant role in various physiological processes. 3. **Leptin-mediated signaling pathway**: The UGCG gene is involved in the regulation of the leptin-mediated signaling pathway, which is crucial for energy balance and metabolism. 4. **Golgi membrane**: UGCG is localized to the Golgi membrane, where it can interact with other proteins and lipids to regulate glycosphingolipid biosynthesis. **Clinical Significance** 1. **Epidermal disorders**: Mutations in the UGCG gene have been associated with epidermal disorders, such as ichthyosis and epidermolysis bullosa simplex. 2. **Cancer**: Alterations in glycosphingolipid biosynthesis, mediated by UGCG, have been implicated in cancer development and progression. 3. **Neurological disorders**: UGCG has been implicated in the regulation of neuronal development and function, and alterations in glycosphingolipid biosynthesis have been associated with neurological disorders, such as Alzheimer's disease. 4. **Metabolic disorders**: The UGCG gene is involved in the regulation of signal transduction pathways, including the leptin-mediated signaling pathway, which is crucial for energy balance and metabolism. Alterations in UGCG expression have been associated with metabolic disorders, such as obesity and insulin resistance. In conclusion, the UGCG gene plays a crucial role in epithelial cell differentiation, lipid metabolism, and the regulation of signal transduction pathways. Its clinical significance extends to various diseases, including epidermal disorders, cancer, neurological disorders, and metabolic disorders. Further research is needed to fully elucidate the functions of UGCG and its role in human disease.

Genular Protein ID: 415759383

Symbol: CEGT_HUMAN

Name: GLCT-1

UniProtKB Accession Codes:

Q16739 Q5T258

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 16 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 6 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 2 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8643456

Title: Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis.

PubMed ID: 8643456

DOI: 10.1073/pnas.93.10.4638

PubMed ID: 8901638

Title:

PubMed ID: 8901638

DOI: 10.1073/pnas.93.22.12654

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1532799

Title: Glucosylceramide is synthesized at the cytosolic surface of various Golgi subfractions.

PubMed ID: 1532799

DOI: 10.1083/jcb.117.2.259

PubMed ID: 9545298

Title: Up-regulation of glucosylceramide synthase expression and activity during human keratinocyte differentiation.

PubMed ID: 9545298

DOI: 10.1074/jbc.273.16.9651

PubMed ID: 12873973

Title: Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells.

PubMed ID: 12873973

PubMed ID: 33361282

Title: Human glucocerebrosidase mediates formation of xylosyl-cholesterol by beta-xylosidase and transxylosidase reactions.

PubMed ID: 33361282

DOI: 10.1194/jlr.ra120001043

Sequence Information:

  • Length: 394
  • Mass: 44854
  • Checksum: 3B998569F8A96449
  • Sequence:
    • MALLDLALEG MAVFGFVLFL VLWLMHFMAI IYTRLHLNKK ATDKQPYSKL PGVSLLKPLK 
GVDPNLINNL ETFFELDYPK YEVLLCVQDH DDPAIDVCKK LLGKYPNVDA RLFIGGKKVG 
INPKINNLMP GYEVAKYDLI WICDSGIRVI PDTLTDMVNQ MTEKVGLVHG LPYVADRQGF 
AATLEQVYFG TSHPRYYISA NVTGFKCVTG MSCLMRKDVL DQAGGLIAFA QYIAEDYFMA 
KAIADRGWRF AMSTQVAMQN SGSYSISQFQ SRMIRWTKLR INMLPATIIC EPISECFVAS 
LIIGWAAHHV FRWDIMVFFM CHCLAWFIFD YIQLRGVQGG TLCFSKLDYA VAWFIRESMT 
IYIFLSALWD PTISWRTGRY RLRCGGTAEE ILDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.